جست‌وجوی استاد و پژوهشگر

Barbara Namerمشاهده پروفایل

استاد مدعو

• Translational Pain Research
• Neurophysiology
• Peripheral Nervous System
• +۶ مورد دیگر

Barbara Namer is an Adjunct Professor at Friedrich-Alexander University Erlangen-Nuremberg and leads the IZKF-funded "Neuroscience: translational pain research" group at RWTH Aachen University Hospital. Her career spans 20+ years in neurophysiological pain research with clinical translations. Doctor of Medicine (2000-2004), Erlangen-Nuremberg Venia Legendi (Habilitation) in Physiology (2010) Adjunct Professor title (2018) Her research focuses on nociceptor mechanisms in diabetic neuropathy, migraine pathophysiology, and TRPA1 channel dynamics . Computational modeling and human microneurography techniques are central to her work. Key publication trends show expertise in peripheral nerve sensitization , diabetic pain mechanisms , translational pain modeling , and ion channel pharmacology . She has received multiple DGSS and German Neurology Society awards for her pain research. 2019 - DGSS Poster Award 2015 - DGSS Poster Award 2010 - EFIC Grünenthal Grant 2003 & 2018 - German Neurology Society Awards National and international collaborations include research stays in Norway and Sweden, with extensive grant funding from DFG and IZKF projects.

Gerhard Wolberمشاهده پروفایل

استاد

• Computational Drug Design
• G-Protein Coupled Receptors (GPCRs)
• Cytochrome P450 Enzymes
• +۳ مورد دیگر

Professor Gerhard Wolber leads the Molecular Drug Design research group at the Institute of Pharmacy , Freie Universitaet Berlin. His work focuses on computational approaches to drug discovery, with expertise in G-protein coupled receptors (GPCRs) , cytochrome P450 enzymes , Toll-like receptors , and viral protease inhibitors . He supervises a team of 13 PhD candidates 3 researchers 2 Master's students engaged in projects ranging from calcium channel blockers to CYP enzyme modulators for cancer therapy. Recent publications highlight his lab's contributions to pan-coronavirus drug discovery, TLR8 antagonism, and calcium channel inhibition. The team employs advanced methodologies including Molecular dynamics simulations Fragment-based de novo design Bayesian neural networks DFT calculations 3D pharmacophore modeling to bridge computational predictions with experimental validation. Notable projects include Virtual screening for TREM2-targeted glioblastoma therapeutics Allosteric communication path analysis via MDPath Immune checkpoint inhibitors for cancer immunotherapy Biased GPCR ligand development demonstrating a multidisciplinary approach to contemporary drug design challenges.

Robert N. Benمشاهده پروفایل

استاد

• Organic Chemistry
• Bioorganic Chemistry
• Carbohydrate Chemistry
• +۵ مورد دیگر

Robert N. Ben is a Full Professor in the Department of Chemistry and Biomolecular Sciences at the University of Ottawa. His research focuses on organic and bioorganic chemistry, particularly the development of small-molecule ice recrystallization inhibitors (IRIs) for improving cryopreservation techniques. These inhibitors enhance the viability of cells, tissues, and biological systems during freezing and thawing processes, with applications in regenerative medicine, stem cell therapy, and biomedical engineering. He holds a B.Sc. from Laurentian University (1990) and a Ph.D. from the University of Ottawa (1994). His work bridges synthetic chemistry and biological applications, aiming to design cryoprotectants with enhanced stability and activity for medical and industrial uses. Key research areas include asymmetric synthesis of bioactive compounds, carbohydrate chemistry, and glycoprotein design. Ben’s lab investigates the structure-activity relationships of IRIs, their mechanisms of action, and their utility in preserving diverse biological materials, including red blood cells, stem cells, and tissues. His contributions have advanced understanding of how small molecules mitigate ice crystal growth, reducing cryopreservation damage in cellular therapies and organ preservation. Despite no listed awards, his prolific research output (over 50 publications from 2013–2024) highlights his leadership in cryopreservation science. He advises students in synthetic and bioorganic chemistry but no specific advisees are named in the provided texts. Current projects emphasize translating IRI-based technologies into clinical applications, such as improving platelet and cord blood storage.

