جست‌وجوی استاد و پژوهشگر

Cyrus K. Aidunمشاهده پروفایل

استاد

• Fluid Mechanics
• Bioengineering
• Renewable Bioproducts
• +۵ مورد دیگر

Cyrus K. Aidun serves as a Professor in the Woodruff School of Mechanical Engineering within the College of Engineering at Georgia Institute of Technology. His academic journey includes significant leadership roles, having joined Georgia Tech in 1988 as an Assistant Professor at the Institute of Paper Science and Technology before becoming a full Professor in 2003 after serving as a program director at the National Science Foundation. Dr. Aidun's educational background includes a Ph.D. from Clarkson University (1985), M.S. from Rensselaer Polytechnic Institute (1980), and B.S. from Rensselaer Polytechnic Institute (1978). Prior to his current position, he held research positions at Battelle Research Laboratories, Cornell University as a Postdoctoral Associate, and the National Science Foundation's Supercomputer Center at Cornell. His research spans fluid mechanics, bioengineering, renewable bioproducts, and industrial decarbonization, with particular emphasis on cellular blood flow dynamics and applications to cardiovascular diseases. Dr. Aidun pioneered the Lattice-Boltzmann method for suspension hydrodynamics, enabling advanced computational analysis of deformable particle/fiber suspensions. His work bridges fundamental physics with engineering applications, including blood cell transport interactions with glycoproteins, platelet margination, thrombus formation, and plant somatic embryogenesis for clonal propagation. His recent publications demonstrate strong focus on computational hemodynamics, particularly blood flow in cardiovascular systems and mechanical heart valves, with emerging work on industrial decarbonization through process modifications. This research portfolio shows consistent evolution from fundamental fluid dynamics to targeted biomedical and industrial applications. Dr. Aidun has received significant recognition including: National Science Foundation Presidential Investigator award Gunnar Nicholson Fellowship International Society of Coating Science and Technology's L. E. Scriven award His research is supported by major funding from the Department of Energy and industrial collaborators, particularly for decarbonization projects. Dr. Aidun holds multiple patents related to plant propagule devices and somatic embryo processing, demonstrating translational impact from his research. His laboratory focuses on developing novel computational methods for direct numerical simulation of suspension hydrodynamics, biotransport, and whole blood flow, with applications spanning cardiovascular medicine and renewable bioproducts engineering.

Jean (Jiayu) Wenمشاهده پروفایل

دانشیار

• RNA Biology
• Computational Biology
• MicroRNA Regulation
• +۵ مورد دیگر

Associate Professor Jean (Jiayu) Wen holds positions at The Australian National University (ANU), including Group Leader of The Wen Group, ARC Future Fellow, and Deputy Director of The Shine-Dalgarno Centre for RNA Innovation. She specializes in computational and molecular biology, focusing on RNA regulation, gene expression, and cancer genomics. Her affiliations include ANU’s Division of Genome Sciences and Cancer, and the Centre for Computational Biomedical Sciences. Education: BEng in Electronic Engineering (Beijing), MSc in Computer Science (Lakehead University), PhD in Computational Biology (ANU). Postdoctoral training at Copenhagen University and Memorial Sloan-Kettering Cancer Center. Research interests span RNA structures, microRNA biogenesis, transcriptome dynamics, and epigenetic regulation. Her work addresses intragenomic conflicts, cancer mechanisms, and neural development. Notable projects include RNA-based machine learning models for RNA-RNA interactions and immune cell differentiation studies. Publications highlight contributions to RNA interference pathways, tumor development, and Drosophila genetics. Awards include the ARC Future Fellowship. She leads interdisciplinary teams advancing computational and experimental approaches in genomics and systems biology.

