جستجوی استاد راهنمای دانشگاهی

Nianli Sangمشاهده پروفایل

دانشیار

• Cellular Response to Nutrient Stress
• Hypoxia Signaling
• Cancer Biology
• +۵ مورد دیگر

Nianli Sang, PhD, is an Associate Professor in the Department of Biology at Drexel University. Her research focuses on cellular responses to nutrient insufficiency in tumor microenvironments and ischemic conditions, with emphasis on hypoxia-inducible factor 1 (HIF-1α), ER stress pathways, and metabolic reprogramming. She leads the Sang Lab located in PISB 401 H2, investigating mechanisms of tumor migration, metastasis, and chemotherapy resistance. Education: BMed (Fudan University), MSurgery (Zhongshan Hospital), PhD (Thomas Jefferson University), Postdocs (University of Pennsylvania, Thomas Jefferson University). Research interests include nutrient sensing systems, oncogenic signaling, and therapeutic targets for nutrient stress. She secured a $1.56M NIH/NCI R01 grant (2008–2013) as PI for studying HIF-1 repression mechanisms. Her work bridges basic science and translational applications in cancer biology and gene therapy. Publications span over 40 peer-reviewed articles, covering HIF regulation, AAV vector engineering, and metabolic pathways in cancer. Her lab explores interdisciplinary approaches to understand how cells adapt to low oxygen, glucose, and glutamine levels, with implications for cancer therapy and ischemic diseases.

• Tissue Engineering
• Osteochondral Repair
• Inflammation Modulation

Dr. Tom Hodgkinson is a Research Lecturer in Anatomy and Regenerative Medicine at RCSI, focusing on regenerative strategies for osteochondral repair and osteoarthritis treatment. His research develops biomaterial-based nucleic acid delivery systems to control inflammation and promote tissue regeneration. Current projects explore mechanical regulation of cell behavior and epigenetic reprogramming for cartilage rejuvenation. Research interests include biomaterial-mediated gene delivery, cellular mechanobiology, and metabolic regulation in age-related tissue degeneration. His work spans fundamental biomaterial design to translational applications for cartilage and bone repair, employing 3D bioprinting, nanovibration platforms, and siRNA-activated scaffolds. Publication analysis shows progressive development of biomaterial systems for joint repair, from early growth factor delivery work to advanced gene-activated scaffolds. Recent innovations include albumin nanoparticles for intra-articular drug delivery and 3D printable collagen-hyaluronic acid hydrogels. Major grants include Horizon Europe and Science Foundation Ireland funding for inflammation-responsive gene circuits and cartilage regeneration strategies. Professional memberships include Orthopaedic Research Society and Controlled Release Society. Laboratory research focuses on developing adaptable biomaterial platforms for diverse tissue environments, with particular emphasis on overcoming inflammation-mediated regeneration barriers in osteoarthritis.

Volker Patzelمشاهده پروفایل

مدرس ارشد

• RNA Technologies
• Gene Expression Regulation
• Gene Therapy
• +۴ مورد دیگر

Volker Patzel is a Senior Lecturer at the Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore. His research focuses on RNA technologies for gene expression modulation, including antisense, RNA interference, and CRISPR/Cas systems. He leads projects in computational RNA design and delivery strategies for therapeutic applications. Specializes in RNA structure optimization Develops delivery systems for nucleic acids Pioneers computational platforms for RNA design Research Highlights: The team works on three major pillars: in silico RNA design algorithms, in vitro synthesis of functional RNA molecules, and in vivo delivery optimization using DNA vectors, peptides, and polymer capsules. Current projects target HIV-1, HPV-16, and disease-related cellular genes. Delivery Innovation: Key contributions include novel delivery strategies like dumbbell-shaped DNA vectors, cell-penetrating peptides, and micrometer-scale polymer capsules enabling RNA delivery into stem cells for gene therapy and vaccination. Scientific Recognition: 2 patent applications in nucleic acid delivery Published in high-impact journals like Nature Biotechnology and Nucleic Acids Research

Francesco Sansoneمشاهده پروفایل

استاد

• Organic Chemistry
• Supramolecular Chemistry
• Materials Science
• +۶ مورد دیگر

