جست‌وجوی استاد و پژوهشگر

Eman Solimanمشاهده پروفایل

استادیار

• Neuroimmunology
• Traumatic Brain Injury
• Efferocytosis
• +۵ مورد دیگر

Eman Soliman is an Assistant Professor at the Brody School of Medicine , East Carolina University, specializing in Pharmacology & Toxicology . Her research focuses on neuroimmune interactions in traumatic brain injury recovery, with a particular emphasis on efferocytosis, microglial and macrophage function, and neuroinflammatory signaling pathways. B.S. in Pharmaceutical Sciences, Zagazig University, Egypt M.Sc. in Pharmacology, Zagazig University, Egypt Ph.D. in Pharmacology and Toxicology, East Carolina University Post-doctoral Fellowships in Immunology (East Carolina University) and Neuroimmunology (Virginia Tech) Her work employs transgenic mouse models, bone marrow chimeras, and advanced 3D imaging to investigate spatial, temporal, and sex-specific regulation of inflammation resolution in the brain. Key themes include the role of EphA4 signaling in efferocytosis, microglia-macrophage communication, and neuroprotective mechanisms after injury. Recent publications highlight her contributions to understanding endothelial-astrocyte interactions, Tie2/Akap12 signaling, and NLRX1-cGAS-STING pathways in neuroinflammation. Articles also explore ABCG1 deficiency, PPARγ roles in granulomatous inflammation, and translational applications of cannabinoids in cancer and neuroinflammatory diseases. The Soliman Lab collaborates with researchers on topics like EphA4 deletion, prostamide therapies, and mitochondrial dysfunction in chronic diseases. Current projects aim to identify targetable mechanisms for enhancing neuroprotection and functional recovery following brain injury.

Jin Chenمشاهده پروفایل

استاد

• Tumor Immunology
• Tumor Metabolism
• Tumor Angiogenesis
• +۴ مورد دیگر

Jin Chen is a Professor of Medicine and Cell and Developmental Biology at Vanderbilt University School of Medicine . As a member of the Vanderbilt-Ingram Cancer Center , her research focuses on Eph receptor tyrosine kinases in tumor biology, particularly EphA2 and its roles in tumor metabolism, metastasis, and immune interactions. Current Research : Investigating EphA2's dual roles in tumor cells and blood vessels, exploring mTOR signaling in tumor subtypes with PTEN deletion or Rictor amplification, and developing mTORC2-specific inhibitors. Methodology : Combining human cancer datasets with CRISPR/Cas9 animal models and biochemical cell biology techniques. Her laboratory's work, funded by National Cancer Institute and Department of Veterans Affairs grants, addresses critical questions in tumor-immune crosstalk and metabolic reprogramming. Dr. Chen serves on NIH/ACS/VA grant review panels and the CABTRAC Board of Directors . Recent publications highlight her contributions to STING-activating immunotherapies , USP11-mediated metastasis , and endothelial metabolic regulation in cancer progression.

