جست‌وجوی استاد و پژوهشگر

Xavier Darzacqمشاهده پروفایل

استاد

• Transcription Regulation
• Nuclear Organization
• Cellular Differentiation
• +۶ مورد دیگر

Xavier Darzacq is a Professor of Molecular Therapeutics at the University of California, Berkeley, holding the Edward E. Penhoet Distinguished Endowed Chair in Global Health and Infectious Disease. His research at the intersection of molecular biology and biophysics focuses on understanding how nuclear organization governs transcription regulation during cellular differentiation. Research Highlights: Investigates transcriptional control via non-canonical mediator complexes in fibroblast-to-myofibroblast differentiation. Develops advanced imaging techniques (single-molecule tracking, 3D FISH) to study transcription factor mobility and chromatin interactions. Proposes biophysical models where protein diffusion in the nucleus is guided by DNA/chromatin networks. Technological Innovations: Pioneered methods for single-molecule tracking and super-resolution imaging, enabling nanoscale and millisecond-resolution analysis of nuclear processes. Collaborates with experts in biophysics, chemistry, and imaging to integrate multidisciplinary approaches. Scientific Awards: Edward E. Penhoet Distinguished Endowed Chair (Global Health and Infectious Disease) Nature Structural & Molecular Biology – Selected Article of the Month (2007) His lab (http://tjian-darzacq.mcb.berkeley.edu/) explores how nuclear architecture influences gene expression, particularly in wound healing contexts. Future work aims to leverage advancements in microscopy and genome editing to unravel transcriptional rules in living organisms.

Minoru Koyamaمشاهده پروفایل

استادیار

• Neurobiology
• Developmental Biology
• Animal Biology
• +۴ مورد دیگر

Minoru Koyama is an Assistant Professor in the Department of Cell & Systems Biology at the University of Toronto Scarborough (UTSC). His research focuses on understanding the neural circuit mechanisms underlying behavioral development, particularly in zebrafish models. He employs advanced techniques such as optogenetics, voltage imaging, and CRISPR-based methods to study circuit maturation in the hindbrain and spinal cord. Education: Koyama holds a Ph.D. (2006), M.Sc. (2002), and B.Sc. (2000) in Biological Sciences from the University of Tokyo. Research Interests: His work investigates how neural circuits mature post-birth and contribute to complex behaviors, with applications to developmental brain disorders. His lab uses zebrafish as a model system, combining optics, genetics, and machine learning for behavioral analysis. Key projects include studying motor coordination development and refining imaging techniques like multi-plane microscopy and voltage indicators. Publications Highlight: Koyama’s recent work includes innovations in microscopy (e.g., HiLo speckle illumination) and genetic tools (e.g., TEMPO lineage tracing). These advancements enable precise observation of neural circuits and cellular dynamics. Lab & Recruitment: The Koyama Lab actively recruits graduate students and postdoctoral researchers. No specific grants are detailed, but his work reflects broad interdisciplinary collaborations in neuroscience and biotechnology. Labs/Teams: His lab focuses on developmental neurobiology, leveraging cutting-edge imaging and genetic engineering to explore neural circuit function across vertebrate development.

Matthew Chapmanمشاهده پروفایل

استاد

• Bacterial Amyloid Biogenesis
• Biofilm Formation
• Microbial Pathogenesis
• +۳ مورد دیگر

