جست‌وجوی استاد و پژوهشگر

Elizabeth Lipkeمشاهده پروفایل

استاد

• Tissue Engineering
• Cancer Research
• Cardiac Tissue Engineering
• +۵ مورد دیگر

Dr. Elizabeth Lipke is the Mary and John H. Sanders Professor of Chemical Engineering at Auburn University’s Samuel Ginn College of Engineering. Her lab focuses on tissue engineering, particularly in cancer and cardiovascular systems, with a focus on 3D in vitro models for drug screening and disease mechanisms. She leads interdisciplinary research combining biomaterials, microfluidics, and stem cell technologies to model complex biological systems. Education & Affiliations: PhD in Chemical Engineering (assumed based on role) Director of the Lipke Lab at Auburn University Collaborator with Dr. Arnold (cancer biology) and Dr. Mistriotis (biomedical engineering) Research Interests: Engineered cancer models to study obesity-related colorectal cancer progression Cardiac tissue engineering using pluripotent stem cells Microfluidic platforms for scalable production of hydrogel microspheres Drug efficacy testing in vascularized tumor models Awards & Recognition: 2024 AIMBE College of Fellows Inductee (top 2% in medical/biological engineering) NSF Grant ($621,934) for cardiac tissue manufacturing research (2018) Alabama Launchpad $25,000 award for Vivosphere technology (2023) Lab Highlights: Developed tumor-mimetic microvascular platforms for anti-cancer drug screening Engineered insulin-sensitive/insulin-resistant colorectal cancer models Pioneered scalable production of cardiac tissue microspheres from hiPSCs Grants & Funding: NSF RECODE Grant (2021) LAUNCH Innovation Grant (2023) Labs/Teams: Lipke Lab at Auburn University Collaborations with Arnold Lab (cancer biology) and Mistriotis Lab (biomedical engineering)

Andrew Braunمشاهده پروفایل

استاد

• KCa Channels
• Nitric Oxide
• Calcium Signaling
• +۷ مورد دیگر

Andrew Braun is a Professor at the University of Calgary, affiliated with the Libin, Hotchkiss Brain Institute, and Snyder Institute. His research focuses on vascular physiology, particularly the role of potassium channels in regulating blood flow and pressure, with applications in diabetes and neurodegenerative diseases. He utilizes advanced techniques like patch clamping and arterial pressure myography. His work explores KCa channels , nitric oxide signaling , and calcium dynamics in vascular cells, aiming to develop novel therapies for endothelial dysfunction. He investigates how these channels affect myogenic tone , vasodilation , and coronary circulation in diseased states such as Type 2 Diabetes and Alzheimer's. The 15 most recent publications highlight his focus on pharmacological targeting of KCa channels to treat vascular complications in diabetes, aging, and atherosclerosis. Key subfields include platelet aggregation , genetic mutations in IP3 receptors , glycation effects on vascular function , and sex-dependent cerebrovascular defects . Contact information: Email abraun@ucalgary.ca. Administrative Assistant: Theresea Connolly (tconnoll@ucalgary.ca, 403-220-3018).

• General Cardiology
• Pulmonary Hypertension
• Heart Failure
• +۴ مورد دیگر

John J. Ryan is a Professor of Medicine in the Division of Cardiovascular Medicine at the University of Utah School of Medicine , specializing in General Cardiology and Pulmonary Hypertension . He holds adjunct associate professorships in Family & Preventive Medicine, Orthopaedics, and Radiology & Imaging Sciences. Dr. Ryan’s research focuses on heart failure with preserved ejection fraction , pulmonary vascular disease , and right ventricular function . His work explores statin therapy , microvascular dysfunction , and novel treatments for pulmonary hypertension . His publications emphasize cardiovascular outcomes in pulmonary hypertension, exercise physiology in heart failure, and digital health tools. He is board-certified in Advanced Heart Failure & Transplant Cardiology , Cardiovascular Disease , and Echocardiography . Clinically, he practices at the University of Utah Hospital , with consistently high patient satisfaction scores ( 4.9/5 ). His academic training includes M.D. from University College Cork , followed by residency at Boston Medical Center and fellowships at the University of Chicago Medical Center .