Kristen Brennandمشاهده پروفایل

استاد

• Psychiatric Genomics
• Stem Cell Biology
• Neurogenetics
• +۳ مورد دیگر

Kristen Brennand is the Elizabeth Mears and House Jameson Professor of Psychiatry and Professor of Genetics at Yale School of Medicine. She leads research at the intersection of genomic engineering, neuroscience, and stem cell biology to decode mechanisms underlying brain diseases. Her work focuses on translating genetic insights into medically actionable information for schizophrenia, autism, PTSD, and Alzheimer’s disease. Education: PhD in Molecular and Cellular Biology from Harvard (2008), Postdoc at Salk Institute Key research areas: Gene-environment interactions , neuronal circuit dysfunction , precision psychiatry , and reversible disease mechanisms Recent publications span single-cell transcriptomics , neurogenetic atlases , and computational psychiatry methods . Awards: Executive Leadership in Academic Medicine (ELAM) Fellowship (2025) Funded by NIH, New York Stem Cell Foundation, Brain Research Foundation, and Brain and Behavior Research Foundation Laboratory: Brennand Lab at Yale School of Medicine

• Neurodegenerative Diseases
• Axonal Transport
• Motor Neurone Disease
• +۳ مورد دیگر

Dr Andrew Grierson is a Senior Lecturer in Neuroscience at the School of Medicine and Population Health, University of Sheffield, based at the Sheffield Institute for Translational Neuroscience (SITraN). His research focuses on molecular mechanisms of neurodegenerative diseases with translational applications. His educational background includes: PhD in Molecular Genetics from the University of Sheffield (1991-1994) BSc in Genetics from the University of Sheffield (1988-1991) Dr Grierson's work centers on axonal transport regulation in motor neurone disease (MND) and hereditary spastic paraplegia (HSP) , utilizing zebrafish and mouse models to investigate disease mechanisms and therapeutic interventions. Current projects include HDAC6 inhibition studies for CMT2A and HSP, C9ORF72 protein function analysis in ALS, and spastin gene replacement therapy development. His laboratory emphasizes preclinical translation with strong industry and charity partnerships. Analysis of his 15 most recent publications (2013-2022) reveals consistent focus on ALS/MND pathophysiology, with increasing emphasis on C9ORF72-related mechanisms , mitochondrial dysfunction , and therapeutic target validation . The work bridges basic molecular neuroscience and clinical applications, predominantly using in vivo models and translational biomarkers . Dr Grierson supervises multiple PhD students and collaborates with Pamela Shaw and Bob Johnston at Sheffield. His research group includes technicians Katie Adamson and Gary Shaw, operating within SITraN's specialized facilities for neurodegenerative disease research.