Jyoti Nangaliaمشاهده پروفایل

استاد

• Somatic mutagenesis
• Clonal evolution in blood cancers
• Genomic sequencing in clinical decision-making
• +۳ مورد دیگر

Dr. Jyoti Nangalia is a Principal Investigator at the Wellcome-MRC Cambridge Stem Cell Institute and a Cancer Research UK Clinician Scientist at the Wellcome Sanger Institute. She holds a dual affiliation with the Department of Haematology at the University of Cambridge. Dr. Nangalia is also a Consultant Haematologist specializing in myeloproliferative neoplasms (MPN). Her research focuses on somatic mutagenesis, clonal evolution in blood cancers, and the integration of genomic data into clinical practice. Education: MBBS (Medicine) from the University of Cambridge, followed by a PhD at the Cambridge Institute of Medical Research, where she discovered CALR mutations in JAK2-unmutated MPNs. This discovery has become a standard diagnostic criterion in clinical practice. Research Interests: Her lab explores clonal trajectories in blood cancers, methylation dynamics across human lifespan, and personalized cancer prognosis modeling. Recent work includes tracing the evolutionary history of MPNs over decades, revealing disease origins decades before clinical presentation. Grants & Funding: Supported by CRUK, Rosetrees Trust, Alborada Trust, and MPN Research Foundation. Her group collaborates with clinical teams to inform early intervention strategies and refine diagnostic tools. Labs/Teams: The Nangalia Group operates at both the Stem Cell Institute and Sanger Institute, focusing on translational research in haematological malignancies. Advising: Supervises postgraduate students (e.g., Aleksandra Kamizela, Sreeya Kodavali) and mentors visiting researchers in genomic analysis and clonal evolution studies.

• Soft Matter
• Nanoparticles
• Molecular Dynamics
• +۵ مورد دیگر

Dr Stefano Angioletti-Uberti is a Lecturer at Imperial College London, specializing in theoretical and computational modeling of Soft Matter systems. He also holds an Adjunct Professor position at the Beijing Advanced Centre for Soft Matter Science and Engineering since 2015. His work focuses on understanding how materials behavior can be controlled through functionalization with ligands of biological and synthetic origin. PhD in Materials Science from Imperial College London (2010). Postdoctoral research in Soft Matter at the University of Cambridge and Humboldt University of Berlin. His research spans Nanoparticles , Molecular Dynamics , and Surface Engineering , with applications in biomedical and materials science. Recent work includes modeling ligand-receptor interactions , polyelectrolyte-surfactant lubrication , and nanoparticle organization for enhanced binding selectivity. His publications emphasize computational approaches to colloidal systems , DNA-coated colloids , and stimulus-responsive nanoreactors . Dr Angioletti-Uberti was awarded an Alexander von Humboldt Research Fellowship in 2013. His work has implications for drug delivery , biomimetic surfaces , and polymer physics . He currently leads research at Imperial College London, integrating Soft Matter theory with practical applications in nanotechnology and biomedical engineering.

Jesse R. Dixonمشاهده پروفایل

دانشیار

• Chromatin structure
• 3D genome organization
• Gene regulation
• +۴ مورد دیگر

Jesse R. Dixon, M.D., Ph.D., is an Associate Professor at the Gene Expression Laboratory of the Salk Institute for Biological Studies in La Jolla, California. His research explores 3D genome architecture, chromatin organization, and gene regulation mechanisms, with implications for cancer and developmental disorders. He employs cutting-edge genomic technologies like Hi-C and single-cell multi-omics to investigate how chromosomal rearrangements impact gene expression. Dr. Dixon's work focuses on: Topological Domains (TADs) and their role in enhancer-promoter communication Haplotype phasing using chromatin conformation data Structural variant-driven oncogene activation in cancer Single-cell mapping of chromatin and DNA methylation dynamics His publications consistently demonstrate innovations in 3D genome analysis, particularly in neurobiology and oncology contexts, with recurring themes of chromatin topology, epigenetic regulation, and computational genomics. Awards & Honors: Pew Biomedical Scholar (2024) Helmsley Salk Fellow He mentors graduate and postdoctoral researchers in genomics and computational biology, with current projects on chromatin dynamics in cancer and development. The Dixon Lab actively develops novel methodologies for studying genome architecture.