Prof. Francesco Sansone is a Full Professor of Organic Chemistry at the University of Parma's Department of Chemical, Life and Environmental Sustainability Sciences. He earned his PhD from the University of Parma in 1998 and held roles as a university researcher and Associate Professor before attaining his current rank in 2017. His research focuses on calixarene-based molecules for biomacromolecule recognition, bio-nanotechnology applications, and sustainable materials. He has led or collaborated on numerous national and international projects, including NATO-funded initiatives and EU programs. His work spans environmental remediation, drug delivery systems, and photovoltaic materials. Prof. Sansone has published over 90 peer-reviewed articles, achieving an H-index of 33 (Scopus, 2018). He also holds teaching roles in Bio-organic Chemistry and Organic Chemistry of Biomolecules, and actively contributes to university governance, including orientation programs for incoming students and scientific outreach. His lab engages in interdisciplinary collaborations, combining synthetic chemistry with biochemistry, materials science, and nanotechnology. Education: PhD in Organic Chemistry, University of Parma (1998) Master's in Chemistry, University of Parma (1993) Research at Twente University (1992) and University of Ferrara (1995) Research Interests: Calixarene-functionalized receptors, nano-biomaterials, enzyme mimics, environmental detoxification, and lipid-based biofuels. His work integrates synthetic chemistry with applications in medicine, energy, and sustainability. Grants & Projects: Principal Investigator: €120k project on non-viral gene therapy vectors (2007-2010) Co-Director: NATO-funded €368k explosives detection project (2018-2021) Key roles in EU projects like ACSEPT and SACSESS (nuclear waste treatment) ENI-funded research on lubricant additives (€426k total) Teaching: Leads courses in Bio-organic Chemistry, Organic Chemistry of Biomolecules, and Organic Chemistry for Biotechnology at both undergraduate and graduate levels. Awards: Best Poster Awards at three international congresses, H-index 33 (2018). Labs & Collaborations: Active in supramolecular chemistry, nanomaterials, and interdisciplinary teams across Europe. Lab activities include synthesis of calixarene-based systems, drug delivery carriers, and environmental sensors.

Brittany Allen-Petersenمشاهده پروفایل

استادیار

• Cancer Biology
• Signal Transduction
• Therapeutics
• +۶ مورد دیگر

Brittany Allen-Petersen is an Assistant Professor in the Department of Biological Sciences at Purdue University, affiliated with the Purdue Institute for Cancer Research and the College of Science. Her lab focuses on understanding the role of Protein Phosphatase 2A (PP2A) in tumor initiation, progression, and therapeutic resistance, particularly in pancreatic and lung cancers. Research areas include PP2A-dependent signaling pathways in cellular plasticity, metabolic plasticity in nutrient-stressed cancer cells, and PP2A regulation of epithelial-mesenchymal transition (EMT) during metastasis. Affiliations: Purdue Institute for Cancer Research, Indiana University Pancreatic Cancer Working Group Education: PhD in Cell and Developmental Biology (University of Colorado Anschutz), BS in Molecular, Cellular, and Developmental Biology (University of Michigan) Postdoctoral Training: Oregon Health & Science University Her work employs genetic mouse models, 3D cell culture systems, and molecular biology techniques. Key findings include PP2A’s role in suppressing oncogenic pathways and its context-dependent oncogenic feedback loops via EGFR signaling. Awards include the PanCAN Career Development Award and Concern Foundation Grant. Lab members include graduate students Claire Pfeffer, Garima Baral, and undergraduates Roe Chianis, among others. Recent projects include developing bioprinted tumor models and exploring PP2A activators as therapeutic strategies. Collaborations extend to institutions like the Medical College of Wisconsin and Indiana University.

Gary Yellenمشاهده پروفایل

استاد

• Neuronal Metabolism
• Ion Channels
• Epilepsy Mechanisms
• +۳ مورد دیگر

Dr. Gary Yellen is the Dr. George Packer Berry Professor of Neurobiology at Harvard Medical School. His research focuses on neuronal metabolism and ion channel physiology, particularly the interplay between cellular energy metabolism and neuronal excitability. He investigates mechanisms underlying the anticonvulsant effects of the ketogenic diet, KATP channel function, and develops fluorescent biosensors to monitor metabolites in live cells. His lab uses electrophysiology, mass spectrometry imaging (Slice-MSI), and genetically encoded sensors such as Perceval (ATP/ADP ratio), Peredox (NADH/NAD+), and LiLac (lactate) to explore metabolic dynamics in brain tissue. Collaborations involve Prof. Nika Danial (DFCI) on BAD protein-mediated seizure resistance and Prof. Nathalie Agar (BWH) on MALDI-MSI brain slice analysis. Research interests include metabolic seizure resistance, metabolic compartmentation, and ion channel biophysics. Key projects address how metabolic shifts (e.g., ketone body utilization) modulate KATP channel activity to suppress seizures, and how neuronal glycolysis responds to stimulation. Experimental tools include engineered mouse models, single-channel recording, and advanced imaging techniques like two-photon FLIM microscopy. Articles highlight advancements in biosensor design, metabolic pathway mapping, and the mechanistic basis of epilepsy therapies. Ongoing work aims to translate metabolic insights into improved treatments for neurological disorders.

