معرفی
Kajsa Paulsson is a Professor of Medical Genetics at Lund University, where she runs the Aneuploidy in Cancer research group at the Division of Clinical Genetics. She serves as a Principal Investigator at the Lund University Cancer Centre (LUCC) and manages the research team focused on aneuploidy in cancer.
Dr. Paulsson is an expert in cancer genomics with extensive experience in classic genetic techniques including chromosome analysis and fluorescence in situ hybridization, as well as state-of-the-art methodologies such as SNP array analysis and next generation sequencing (NGS). Her research primarily focuses on understanding how aneuploidy (aberrant chromosome numbers) arises in somatic cells, how it affects tumorigenesis, and its correlation with prognosis and treatment response in cancer. Her specialized studies concentrate on high hyperdiploid and hypodiploid childhood acute lymphoblastic leukemia, with the ultimate goal of improving cancer patient survival through insights into tumorigenesis mechanisms.
Analysis of Dr. Paulsson's publication record reveals a strong focus on the genomic architecture of pediatric acute lymphoblastic leukemia, with particular attention to chromosomal abnormalities, mutational signatures, and regulatory mechanisms. Her work spans from fundamental research on aneuploidy development to clinical applications examining treatment outcomes in specific leukemia subtypes. The research demonstrates increasing methodological sophistication with integration of multi-omics approaches including proteogenomics, Hi-C chromatin conformation analysis, and single-cell genomics, reflecting the evolving landscape of cancer genomics research.
Dr. Paulsson has received significant recognition for her work, including the prestigious Samfundet Folkhälsan Albert de la Chapelle Prize in Medical Genetics in 2022 and the Senior Investigator Award from Cancerfonden in 2015. Her publications have been widely disseminated, with multiple papers highlighted by news outlets, referenced in clinical guidelines, and extensively read on academic platforms, demonstrating the translational impact of her research.
As a supervisor and mentor, Dr. Paulsson leads active research projects including 'Non-coding mutations in pediatric acute lymphoblastic leukemia' (2021-2025), where she serves as the primary supervisor. She has been involved in the Epigenetics Theme at Pufendorf IAS, demonstrating her commitment to collaborative, interdisciplinary research that spans basic science and clinical applications. Her work contributes to UN Sustainable Development Goals related to health and well-being.
Dr. Paulsson actively participates in the Lund University Cancer Centre (LUCC) ecosystem, regularly organizing and speaking at seminars and conferences including the LUCC Blood, Lymphoma & Myeloma series and the Swedish Cancer Research Meeting. Her laboratory focuses on the molecular mechanisms of aneuploidy in leukemia, particularly investigating how chromosomal abnormalities develop and impact treatment outcomes in childhood cancers, with direct implications for risk stratification and therapeutic decision-making in pediatric oncology.