James Millonigمشاهده پروفایل

دانشیار

• Neuroscience
• Developmental Biology
• Genetics
• +۵ مورد دیگر

James Millonig is an Associate Professor in the Department of Neuroscience and Cell Biology at Rutgers University, where he also serves as the Senior Associate Dean for the Rutgers School of Graduate Studies. He is affiliated with the Center for Advanced Biotechnology and Medicine (CABM) and Robert Wood Johnson Medical School. His research focuses on understanding dorsal central nervous system (CNS) development, particularly through the integration of mouse genetics with neuroanatomy. His lab investigates how signaling centers like the roof plate coordinate CNS development through secreted factors such as Bone Morphogenetic Proteins (BMPs). A significant portion of his work examines the role of transcription factors like Lmx1a and Engrailed-2 in neural development and their potential connections to autism spectrum disorder (ASD). Dr. Millonig's recent publications demonstrate a continued focus on neurodevelopmental disorders, particularly autism spectrum disorder. His work spans from basic developmental neuroscience examining dorsal CNS formation to translational research using patient-derived neural progenitor cells. His laboratory has made significant contributions to understanding how genetic variations affect early brain development in ASD, with recent studies analyzing brain stem cells from ASD patients to identify irregularities in very early brain development. Autism Research Program (ARP) Idea Development Award from Department of Defense (2022) Standing appointment as a member of the National Institute of General Medical Sciences (NIGMS) Training and Workforce Development Subcommittee C (2020) Dr. Millonig has secured multiple federal grants, including an ongoing project titled "Investigation of Professional Coaching as an Intervention to Support the Success of URG Biomedical Ph.D. Students" (2023-2026) funded by the National Institute of General Medical Sciences. He has served as Principal Investigator for projects including "A Mouse Knock-In Model for ENGRAILED 2 Autism Susceptibility" funded by the National Institute of Mental Health and has been Co-Principal Investigator on the "IMSD at Rutgers - New Brunswick" project. The Millonig Lab maintains an active research program with several graduate students and research associates. Current lab members include Stuart Cattel (Graduate Student) and Arif S W Kusuma (Graduate Fellow), with Paul Matteson serving as Research Associate I. The lab has previously trained Marcos Ayala-Rivera, Tomas Kasza, and Monal Mehta, demonstrating a strong commitment to mentoring the next generation of scientists in neuroscience and developmental biology.

• Stem Cell Biology
• Neurosurgery
• Brain Tumor Research
• +۵ مورد دیگر

Viviane Tabar, MD, is a neurosurgeon-scientist and Chair of the Department of Neurosurgery at Memorial Sloan Kettering Cancer Center (MSKCC). Her clinical expertise focuses on brain tumor surgery, including complex gliomas, meningiomas, and skull base tumors. Her research lab explores stem cells for brain repair and tumor modeling. Key projects include using human pluripotent stem cells to model pediatric gliomas and developing therapies for radiation-induced brain injury. She leads collaborations with the Center for Stem Cell Biology and Brain Tumor Center at SKI. Her lab’s work aims to advance cell-based therapies for Parkinson’s disease and identify novel treatments for brain tumors like diffuse intrinsic pontine glioma (DIPG). Education: MD from the American University of Beirut. Affiliations: Memorial Hospital Research Laboratories, Cancer Biology & Genetics Program, Center for Cell Engineering, Center for Stem Cell Biology, Gerstner Sloan Kettering Graduate School. She also holds leadership roles in translational research initiatives, including NYSTEM consortium grants. Labs/Teams: The Viviane Tabar Lab collaborates with the Allis Lab, Studer Lab, and Soulet Lab. Current projects include drug screening for epigenetic therapies targeting histone mutations in tumors and optimizing stem cell-derived dopamine neurons for clinical trials.

Xiaowen Baiمشاهده پروفایل

استاد

• Stem Cell Biology
• Neurodegeneration
• Cardiotoxicity
• +۵ مورد دیگر

Xiaowen Bai, MD, PhD, is a Professor in the Department of Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin. His research focuses on leveraging stem cells to model neurodegenerative diseases and cardiac disorders, with a particular emphasis on non-coding RNAs, mitochondria, and environmental stressors like anesthetics and alcohol. He holds a leadership role as Executive Director of Hematology at the World Federation of Chinese Medicine Societies (WFCMS). Education: MD, Shanxi Medical University (1993) PhD, Beijing University Stem Cell Center (2004) Postdoctoral Training, University of Texas MD Anderson Cancer Center (2007) Research Interests: Neurodegeneration mechanisms involving microRNAs, lncRNAs, and mitochondrial dysfunction Stem cell-based therapies for myocardial regeneration Diabetic cardiomyopathy pathogenesis and cardioprotection 3D organoid models for studying anesthetic and alcohol neurotoxicity Recent Work: Recent publications emphasize translational studies using human-induced pluripotent stem cell (iPSC)-derived models to investigate alcohol-induced brain injury, anesthetic neurotoxicity, and cardiac fibrosis. His lab also explores immunomodulatory pathways and redox signaling in inflammatory diseases. Labs/Teams: The Bai Lab develops novel in vitro models for disease modeling and drug testing, focusing on cerebral organoids and cardiac organoids to bridge basic research and clinical applications.

