جست‌وجوی استاد و پژوهشگر

Hirofumi Fujitaمشاهده پروفایل

استادیار

• Cerebellar Circuitry
• Neuroanatomy
• Neurodevelopment
• +۵ مورد دیگر

Hirofumi Fujita, M.D., Ph.D., serves as Assistant Professor in the Department of Neurology at UT Southwestern Medical Center's School of Medicine, where he joined in 2022. His laboratory investigates cerebellar circuit frameworks connecting to forebrain, brainstem, and spinal cord regions, with focus on developing novel treatments for neurological disorders through cerebellar compensation mechanisms. Education: M.D. and Ph.D. from Tokyo Medical and Dental University, Tokyo, Japan Postdoctoral training at Salk Institute, La Jolla, CA Additional postdoctoral work at Johns Hopkins University, Baltimore, MD Dr. Fujita's research centers on molecular segmentation of cerebellar compartments and input-output organization of cerebellar circuits . His work demonstrates how spatial rearrangement of embryonic cerebellar neurons forms functional zones, with each cortical zone connecting to private target neurons in cerebellar nuclei. This foundational research reveals how distinct cerebellar nuclear neurons generate diverse output patterns enabling both motor and nonmotor functions. Current studies employ disease model mice (spinocerebellar ataxia, autism) and human samples to investigate cerebellar compensation mechanisms in diseased brain circuits. Analysis of Dr. Fujita's publication record shows consistent focus on cerebellar compartmentalization (aldolase C expression, Purkinje cell clusters), axonal projection mapping (olivocerebellar, mossy fiber pathways), and translational applications for neurological disorders. Recent work emphasizes cerebellar roles in cognition through prefrontal interactions and catecholamine signaling, with 2025 publications extending findings to tau pathology and essential tremor. As Principal Investigator of the Fujita Lab, he mentors students in the Neuroscience Graduate Program while directing research on cerebellar modular organization. His laboratory utilizes advanced techniques including birthdate tagging, molecular expression mapping, and circuit-specific manipulations to study cerebellar contributions to both healthy brain function and disease states. Current projects investigate how cerebellar circuits influence forebrain development and maintain neural circuit integrity in neurological disorders.

Judith Agudoمشاهده پروفایل

استادیار

• Immunology
• Stem Cell Biology
• Cancer Immunology
• +۵ مورد دیگر

Judith Agudo is an Assistant Professor of Immunology at Dana-Farber Cancer Institute, Harvard University, focusing on immune privilege mechanisms in tissue-resident stem cells and cancer stem cells. Her work explores how stem cell populations evade immune surveillance and how cancer cells co-opt these mechanisms to escape immunotherapy. Developed the Jedi mouse model (Agudo et al., 2015) for antigen-specific immune studies Identified quiescence-dependent immune evasion via MHC-I downregulation in hair follicle and muscle stem cells Characterized Sox17-driven immune silencing in intestinal cancer precursors (Goto et al., 2024) Created PADME-seq for spatial tumor microenvironment analysis (Baldominos et al., 2022) Her research spans stem cell immunology , cancer immune evasion , and regenerative medicine applications , with particular emphasis on T cell interactions with stem cell populations. Current projects investigate: Molecular pathways of immune privilege in quiescent stem cells Cancer stem cell niches that resist immunotherapy Developing immune-silent tissues for transplantation Metastatic cell immune escape outside primary tumors Publications demonstrate expertise in MHC class I regulation , antigen presentation , and stem cell quiescence , with recent work analyzing immune suppression in ovarian cancer (2024) and stress signaling in breast cancer metastasis (2024). Her lab employs transgenic models, single-cell sequencing, and spatial transcriptomics to dissect tumor-immune interactions.