Michael Greenbergمشاهده پروفایل

استاد

• Neurobiology
• Gene Expression Regulation
• Neurodevelopmental Disorders
• +۵ مورد دیگر

Michael Greenberg is the Nathan Marsh Pusey Professor of Neurobiology at Harvard Medical School and Professor of Neurology at Boston Children's Hospital. He directs the Hock E. Tan and K. Lisa Yang Center for Autism Research at Harvard Medical School. His work focuses on how neuronal activity regulates gene expression and neural circuit development, with particular emphasis on autism spectrum disorders and Rett syndrome. His research employs molecular, genetic, and genomic approaches to study activity-dependent transcriptional programs and their clinical relevance in neurological conditions. Key research interests include: Activity-driven gene regulation in neurons Role of enhancer elements in neuronal plasticity Human-specific neurobiological mechanisms Pathways underlying Rett syndrome and autism Neurotrophin signaling and calcium-dependent pathways Recent studies highlight his lab's exploration of sensory-driven circuit development, evolutionary aspects of gene regulation in the primate brain, and drug discovery for neurodevelopmental disorders. The lab's work often integrates advanced genomic technologies, viral vector engineering, and animal models to dissect molecular mechanisms in vivo. Publications emphasize themes such as chromatin remodeling via the BAF complex, thyroid hormone's role in cortical metabolism, and microglial contributions to neural connectivity. His research has identified critical pathways linking neuronal activity to disease states, with translational potential in therapies for autism and related disorders.

• Gene Therapy
• Diabetes Mellitus
• Molecular Biology
• +۵ مورد دیگر

Prof. Ann Simpson is a Professor of Biochemistry at the University of Technology Sydney (UTS), affiliated with the School of Life Sciences and the Centre for Health Technologies. She holds leadership roles as Head of the Department of Medical and Molecular Biosciences and Director of the Research Centre for Health Technologies since 2002 and 2006, respectively. Her academic journey includes a BSc (Hons) and PhD in Veterinary Science from the University of Sydney (1986). Her research focuses on gene therapy for Type 1 diabetes, particularly engineering insulin-producing cells (e.g., Melligen cells) and developing viral vector-based therapies. Collaborations span institutions like Cambridge University and commercial entities like Austrianova Singapore. She has secured funding from NHMRC, ARC, JDRF, and others, leading to over 140 research outputs. Teaching responsibilities include coordinating Medical and Diagnostic Biochemistry (91344) and Advanced Medical Biochemistry (91193). Prof. Simpson has advised postgraduate students and contributed to grants totaling millions. Her scientific awards include the Australian Diabetes Society Skip Martin Award (2013). Active in professional societies, she is a member of the Australasian Gene Therapy Society and the Australian Diabetes Society. Her lab includes a Research Fellow, Assistant, and students, with projects on insulin secretion mechanisms, microRNA regulation, and liver cell engineering. Notable achievements include reversing diabetes in animal models and advancing clinical trials for gene therapy applications.

Bradley Stevensonمشاهده پروفایل

استاد پژوهش

• Microbial Ecology
• Biogeochemistry
• Subsurface Microbiology
• +۲ مورد دیگر

Dr. Bradley Stevenson is a Research Associate Professor in the Department of Earth, Environmental, and Planetary Sciences at Northwestern University. His research investigates microbial ecosystems in extreme subsurface environments, with applications to biogeochemistry, astrobiology, and public health surveillance. Current projects span: Deep subsurface microbial adaptations Wastewater-based epidemiology Biogeochemical cycling in cave systems Planetary analog environments Anthropogenic impacts on subsurface ecology Publications demonstrate dual focus on fundamental subsurface microbiology and applied environmental monitoring. Recent work includes wastewater surveillance for pathogens like SARS-CoV-2 and West Nile virus, deep biosphere characterization in geological formations, and astrobiological investigations in analog environments. Methodological approaches include stable isotope analysis, metagenomics, geochemical characterization, and development of novel surveillance techniques. Field sites encompass Mammoth Cave systems, Colorado Plateau aquifers, and urban wastewater infrastructure. Research contributes to understanding microbial life in energy-limited environments, planetary habitability models, and public health monitoring frameworks through environmental sampling and molecular analysis.