John Eberthمشاهده پروفایل

دانشیار

• Cardiovascular Engineering
• Biomechanics
• Mechanobiology
• +۹ مورد دیگر

Dr. John F. Eberth is an Associate Professor at Drexel University's School of Biomedical Engineering, Science and Health Systems. As a cardiovascular engineer with expertise in mechanical controls, continuum biomechanics, and hydrogel-based extracellular matrix mimetics, he leads the Applied Biomechanics and Mechanobiology Lab (ABML) to investigate vascular behavior under mechanical stimuli. PhD in Biomedical Engineering from Texas A&M University (2008) MS in Mechanical Engineering from Clemson University (2004) BS in Mechanical Engineering from Clarkson University (2001) His research focuses on vascular pathology and mechanobiology, including: Aortopathy and aneurysm mechanics Endothelial dysfunction and arterial stiffening Hydrogel-based vascular grafts Calcification chelation therapy Coronary artery disease Perfusion tissue culture Recent publications demonstrate expertise in vascular imaging techniques, mechanical modeling, and therapeutic interventions. Key themes include drug-coated balloon development, collagen fiber mechanics, and bioreactor systems for vascular conditioning.

• Medicinal Chemistry
• Chemical Biology
• Organic Synthesis
• +۳ مورد دیگر

Wei Shi is an Associate Professor of Chemistry (Organic) at Ball State University’s College of Sciences and Humanities, Department of Chemistry. He joined the institution in 2019, specializing in teaching Organic Chemistry and conducting research in Medicinal Chemistry, Chemical Biology, and Organic Synthesis. His research focuses on designing chemical probes derived from natural products to understand small molecule regulation of macro-biomolecules for disease treatment. Education: B.Sc. in Electrochemistry from Shanghai Jiao Tong University (China), M.Sc. in Bioorganic Chemistry from East China University of Science & Technology (China), Ph.D. in Chemistry from the University of Alberta (Canada), and postdoctoral training at Johns Hopkins School of Medicine (USA). Research Interests: Explores the pharmaceutical potential of bioactive natural products, particularly glycoconjugates, aiming to design novel drug candidates with enhanced therapeutic profiles. Key projects include studying ipomoeassin F’s mechanism of action as an ER translocon inhibitor and developing itraconazole analogs for antiangiogenic and anticancer applications. Selected Publications: Over 20 peer-reviewed articles, including landmark studies on ipomoeassin F’s Sec61α binding, itraconazole’s dual targeting of NPC1/VDAC1, and structural analog design. Recent work highlights Sec61 translocon inhibition mechanisms in Mycobacterium ulcerans pathogenesis and ER stress response modulation in cancer cells. Labs/Teams: Director of the Shi Research Group , focusing on natural product-inspired drug discovery and chemical biology.