Michael Schatzمشاهده پروفایل

استاد

• Computational biology
• Genomics
• DNA sequencing & analysis
• +۶ مورد دیگر

Michael Schatz is the Bloomberg Distinguished Professor of Computational Biology and Oncology at Johns Hopkins University, with joint appointments in the Department of Computer Science at the Whiting School of Engineering and the Department of Biology at the Krieger School of Arts and Sciences. He also serves as a member of the Cancer Prevention and Control Program at Johns Hopkins' Sidney Kimmel Comprehensive Cancer Center and maintains an adjunct position at Cold Spring Harbor Laboratory. Dr. Schatz's research focuses on computational biology and genomics, with particular expertise in DNA sequencing analysis and scalable computing solutions for genomic data. His work spans medical applications for understanding autism spectrum disorders and cancer, as well as agricultural applications for crop improvement. He founded and directs the Schatz Lab, which has developed numerous widely-used computational tools including NGMLR, Sniffles, Scalpel, GECCO, Ginkgo, FALCON, Assemblytics, CloudBurst, and Crossbow. His recent work has made significant contributions to understanding structural variations in cancer genomes, analyzing South Asian genomic diversity, and identifying genes responsible for size variations in nightshade plants like tomatoes and eggplants. Dr. Schatz has pioneered the use of cloud computing in genomics and remains at the forefront of developing algorithms for large-scale biological sequence analysis. Alfred P. Sloan Foundation Fellowship (2015) NSF CAREER Award (2014) Genome Technology's Young Investigator of the Year (2010) Winship Herr Award for Excellence in Teaching (twice) TIME100 recipient (2022) Dr. Schatz actively advises PhD students including Arun Das (recently defended) and Mahler Revsine (NSF GRFP fellow). He serves on editorial boards for Genome Biology, GigaScience, and Cell Systems, and regularly participates in major genomics conferences including the Cold Spring Harbor Laboratory meetings. His lab continues to develop innovative computational approaches at the intersection of biotechnology and algorithmics, with applications spanning human health, agriculture, and evolutionary biology.

Kajsa Paulssonمشاهده پروفایل

استاد

• Cancer Genomics
• Leukemia Research
• Genetics
• +۳ مورد دیگر

Kajsa Paulsson is a Professor of Medical Genetics at Lund University, where she runs the Aneuploidy in Cancer research group at the Division of Clinical Genetics. She serves as a Principal Investigator at the Lund University Cancer Centre (LUCC) and manages the research team focused on aneuploidy in cancer. Dr. Paulsson is an expert in cancer genomics with extensive experience in classic genetic techniques including chromosome analysis and fluorescence in situ hybridization, as well as state-of-the-art methodologies such as SNP array analysis and next generation sequencing (NGS). Her research primarily focuses on understanding how aneuploidy (aberrant chromosome numbers) arises in somatic cells, how it affects tumorigenesis, and its correlation with prognosis and treatment response in cancer. Her specialized studies concentrate on high hyperdiploid and hypodiploid childhood acute lymphoblastic leukemia, with the ultimate goal of improving cancer patient survival through insights into tumorigenesis mechanisms. Analysis of Dr. Paulsson's publication record reveals a strong focus on the genomic architecture of pediatric acute lymphoblastic leukemia, with particular attention to chromosomal abnormalities, mutational signatures, and regulatory mechanisms. Her work spans from fundamental research on aneuploidy development to clinical applications examining treatment outcomes in specific leukemia subtypes. The research demonstrates increasing methodological sophistication with integration of multi-omics approaches including proteogenomics, Hi-C chromatin conformation analysis, and single-cell genomics, reflecting the evolving landscape of cancer genomics research. Dr. Paulsson has received significant recognition for her work, including the prestigious Samfundet Folkhälsan Albert de la Chapelle Prize in Medical Genetics in 2022 and the Senior Investigator Award from Cancerfonden in 2015. Her publications have been widely disseminated, with multiple papers highlighted by news outlets, referenced in clinical guidelines, and extensively read on academic platforms, demonstrating the translational impact of her research. As a supervisor and mentor, Dr. Paulsson leads active research projects including 'Non-coding mutations in pediatric acute lymphoblastic leukemia' (2021-2025), where she serves as the primary supervisor. She has been involved in the Epigenetics Theme at Pufendorf IAS, demonstrating her commitment to collaborative, interdisciplinary research that spans basic science and clinical applications. Her work contributes to UN Sustainable Development Goals related to health and well-being. Dr. Paulsson actively participates in the Lund University Cancer Centre (LUCC) ecosystem, regularly organizing and speaking at seminars and conferences including the LUCC Blood, Lymphoma & Myeloma series and the Swedish Cancer Research Meeting. Her laboratory focuses on the molecular mechanisms of aneuploidy in leukemia, particularly investigating how chromosomal abnormalities develop and impact treatment outcomes in childhood cancers, with direct implications for risk stratification and therapeutic decision-making in pediatric oncology.

