- Molecular Biology
- RNA Biology
- Ribosome Biogenesis
- +۱۲ مورد دیگر
Markus Bohnsack is a Professor of Molecular Biology at the University Medical Center Göttingen, part of the University of Göttingen. He leads a research group focused on RNA-protein complexes (RNPs), ribosome biogenesis, and RNA modifications. He has held leadership roles as Speaker of the PhD program 'Molecular Biology of Cells' since 2014 and Speaker of the Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences (GGNB) since 2019. 2005: Dr. rer. nat. (PhD), Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg 2006–2008: Postdoctoral Fellow, University of Edinburgh, UK 2008–2012: Group Leader, Goethe University, Frankfurt 2009–2012: Adjunct Investigator, Cluster of Excellence Frankfurt Since 2012: Professor of Molecular Biology, University Medical Center Göttingen His research centers on the biogenesis, dynamics, and function of RNA-protein complexes in yeast and mammalian cells. He employs genome-wide techniques like CRAC and proteomics to study protein-RNA and protein-protein interactions. A major focus is ribosome biogenesis, particularly the roles of RNA helicases and methyltransferases in driving structural transitions and maturation. His work also investigates how RNA modifications regulate gene expression and how defects in these processes lead to diseases like ribosomopathies. He explores the cross-regulation of RNA metabolic pathways by multifunctional enzymes. The recent publications highlight a strong trend in understanding the molecular mechanisms of ribosome assembly, RNA helicase function, and RNA modifications. These works span from fundamental enzymatic mechanisms to disease implications, with recurring themes in structural dynamics, regulatory networks, and translational control. Techniques such as CRAC, mass spectrometry, and functional assays are consistently used across studies. Markus Bohnsack has not been mentioned with any scientific awards in the provided text. He advises graduate students through the GGNB and IMPRS programs and leads funded research projects on RNP dynamics and ribosome biogenesis. His group investigates how ribosome production is modulated during development and in disease contexts. While specific grants are not listed, the depth and continuity of research suggest sustained funding from national and institutional sources. He mentors students in interdisciplinary approaches combining molecular biology, biochemistry, and bioinformatics. His laboratory, the Molecular Biology Research Group (AG M. Bohnsack), is based at the Department of Molecular Biology, University Medical Center Göttingen. The team uses integrative methods including CRAC, proteomics, and functional assays to study RNPs. They are actively involved in training through PhD programs and collaborate within the GGNB network, focusing on biomolecules, molecular medicine, and cellular dynamics.