Daniel Claiborneمشاهده پروفایل

استادیار

• Immunology
• HIV Research
• T Cell Immunotherapies
• +۵ مورد دیگر

Daniel Claiborne, Ph.D. is an Assistant Professor at The Wistar Institute, where he serves as the Scientific Director of the Histotechnology Facility. He holds appointments at the HIV Cure and Viral Diseases Center, Vaccine & Immunotherapy Center, and Genome Regulation and Cell Signaling Program within the Ellen and Ronald Caplan Cancer Center. Dr. Claiborne is an immunologist focused on understanding how T cell function is modulated to create improved immunotherapies, including CAR T cell therapies, against HIV. Dr. Claiborne earned his B.S. in Biochemistry from Florida State University and a Ph.D. in Immunology and Molecular Pathogenesis from Emory University. He completed his postdoctoral training at the Ragon Institute of MGH, MIT, and Harvard and joined The Wistar Institute in 2021 as a Caspar Wistar Fellow. Dr. Claiborne's research centers on T cell immunotherapies for the treatment of malignancies and chronic diseases. His lab investigates the mechanisms underlying T cell exhaustion to revolutionize T cell immunotherapies like CAR T cell therapy. The Claiborne laboratory leverages HIV-infected humanized mice coupled with HIV-directed CAR T cells to study the evolution of antigen-specific T cell function over time. Key research areas include mapping dysfunctional CAR T cell phenotypes, inhibitory receptor expression kinetics, viral characteristics' influence on HIV-specific T cell function, and the role of the innate immune system in modulating CAR T cell function. His work has significant implications for developing a functional HIV cure through optimized CAR T cell therapies. Dr. Claiborne's publication record shows a strong trajectory in HIV immunology and immunotherapy research, with increasing interdisciplinary connections between HIV pathogenesis and cancer immunotherapy. His recent work demonstrates expertise in humanized mouse models, CAR T cell engineering, and viral pathogenesis. Caspar Wistar Fellow at The Wistar Institute Dr. Claiborne leads a research team including graduate students (Reyes Acosta from UPenn-CAMB and Federica Severi from UniBO) and postdoctoral fellows (Francesco Pennino and Nur Izzah Binti Ismail). His laboratory has received significant grant support for HIV research, including two grants specifically mentioned to explore using CAR T cells as HIV therapy. The lab maintains active collaborations with researchers at Harvard, MIT, and other institutions, reflecting Dr. Claiborne's strong network from his postdoctoral training at the Ragon Institute. The Claiborne Laboratory operates within The Wistar Institute's state-of-the-art facilities, with Dr. Claiborne serving as Scientific Director of the Histotechnology Facility. His team utilizes advanced model systems including humanized mice for HIV research and has developed novel in vitro models for chronic antigen stimulation of CAR T cells. The lab's work bridges basic immunology, virology, and translational medicine with the ultimate goal of developing effective immunotherapies for HIV and related conditions.

• Mitochondrial Function
• Aging Research
• Immunometabolism
• +۵ مورد دیگر

Helena Borland Madsen serves as an Assistant Professor in the Department of Biomedical Sciences at the University of Copenhagen's Faculty of Health and Medical Sciences, specializing in Endocrinology and Metabolism. Her research integrates molecular biology, immunology, and aging science to investigate fundamental cellular processes. Dr. Madsen's research interests focus on mitochondrial function and its critical role in aging, neurodegenerative diseases, and immune regulation. Her work examines how metabolic pathways influence cellular senescence, neuroinflammation, and age-related pathologies, with particular emphasis on the cGAS-STING pathway, nucleotide metabolism, and mitochondrial quality control mechanisms. She investigates how compounds like urolithin A can modulate these pathways to potentially mitigate age-related decline. Analysis of her publication record reveals a strong thematic focus on the intersection of metabolism, immunity, and aging. Her recent work demonstrates how mitochondrial dysfunction contributes to post-viral syndromes like long COVID and neurodegenerative conditions including Alzheimer's disease. She has made significant contributions to understanding how metabolic interventions can restore cellular homeostasis in aging and disease contexts. Dr. Madsen actively collaborates with leading researchers in aging and mitochondrial biology, including Claus Desler and Vilhelm Bohr, working within research networks that investigate the fundamental mechanisms of aging and age-related diseases. Her laboratory employs advanced cellular and molecular techniques to investigate the connections between metabolic regulation, immune function, and cellular aging processes.

• Cardiovascular Science
• Cardiac Fibrosis
• Primary Cilia
• +۳ مورد دیگر

Elisa Villalobos is a Postdoctoral Research Fellow at the Centre for Cardiovascular Science, University of Edinburgh, with prior research experience at UT Southwestern Medical Center and the University of Chile. Her work bridges cardiovascular biology and metabolic disease research, focusing on molecular mechanisms of cardiac fibrosis and inflammation in obesity. Her research interests center on primary cilia as cardiac mechanosensors and calcium signaling pathways in adipose tissue. Key investigations include polycystin-dependent regulation of fibroblast activity in heart failure, cGAS-mediated inflammatory responses in myocardial injury, and calcium sensing receptor modulation of adipocyte inflammation. This work reveals fundamental connections between cellular structures, signaling pathways, and disease pathogenesis. Analysis of her 14 publications shows consistent progression from metabolic inflammation research (2011-2014) toward cardiovascular mechanisms (2015-2019), with increasing emphasis on translational aspects of heart failure. Her recent work in Nature and Circulation demonstrates significant contributions to understanding nitrosative stress in diastolic dysfunction and primary cilia in cardiac fibrosis. Dr. Villalobos actively contributes to the academic community through editorial roles at Frontiers in Physiology and peer review for major cardiology journals. While not independently supervising students, she mentors junior researchers within collaborative projects funded by British Heart Foundation grants at the Centre for Cardiovascular Science, which provides state-of-the-art facilities for cardiovascular research including advanced imaging and molecular phenotyping platforms.