• Pharmacology
• Nutritional Sciences
• Cancer Research
• +۴ مورد دیگر

Lindsay Cormier is an Associate Professor at the University of Kentucky, affiliated with the Department of Pharmacology and Nutritional Sciences. She is also a member of the Markey Cancer Center and the Translational Oncology Research Program. Education: Master of Public Health (MPH), Eastern Kentucky University (2019) Doctor of Philosophy (Ph.D.), University of Kentucky (2012) Bachelor of Science (B.S.), University of Kentucky (2006) Cormier's research focuses on vascular remodeling and inflammation related to calcium-independent phospholipase A2 and microRNA-1. Her work intersects pharmacology, nutritional sciences, and translational oncology, with an emphasis on molecular mechanisms in disease progression. Scientific Awards: Fellowship from American Heart Association Great Rivers Affiliate Cormier has contributed to projects involving transgenic mouse models, cell function analysis, and microRNA/phospholipase A2 research. Her collaborative work includes a research project with Gong, M. (PI) on AngII-induced vascular remodeling. Labs & Teams: She is affiliated with the Markey Cancer Center and the Translational Oncology Research Program, contributing to interdisciplinary cancer research initiatives.

Benjamin D Singerمشاهده پروفایل

دانشیار

• Pulmonary and Critical Care Medicine
• Internal Medicine
• Epigenetics
• +۷ مورد دیگر

Benjamin D Singer, MD is an Associate Professor of Medicine (Pulmonary and Critical Care) and Biochemistry and Molecular Genetics at Northwestern University Feinberg School of Medicine, where he holds the Lawrence Hicks Professorship in Pulmonary Medicine. He serves as Vice Chair for Research in the Department of Medicine and leads the Singer Lab focused on lung inflammation and repair mechanisms. His work bridges clinical practice in critical care medicine with fundamental research in immunology and epigenetics. Dr. Singer received his MD from Northwestern University Feinberg School of Medicine in 2007, completed residency and chief residency in Internal Medicine at Northwestern University, McGaw Medical Center in 2010, and finished fellowship training in Pulmonary & Critical Care Medicine at Johns Hopkins University School of Medicine in 2015 before returning to Northwestern as faculty. Dr. Singer's research focuses on the epigenetic control of lung lymphocytes, particularly how DNA methylation and gene expression define T lymphocyte immunoregulatory phenotype and pro-repair function in the context of acute lung inflammation and injury. His laboratory investigates how these epigenetic phenomena can potentiate resolution of acute lung inflammation and repair of lung damage, with applications extending to aging, autoimmune conditions, malignancy, and organ allograft rejection. His work utilizes transgenic mouse models, primary cell culture, multiparameter flow cytometry, and next-generation sequencing techniques to reveal molecular networks controlling the balance between inflammation/injury and repair/resolution. Elected member, American Society for Clinical Investigation (ASCI) (2024) Alpha Omega Alpha (AOA) Distinguished Speaker, Northwestern University Feinberg School of Medicine Chapter (2025) Carol Basbaum Award for outstanding scientific achievement, mentorship, and leadership, American Thoracic Society (2020) Young Physician-Scientist Award, American Society for Clinical Investigation (ASCI) (2019) Mentor of the Year, Department of Medicine, Northwestern University Feinberg School of Medicine (2022) Multiple Excellence in Teaching Awards from residents and fellows Dr. Singer has mentored numerous trainees, as evidenced by his multiple teaching and mentorship awards including 'Mentor of the Year' (2022) and several 'Excellence in Teaching Awards.' He serves in editorial roles for prestigious journals including as Associate Editor for the Journal of Clinical Investigation (2022-present) and Science Advances (2021-present), and holds leadership positions in professional societies including the American Society for Clinical Investigation and American Thoracic Society. His research has been supported by NIH funding, including a recent $12 million grant for lung disease studies. The Singer Lab operates within the Simpson Querrey Lung Institute for Translational Science (SQLIFTS) and collaborates with multiple internal and external researchers including Ali Shilatifard, Alexander Misharin, GR Scott Budinger, and colleagues at Johns Hopkins University, Wake Forest University, and University of North Carolina Chapel Hill. The lab's work focuses on understanding the molecular mechanisms that determine how lung immune cells drive tissue injury, inflammation and repair in conditions like severe pneumonia, lung transplantation, and asthma.