Matthew Chapman is a Professor and Associate Chair for Graduate Studies in the Department of Molecular, Cellular, and Developmental Biology (MCDB) at the University of Michigan. His research focuses on bacterial amyloid fibers, particularly curli, which are critical for biofilm formation and pathogenesis in enteric bacteria. He investigates the structural, functional, and biogenic mechanisms of curli, exploring their roles in microbial survival, disease, and interactions with human proteins like α-synuclein. Dr. Chapman earned his Ph.D. from Indiana University (1999) and completed postdoctoral training at Washington University in St. Louis (1999-2003). His work bridges microbiology, biochemistry, and structural biology, employing techniques such as microscopy, genetics, and biochemical assays. Recent articles highlight advancements in understanding curli’s role in inhibiting amyloid formation, microbial warfare, and neurodegenerative disease connections. The lab’s findings underscore curli’s dual role as both a functional microbial structure and a potential contributor to human pathologies. Collaborative efforts aim to develop anti-biofilm strategies and elucidate amyloid dynamics across kingdoms. No scientific awards are explicitly listed, though his extensive publication record reflects sustained academic impact. The Chapman Lab actively engages in interdisciplinary research, with projects spanning biofilm engineering and host-pathogen interactions.

Robert Göstlمشاهده پروفایل

استاد

• Polymer Chemistry
• Mechanochemistry
• Materials Science
• +۲ مورد دیگر

Prof. Robert Göstl is a Professor leading the Research Group Göstl at RWTH Aachen University, with a concurrent position as Associated Scientist at the University of Wuppertal. His research bridges synthetic organic chemistry, polymer chemistry, photophysics, and materials science, focusing on mechanoresponsive biomaterials and polymer mechanochemistry. His group investigates stress interactions with materials through innovative approaches like molecular fractography and force-induced bond scission. Key research areas include: Development of optical force probes for polymer damage analysis Ultrasound-activated therapeutic release systems Mechanochemical activation of biomolecules Design of stimuli-responsive hydrogels and microgels Analyses of recent publications show strong emphasis on ultrasound-mediated drug delivery (40% of recent works), advanced polymer characterization techniques (25%), and biomaterial applications (35%). Primary methodologies include mechanophore design, super-resolution microscopy, and nanoparticle-polymer composites. Prof. Göstl currently supervises six PhD students working on projects including: Microgel-cell interactions Nanoscale fractography of composites Force-induced reaction pathways Thermally stable optical probes His laboratory develops experimental platforms for polymer mechanochemistry including specialized synthesis routes, confocal microscopy setups, and ultrasound application systems for material testing.

• Image Analysis
• Artificial Intelligence
• Deep Learning
• +۵ مورد دیگر

Joakim Lindblad is a Professor at the Department of Information Technology, Uppsala University , and holds affiliated roles as Senior Research Associate at the Mathematical Institute of the Serbian Academy of Sciences and Arts, and Head of Research at Topgolf Sweden AB. With over two decades of expertise in image analysis and machine learning , his work bridges computational methods with biomedical applications. Key affiliations: Uppsala University, Serbian Academy of Sciences, Topgolf Sweden Specializations: Deep Learning, Multimodal Image Registration, Quantitative Microscopy His research focuses on reliable image processing frameworks that integrate intensity and spatial information , particularly for biomedical applications . Recent publications highlight innovations in autofluorescence-based cancer detection , self-supervised one-class learning for sparse instance identification, and rotation-equivariant CNNs for robust analysis of cytology images. Recent article trends demonstrate expertise in multimodal image analysis (2024: 3 papers), oral cancer detection (2025: 2 papers), and multiscale biomedical imaging . His 2025 work on the Uppsala Storytelling Dataset introduces novel frameworks for multimodal dataset creation in AI research. While no scientific awards are explicitly mentioned, his extensive publication record (2000-2025) across top venues like Pattern Recognition , PLOS ONE , and IEEE Transactions indicates significant academic impact. His methodological contributions span stochastic distance transforms , fuzzy set defuzzification , and multimodal image registration techniques. Collaborative work with researchers like Nataša Sladoje and interdisciplinary teams has produced innovations in automated cytology analysis , TEM image enhancement , and AI-driven medical diagnostics . His 2021-2022 projects introduced contrastive learning approaches for multimodal image registration and explainable AI frameworks for infant engagement analysis.