Hannah Spitzerمشاهده پروفایل

استادیار

• Computational Biology
• Machine Learning
• Spatial Omics
• +۴ مورد دیگر

Hannah Spitzer is a Research Group Leader at the Institute for Stroke and Dementia Research (ISD) at Ludwig Maximilian University of Munich and an associated Research Group Leader at Helmholtz Munich's Computational Health Center. She leads the Spitzer Lab, focusing on computational analysis of multimodal brain datasets to advance understanding of neurovascular and neurodegenerative diseases. Her educational background includes: PhD in Computer Science from Heinrich-Heine University Düsseldorf and Research Center Jülich (2015-2020) Master's in Computer Science from RWTH Aachen (2013-2015) Bachelor's in Computer Science from RWTH Aachen (2009-2013) Dr. Spitzer's research integrates computational biology and machine learning to decode brain complexity, with emphasis on spatial omics analysis , interpretable image representation learning , and cross-modal data integration . Her group develops tools like squidpy and campa for spatial omics while applying graph neural networks to epilepsy lesion detection through the international MELD project, prioritizing biological interpretability in AI models. Recent publications reveal strong trends in leveraging graph neural networks for subtle brain lesion detection and creating computational frameworks for spatial omics integration. Her work consistently bridges advanced machine learning with clinical neuroscience to uncover disease mechanisms in neurodegeneration and vascular disorders. Dr. Spitzer actively mentors students including current PhD candidate Beatrice Guastella and alumni Deniz Fettahoglu (MSc) and Katia Berr (PhD). Her lab operates through major collaborations including the MELD epilepsy consortium and Helmholtz Imaging Project, with funding supporting computational pipeline development for small-vessel disease prediction and multimodal brain atlasing. The Spitzer Lab comprises postdoc Wasim Aftab and PhD student Beatrice Guastella, working on computational pipelines that integrate histology, spatial omics, and neuroimaging data to decode brain disease mechanisms through interpretable AI approaches.

Michael S. Wolinمشاهده پروفایل

استاد

• Oxidative Stress Signaling
• Pulmonary Hypertension
• Vascular Physiology
• +۷ مورد دیگر

Michael S. Wolin, Ph.D., is a distinguished Professor of Physiology at the School of Medicine, New York Medical College (NYMC). With a career spanning several decades, Dr. Wolin has established himself as a leading researcher in vascular physiology, redox biology, and pulmonary hypertension. His work began with groundbreaking research on nitric oxide signaling as a postdoctoral fellow with Lou Ignarro at Tulane University, contributing to aspects of research that led to Ignarro's 1998 Nobel Prize in Physiology and Medicine. Dr. Wolin's research interests focus on oxidative stress signaling , pulmonary hypertension , vascular physiology , redox biology , nitric oxide signaling , and mitochondrial function . His NIH-funded laboratory at NYMC has made significant contributions to understanding how cellular regulatory systems—including mitochondrial function, oxidases, ROS metabolizing enzymes, and cellular redox control systems—function in physiological processes and pathophysiological conditions. His work has particularly advanced our understanding of oxygen sensing mechanisms, hypoxic pulmonary vasoconstriction, and the role of hydrogen peroxide as a signaling molecule. Dr. Wolin's recent publications (2019-2025) demonstrate continued research productivity with significant contributions to understanding placental development in maternal undernourishment, pulmonary vascular function, oxidative stress mechanisms in hypertension, and the role of various signaling molecules in cardiovascular disease progression. His work shows a consistent focus on the interplay between redox signaling, mitochondrial function, and vascular pathophysiology. Notable awards and honors include: Distinguished Scientist Award – American Chemical Society, Westchester Section (2010) Outstanding Faculty Award – Graduate Student Association of Basic Medical Sciences at NYMC (2009) Robert M. Berne – Distinguished Lectureship Awardee – American Physiological Society (2008) Merit Award – National Heart, Lung & Blood Institute, NIH (1995) Dr. Wolin has maintained significant editorial and service roles, including serving as Chair of the Integrative Vascular Physiology Pathology NIH Study Section (2021-2023), Consulting Editor for the American Journal of Physiology: Heart & Circulatory Physiology (2011-2018), and as a Fellow of the American Heart Association since 2001. His teaching responsibilities at NYMC include directing multiple physiology courses and mentoring graduate students through thesis research.