Craig Weissمشاهده پروفایل

استاد پژوهشی

• Learning and Memory
• Alzheimer's Disease
• Aging
• +۷ مورد دیگر

Craig Weiss is a Research Professor in the Department of Neuroscience at the Feinberg School of Medicine, Northwestern University. His work is supported by affiliations with the Mesulam Center for Cognitive Neurology and Alzheimer's Disease and the Simpson Querrey Institute for Epigenetics. Education: PhD, Northwestern University (1986) Postdoctoral Fellowship, University of Southern California, Neurobiology (1991) Dr. Weiss's research centers on learning and memory, Alzheimer's disease, and aging. Using electrophysiology, fMRI, and behavioral studies in animal models (including rabbits and transgenic mice), he investigates the roles of the hippocampus and cerebellum in cognitive processes and their decline with age and disease. His recent publications (2024-2025) address aging-related topics such as neuroinflammation after traumatic brain injury, gait changes in nerve injury models, and muscle recovery in viral pneumonia. This continues his long-standing focus on the biological mechanisms of memory and aging, as seen in his 1998 work on spatial learning in mice. Dr. Weiss serves on the Editorial Board of Frontiers in Neuroscience and as an Advisor for the Rhode Island Research Alliance. He is a member of several Northwestern research institutes including the Center for Autism and Neurodevelopment, NUCATS, and the Stephen M. Stahl Center for Psychiatric Neuroscience. No scientific awards were listed in the provided information. Details about students, grants, and specific laboratory teams were not provided.

G. Vazquezمشاهده پروفایل

استاد

• Atherosclerosis
• Cardiovascular Disease
• Ion Channels
• +۷ مورد دیگر

G. Vazquez is a tenured Professor in the Department of Physiology and Pharmacology at the University of Toledo College of Medicine, where he has held leadership roles such as Program Director of the Medical Sciences Program (MSBS-MS) and Associate Director of the Center for Hypertension and Precision Medicine since 2015. His research focuses on the molecular mechanisms of atherosclerosis and cardiovascular disease, particularly the roles of TRPC channels and nicotinic acetylcholine receptors in endothelial dysfunction, macrophage survival, and inflammation. Education: BSc and PhD in Biochemistry from National University of the South, Argentina Postdoctoral Training: CONICET (Argentina), NIEHS (USA) His lab employs in vitro and in vivo models, including transgenic and knockout mice, to investigate calcium signaling pathways in vascular pathologies. Recent studies highlight TRPC3's role in endoplasmic reticulum stress, macrophage efferocytosis, and atherosclerotic plaque stability. Notable awards include the 2017 Dean's Award for Mentoring and 2011 Dean’s Award for Research to New Investigator at the University of Toledo. He serves as an honorary mentor for the Graduate Program on Biochemistry and Pharmacology at his alma mater and actively participates in professional societies like the American Heart Association and American Society for Pharmacology & Experimental Therapeutics.