Sahand Hormozمشاهده پروفایل

استادیار

• Systems Biology
• Computational Biology
• Single-Cell Analysis
• +۹ مورد دیگر

Sahand Hormoz is an Assistant Professor at Harvard Medical School and a faculty member in the Department of Data Science at Dana-Farber Cancer Institute. His research focuses on controlling biological systems to understand cell state transitions and develop technologies for single-cell analysis, synthetic biology, and organoid modeling. PhD in Applied Physics from Harvard University (advised by Michael Brenner) Postdoctoral work at Kavli Institute for Theoretical Physics (UCSB) and Elowitz Lab at Caltech Research Interests His lab combines high-throughput single-cell measurements with differential geometry and machine learning to analyze complex biological data. They engineer cells for lineage tracing, develop organoid systems, and aim to automate biological modeling to overcome human cognitive limitations in understanding life systems. Publication Trends Key areas in his recent work include: Computational methods for single-cell and lineage analysis Cancer evolution in myeloproliferative neoplasms Synthetic biology tools for DNA-based cellular memory Integration of machine learning with biological dynamics Applications in stem cell biology and microbial systems Development of microfluidic platforms Labs & Teams Hormoz Lab at Harvard Medical School collaborates with Dana-Farber's Data Science Department to advance quantitative biology approaches.

Evan Biederstedtمشاهده پروفایل

پژوهشگر

• Computational Biology
• Cancer Genomics
• Bioinformatics
• +۳ مورد دیگر

Evan Biederstedt is an Associate in Biomedical Informatics at Harvard Medical School, affiliated with the Gehlenborg Lab. He holds a Master of Science (MSc) and specializes in computational biology with a focus on cancer genomics. His work includes developing the Cell Annotation Platform (CAP) to enhance cellular state interpretation through metadata and molecular signature analysis. Biederstedt’s research spans single-cell analysis, spatial transcriptomics, and genomic tools for structural variant discovery. His contributions include scaling cross-tissue annotation models and haplotype-aware somatic variation analysis. Key areas of focus include bioinformatics tool development, cancer genomics, and genomic data integration. He has collaborated on projects like the Virus Discovery Codeathon and international hackathons for genomic analysis. Biederstedt’s GitHub profile showcases his open-source contributions. His publications highlight advancements in tensor decomposition for patient cohort analysis, spatial transcriptomics, and pangenome strategies. Biederstedt’s work bridges computational methods with biomedical applications, emphasizing scalable solutions for complex genomic data challenges.

