جست‌وجوی استاد و پژوهشگر

• Computational Medicinal Chemistry
• Chemoinformatics
• Glycoscience
• +۴ مورد دیگر

Robert J. Doerksen is Professor of Medicinal Chemistry in the Department of BioMolecular Sciences at the University of Mississippi School of Pharmacy , Associate Dean of the Graduate School , and Research Professor in the Research Institute of Pharmaceutical Sciences . Since 2004 he has combined computational chemistry with experimental collaborations to advance drug discovery, particularly in glycoscience and cannabinoid research. Education: B.S. (Double First Class Honours) in Mathematics & Physics, University of New Brunswick, 1986 Graduate Diploma in Christian Studies, Regent College, Vancouver, 1996 Ph.D. in Chemistry, University of New Brunswick, 1998 (Advisor: Prof. Ajit Thakkar) Postdoctoral Fellow, UC Berkeley (with Prof. Martin Head-Gordon) Postdoctoral Fellow, University of Pennsylvania (with Prof. Michael Klein) Research Interests: Dr. Doerksen’s laboratory develops and applies computational medicinal chemistry approaches spanning chemoinformatics , molecular dynamics , virtual screening , and machine learning to understand how small molecules interact with proteins. Central themes include: Glycoscience : lectin–glycan interactions, glycosyltransferase regulation, glycomimetic design. Cannabinoids : CB1/CB2 receptor allosteric modulation, cannabidiol pharmacology, synthetic cannabinoid SAR. Neglected & Infectious Diseases : malaria, hepatitis B, tuberculosis, SARS-CoV-2, urinary-tract infections. Drug Delivery & Formulation : nanoparticle coatings, pharmacokinetic optimization, bioavailability enhancement. Publications Trend: Over 2023–2025 his 15 most recent papers reveal intense activity at the intersection of AI-driven discovery , glycobiology , and cannabinoid pharmacology , with emphasis on anti-infective, anticancer, and CNS-active agents. Key contributions include first-in-class MraY inhibitors for TB, cannabinoid-inspired antivirals against SARS-CoV-2, and glycomimetic antagonists of bacterial adhesins for UTI prevention. Scientific Awards & Honors: UM School of Pharmacy Faculty Service Award (2015–2016) UM School of Pharmacy Faculty Service Award (2010–2011) Editorial Boards: Molecules , AIMS Biophysics , Pharmaceutical Sciences , Perspectives in Medicinal Chemistry Repeated NIH, DoD, NSF, Wellcome Trust, and international grant-review panels (2010–present) Guest Editor for multiple special issues in Molecules and Frontiers journals Advising & Mentoring: As Associate Dean, Dr. Doerksen oversees University-wide graduate programs, chairs the Graduate Recruiting Fellowship and Scholarship Committee, and mentors students across disciplines. Faculty advisor for the UM chapters of the Christian Pharmacists Fellowship International (since 2005) and Taiwanese Student Association (2022–2025). He actively participates in PhD and MS thesis committees worldwide and has delivered NSF GRFP information sessions to support trainee funding. Laboratories & Teams: He directs research within the Computational Chemistry and Bioinformatics Research CORE (CCBRC) , fostering collaborative projects involving medicinal chemists, structural biologists, pharmacologists, and data scientists. The group leverages high-performance computing resources at the University of Mississippi to perform large-scale virtual screening, AI/ML model development, and integrative structural biology studies.

Thomas J.D. Jørgensenمشاهده پروفایل

دانشیار

• Biomedical Mass Spectrometry
• Systems Biology
• Protein Dynamics
• +۴ مورد دیگر