Mansoureh Eghbaliمشاهده پروفایل

استاد

• Pulmonary Hypertension
• Myocardial Ischemia-Reperfusion Injury
• Sex Differences in Cardiovascular Disease
• +۳ مورد دیگر

Mansoureh Eghbali, PhD, is a Professor in the Department of Anesthesiology at the David Geffen School of Medicine, University of California, Los Angeles. Her research program investigates molecular mechanisms of cardiovascular and pulmonary diseases with emphasis on sex-specific pathophysiology. She leads an active NIH-funded laboratory focused on pulmonary hypertension, myocardial ischemia-reperfusion injury, and the role of RNA-binding proteins in vascular remodeling. Her research integrates multiomics approaches to explore: Sex chromosome influences (Y-gene Uty) in pulmonary vascular protection MicroRNA regulation of cardiac fibrosis and calcification (e.g., miR-129-5p/Asporin axis) Gut-heart-lung interactions in diet-induced pulmonary hypertension Endothelial subpopulations (TM4SF1+) in disease progression Analysis of her recent publications reveals strong emphasis on: Integrative multiomics in vascular diseases Sex differences in drug responses Novel therapeutic targeting of RNA-binding proteins Cross-organ communication in cardiopulmonary pathologies She directs multiple NIH grants including: R01HL159865: Role of Chromosome Y gene, Uty (2021-2025) R01HL147586: Role of miR125 in pulmonary hypertension (2019-2023) R01HL129051: Role of miR193 in oxidized lipid-induced PH (2016-2021) R01HL131182: Epigenetic regulation by X chromosome (2016-2021)

Katrien De Bockمشاهده پروفایل

استاد

• Muscle Microenvironment
• Angiogenesis
• Metabolic Crosstalk
• +۴ مورد دیگر

Prof. Dr. Katrien De Bock is a Full Professor and Deputy Head of the Department of Health Sciences and Technology at ETH Zurich. Her research focuses on angiogenesis, metabolic crosstalk in muscle microenvironments, and the impact of exercise on muscle regeneration. She leads a team investigating cellular interactions in skeletal muscle, particularly how metabolic signals regulate blood vessel growth and muscle repair. Key areas include understanding fibroadipogenic progenitors' role in muscle physiology, the role of histamine in exercise responses, and age-related muscle decline. Her work integrates molecular biology, single-cell transcriptomics, and computational approaches to dissect mechanisms underlying tendon pathologies, ischemic muscle injury, and metabolic adaptations to exercise. She supervises Master's programs in Human Movement Science and collaborates on projects involving muscle stem cell therapies and vascular engineering. Prof. De Bock also explores interventions like NAD+ precursors to counteract age-related sarcopenia and promotes translational research in regenerative medicine. Research Interests: Exercise-induced metabolic pathways in muscle repair Angiogenesis regulation in health and disease Hypoxia signaling in tendons and muscles Epigenetic modifications during tissue regeneration Stem cell fate determination in muscle microenvironments Notable Projects: Developing AI-driven histologic analysis for tendinopathy diagnosis Mapping the human brain vasculature at single-cell resolution Testing sulfur amino acid restriction to enhance exercise capacity

Stephen Renaudمشاهده پروفایل

دانشیار

• Placental Development
• Reproductive Biology
• Cellular and Molecular Mechanisms
• +۳ مورد دیگر

Dr. Stephen Renaud is an Associate Professor in the Department of Anatomy and Cell Biology at Western University. He holds a PhD and B.Sc. from Queen's University. His research focuses on placental development and function, particularly the cellular and molecular mechanisms underlying trophoblast differentiation and maternal-fetal immune interactions. Key interests include OVO-like transcription factors, endogenous retroviral genes, and maternal immune tolerance. His work bridges basic science with public health implications, addressing complications like pre-eclampsia and fetal growth restriction. Publications emphasize placental biology, immunology, and developmental mechanisms, with contributions to journals like Placenta , Proceedings of the National Academy of Sciences , and Cellular and Molecular Life Sciences . No scientific awards are listed, but his research has been widely cited (h-index 28). He advises no listed students but maintains an active lab exploring placental biology. His office is in the Medical Sciences Building, Room 428, with contact via srenaud4@uwo.ca.