Julie McElrathمشاهده پروفایل

عضو هیئت علمی

• HIV Vaccine Development
• Mucosal Immunology
• T-Cell Responses
• +۴ مورد دیگر

Julie McElrath is a Professor at the Fred Hutchinson Cancer Research Center and holds the Joel D. Meyers Endowed Chair . She serves as Director of the Vaccine and Infectious Disease Division and Principal Investigator of the HIV Vaccine Trials Network (HVTN) Laboratory Center . Her work spans international HIV vaccine trials, mucosal immunity studies, and collaborations with institutions like the University of Washington (Department of Medicine, Global Health, and Laboratory Medicine & Pathology) and the Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD) . Education: MD, Medical University of South Carolina (1980) PhD, Medical University of South Carolina (1978) Dr. McElrath’s research focuses on multi-disciplinary approaches to HIV vaccine development, immune correlates of protection, and mucosal transmission mechanisms. Her lab investigates innate immune responses to vaccines and conducts longitudinal studies on long-term non-progressors. Recent work includes collaborations on coronavirus , malaria , and tuberculosis vaccines, leveraging systems biology tools. She leads initiatives like the Seattle HIV Vaccine Trials Unit and the Cape Town HVTN Immunology Laboratory . Her publications highlight immune profiling in HIV vaccine trials, adenovirus vector immunogenicity , and vaccine-induced antibody functions . She advocates for improving assay standardization and cross-pathogen immunity through networks like the Infectious Diseases Clinical Research Consortium (IDCRC) .

• Virology
• Genomics
• Viral Evolution
• +۱ مورد دیگر

Anna Gatseva is a Research Fellow in Molecular Biosciences at the University of Glasgow. Her research investigates viral evolution and genome analysis through advanced bioinformatics approaches. She holds a publication record demonstrating expertise in paleovirology and disease mechanisms. Research focuses on viral fossil records in vertebrate genomes, emergence patterns of lentiviruses, and molecular foundations of diseases. Her work utilizes cutting-edge genomic techniques to explore host-pathogen evolutionary relationships across species. Publications show consistent focus on viral genetics and molecular pathology, with recent work examining Huntington's disease mechanisms and vertebrate virus evolution. Collaborative research dominates her publication history, indicating strong interdisciplinary engagement.

• Genomic Biomarkers
• Thoracic Oncology
• Tumor Immunology
• +۳ مورد دیگر

Amin Nassar, M.D., is a Clinical Fellow in Medical Oncology and Hematology at Yale School of Medicine. He holds a medical degree from the American University of Beirut and completed residency at Brigham and Women’s Hospital. His postdoctoral training under Professors David Kwiatkowski, Toni Choueiri, and Matthew Freedman at Harvard Medical School focused on genomic biomarkers across ancestral populations with cancer. Currently pursuing a PhD in tumor immunology at the Flavell lab, he is dedicated to becoming a physician-scientist specializing in thoracic oncology. His research explores genetic and epigenetic factors influencing cancer outcomes, including tumor mutational burden (TMB) recalibration across ethnicities, KRAS mutations, and immune checkpoint inhibitor efficacy in diverse populations. He has authored over 50 peer-reviewed articles in high-impact journals like Nature Communications , Cancer Cell , and New England Journal of Medicine . Nassar serves on editorial boards for Frontiers in Oncology , Molecular Biology Reports , and Translational Oncology , and has received awards including the ASH Achievement Award (2022) and Alpha Omega Alpha (2016). His work bridges clinical practice and research, emphasizing health equity and precision medicine.

• Neurosurgery
• Neuro-Oncology
• Genomics
• +۴ مورد دیگر

Hasan Alanya is a Researcher in the Department of Neurosurgery at Yale School of Medicine. His work focuses on genomic characterization of brain tumors, including meningiomas, pituitary adenomas, and other neurological disorders. He specializes in molecular pathology, somatic mutations, and the genetic basis of tumor behavior. His research bridges clinical neurosurgery with advanced genomic techniques to understand tumor progression and racial/ethnic variations in disease outcomes. Key research interests include neuro-oncology, somatic mutation analysis, and translational applications of genomic data. His studies investigate how genetic mutations drive tumor development and response to therapy, particularly in pituitary and spinal tumors. Recent work emphasizes the role of thrombocytes in immune responses and the utility of single-cell data for refining bulk genomic analyses. Publications highlight interdisciplinary approaches, combining genomics with clinical observations to address gaps in understanding tumor heterogeneity and treatment strategies. Collaborations span neurosurgery, oncology, and computational biology to advance personalized medicine in neuro-oncology.