Thomas J.D. Jørgensen is an Associate Professor at the Department of Biochemistry and Molecular Biology, University of Southern Denmark. His work focuses on Biomedical Mass Spectrometry and Systems Biology, with a particular emphasis on protein dynamics, lipoprotein metabolism, and structural characterization. Current research involves lipoprotein lipase regulation (ANGPTL3/8, APOC2) and GPIHBP1-heparan sulfate interactions Expertise in Hydrogen/Deuterium Exchange Mass Spectrometry and glycopeptide analysis Scientific Leadership: Active in Ph.D. evaluation committees (Swedish Research Council, 2015; multiple international roles) and peer review activities. Funding Involvement: Participates in major projects including Leducq Foundation grants for triglyceride metabolism research, Novo Nordisk Foundation ONE IDP initiatives, and collaborations with GlyProVac ApS. Research Trends: Publications show strong focus on structural dynamics of lipid metabolism proteins (47% of 2023-2025 work), glycopeptide characterization (100% in 2023), and allosteric regulation mechanisms (100% in DNA repair proteins). Collaborations: International partnerships in cardiovascular biology, Parkinson's disease (Michael J. Fox Foundation), and biopharmaceutical safety. Media coverage includes breakthroughs in lipoprotein structure (2014) and Parkinson's research (2014).

Martina Delbiancoمشاهده پروفایل

استاد پژوهشی

• Carbohydrate Materials
• Glycan Foldamers
• Supramolecular Chemistry
• +۵ مورد دیگر

Dr. Martina Delbianco is a Group Leader in the Carbohydrate Materials group within the Department of Biomolecular Systems at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany. Her research focuses on designing and engineering synthetic carbohydrate-based materials with controlled structures and functions. Dr. Delbianco's research interests center on carbohydrate chemistry, particularly the development of well-defined polysaccharides and glycan foldamers. Her work explores how these biomolecules can form supramolecular structures through hydrogen bonding and other interactions, with applications in therapeutics and advanced materials. She specializes in automated synthesis methods for creating precisely structured carbohydrates that can adopt specific shapes from helices to sheets. Her recent publications demonstrate significant advances in glycan foldamer science, including the development of catalytic glycans and methods for controlling glycan folding through ionic functional groups. These innovations represent groundbreaking work at the intersection of carbohydrate chemistry and materials science. Feltrinelli Prize for research on carbohydrate-based materials ERC Proof of Concept Grant (2024) for the GlycoRoads project Dr. Delbianco actively mentors students and postdoctoral researchers, supervising Bachelor's and Master's theses in her group. Her GlycoRoads ERC project aims to develop tools for designing glycans with specific shapes for therapeutic and materials applications. She collaborates extensively with researchers across Europe, including Yu Ogawa's group, and participates in major scientific conferences such as the Gordon Research Conference on Carbohydrates. Her laboratory focuses on creating software for glycan design, integrating molecular dynamics simulations and data analytics to facilitate the development of custom carbohydrate structures. This work positions her at the forefront of computational glycoscience and biomaterials engineering.

Sandra Rotherمشاهده پروفایل

استادیار

• Glycosaminoglycans
• Extracellular Matrix Biology
• Cancer Research
• +۵ مورد دیگر

Dr. Sandra Rother is an Assistant Professor at Saarland University's School of Medicine, affiliated with the Center for Integrative Physiology and Molecular Medicine (CIPMM) in Homburg. She leads an active research laboratory focused on glycosaminoglycan-mediated signaling pathways and their implications in biomedical conditions including cancer, chronic wounds, and inflammation. Her work bridges fundamental biochemistry with clinical applications through biomimetic material development. Her primary research examines how glycosaminoglycans regulate extracellular matrix dynamics and growth factor signaling (particularly TGF-β cytokines) in pathological contexts. The lab employs cutting-edge techniques including Surface Plasmon Resonance (SPR), Fluorescence-Activated Cell Sorting (FACS), LC-MS glycosaminoglycan analysis, CRISPR/Cas9 gene editing, and engineered 3D cell culture systems to investigate structural modifications affecting protein binding and cellular responses. Current research priorities include: Glycocalyx manipulation for melanoma therapeutics Development of glycosaminoglycan-functionalized hydrogels for angiogenic regulation Impact of advanced glycation products on extracellular matrix Glycosaminoglycan mimetics from sustainable sources Her research is funded by: Dr. Rolf M. Schwiete Stiftung (Project 2024-021: Targeting the glycocalyx for melanoma treatment) WISNA-Program (Federal-State Program for the Promotion of Young Scientists) Dr. Rother leads a diverse team including 6 current students (PhD, MD, and Bachelor/Master candidates) and 8 alumni. She actively recruits postdoctoral researchers and students interested in glycoscience, emphasizing diversity and equity in her laboratory. Current team projects include bioactive hydrogel development, glycocalyx imaging, and biomimetic implant coatings.