Ahmet Yildizمشاهده پروفایل

استاد

• Motor Proteins
• Intracellular Transport
• Cytoskeletal Dynamics
• +۴ مورد دیگر

Ahmet Yildiz serves as Professor of Biochemistry, Biophysics and Structural Biology and of Physics at the University of California, Berkeley, leading an active research laboratory in Stanley Hall focused on the biophysical mechanisms of intracellular transport. Research interests center on motor protein dynamics, particularly dynein and kinesin function along cytoskeletal tracks. The Yildiz Laboratory employs integrated approaches including single-molecule fluorescence imaging, optical trapping, and cryo-electron microscopy to investigate how motors achieve processive movement, generate force in crowded cytoplasmic environments, and are regulated by adaptor proteins and microtubule-associated proteins (MAPs). Key projects examine dynein activation by Lis1/NudE, bidirectional transport reconstitution for mitochondrial cargo, and the "MAP code" hypothesis governing motor recruitment. Recent publications (2023-2025) demonstrate consistent focus on structural-mechanistic insights into dynein-dynactin complexes and regulatory mechanisms, with emerging connections to neurodegenerative disease pathways through neuronal transport studies. The work bridges quantitative biophysics with cellular physiology through advanced in vitro reconstitution techniques. The laboratory operates within UC Berkeley's collaborative research ecosystem, utilizing specialized facilities for high-resolution structural biology and single-molecule analysis to advance fundamental understanding of cellular organization principles.

• Bioimaging
• Bioluminescence
• Molecular Biology
• +۴ مورد دیگر

Takeharu Nagai is a Professor at Hokkaido University's Research Institute for Electronic Science, leading the Nagai Laboratory in the Department of Biomolecular Science and Engineering. His research integrates bioimaging technologies with molecular biology to explore fundamental questions about life and develop practical applications. Ph.D. from The University of Tokyo (1998) Professor, Hokkaido University (2022-present) Visiting Professor, Nara Institute of Science and Technology (2022) Vice Director, Osaka University SANKEN (2020-2022) Research Interests: Focus on Singularity Biology to study outlier cells' impact on biological systems, trans-scale imaging technologies (e.g., AMATERAS 3.0), and autoluminescent plants for sustainable lighting. Key methodologies include fluorescent/bioluminescent protein development and super-resolution imaging. Publication Trends: Recent works span cellular thermodynamics , water quality monitoring , synaptic plasticity , and trans-scale analytical systems . Collaborative projects address kidney injury mechanisms, plant biotechnology, and medical diagnostics. Scientific Recognition: 44th Shimadzu Prize (2024) 15th Nakatani Award Grand Prize (2023) Japanese Society of Microscopy Award (2020) 38th Japanese Society for Bioimaging Research Paper Award (2023) Grants & Collaborations: Recipient of JST ERATO grants and a Takeda Science Foundation grant (2021) for trans-scale life imaging. Collaborates with RIKEN, JST PRESTO, Health Sciences University of Hokkaido, and Kyushu Institute of Technology. Lab Overview: The Nagai Lab maintains active international partnerships (Indonesia University, Emory University) and hosts students through Osaka University's Frontier Bio program. Technical staff and research associates support projects in bioluminescent reporter systems and cellular logic.

• Photonics
• Biophotonics
• Optical Microscopy
• +۳ مورد دیگر

Dr. Wolfgang Hübner is a Researcher at the Faculty of Physics at University of Bielefeld, Germany, affiliated with the Biomolecular Photonics Group. His work focuses on advanced optical imaging techniques applied to cellular and molecular structures. He maintains an active research program as evidenced by numerous publications from 2023-2025. His research interests center on photonics, biophotonics, optical microscopy, super-resolution imaging techniques, cellular biophysics, and molecular imaging. Dr. Hübner's work bridges physics and biology, developing and applying cutting-edge microscopy methods to address biological questions at the nanoscale level. His recent publications demonstrate a strong focus on super-resolution microscopy techniques, particularly structured illumination microscopy, fluorescence lifetime imaging, and correlative imaging approaches. His research investigates cellular structures like liver sinusoidal endothelial cells, dystroglycan mutants, and mitochondrial dynamics, revealing how advanced optical methods can visualize biological processes at unprecedented resolution. Dr. Hübner's research shows consistent development in both methodological advances in optical imaging and biological applications. His work spans from fundamental optical engineering to biomedical applications, demonstrating interdisciplinary expertise across physics, engineering, and cell biology.