• Neuroscience
• Neuropharmacology
• Neurodegenerative Diseases
• +۵ مورد دیگر

Professor Aideen Sullivan is Head of the Department of Anatomy and Neuroscience at University College Cork (UCC). With a career spanning over two decades at UCC, she leads research on neuroprotective therapies for Parkinson's disease, focusing on growth factors, stem cell applications, and epigenetic mechanisms. She established Ireland's first BSc in Neuroscience and co-developed the cross-College BSc in Medical and Health Sciences (CK707). BSc (First Class Honours) in Pharmacology, University College Dublin (1992) PhD in Neuropharmacology, University of Cambridge (1995) Her research program investigates Parkinson's disease through five key themes: viral vector delivery of neurotrophic factors, molecular mechanisms of neuroprotection, biomarker discovery, neuronal degeneration models, and stem cell-based treatments. She has secured significant grants from Health Research Board, Enterprise Ireland, and the Wellcome Trust. Recent publications (2022-2020) emphasize epigenetic regulation (HDAC inhibitors), microbiome-gut-brain axis interactions, and novel neurotrophic strategies. Articles highlight GDF5's neuroprotective effects, miRNA modulation, and molecular pathways like BMP-Smad and p38-MAPK. Scientific awards include: Postgraduate Certificate in Teaching and Learning (UCC, 2006) FETAC Certificate in Peer-Mentoring (2010) Leadership Foundation Aurora Programme Scholarship (2015) Over €2 million in research grants She mentors undergraduate and postgraduate students, chairs UCC's Athena SWAN 'Flexible Working' group, and serves as Editor-in-Chief of Neuronal Signaling . Her work spans laboratory research, public engagement, and educational innovation.

Joseph M Castellanoمشاهده پروفایل

دانشیار

• Aging
• Alzheimer's Disease
• Blood-Brain Barrier
• +۱۲ مورد دیگر

Joseph M. Castellano is an Associate Professor in Neuroscience and Neurology at the Icahn School of Medicine at Mount Sinai. His research focuses on molecular mechanisms underlying aging and Alzheimer's disease (AD) pathogenesis, particularly the role of blood-CNS interactions in regulating synaptic and neuroimmune function. PhD from Washington University in St. Louis Postdoctoral training at Stanford University His work spans several key areas: Aging , Alzheimer's Disease , Microglia , Immunology , and Stem Cells . Notable contributions include demonstrating how APOE4 impedes amyloid-beta clearance and identifying youth-associated peripheral factors like TIMP2 that reverse brain aging. Recent publications highlight his exploration of neuroimmune regulation via blood-borne factors, proteomic changes linked to APOE genotype, and therapeutic strategies targeting aging-associated conditions. His lab employs advanced techniques like microdialysis and in vivo imaging to study these mechanisms. 2021 ISMMS ADRC Developmental Project Grant 2020 Black Family Stem Cell Institute Pilot Award 2018 Katz and Martin Friedman Brain Institute Research Scholar 2016 K99/R00 Pathway to Independence Award (NIA/NIH) Dr. Castellano's research bridges fundamental aging biology with translational neurodegeneration studies, supported by grants from NIH and private foundations. His lab continues to investigate how systemic factors influence brain health, aiming to develop novel AD interventions.