Leonhard Möcklمشاهده پروفایل

استاد

• Nano-optical Imaging
• Super-resolution Microscopy
• Glycocalyx Structure and Function
• +۴ مورد دیگر

Leonhard Möckl is a Professor of Nano-optical Imaging at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and an Associated Group Leader at the Max Planck Institute for the Science of Light. He holds a PhD from LMU Munich (2015) and completed postdoctoral research at Stanford University (2016–2020), focusing on glycocalyx dynamics using super-resolution microscopy and deep learning. His research integrates biophysics, nanotechnology, and computational methods to study cell membrane organization and disease mechanisms. Key research areas include glycocalyx architecture, single-molecule imaging, and nano-optical techniques for biomedical applications. He leads the Physical Glycosciences Research Group, developing tools like XLuminA for automated microscopy design and novel drug delivery systems. Notable contributions include studies on RNA-binding proteins in leukemia treatment and glycocalyx-based drug targeting. Publications span high-impact journals like Nature Biotechnology , Cell , and Nature Communications , reflecting his expertise in imaging, glycobiology, and molecular pharmacology. His work bridges fundamental science and translational medicine, addressing challenges in cancer therapy, infectious diseases, and cell engineering.

• Carbohydrate Chemistry
• Organic Synthesis
• Glycosylation Methods
• +۵ مورد دیگر

Dr. Jianglong Zhu is a Professor in the Department of Chemistry & Biochemistry at the University of Toledo, within the College of Natural Sciences and Mathematics. His research focuses on developing novel synthetic methodologies for carbohydrate chemistry, with particular emphasis on glycosylation techniques and the synthesis of complex oligosaccharides and glycoconjugates. Dr. Zhu's research interests center on carbohydrate chemistry and synthetic methodology development. He has made significant contributions to the field of stereoselective glycosylation, particularly through anomeric O-alkylation techniques and gold-catalyzed glycosylation methods. His work has applications in synthesizing bacterial carbohydrate antigens for vaccine development, antitumor antibiotics, and complex glycans found in biological systems. His research bridges organic chemistry, chemical biology, and medicinal chemistry, with implications for understanding and treating diseases including cancer. Analysis of Dr. Zhu's publication record reveals a strong focus on developing innovative methods for constructing challenging glycosidic linkages, particularly β-mannosidic bonds which are notoriously difficult to form. His work spans from fundamental methodology development to applications in synthesizing biologically relevant carbohydrate structures including bacterial antigens, tumor-associated carbohydrate antigens, and complex natural products. Recent work has emphasized cationic gold(I)-catalyzed glycosylation and cesium carbonate-mediated anomeric alkylation techniques.

WanTien Chiangمشاهده پروفایل

استادیار

• Systems Immunology
• Bioinformatics
• Computational Biology
• +۶ مورد دیگر

WanTien (Austin) Chiang is an Assistant Professor at the Medical College of Georgia , Augusta University, affiliated with both the Department of Medicine and the Immunology Center of Georgia . With expertise spanning systems immunology, bioinformatics, and computational biology, Dr. Chiang develops biological modeling algorithms to study complex immunological systems and human diseases.

• Glycobiology
• Synthetic Chemistry
• Chemical Biology
• +۳ مورد دیگر

Ben Schumann is a Senior Lecturer in Chemical Biology at Imperial College London and a Group Leader at the Francis Crick Institute, UK. Diploma in Biochemistry (2010, Tübingen University) Doctor of Natural Sciences (2015, Max Planck Institute & Freie Universität Berlin) Postdoctoral Fellow (2016, Stanford University) under Alexander von Humboldt Foundation Feodor Lynen Fellowship His research focuses on glycobiology , particularly O-glycosylation and bioorthogonal chemistry , applying synthetic precision tools to study glycan roles in diseases like cancer and infectious pathogens. His work bridges organic synthesis , molecular biology , and proteomics , with a focus on GalNAc transferases and glycan analysis . Recent publications highlight trends in glycan engineering , cell-specific tagging , and glycoprotein profiling using bump-and-hole strategies and metabolic labeling. Collaborations span structural biology, proteomics, and computational biology. Scientific Awards Otto Hahn Medal (2017) Award for Excellence in Glycosciences He co-authored 27 Crick publications (2018–2025) and 8 pre-Crick works. As Director of Imperial's MRes in Drug Discovery and Development, he trains next-generation scientists. His lab integrates genome engineering, chemo-enzymatic synthesis, and quantitative biology to unravel glycan functions.