Joseph J. Sarverمشاهده پروفایل

استاد آموزشی

• Biomechanics
• Orthopaedic Biomechanics
• Tendon Mechanics
• +۵ مورد دیگر

Dr. Joseph J. Sarver serves as a Teaching Professor at Drexel University's School of Biomedical Engineering, Science & Health Systems since 2012, maintaining concurrent research affiliation with the University of Pennsylvania's McKay Orthopaedic Laboratory since 2001 where he progressed from post-doctoral fellow to Senior Research Investigator under Dr. Louis J. Soslowsky. His educational foundation includes: B.S. in Mechanical Engineering from Purdue University (1994) M.S. in Biomedical Engineering from Drexel University (1997) Ph.D. in Biomedical Engineering from Drexel University (2001) Postdoctoral training in Orthopaedic Surgery at the University of Pennsylvania (2003) Dr. Sarver's research program centers on orthopaedic biomechanics with emphasis on tendon mechanics, rotator cuff repair optimization, and neuromuscular adaptation to injury. His methodology integrates animal models (primarily rat and mouse), mechanical testing apparatus development, and advanced imaging techniques including MRI texture tracking and double-quantum-filtered NMR. Key investigations include the REMO project on remobilization after rotator cuff repair and studies of intervertebral disc degeneration. Analysis of his 15 most recent publications reveals consistent focus on shoulder biomechanics (2008-2011) examining rotator cuff repair outcomes, immobilization effects, and functional recovery in rat models, building upon earlier foundational work (1999-2007) in spinal biomechanics, neuromuscular fatigue quantification, and spinal cord injury rehabilitation. Dr. Sarver has actively mentored undergraduate students, Drexel co-op participants, and senior design teams, particularly in developing mechanical testing equipment like the planar biaxial system for soft tissue analysis. His collaborative research network extends to ultrasound experts (Dr. Seghal at Penn), NMR specialists (Dr. Wehrli), and muscle adaptation researchers (Sam Ward at UCSD). He maintains primary laboratory affiliation with the McKay Orthopaedic Laboratory at Penn while directing biomechanics instruction at Drexel, contributing to both institutions' research infrastructure through equipment development and collaborative projects spanning orthopaedic surgery, rehabilitation science, and biomedical engineering.

Christopher Loweمشاهده پروفایل

استاد

• Evolutionary Developmental Biology
• Deuterostome Evolution
• Comparative Genomics
• +۴ مورد دیگر

Christopher Lowe is a Professor of Biology at Stanford University, with his research laboratory based at the Hopkins Marine Station in Monterey. He holds additional appointments as a Member of Bio-X and the Wu Tsai Neurosciences Institute, and serves as Director of the Center of Cellular and molecular Diversity (2022-Present). His academic journey began with a BSc. Hons in Biology with European Studies from the University of Sussex (1991), followed by a PhD in Ecology and Evolution from SUNY Stony Brook (1998). University of Sussex: BSc. Hons, Biology with European Studies (1991) SUNY Stony Brook: PhD, Ecology and Evolution (1998) UC Berkeley: Miller Fellow (1998-2001) University of Chicago: Assistant Professor, Department of Organismal Biology and Anatomy (2005) Stanford University: Professor of Biology (2010-Present) Professor Lowe's primary research focuses on evolutionary developmental biology, specifically investigating how major animal groups evolved through the lens of deuterostome evolution. His work integrates molecular genetics, comparative genomics, and developmental biology to understand body plan evolution, particularly using hemichordates as model organisms. He has pioneered techniques for studying non-model marine organisms and has adapted emerging biotechnologies for application in diverse species. His location at Hopkins Marine Station provides unique access to the rich biodiversity of Monterey Bay, which informs his research on marine invertebrate development and evolution. Analysis of Professor Lowe's recent publications reveals a consistent focus on deuterostome evolution, with particular emphasis on hemichordates as key organisms for understanding chordate origins. His work spans multiple disciplines including developmental genetics, comparative genomics, neuroanatomy, and evolutionary immunology. A notable trend is the integration of cutting-edge molecular techniques with classical comparative morphology to address fundamental questions about body plan evolution. His research has significantly contributed to understanding anteroposterior patterning, nervous system organization, and the molecular basis of morphological innovation across deuterostomes. BioHub Investigator, Chan/Zuckerberg BioHub (2022-2027) Searle Scholars Fellow, Searle Scholars Program (2008-2011) Miller Postdoctoral Fellowship, UC Berkeley (1998-2001) Professor Lowe actively mentors the next generation of scientists, serving as Doctoral Dissertation Advisor for multiple PhD students including Christopher Kirby, Lauren Lubeck, Albert Marti i Sabari, Brennan McDonald, and Heidi Tate. He also sponsors postdoctoral researchers such as Laurent Formery and Jana Sipkova, and serves as a Doctoral Dissertation Reader for Joel Erberich. His laboratory at Hopkins Marine Station functions as a hub for evolutionary developmental biology research, focusing on comparative studies of deuterostome development. The lab has developed innovative techniques for studying non-model marine organisms, including transgenic methods for hemichordates and tissue clearing protocols for opaque invertebrates. Professor Lowe's research group collaborates extensively with other institutions to advance our understanding of evolutionary processes that shaped animal diversity.

