Özgün Gökce

Özgün Gökce is a Professor at the Medical Faculty of the University of Bonn and affiliated with the German Center for Neurodegenerative Diseases (DZNE) in Bonn, Germany. His research group operates at the intersection of quantitative genomics and neuroscience, developing cutting-edge methodologies to investigate age-related brain disorders.

His research focuses on decoding cellular aging responses and molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders. The lab integrates multi-disciplinary approaches including single-cell RNA sequencing, spatial transcriptomics, electron microscopy, and machine learning algorithms to achieve holistic understanding of complex biological processes in brain aging and disease.

Recent publications reveal strong trends in applying multi-omics techniques to study lipid metabolism dysregulation in neurodegenerative contexts (particularly C9orf72-related ALS/FTD) and exploring cardiovascular-neurodegenerative disease connections through chemokine biology. The work bridges neuroscience, genomics, and computational biology to address fundamental questions in brain pathology.

The Gökce Lab functions as a synergistic multi-disciplinary team at the forefront of quantitative neuroscience, utilizing advanced genomic technologies within the Bonn Center of Immunology ecosystem to tackle critical challenges in age-related brain disorders.