Peter H. Seebergerمشاهده پروفایل

استاد

• Glycosciences
• Carbohydrate Chemistry
• Vaccine Development
• +۳ مورد دیگر

Peter H. Seeberger is Director at the Max-Planck Institute for Colloids and Surfaces in Potsdam, Professor at the Freie Universität Berlin, and honorary Professor at Potsdam University. He previously served as Affiliate Professor at the Sanford-Burnham Institute for Medical Research (2003-2014) and Professor at ETH Zurich. Since 2021, he has been Vice President of the German Research Foundation (DFG), and since 2023 has served as Founding Director of the Center for the Transformation of Chemistry with €1.25 billion funding. His research spans glycosciences, carbohydrate chemistry, vaccine development, and continuous flow synthesis. Seeberger developed the chemical basis for automated glycan assembly, enabling the synthesis of complex polysaccharides up to 100-mers. His work has opened new pathways for synthetic glycoconjugate vaccines against pathogens including Streptococcus pneumoniae, Clostridium difficile, and Klebsiella pneumoniae. He also pioneered continuous photochemical processes for artemisinin production to combat malaria. Seeberger's recent publications reveal a strong trend toward applying glycobiology to vaccine development, diagnostics, and nanotechnology. His work increasingly focuses on translating basic research into clinical applications, with several vaccine candidates in human trials. The integration of continuous flow chemistry with glycan synthesis represents a major technological advancement in his field. ACS Award for Affordable Green Chemistry (2021) Stifterverband Science Prize (2017) Körber European Science Award (2007) Arthur C. Cope Young Scholar Award (2003) Elected to Berlin-Brandenburg Academy of Sciences (2013) Over 40 international awards total Seeberger's laboratory has produced over 690 peer-reviewed articles, 5 books, and 60+ patent families. His research has spawned multiple spin-off companies including Vaxxilon AG (acquired by Idorsia), Tacalyx, ArtemiFlow, and GlycoUniverse. As editor of the Beilstein Journal for Organic Chemistry since 2009, he promotes open access publishing. His work on the Center for the Transformation of Chemistry represents a major funding initiative to reshape chemical research and industry. Seeberger leads the Biomolecular Systems department at the Max Planck Institute, which includes research groups focused on automated glycan assembly, glycoconjugate vaccine development, and continuous flow synthesis. His Center for the Transformation of Chemistry represents a major collaborative effort across German research institutions with significant government funding.

• Structural Glycoscience
• NMR Spectroscopy
• Structure-guided Drug Design
• +۱۲ مورد دیگر

Associate Professor Thomas Haselhorst is a research leader at the Institute for Biomedicine and Glycomics , Griffith University, with a distinguished career in structural glycoscience and NMR spectroscopy . His expertise spans glycan-virus interactions , structure-guided drug design , and targeted drug delivery for diseases like SARS-CoV-2, HIV, and Non-Hodgkin’s Lymphoma. He has pioneered NMR methodologies to study glycan-cell receptor dynamics and developed glycan-based prebiotics to reduce Campylobacter jejuni in poultry. Education: Doctor of Natural Science (Dr rer nat), Medical University Lübeck (1996-1999) Research Interests: Structural analysis of glycan-pathogen interactions Design of prebiotic supplements for agricultural applications Development of glycan-targeted therapies for viral and fungal diseases Innovative NMR approaches for ligand-binding studies Article Trends: Focus on glycan-virus binding mechanisms (SARS-CoV-2, Influenza, Rotavirus) Structural characterization of antifungal and anticancer agents Methodological advancements in NMR-based glycan analysis Exploration of glycan-glycan crosslinking in disease Scientific Awards: ARC Future Fellow Alexander von Humboldt Fellow Supervision: Principal/Associate Supervisor for 15+ doctoral students Research on glycan roles in HIV, cancer, and pathogenic fungi Collaborative Networks: International partnerships in glycomics and virology Multi-million-dollar grants from ARC, NHMRC, and industry