• Pharmacology
• Cannabinoid Research
• Neuroscience
• +۴ مورد دیگر

Federica POLLASTRO is an Associate Professor at the University of Eastern Piedmont 'Amedeo Avogadro', Department of Pharmaceutical Sciences. Her research focuses on cannabinoid pharmacology, drug delivery systems, and neuropharmacology, with particular emphasis on the therapeutic potential of cannabinoids in neurodegenerative and inflammatory diseases. She leads projects such as NOrCa (Exploring Cannabis waste for circular economy applications) and has collaborated on initiatives like PRIME (green chemistry processes) and NUTRAcore (bioeconomy-driven food ingredients). Her work addresses cannabinoid synthesis, cytotoxic effects on cancer cells, and molecular mechanisms underlying neuroprotection. Key collaborations span European institutions, with projects funded by the Italian Ministry of Research and Piedmont Region. Publications emphasize transcriptomic analysis of cannabinoids' effects on Alzheimer's, Parkinson's, and glioblastoma models. Research activity highlights include: Over 150 peer-reviewed articles (2005–2025) Principal Investigator on grants totaling €2M+ (e.g., FFABR 2017, NOrCa 2023–2025) Development of novel cannabinoid derivatives and drug delivery systems Investigations into bitter taste receptor signaling in gastrointestinal physiology

Kyongbum Leeمشاهده پروفایل

استاد

• Metabolic Engineering
• Tissue Engineering
• Systems Biology
• +۳ مورد دیگر

Kyongbum Lee is the Karol Family Professor and Dean of Engineering at Tufts University School of Engineering, where he also serves as Professor in the Department of Chemical and Biological Engineering. His research integrates metabolic engineering, tissue engineering, and systems biology to study cellular metabolism and develop technologies for biomedical applications. Dr. Lee directs a laboratory focused on host-microbe interactions, cell-based bioprocesses, and metabolic regulation in diseases like obesity. Education Ph.D., Massachusetts Institute of Technology, 2002 B.S., Stanford University, 1995 Research Focus Dr. Lee's group employs systems approaches combining experimental and computational methods to investigate how metabolites regulate cellular communication. Current projects examine gut microbiome interactions, metabolic flux in engineered tissues, and development of therapeutic strategies targeting metabolic disorders. The lab specializes in bioreactor systems, metabolomic profiling, and mechanistic studies of metabolite signaling pathways. Publication Trends Recent publications emphasize gut microbiota metabolism, microbial metabolite therapeutics, and engineered tissue models. Work consistently demonstrates translational focus—from computational prediction of metabolic pathways (e.g., flavonoid biotransformation algorithms) to preclinical validation of microbial metabolites in disease models (e.g., steatosis reduction via indole derivatives). Recurring themes include nuclear receptor modulation, HDAC/IFN-γ pathway regulation, and high-throughput screening platforms. Awards Karol Family Professorship (endowed position recognizing scholarly excellence) Research Operations The laboratory actively recruits postdoctoral researchers and graduate students through Tufts' Chemical and Biological Engineering program. Current projects are supported by specialized infrastructure for metabolomics, bioreactor systems, and 3D tissue culture. The team emphasizes interdisciplinary collaboration, particularly at the interface of engineering, microbiology, and translational medicine.

• Biomechanics
• Tissue Engineering
• Prosthetics Design
• +۵ مورد دیگر

Professor Mark Thompson is an Associate Professor in Engineering Science at the University of Oxford and a Tutor/Fellow at Wadham College. He holds an MEng in Engineering and Materials Science (Oxford, 1997) and a PhD in Biomechanics from the University of London (2001). His research focuses on biomechanical engineering with emphasis on tissue repair, prosthetic design, and trauma modeling. Key projects include the OxVent ventilator and in vitro microvasculature systems for traumatic injury studies. His work bridges clinical and engineering challenges, addressing issues like prosthetic maintenance, musculoskeletal modeling, and biomaterials for regenerative medicine. Thompson collaborates with institutions like the Institute of Biomedical Engineering and has contributed to open-source frameworks for motion capture analysis. Current research trends involve mechanobiology of soft tissues and bioprinting for trauma research. Labs/Teams: Affiliated with the Institute of Biomedical Engineering and Oxford e-Research Centre. His work aligns with translational medicine and emergency medical device development. Future directions include optimizing 3D-printed bio-artificial tissues and advancing tactile feedback systems for prosthetics.