Min Jee Jangمشاهده پروفایل

استادیار

• Neural Engineering
• Cell and molecular engineering
• Molecular imaging
• +۴ مورد دیگر

Min Jee Jang is an Assistant Professor in the Department of Bioengineering at the University of Illinois Urbana-Champaign (UIUC), affiliated with the Carl R. Woese Institute for Genomic Biology and the Neuroscience Program. She holds a B.S., M.S., and Ph.D. in Bio and Brain Engineering from KAIST (2009–2015). Her research focuses on developing advanced gene delivery technologies for studying and treating neurological disorders, leveraging viral vector engineering and spatial transcriptomics. Jang is also the Chief Science Officer at Genixcure (South Korea) and actively contributes to professional societies like the Biomedical Engineering Society and Society for Neuroscience. Her research interests include targeted genetic access to brain cells, overcoming limitations in cell-type specificity and temporal resolution. Her lab integrates viral vector design, spatial omics, and computational methods to understand brain cell dynamics and develop programmable gene delivery systems. Key achievements include pioneering systemic AAV vectors for primate brain gene transfer and spatial transcriptomics profiling of viral tropism. Notable awards include the NARSAD Young Investigator Award (2021–2023) and Caltech Postdoctoral Fellowship (2018–2020). Jang has presented widely, including seminars at Seoul National University, Stanford, and Brown. Her lab at UIUC, established in 2024, recruits students/postdocs passionate about translational neuroengineering and genetic medicine.

• Non-coding RNA research
• Gene expression regulation
• CRISPR/Cas9 technology
• +۳ مورد دیگر

Professor Gyorgy Hutvagner is a leading researcher in non-coding RNA and gene regulation at the University of Technology Sydney (UTS). He holds a Professorship in the School of Biomedical Engineering within the Faculty of Engineering and Information Technology. His career includes postdoctoral training in The Netherlands and the U.S., followed by establishing his research group in Dundee supported by Wellcome Trust and European grants. In 2011, he joined UTS and received an ARC Future Fellowship. Education: MSc in Biotechnology (Hungary), PhD in Biology (Hungary). Research focuses on miRNA pathways, CRISPR/Cas9 applications, and bioinformatics-driven genomic analysis. Key projects include developing AGO2-based cancer biomarkers and investigating viral codon fitness using machine learning. Recent work emphasizes tumor heterogeneity studies and CRISPR delivery challenges. He has secured grants such as the AIMS PhD Research Seeding Grant (2023-2024), Medtronic Australia grants (2022-2025), and ARC Discovery Projects (2018-2022). Awards include the prestigious ARC Future Fellowship and Wellcome Trust Career Development Fellowship. Supervision includes Masters, Honours, and PhD students in capstone projects and genomics research. Active in organizing conferences like the 2015 AGTA and Australia-Japan RNA meetings. Teaches courses on biomedical engineering fundamentals and regulatory genomics.

• Cardiovascular Medicine
• Inflammation Biology
• Immunology
• +۴ مورد دیگر

Shoumo Bhattacharya is a Professor of Cardiovascular Medicine at the University of Oxford, affiliated with the Radcliffe Department of Medicine and the Wellcome Trust Centre for Human Genetics. He is also an Honorary Consultant Cardiologist. His research focuses on developing anti-inflammatory peptide therapeutics derived from tick saliva (evasins) to combat inflammatory cardiovascular diseases such as atherosclerosis and myocarditis. He leads the Bhattacharya Group, which explores chemokine-driven inflammation and translational drug development. Education: MBBS from All India Institute of Medical Sciences (New Delhi), cardiology training at Northwick Park and Hammersmith Hospitals (London), and postdoctoral fellowships at the MRC, Dana-Farber Cancer Institute, and Wellcome Trust. He holds prestigious awards including the BHF Chair (2009) and Fellowship in the Academy of Medical Sciences (2006). Research interests span molecular cardiology, chemokine biology, and translational medicine. Key innovations include engineering evasins to neutralize disease-relevant chemokine networks, with applications in myocardial fibrosis and post-infarction injury. His lab employs cutting-edge techniques like phage display, computational modeling, and genetic engineering. Scientific contributions include over 30 peer-reviewed publications, with recent work emphasizing combinatorial mutagenesis of anti-inflammatory peptides and targeted drug delivery systems. Awards highlight his impact in cardiovascular research, including the Graham Bull Prize (2005). Collaborations include joint supervision with Prof. Gillian Douglas, focusing on atherosclerosis inflammation. He mentors students in molecular biology, protein chemistry, and cardiovascular model systems, emphasizing translational impact. Labs/Teams: Bhattacharya Group at the Wellcome Trust Centre for Human Genetics collaborates with the Douglas Lab, leveraging BHF-funded program grants to advance cardiovascular therapies. Training opportunities include DPhil courses in molecular medicine and interdisciplinary skill development.