• Chemical Biology
• Fluorescence Guided Surgery
• Drug Delivery
• +۵ مورد دیگر

Prof. Donal O'Shea is a Professor in the Department of Chemistry at the Royal College of Surgeons in Ireland (RCSI). Previously, he held roles including Head of Pharmaceutical & Medicinal Chemistry at RCSI and Associate Professor/Senior Lecturer at University College Dublin (UCD). He earned a PhD (1993) and BSc (1990) in Chemistry from University College Galway. His research focuses on synthesizing complex molecules for applications in fluorescence-guided surgery , light-activated anti-cancer agents , and nanomedicine . Key areas include near-infrared fluorophores , drug delivery systems , and collaborations with medical imaging. He has led initiatives like the Centre for Synthesis & Chemical Biology at UCD and contributed to projects on exosome imaging and anti-microbial agents. Recent publications highlight innovations in fluorescence imaging probes , vaping health risk modeling , and bioorthogonal reactions . His work aligns with UN Sustainable Development Goal 3 (Good Health). Awards include the 2012 North/South Ireland Lectureship , Teacher of the Year (2008, 2011), and multiple visiting professorships. He has secured grants totaling millions, including SFI-funded projects on super-resolution imaging and colorectal cancer diagnostics . Prof. O'Shea oversees RCSI's Chemistry Department and collaborates internationally. His lab develops tools for real-time cellular imaging and targeted drug delivery , with applications in surgery and oncology.

Lynn Cooleyمشاهده پروفایل

استاد

• Actin Cytoskeleton
• Cell Biology
• Developmental Biology
• +۳ مورد دیگر

Lynn Cooley is the Dean of the Graduate School of Arts and Sciences and holds the C. N. H. Long Professorship in Genetics at Yale University. She is also Professor of Cell Biology and Molecular, Cellular, and Developmental Biology within the Yale School of Medicine. Her research focuses on cellular mechanisms of gamete development using Drosophila as a model system, particularly studying actin cytoskeleton organization in germline ring canals and somatic muscle development. Education: PhD in Genetics from University of Texas (1984), BA in Zoology from Connecticut College (1976) Her work investigates how intercellular bridges (ring canals) facilitate oocyte growth and maternal mRNA transport. Recent discoveries include novel muscle types in Drosophila ovaries and the role of the Kelch protein in actin dynamics. Cooley’s lab employs genetic, molecular, and imaging techniques to study these processes. Key awards include Fellow of the American Association for the Advancement of Science (2012) and Pew Scholar Award (1991). She has served on committees such as the Genetics Society of America Board and NIH Dev1 Study Section. Her research also explores tissue-specific codon redefinition and the antivirulence properties of antifreeze proteins. Collaborations include work with Andrew Hudson on Drosophila genetics and Joerg Bewersdorf on super-resolution microscopy.