Philip W Jordanمشاهده پروفایل

دانشیار

• Stem cell biology
• Reproductive biology
• Neurodevelopment
• +۷ مورد دیگر

Philip W Jordan is an Associate Professor in the Department of Biochemistry at the Uniformed Services University of the Health Sciences (USUHS) School of Medicine in Bethesda, MD. He joined USUHS in 2022 after serving as a principal investigator at Johns Hopkins University Bloomberg School of Public Health for ten years. Education: Bachelor of Biotechnology (Hns) – Flinders University of South Australia, Australia (1997-2001) Ph.D. in Cell and Molecular Biology - University of Edinburgh, Scotland (2002-2006) Post-graduate Certificate in Higher Education - University of Sussex, England (2007-2009) Post-doctoral training in Genome maintenance - University of Sussex, England (2007-2010) Post-doctoral training in Reproductive Biology – The Jackson Laboratory, Maine, USA (2010-2013) Dr. Jordan's research focuses on understanding the molecular mechanisms that monitor DNA replication accuracy and DNA damage repair proficiency, as well as processes that ensure accurate chromosome segregation and cell cycle progression. His lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly Polo-like (PLK) kinases and Aurora kinases. They use mouse as a model organism to study consequences of gene mutation and chromosome missegregation, which give rise to physical and cognitive developmental defects, infertility and cancer predisposition. They also use mouse and human pluripotent stem cells to help define the function of these proteins within essential molecular pathways of the cell. Their current research encompasses gametogenesis (spermatogenesis and oogenesis), pluripotent stem cell genome maintenance, and neurodevelopment. Dr. Jordan's recent publications demonstrate a strong focus on meiosis, chromosome segregation, and genome maintenance mechanisms. His work spans reproductive biology, neurodevelopment, and stem cell research, with particular emphasis on SMC complexes and cell cycle kinases. The research employs advanced techniques including transgenic models, pluripotent stem cells, and the auxin-inducible degron (AID) system for protein degradation studies. Scientific Awards: UK Fulbright Distinguished Scholar Award from the US-UK Fulbright Commission, 2010 K99-R00 Pathway to Independence Award from NICHD, NIH, 2012-2016 Ho-Ching Yang Memorial Faculty Fellowship in Cancer Prevention, 2014-2015 Discovery Award from Johns Hopkins University, 2015-2016 American Society for Reproductive Medicine (ASRM) KY Cha Award, 2017-2018 Catalyst Award from Johns Hopkins University, 2018-2019 Discovery Award from Johns Hopkins University, 2022-2024 Dr. Jordan has successfully mentored numerous PhD and Masters students through their graduate programs, with many going on to pursue further doctoral studies or medical school. His lab has secured significant grant funding including R01 research grants from NIGMS and NICHD, as well as equipment grants from NIGMS. The lab has also received multiple Discovery and Catalyst Awards from Johns Hopkins University, demonstrating the innovative nature of their research. The Jordan Lab at USUHS maintains an active research program with multiple postdoctoral researchers, PhD students, and undergraduate researchers working collaboratively on projects related to genome maintenance, meiosis, and neurodevelopment. The lab has recently received R01 grant renewals and new R01 grants, indicating continued strong support for their research program.

Xiaohe Yangمشاهده پروفایل

استاد

• Breast cancer research
• Receptor tyrosine kinase signaling
• Cancer stem cells
• +۸ مورد دیگر