• Gene Therapy
• Molecular Therapy
• Respiratory Diseases
• +۵ مورد دیگر

Stephen Hyde is a Professor of Molecular Therapy at the Radcliffe Department of Medicine, University of Oxford , and Co-Director of the Gill and Hyde Group: Gene Medicine Group . His research focuses on developing gene therapy technologies for respiratory diseases, particularly cystic fibrosis. He pioneered the use of gene transfer to correct cystic fibrosis defects in transgenic mice, leading to multiple clinical trials, including a phase IIb study showing improved lung function in patients. Hyde is a founding Principal Investigator of the UK Cystic Fibrosis Gene Therapy Consortium , a collaborative initiative involving Oxford, Edinburgh, and Imperial College London. His expertise includes viral/non-viral vector design, aerosol delivery systems, and GMP-compliant production. He advises UK health authorities on gene therapy safety and edits journals like Journal of Gene Medicine and Nature Scientific Reports . Current Research: CpG-free non-viral formulations, lentiviral vector engineering, and CRISPR/Cas9 applications. Recent work includes a first-in-human lentiviral trial and studies on SARS-CoV-2 immune responses. Key Collaborations: Department of Health’s Gene Therapy Advisory Committee, Committee on the Safety of Medicines.

Thomas Meadeمشاهده پروفایل

استاد

• Molecular Imaging
• Theranostics
• Inorganic Coordination Chemistry
• +۵ مورد دیگر

Thomas J. Meade is the Eileen M. Foell Professor of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology at Northwestern University. He also serves as Director of the Center for Advanced Molecular Imaging. His research focuses on inorganic coordination chemistry applied to molecular imaging, theranostics, and electronic biosensors, with emphasis on transition metal complexes for MRI contrast agents and drug delivery systems. The Meade Lab develops advanced imaging probes for applications in cancer, neurodegeneration, and regenerative medicine. Key recent work includes self-immolative probes for β-galactosidase imaging and Gd(III)-Pt(IV) theranostic agents. Research interests span: Molecular imaging of gene expression and intracellular messengers Transition metal enzyme inhibitors Electronic biosensors for DNA/protein detection Theranostic nanoparticles for combined therapy and imaging Bioresponsive MR probes for real-time tracking Current projects emphasize: Senescence detection in osteoarthritis AAV gene therapy monitoring Targeted imaging of prostate cancer (PSMA) Nanoparticle-based MRI contrast agents Lab infrastructure includes facilities for organic/inorganic synthesis, X-ray crystallography, cell culture, and advanced imaging techniques. Group members engage in interdisciplinary collaborations across chemistry, engineering, and medicine.

Kichoon Leeمشاهده پروفایل

استاد

• Functional Genomics
• Bioinformatics
• Adipose Development
• +۳ مورد دیگر

Kichoon Lee is a Professor in the Department of Animal Sciences at The Ohio State University , part of the College of Food, Agricultural, and Environmental Sciences (CFAES) . His research focuses on functional genomics, bioinformatics, and CRISPR gene-editing in poultry to enhance muscle growth and reduce fat content. He holds a Postdoctoral degree from the University of California, Berkeley, and a Ph.D. and M.S. from the University of Georgia. Research interests include adipose and muscle development, with breakthroughs in generating genome-edited poultry lines (quail, chickens, ducks) using CRISPR/Cas9 adenoviral delivery systems. Key targets include mutations in the myostatin (MSTN) and melanophilin (MLPH) genes to improve feed efficiency, eggshell quality, and resistance to viral infections. Recent articles highlight studies on genomic imprinting (e.g., MIMT1 lncRNA , ZNF791 ), adipogenesis regulation, and CRISPR applications. His work bridges basic science and industrial applications, addressing challenges in livestock productivity and health. Advising: Madeline Karolak (Ph.D. student). Lab focus: Avian genomics, gene-editing technologies, and poultry biotechnology.