• Genetics
• Alzheimer's Disease
• Autism Spectrum Disorders
• +۴ مورد دیگر

Dr. Holly N. Cukier serves as a Research Assistant Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics at the University of Miami Miller School of Medicine, where she investigates the genetic foundations of Alzheimer's disease and autism spectrum disorders through family studies and minority population analyses. Her academic credentials include: PhD in Molecular and Human Genetics from Baylor College of Medicine (2007) BS in Biology with Chemistry minor from the University of Miami (1999) Dr. Cukier's research integrates population genetics with cutting-edge stem cell technology, focusing on identifying genetic risk variants in diverse cohorts and developing patient-derived induced pluripotent stem cell (iPSC) models to dissect disease mechanisms. Her work specifically examines how genetic differences in African American populations contribute to Alzheimer's pathology and autism susceptibility, with emphasis on cellular phenotypes like cytoskeletal organization and synaptic function. Recent publications demonstrate her leadership in functional genomics of Alzheimer's disease, particularly through investigations of TTC3 and ABCA7 variants using iPSC-derived neuronal models. These studies reveal novel pathways linking genetic risk to cellular dysfunction in neurodegeneration, with strong translational potential for therapeutic development. Her scientific contributions have been recognized with prestigious awards including: New Investigator Research Grant from the Dale Schenk Alzheimer’s Association Research Roundtable Grant Program NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation Ed and Ethel Moore Alzheimer’s Disease Research Grant from the Florida Department of Health Ruth L. Kirschstein National Research Service Award from NIH Travel Fellowship from Alzheimer’s Association International Conference Reviewers’ Choice Abstract at American Society of Human Genetics Annual Meeting Travel Award and Trainee Research Award Semifinalist at International Congress of Human Genetics Baylor Research Advocates for Student Scientists Scholar Finalist Elizabeth Wagner Internship at Duke University Henry King Stanford Half Tuition Scholarship Phi Kappa Phi Honor Society membership Patricia Schneller Scholarship Vice President’s Award for Service nomination Dr. Cukier's grant portfolio demonstrates sustained funding success, with current projects supporting her innovative work on patient-specific iPSC models to bridge genetic findings with functional neurobiology in Alzheimer's disease. Her research directly informs precision medicine approaches for neurodegenerative disorders. She directs a research program generating induced pluripotent stem cell lines from Alzheimer's patients to create physiological models of disease, with particular focus on how population-specific genetic variants alter cellular pathways. This work establishes critical infrastructure for testing therapeutic interventions in genetically defined patient subgroups.

• Neurotoxicology
• Toxicology
• In Vitro Toxicology
• +۶ مورد دیگر

Remco Westerink is Associate Professor at Utrecht University's Faculty of Veterinary Medicine and head of the Neurotoxicology Research Group at the Institute for Risk Assessment Sciences (IRAS). His work focuses on cellular and molecular mechanisms of neurotoxicants in food, drugs, and environmental pollutants. Expertise Areas: In vitro toxicology, developmental neurotoxicology, neuropharmacology, microplastics, risk assessment of chemicals Techniques: Multi-electrode arrays, calcium imaging, PC12 cell models, human iPSC-derived neurons Research explores how pollutants like pesticides, flame retardants, and microplastics affect brain development, function, and degeneration through key projects including EU-funded initiatives (TUBE, ENDpoiNTs) and national collaborations. Recent articles highlight his team's work on neurotoxic effects of: Microplastics crossing blood-brain barrier Bisphenols and PFAS disrupting neuronal networks Insecticides altering calcium signaling Organophosphate flame retardants (TCP) linked to aerotoxic syndrome Designer drugs affecting neurotransmission Scientific Contributions: Editorial Board: NeuroToxicology , Toxicology in Vitro Keynote Speaker: 1st International Congress on Global Environmental Contamination (2014) Invited Talks: International Neurotoxicology Association meetings (2012-2017) Westerink leads research into advanced in vitro models to replace animal testing, including development of 48-well microelectrode array platforms and collaborations with Mimetas and RIVM for organ-on-a-chip technology.