Dr. Xiaohe Yang serves as the Glaxo Professor in Biological and Biomedical Sciences at North Carolina Central University (NCCU), where he leads research at the Julius L. Chambers Biomedical and Biotechnology Research Institute (JLC-BBRI). He also holds an associate membership at the Lineberger Comprehensive Cancer Center at UNC-Chapel Hill. His position as a named professor indicates his significant standing within the university's academic structure. Dr. Yang's educational background includes medical training from Luoyang Medical College, an M.S. in Pathophysiology from the Institute of Basic Medical Sciences in Beijing, China, a Ph.D. in Microbiology/Immunology from Rosalind Franklin University of Medicine and Science, and postdoctoral training at Northwestern University. Prior to joining NCCU in 2011, he held an associate professor position in pathology at the University of Oklahoma Health Sciences Center. Dr. Yang's research program centers on breast cancer biology with multiple interconnected foci. His laboratory investigates deregulation of receptor tyrosine kinase signaling (particularly erbB2/EGFR, FGFR and c-Met) in breast cancer development and therapeutic resistance, examining crosstalk with Wnt and Notch pathways. He also studies alcohol-associated breast cancer risk mechanisms, dietary and metabolic modulation of cancer risk (including soy/genistein, caloric restriction and metformin), the impact of in utero exposure to endocrine-disrupting chemicals like BPA, and the role of mammary stem cells in cancer etiology. A significant portion of his work addresses triple-negative breast cancer and health disparities, particularly why African American women face higher breast cancer mortality rates. Analysis of Dr. Yang's recent publications reveals a consistent progression from fundamental molecular mechanisms to translational applications. His work demonstrates increasing sophistication in modeling breast cancer through transgenic mouse systems while maintaining focus on clinically relevant questions about therapeutic resistance and prevention strategies. The research shows particular strength in connecting metabolic interventions with molecular signaling pathways in cancer. American Cancer Society research scholar Career Development Award from the Department of Defense Breast Cancer Research Program Three-time recipient of the AACR Minority-Serving Institute Faculty Scholar Award Dr. Yang's research program has received substantial funding from the National Institutes of Health (NIH), Department of Defense, American Cancer Society, and local agencies. His work bridges basic molecular mechanisms with clinical applications, particularly in developing strategies to overcome therapeutic resistance in breast cancer. As an editorial board member for several scientific journals, he contributes significantly to the scholarly community beyond his own research program. Dr. Yang leads an active research laboratory within the JLC-BBRI at NCCU, utilizing various cellular and animal models to investigate breast cancer mechanisms. His collaborative work with UNC-Chapel Hill's Lineberger Comprehensive Cancer Center enhances the translational impact of his research findings, connecting basic science with potential clinical applications.

• Reproductive Biology
• Neurobiology
• Developmental Biology
• +۳ مورد دیگر

Anders Hay-Schmidt serves as Professor with special responsibilities at the Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen. His academic position is specifically listed as Professor MSO (Med Specialeansvar), indicating a professorial role with special responsibilities within the Danish academic system. His research spans multiple disciplines at the intersection of reproductive biology, neurobiology, and developmental biology. Professor Hay-Schmidt's research interests focus on reproductive endocrinology, particularly sex steroid dynamics in follicular development, and neurobiological mechanisms related to migraine pathophysiology and neuroglobin function. His work bridges basic science with clinical applications, examining how molecular mechanisms influence organ development, neural function, and reproductive health. He has made significant contributions to understanding PACAP signaling in migraine models, cytoglobin's role in cilia motility and organ laterality, and the impact of pharmaceuticals on embryonic development. Analysis of his recent publications reveals a strong interdisciplinary approach connecting reproductive biology with neurobiology. His work demonstrates expertise in both in vitro and in vivo models, with particular emphasis on molecular signaling pathways, hormone dynamics, and developmental processes. The research spans from fundamental cellular mechanisms to potential clinical applications in reproductive medicine and neurology. Professor Hay-Schmidt has published extensively with 98 research outputs documented, including high-impact publications in journals such as Nature Communications, Human Reproduction, and Fertility and Sterility. His work has garnered attention across multiple platforms, with mentions in news outlets, social media, Wikipedia, and academic sharing platforms like Mendeley. His collaborative network is extensive, with frequent co-authorship across multiple institutions and disciplines. While specific grant information isn't detailed in the available text, his research output suggests active funding support for his interdisciplinary investigations in reproductive biology and neurobiology. Based at the University of Copenhagen's Department of Odontology, Professor Hay-Schmidt contributes to the academic and research mission of one of Europe's leading medical faculties, bridging dental medicine with broader biomedical research through his specialized expertise in molecular and cellular mechanisms relevant to human health and disease.