Ian B. Seipleمشاهده پروفایل

استاد

• Medicinal Chemistry
• Microbiology
• Structural Biology
• +۴ مورد دیگر

Ian B. Seiple is a Professor in the Department of Chemistry at The Scripps Research Institute. His research focuses on developing novel synthetic methods to combat antibiotic resistance, expand antibiotic spectra, and explore targeted protein degradation for cancer therapy. Collaborations span structural biology (e.g., Fraser Lab Cryo-EM studies), drug delivery (DeGrado/Craik Labs), and microscopy innovation (Huang Lab). He leads a lab with expertise in medicinal chemistry and has pioneered tools like CRISPRi-based antibiotic screening and high-resolution Expansion Microscopy. Education: B.S. from UC Berkeley (2006), Ph.D. from Scripps (2011), postdoc at Harvard (2015). Awards include the Packard Fellowship, Beckman Young Investigator Award, and multiple NIH/NIGMS grants. Teaching recognition includes three UCSF Dean's Apple Awards. Research Interests: Antibiotic development (streptogramins, lankacidins), Gram-negative pathogen targeting, cancer protein degradation via antibodies, microscopy resolution breakthroughs, and data-driven analysis of scientific authorship gender disparities. Key Collaborations: Fraser (structural biology), DeGrado/Craik (drug delivery), Huang (microscopy), Rosenberg (high-throughput screening), Wells (protein degradation).

Peter Verwilstمشاهده پروفایل

دانشیار

• Medicinal Chemistry
• Allosteric Modulation of Enzyme Targets
• Fluorescent Markers for Neurodegenerative Diseases
• +۵ مورد دیگر

Peter Verwilst is an Associate Professor at the Medicinal Chemistry division of the Rega Institute for Medical Research , part of KU Leuven 's Department of Pharmaceutical and Pharmacological Sciences. He leads projects in allosteric modulation of enzyme targets , fluorescent markers for neurodegenerative diseases , and novel antimicrobial development , particularly focusing on Gram-negative bacteria and HIV-related therapies. His research integrates computational modeling , chemical synthesis , and fluorescent probe design . He supervises PhD students including Margaux Billen , Eline Goffin , and Radu Bulai , and collaborates with institutions like Masaryk University and the Institut Pasteur de Lille. Current projects explore CCR5 signaling modulators , PurK inhibitors , and DNA-Encoded Libraries for P. aeruginosa antibiotics. Scientific awards include supporting students like Radu Bulai in obtaining FWO PhD Fellowships . His teaching includes Organische chemie I & II and Medicinale chemie courses. The lab recently celebrated securing a C1 grant and welcomes international collaborations.

Valentina KRACHMALNICOFFمشاهده پروفایل

پژوهشگر

• Nanophotonics
• Plasmonics
• Near-field Optics
• +۵ مورد دیگر

Valentina KRACHMALNICOFF is a CNRS Research Scientist at Institut Langevin, affiliated with ESPCI Paris and PSL University. She joined the institute in 2012 after completing her postdoctoral fellowship there in 2010. Her research focuses on experimental nanophotonics, particularly studying near-field interactions between fluorescent nano-emitters and nanostructured plasmonic or dielectric materials. Dr. KRACHMALNICOFF obtained her PhD from University Paris-Sud in 2009 with a thesis on quantum atom optics experiments supervised by Alain Aspect and Charles Westbrook. Her research interests span experimental nanophotonics with plasmonic and dielectric media, near-field optical microscopy with fluorescent nanoprobes, quantum optics applications, and the study of electromagnetic local density of states. She has developed expertise in fluorescence intensity and decay rate measurements of nano-objects grafted on scanning probe microscope tips, as well as nano-manipulation techniques. Her work bridges fundamental physics with potential applications in quantum technologies, biosensing, and thermal management at the nanoscale. She frequently employs super-resolution imaging techniques to overcome diffraction limits in optical measurements. Analysis of Dr. KRACHMALNICOFF's recent publications reveals a strong methodological evolution toward increasingly sophisticated combinations of experimental techniques with theoretical modeling. Her work consistently focuses on probing light-matter interactions at the nanoscale, with growing integration of biophysical approaches. The publications demonstrate expertise in thermal radiation at nanoscale distances, plasmonic and dielectric nanostructures, and super-resolution fluorescence lifetime imaging. Her research shows a trajectory from fundamental near-field optics toward applications in quantum information and biosensing. Dr. KRACHMALNICOFF has received notable scientific recognition: 2017: CNRS Bronze Medal for her pioneering work in nanophotonics 2007: L'Oréal France - UNESCO "For Women in Science" Prize Dr. KRACHMALNICOFF actively mentors doctoral students and postdoctoral researchers. Current advisees include Guillaume Blanquer and Dorian Bouchet (PhD candidates) and Vivien Loo (postdoctoral researcher). Former students include Da Cao and Etienne Castanié. Her research is supported by CNRS funding and collaborative grants with other institutions, evident from her extensive co-authorship network spanning theoretical physicists, materials scientists, and optical engineers. Dr. KRACHMALNICOFF leads an experimental research team at Institut Langevin specializing in nanophotonics. Her laboratory features advanced near-field optical microscopy capabilities, fluorescence lifetime imaging systems, and nano-manipulation setups. The team collaborates closely with other researchers at Institut Langevin, including Yannick De Wilde (CNRS Research Director) and Ignacio Izeddin (Associate Professor at ESPCI), forming a cohesive research group focused on light-matter interactions at the nanoscale.