Justin Chu Jang Hannمشاهده پروفایل

دانشیار

• Molecular RNA Virology
• Antiviral Strategies
• Viral Pathogenesis
• +۳ مورد دیگر

Associate Professor Justin Chu Jang Hann is affiliated with the Department of Microbiology and Immunology at the National University of Singapore (NUS), within the Yong Loo Lin School of Medicine. He holds additional roles as Assistant Dean (Academic Affairs) in the School of Medicine, Director of the NUS Medicine BSL-3 & ABSL-3 Core Facility, and Joint Senior Principal Investigator at the Institute of Molecular and Cell Biology (IMCB) A*STAR. His research focuses on molecular RNA virology, antiviral strategies, and high-throughput imaging technologies to study host-pathogen interactions. Key projects include genomic screening of viral-host interactions, high-content bio-imaging platforms, and development of anti-viral compounds against pathogens like SARS-CoV-2, dengue, and enteroviruses. Recent work explores broad-spectrum antivirals, vaccine candidates, and diagnostic approaches for viral infections. His contributions span virology, immunology, and translational medicine, with a strong emphasis on combating emerging and re-emerging RNA viruses.

Pengyi Yangمشاهده پروفایل

دانشیار

• Computational Systems Biology
• Stem Cell Biology
• Bioinformatics
• +۴ مورد دیگر

Pengyi Yang is an Associate Professor and University of Sydney Robinson Fellow at the School of Mathematics & Statistics, University of Sydney. He leads the Computational Systems Biology group at the Charles Perkins Centre and holds a conjoint appointment as Unit Head of Computational Systems Biology at the Children's Medical Research Institute (CMRI). His research focuses on computational approaches to understand trans-regulatory networks in stem cells and their applications in regenerative medicine. Yang holds a Ph.D. and has been recognized with awards such as the National Stem Cell Foundation Metcalf Prize (2021). His research spans computational systems biology, machine learning for bioinformatics, and spatial/single-cell omics analysis. Key projects include modeling pluripotency transitions, developing stem cell-derived organoids, and creating computational tools for phosphoproteomics and multi-omics integration. Collaborations include international initiatives like the Laboratory of Data Discovery for Health (InnoHK). Yang advises multiple PhD students and leads grants on topics like stem cell-derived brain organoids and embryonic development modeling. His lab develops tools like Cepo, PhosR, and CiteFuse for omics data analysis. He teaches data science and molecular systems biology at the University of Sydney.

• Neurodevelopmental Disorders
• Autism Spectrum Disorder
• Genetic Syndromes
• +۳ مورد دیگر

Dr. Joanna Moss is an Associate Professor in Psychology at the University of Surrey, affiliated with the School of Psychology and the Development, Education, Language and Outreach in Psychology (DevELOP) Research Group. She completed her PhD at the University of Birmingham in 2005, followed by research roles at the Institute of Psychiatry, Psychology & Neuroscience and the Cerebra Centre for Neurodevelopmental Disorders. Her research focuses on autism characteristics in individuals with genetic syndromes, employing methodologies like eye-tracking, EEG, and behavioral assessments. She has secured funding from the Academy of Medical Sciences, British Academy, and others. Dr. Moss co-chairs the Scientific and Clinical Advisory Team for the Cornelia de Lange Syndrome Foundation and advises on international research committees. She teaches a final-year undergraduate module on neurodevelopmental conditions and advises PhD students. Her lab, NDEV Research Lab, explores social-cognitive mechanisms in neurogenetic syndromes. Recent work emphasizes inclusive autism research, anxiety in high-risk groups, and machine learning approaches to phenotype analysis. Education: PhD in Psychology, University of Birmingham (2005) Roles: Senior Academic Tutor, Module Convenor for Neurodevelopmental Conditions Labs/Teams: NDEV Research Lab (www.ndevresearchlab.com) Her research highlights syndrome-specific profiles of autism traits, emphasizing the need for tailored assessments and interventions. Key findings include distinct gaze-following patterns in genetic syndromes and the role of executive dysfunction in repetitive behaviors. She advocates for ethical research practices, including preregistration in undergraduate studies.