Martin Heinمشاهده پروفایل

پژوهشگر

• Organic Chemistry
• Fluorinated Carbohydrates
• Liquid Crystals
• +۵ مورد دیگر

Dr. Martin Hein is a Research Assistant in the Department of Organic Chemistry at the Institute of Chemistry, University of Rostock, where he has been actively contributing to research and teaching since 2001. He is affiliated with the research group of Prof. P. Langer and plays a key role in both synthetic organic chemistry research and laboratory instruction. Diplom in Chemistry, University of Rostock (1995) Doctorate (Dr. rer. nat.), University of Rostock (1999) His primary research interests lie in organic synthesis , particularly the fluorination and fluoroalkylation of carbohydrates and the investigation of their liquid crystalline properties . He also focuses on the synthesis of N-glycosylated indigo, indirubin, and isoindigo derivatives , compounds with potential applications in medicinal chemistry due to their anti-proliferative effects. His work bridges synthetic methodology with functional material and drug discovery applications. The key publications highlight a strong trend in carbohydrate-based functional molecules , combining fluorine chemistry with glycoscience to create novel materials and bioactive compounds. His research integrates synthetic organic techniques with biological evaluation and materials characterization. Dr. Hein has not been publicly recognized with scientific awards based on available information. He is actively involved in academic mentoring and education, serving as practical course supervisor for advanced organic chemistry and organic synthesis for biology students. He teaches the lecture on Retrosynthesis and leads seminar exercises for foundational organic chemistry. While no formal grants are listed, his sustained research output suggests ongoing institutional or collaborative funding support. He is a member of the research group led by Prof. P. Langer and contributes to specialized safety and regulatory functions as the Commissioner for the trade in Category 1 raw materials since 2007.

Marcelo Limaمشاهده پروفایل

مدرس

• Structural Biology
• Glycobiology
• Biochemistry
• +۵ مورد دیگر

Dr. Marcelo Andrade Lima is a Lecturer in Biomedical Sciences at the School of Life Sciences, Keele University , where he serves as PGR Co-ordinator. He holds a PhD (2012) and post-doctoral experience (2014) in Molecular Biology from the Federal University of São Paulo, with prior degrees in Biology (2008) and Molecular Biology (2010) from the Federal University of Rio Grande do Norte. His research focuses on the structural and functional relationships of biological macromolecules , particularly glycosaminoglycans and heparin , with groundbreaking work on their roles in anticoagulant drug quality control, SARS-CoV-2 interaction mechanisms, and Alzheimer's disease pathogenesis . He also explores super-resolution microscopy and CARS (Coherent Anti-Stokes Raman Scattering) for cellular structure analysis. The most recent articles highlight his expertise in heparin's pharmacological applications (e.g., SARS-CoV-2 inhibition, anti-inflammatory strategies), biocatalytic systems for nucleotide sugar production, and marine-derived glycosaminoglycans with unique antithrombotic properties. His work bridges structural biology, biomedical chemistry, and translational research , often challenging established models of glycosaminoglycan biosynthesis. Dr. Lima's collaborations span institutions in the UK, Brazil, and beyond, with contributions to peer-reviewed journals in biochemistry, pharmacology, and virology . His lab employs advanced techniques like NMR spectroscopy, SPR analysis, and molecular dynamics simulations to dissect carbohydrate-protein interactions.