Karen O'Malleyمشاهده پروفایل

استاد

• Neuroscience
• Molecular Neuroscience
• Cellular Neuroscience
• +۵ مورد دیگر

Karen O'Malley is a Professor of Neuroscience at Washington University School of Medicine. She leads the O'Malley laboratory which focuses on the molecular and cellular mechanisms underlying neurological and neuropsychiatric disorders. Dr. O'Malley received her BA with Honors from California State University of Sonoma in 1971, followed by an MS in Biology from Portland State University in 1973. She completed her PhD in Biological Sciences at the University of Texas in Austin in 1980. Her research primarily investigates signal transduction pathways mediated by metabotropic glutamate receptors such as mGluR5, which are widely expressed throughout the CNS and play critical roles in neuronal excitability, brain development, and learning and memory. Notably, her lab discovered that these receptors are not only expressed on the cell surface but also on nuclear membranes where they mediate unique signaling systems associated with synaptic plasticity. The lab has also maintained a longstanding interest in dopamine receptor structure and function, having been among the first to isolate D2-like genes (D2, D3, and D4) and demonstrate their unique signaling functions. Analysis of Dr. O'Malley's recent publications reveals a consistent focus on intracellular receptor signaling, particularly the role of metabotropic glutamate receptors in synaptic plasticity, neurological disorders, and pain pathways. Her work spans molecular neuroscience, cellular signaling, and translational research with implications for understanding and treating neurological conditions. Career Research Award for Women, National Science Foundation (1987) Stanley Foundation Investigator, National Alliance for the Mentally Ill (1989-1991) NARSAD Established Investigator Award (1995) Recognition for Excellence in Mentoring (2004) Outstanding Faculty Mentor Award (2005) First Annual AWN Service Award (2006) Outstanding Faculty Postdoctoral Mentor Award (2007) Distinguished Educator Postdoctoral Research Mentoring (2010) Physician and Scientist Leadership Certification (2012) Washington University School of Medicine Alumni Distinguished Faculty Award (2013) Dr. O'Malley has been recognized extensively for her mentoring excellence, receiving multiple awards for faculty mentoring at both the undergraduate and postdoctoral levels. Her laboratory has received consistent funding to support research on receptor signaling mechanisms and their implications for neurological disorders. The O'Malley lab employs advanced techniques including CRISPR to create transgenic animal models for studying receptor function in vivo. The O'Malley laboratory maintains a strong research program investigating the molecular and cellular bases of neurological disorders. The lab has developed specialized transgenic animal models, including lines expressing mGluR5 only on the cell surface and others expressing it only on the nucleus, to test the specific roles of intracellular mGluR5 in vivo. Current research directions include studying variable tandem repeats in the D4 gene associated with ADHD, ASD, and schizophrenia using humanized mouse models.

Suranjana Palمشاهده پروفایل

پژوهشگر

• Neuroscience
• Developmental Neuroscience
• Neural Circuits
• +۳ مورد دیگر

Dr. Suranjana Pal serves as a Senior Scientist in the Richards Lab at Washington University School of Medicine, focusing on genetic and activity-dependent mechanisms in mammalian neocortical circuit development. Her interdisciplinary work bridges neuroscience, molecular biology, and imaging technology. Her educational background includes: PhD in Neuroscience from Tata Institute of Fundamental Research, Mumbai, India (2019) Integrated MSc in Biotechnology from St. Xavier’s College (Autonomous), Kolkata, India (2013) Her research program investigates cortical development through genetic manipulation and advanced imaging techniques, with particular emphasis on thalamocortical connectivity, transcriptional regulation in brain patterning, and real-time tracking of cellular processes like autophagy. This work integrates molecular genetics with systems neuroscience to understand circuit formation. Publication analysis (2016-2021) reveals three dominant research threads: (1) developmental mechanisms in neocortical organization (40% of output), (2) molecular sensor development for cellular imaging (40%), and (3) evolutionary perspectives on brain development (20%). Her most impactful work combines transgenic models with novel imaging tools to dissect circuit assembly. Her awards demonstrate significant recognition: Inspiring Science Award-TNQ finalist (2022) for best-published life sciences paper from India EMBO Short term Fellowship (2019) at Instituto de Neurociencias-UMH-CSIC, Spain No formal advising relationships or grant funding details were documented in available sources, though her collaborative publications indicate active participation in multi-institutional research networks. She maintains strong ties with the Tata Institute of Fundamental Research through ongoing collaborations. As a core member of the Richards Lab, she contributes to the lab's mission of understanding neural circuit development using cutting-edge molecular and imaging approaches, with particular focus on sensory system wiring and cortical organization.