Neville Sanjanaمشاهده پروفایل

دانشیار

• Genome Engineering
• Neuroscience
• Cancer Research
• +۴ مورد دیگر

Neville Sanjana is an Associate Professor at the Department of Neuroscience , NYU Grossman School of Medicine , with a joint affiliation at the New York Genome Center . His academic journey began with a PhD at Massachusetts Institute of Technology . Research Interests in genome engineering, CRISPR technology, and functional genomics focus on: Dissecting noncoding genomic elements across cancers Developing high-throughput CRISPR screening methods Engineering therapies for neurological and genetic diseases Understanding transcriptional regulation in neuronal differentiation Recent Articles span cancer genomics, synthetic biology, and CRISPR-based diagnostics, with a thematic emphasis on: Drug resistance mechanisms in melanoma Noncoding element function in disease Advancements in base and prime editing Applications in immunotherapy and hemoglobin disorders Scientific Honors : NIH Director's New Innovator Award Sidney Kimmel Scholars Program DARPA Young Faculty Award Simons Foundation Autism Research Initiative Melanoma Research Alliance Young Investigator Award Teaching : In Spring 2022, he taught Special Topics: Genome Engineering (BIOL-UA 920) at NYU Biology, covering CRISPR evolution, gene therapies, and ethical implications of genome editing. Lab Operations : The Sanjana Lab operates from two locations - NY Genome Center (101 Avenue of the Americas, 4th floor, New York, NY 10013) and NYU Biology (755 Brown, 100 Washington Sq East, New York, NY 10003).

Phil H Jonesمشاهده پروفایل

استاد

• Cancer Biology
• Stem Cell Research
• Somatic Mutations
• +۵ مورد دیگر

Phil H Jones is a Senior Group Leader at the Wellcome Sanger Institute and Programme Leader at the MRC Cancer Unit, University of Cambridge. He leads the Jones Group which focuses on understanding how cancer-associated DNA changes in normal stem cells alter their behavior, allowing them to spread through normal tissues—the critical first step toward cancer development. Institution: MRC Cancer Unit, University of Cambridge Research Program: Cancer, Ageing and Somatic Mutation Programme Professional Recognition: Fellow of the Royal Society, Fellow of the Academy of Medical Sciences Dr. Jones's research centers on how mutations that alter the competitive fitness of normal stem cells give mutant stem cells the ability to spread through normal tissues. His current work employs deep sequencing, advanced imaging, gene editing, and single-cell analysis to define how oncogenic mutations alter stem cell behavior during aging and the earliest stages of cancer development in skin and esophagus. His lab-based studies complement his clinical work at Addenbrooke's Hospital, where he treats patients with non-melanoma skin cancer. Analysis of his recent publications reveals a consistent focus on somatic mutations in normal epithelial tissues, particularly examining how specific mutations (such as those in p53, Notch1, and PIK3CA) confer competitive advantages to cells, enabling clonal expansion. His work demonstrates that normal tissues become extensively colonized by mutant cells with age, with some mutations increasing cancer risk while others may actually decrease it. A key finding across multiple publications is that mutant clones can outcompete and eliminate early-stage tumors, suggesting novel approaches to cancer prevention. Fellow of the Royal Society Fellow of the Academy of Medical Sciences Multiple high-impact publications in Nature, Science, and Cell journals Dr. Jones collaborates extensively with Cancer Research UK, the Department of Oncology at the University of Cambridge, and the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. His research is highly translational, aiming to apply fundamental discoveries about somatic evolution in normal tissues to develop rational interventions that reduce cancer risk in high-risk patients. The Jones Group employs a multidisciplinary approach combining experimental biology with computational modeling to understand the evolutionary dynamics of mutant clones in aging tissues. The Jones Group operates within the Cancer, Ageing and Somatic Mutation Programme at the Wellcome Sanger Institute, utilizing advanced 3D culture methods, gene editing, live imaging, and single-cell analysis capabilities. Their research infrastructure supports studies of both skin epidermis and esophageal epithelium, with particular focus on how lifestyle factors (sun exposure, alcohol consumption) and aging influence the somatic mutation landscape of normal tissues.