Yulia Y Tyurinaمشاهده پروفایل

استاد پژوهشی

• Cell Death Pathways
• Lipid Peroxidation
• Ferroptosis
• +۴ مورد دیگر

Yulia Y Tyurina serves as a Research Professor in the Department of Environmental and Occupational Health at the University of Pittsburgh. Her research focuses on the fundamental role of phospholipids and their oxygenated species in cell death pathways including apoptosis, necroptosis, ferroptosis, and mitophagy. She discovered that cardiolipin oxygenated species are essential for apoptotic execution and serve as an 'eat-me' signal for mitochondrial quality control via mitophagy. Dr. Tyurina's educational background includes: 1988: Master of Biochemistry from Saint Petersburg State University, Saint Petersburg, Russia 1995: PhD in Biochemistry from the Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Saint Petersburg, Russia Her research program centers on redox lipid signaling mechanisms in cell death. She has demonstrated that phospholipid peroxidation drives ferroptosis through complex oxidation signatures and identified key roles for 15-lipoxygenase products. This work bridges basic biochemistry with translational applications in cancer, neurodegeneration, and inflammatory diseases, revealing how lipid oxidation products function as death signals across diverse biological contexts. Analysis of her 15 most recent publications (2020-2022) shows consistent focus on lipid peroxidation in ferroptosis across multiple disease models. Her work spans from cyanobacterial cell death to human pathologies including lung injury, SARS-CoV-2 complications, and cancer, with recurring mechanistic themes involving 15-lipoxygenase, cardiolipin oxidation, and mitochondrial dysfunction. Methodologies include advanced lipidomics, molecular imaging, and genetic models. Scientific awards were not mentioned in the provided information. Details about student advising and grant funding were not provided in the available text. Dr. Tyurina operates within a prominent redox biology research group led by Dr. Valerian E. Kagan at the University of Pittsburgh, maintaining extensive collaborations across departments and institutions as evidenced by her co-authorship network spanning immunology, oncology, and infectious disease research.

Fabeha Fazalمشاهده پروفایل

دانشیار

• Pulmonary Medicine
• Cell Biology
• Molecular Pathology
• +۴ مورد دیگر

Fabeha Fazal, Ph.D. is an Associate Professor in the Department of Pediatrics at the University of Rochester Medical Center. Her research focuses on understanding the molecular mechanisms of Acute Lung Injury (ALI)/ARDS pathogenesis, particularly how endothelial cell dysfunction and inflammation contribute to disease progression. Current lab projects explore the role of endoplasmic reticulum BiP and mitochondrial GRP75 in ALI, as well as the link between endothelial cytoskeletal dynamics and inflammatory gene expression. She employs in vitro and in vivo models, including LPS-induced sepsis and thrombin-induced inflammation , to identify novel therapeutic targets for ALI. Her publications reveal expertise in NF-κB signaling , actin cytoskeleton regulation , and organelle crosstalk in inflammatory lung disorders. She has received NIH R01 grants for studying "Regulation of Endothelial-Neutrophil Interaction and Lung Vascular Permeability in Sepsis." Education: PhD in Biochemistry, A.M. University (1992) MSc in Biochemistry, A.M. University (1987) BSc in Chemistry, A.M. University (1985) Scientific Recognition: University Gold Medal for top M.S. Examination (1987) University Gold Medal for top B.S. Examination (1985) Lab Personnel: Collaborates with Principal Investigator Dr. Arshad Rahman and post-doctoral researchers like Dr. Pei Yi Su. Lab technicians and trainees include Antony Leonard (Technical Associate) and previous graduate researcher Moyinoluwa D Adenuga.