• Cancer Biology
• Prostate Cancer
• Molecular Oncology
• +۳ مورد دیگر

Yong Zhang, M.D., serves as a Research Instructor in the Department of Biomedical Sciences at Texas Tech University Health Sciences Center School of Pharmacy, Amarillo campus. His primary research focus centers on prostate cancer biology with emphasis on therapeutic development and chemoprevention strategies. Education: MD, Dalian Medical University, 1996 Dr. Zhang's research program investigates molecular mechanisms of prostate carcinogenesis, specializing in natural compound interventions targeting androgen receptor signaling pathways. His work integrates proteomic profiling of prostate tissue compartments in TRAMP mouse models with pharmacokinetic analysis of bioactive phytochemicals like galbanic acid and decursin derivatives. Current efforts focus on identifying lineage-specific therapeutic vulnerabilities in prostate cancer subtypes and optimizing natural product formulations for cancer prevention. Analysis of his 2011 publications reveals a cohesive research trajectory centered on prostate cancer chemoprevention, with dominant themes in proteomic biomarker discovery, natural product pharmacology, and lobe-specific tumor microenvironment characterization. The work demonstrates methodological expertise in HPLC-based pharmacokinetics, comparative proteomics, and transgenic mouse modeling. No scientific awards or grant funding details are documented in the current profile. Mentoring activities and student supervision are not explicitly referenced in available materials. Research operations appear integrated within the Department of Biomedical Sciences infrastructure, though specific laboratory facilities or collaborative teams are not described in the provided documentation.

Diane E. Merryمشاهده پروفایل

استاد

• Neurodegenerative Diseases
• Molecular Pathogenesis
• Protein Misfolding and Aggregation
• +۵ مورد دیگر

Diane E. Merry serves as Professor in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University's College of Life Sciences, concurrently holding the administrative position of Vice Chair for Faculty Development and Engagement. Her laboratory investigates the molecular mechanisms underlying spinal and bulbar muscular atrophy (SBMA), a motor neuron disease caused by polyglutamine expansion in the androgen receptor (AR). Research Focus Dr. Merry's work centers on two critical pathways: (1) elucidating DHT-dependent AR misfolding, aggregation, and toxicity mechanisms; and (2) decoding molecular pathways leading to motor neuron dysfunction. Key discoveries include the essential roles of androgen binding and nuclear localization in disease pathogenesis, with current investigations examining AR trafficking anomalies, proteolytic cleavage, post-translational modifications, and the neuroprotective function of nuclear proteasomal regulator PA28γ. Her lab has identified AR ligands targeting the N/C interaction that promote motor neuron viability, now undergoing preclinical testing in SBMA transgenic models. Methodology and Impact Employing biochemical, molecular, and cell biological approaches across transgenic mice, cultured cells, and primary motor neuron systems, her research bridges fundamental protein misfolding mechanisms with therapeutic development. This work establishes critical links between proteasome dysfunction in neuronal nuclei and polyglutamine disease progression, offering novel targets for neurodegenerative disorder interventions. Academic Leadership As Vice Chair for Faculty Development and Engagement, Dr. Merry shapes institutional strategies for faculty support and academic community building while maintaining an active research program focused on neurodegeneration mechanisms and therapeutic innovation.