Christopher Shoemaker

Christopher Shoemaker is an Associate Professor in the Department of Biochemistry and Cell Biology at the Geisel School of Medicine, Dartmouth College. His research focuses on molecular mechanisms of autophagy, an intracellular degradation and recycling pathway critical for cellular health.

Dr. Shoemaker's research interests center on autophagy, the cellular process that eliminates unwanted structures such as damaged organelles and protein aggregates. His work investigates how defects in autophagy contribute to human diseases including neurodegeneration, cancer, cardiovascular disease, and aging. Using a multidisciplinary approach involving CRISPR-based genetic screening, flow cytometry, quantitative microscopy, and biochemical analysis, his lab aims to understand autophagy mechanisms to inform therapeutic approaches for autophagy-related diseases. His recent publications demonstrate significant contributions to understanding LC3-interacting regions and protein interaction hubs in regulating cellular degradation pathways.

Dr. Shoemaker leads an active research laboratory that emphasizes collaboration, respect, and scientific integrity. His lab creed emphasizes valuing diverse perspectives, building a collaborative culture, and upholding high standards of professionalism. The lab follows a Scientist's Oath that commits to scientific integrity, respect for the field, and recognition that scientific work is for the advancement of knowledge and public benefit. The lab also emphasizes work-life balance, recognizing that productivity is more important than hours worked while acknowledging that research sometimes requires flexibility around standard work hours.