Alexei V. Demchenkoمشاهده پروفایل

استاد

• Organic Chemistry
• Carbohydrate Chemistry
• Glycosylation Mechanisms
• +۳ مورد دیگر

Alexei V. Demchenko is a Professor and Department Chair in the Department of Chemistry at Saint Louis University. His academic background includes an M.S. in Chemical Engineering from Mendeleev University of Chemical Technology of Russia (1988) and a Ph.D. in Organic Chemistry from the Zelinsky Institute of Organic Chemistry, Russia (1993). His research focuses on stereocontrolled glycosylation, synthetic glycopharmaceuticals, and automated carbohydrate synthesis. Key research interests include the development of expeditious glycan synthesis strategies, human milk oligosaccharide production, and applications of transition-metal-catalyzed reactions. His group’s work is highlighted on the Glycoworld website, emphasizing automated methods and glycobiology applications. Recent publications (2023–2025) emphasize advancements in HPLC-based automation, cooperative catalysis for glycosylation, and novel approaches to carbohydrate synthesis. Awards include the 2024 Melville L. Wolfrom Award and the 2020 Co-Investigators of the Year Award. He holds leadership roles in professional organizations such as the American Chemical Society’s Carbohydrate Chemistry Division and serves as a journal editor. Education: M.S., Chemical Engineering, Mendeleev University, 1988 Ph.D., Organic Chemistry, Zelinsky Institute, 1993 Awards: Melville L. Wolfrom Award (2024) Co-Investigators of the Year Award (2020) Senior Investigator of the Year (2017) Labs/Teams: Demchenko Research Group (Glycoworld website)

Keith Sanderson Wilsonمشاهده پروفایل

استاد

• Structural Biology
• Protein Crystallography
• Enzymology
• +۳ مورد دیگر

Professor Keith Sanderson Wilson is a structural biologist at the University of York, holding a Chair in Chemistry. He leads the York Structural Biology Laboratory (YSBL), specializing in protein crystallography and structural enzymology. His research focuses on enzyme structure-function relationships, methods development (e.g., map interpretation), industrial enzyme applications, and iron uptake mechanisms. Collaborations include Novozymes A/S and the Bijvoet Centre (Utrecht). Education: DPhil (Oxford), postdoctoral work at the Max Planck Institute, and leadership roles at EMBL Hamburg. Research interests include carbohydrate chemistry, enzyme engineering, and structural biology tools like CCP4 software. Recent work highlights artificial metalloenzymes, dispersin scaffolds, and glycosidase structures. Over 400 publications and 42 funded projects demonstrate his impact. He serves on the Diamond Light Source advisory board and contributes to interdisciplinary datasets and supervisory roles.

Ronald L. Schnaarمشاهده پروفایل

استاد

• Glycobiology
• Neuroscience
• Cell Surface Molecular Recognition
• +۵ مورد دیگر

Ronald L. Schnaar, PhD, is the John Jacob Abel Professor of Pharmacology and Interim Director of the Department of Pharmacology and Molecular Sciences at Johns Hopkins University School of Medicine. With appointments in both the Department of Pharmacology and the Department of Neuroscience, he is a leading expert in glycobiology whose research bridges neuroscience and immunology. His research focuses on cell surface molecular recognition, particularly the roles of gangliosides and Siglec receptors in neural cell-cell interactions, myelin maintenance, and axon regeneration. His laboratory has made seminal discoveries showing that gangliosides serve as ligands for myelin-associated glycoprotein (MAG), which has important implications for understanding nerve repair mechanisms. More recently, his work has expanded to explore how Siglec receptors and their glycan ligands regulate inflammatory processes in the airways and brain. Analysis of his recent publications reveals a strong interdisciplinary approach combining chemical biology, neuroscience, and immunology to investigate glycan-mediated interactions. His work demonstrates how basic research on cell surface glycans translates into potential therapeutic applications for neurodegenerative diseases and inflammatory conditions. John Jacob Abel Professor of Pharmacology Dr. Schnaar has mentored over 20 PhD students who have gone on to successful careers in academia, industry, and government. His laboratory, currently comprising research associates, graduate students, and postdoctoral fellows, is supported by multiple NIH grants focusing on glycan biology in neural and immune contexts. The lab has developed innovative chemical biology tools for studying ganglioside interactions in live cells. The Schnaar laboratory maintains active collaborations with researchers across Johns Hopkins and internationally, with particular emphasis on translating basic discoveries about glycan recognition into potential therapeutic approaches for neurological and inflammatory diseases.