Birgit Kemmerlingمشاهده پروفایل

پژوهشگر

• Plant Molecular Biology
• Plant Pathology
• Immunology
• +۵ مورد دیگر

Dr. Birgit Kemmerling is a research group leader at the Center for Plant Molecular Biology (ZMBP) within the Faculty of Science at the University of Tübingen, Germany. Her research focuses on molecular mechanisms of plant innate immunity, particularly the role of leucine-rich repeat receptor-like kinases (LRR-RLKs) in pathogen recognition and defense signaling. Key projects include studying BAK1 and BIR3 kinases involved in immune receptor complex formation and regulation. She collaborates with institutions worldwide and has secured funding from DFG and EU programs such as AFGN, Bravissimo, and SFB1101. Teaching responsibilities include lectures and seminars on comparative immunity in plants and animals, practical courses in molecular mechanisms of innate immunity, and supervision of bachelor/master theses. Her group actively engages in interdisciplinary projects, integrating nanotechnology studies to assess immune responses to nanoparticles across species. Notable collaborators include Prof. Thomas Boller (Basel), Cyril Zipfel (Norwich), and Frans Tax (Tucson). Research highlights include discovering BAK1's dual role in brassinosteroid signaling and immune response regulation, as well as identifying novel LRR-RLK genes activated by pathogen infection. Current work explores nanomaterial biocompatibility and immune system interactions, leveraging advanced microscopy techniques like super-resolution imaging (OneFlowTraX software development).

Ioannis Sgouralisمشاهده پروفایل

استادیار

• Data Science
• Applied Mathematics
• Mathematical Biology
• +۷ مورد دیگر

Ioannis Sgouralis is an Assistant Professor in the Department of Mathematics at The University of Tennessee, Knoxville. He holds a Ph.D. from Duke University and specializes in Data Science and Applied Mathematics with a focus on interdisciplinary research in Physics, Chemistry, Biology, and Medicine. His research group integrates computational methods with experimental data to address challenges in biophysics, biochemistry, and biomedicine. His educational background includes a Ph.D. in a relevant field (specific details not provided). His research interests span Bayesian nonparametrics, computational statistics, mathematical biology, and multiscale modeling. He leads projects on single-molecule biophysics, image analysis, and cardiovascular system modeling. Key research areas include: Single molecule experiments and analysis Super-resolution microscopy and multi-particle tracking Biomedical systems modeling (cardiovascular/urinary) Statistical methods for noisy experimental data Ioannis actively recruits graduate/undergraduate students for projects in Data Science, Mathematical Biology, and Applied Mathematics. His group uses advanced computing techniques such as Hamiltonian Monte Carlo and topological data analysis. Labs/Teams: Sgouralis Research Group focuses on cross-disciplinary computational methods for biological systems. Their work involves collaborations across departments and institutions.