جست‌وجوی استاد و پژوهشگر

Satya Prakashمشاهده پروفایل

استاد

• DNA Replication
• DNA Repair
• Translesion Synthesis
• +۳ مورد دیگر

Satya Prakash, PhD, is a Professor in the Department of Biochemistry & Molecular Biology at the University of Texas Medical Branch (UTMB). He holds a BSc in Biology and Chemistry from Meerut College, an MVSC in Genetics from the Indian Veterinary Research Institute, and a PhD in Genetics from Washington University. His postdoctoral training was at the University of Chicago. Dr. Prakash's research focuses on DNA replication and repair mechanisms, particularly translesion synthesis (TLS) and their role in cancer. His work has been recognized with awards such as the Merit Award from NCI, the Distinguished Faculty Research Award, and Fellowships from AAAS and the American Academy of Microbiology. His research interests include understanding how TLS polymerases facilitate replication through DNA lesions, the interplay between DNA repair and cancer evolution, and mechanisms underlying genome instability. Key findings include the discovery of Pol η's role in XPV syndrome and the elucidation of TLS's role in preventing tumorigenesis. Current studies aim to target error-prone DNA repair pathways for cancer therapy. Dr. Prakash has an extensive publication record spanning DNA repair, TLS mechanisms, and cancer biology. His work bridges biochemical, genetic, and structural approaches to uncover fundamental biological processes and their clinical implications.

• Nucleic Acid Structures
• DNA Repair
• RNA-Protein Interactions
• +۳ مورد دیگر

Prof. Katrin Paeschke is a Professor at the Institute of Clinical Chemistry and Clinical Pharmacology within the Medical Faculty of the University of Bonn. Her research focuses on nucleic acid structures and their roles in cellular processes, including DNA repair, genome stability, and immune regulation. She leads the Paeschke Lab, which investigates G-quadruplex structures in DNA and RNA, their interactions with proteins, and implications for diseases such as cancer and autoimmune conditions. Notable contributions include studies on UV-induced DNA damage repair mechanisms involving ZRF1 and the role of G4 structures in viral biology and antiviral strategies. Her work bridges molecular mechanisms with translational applications in therapy development. Selected research interests include: Mechanisms of G-quadruplex formation and resolution Impact of nucleic acid secondary structures on genome integrity Interplay between DNA damage and immune responses Therapeutic targeting of G-quadruplex structures in cancer Publications highlight interdisciplinary approaches, combining biochemistry, cell biology, and genetics to address fundamental questions in nucleic acid biology. Collaborations span virology, immunology, and oncology, reflecting her transdisciplinary research in TRA-Matter at the University of Bonn.

Hannah L. Kleinمشاهده پروفایل

استاد پژوهشی

• pathways of DNA damage avoidance
• DNA repair and recombination
• genomic instability
• +۲ مورد دیگر

Hannah L. Klein is a Research Professor in the Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine, New York University, with a research focus on DNA damage repair mechanisms and genomic instability. Her work bridges molecular genetics and cancer biology through innovative yeast-based models. Her academic credentials include: PhD from University of Washington Dr. Klein's research program centers on fundamental DNA maintenance processes: Pathways of DNA damage avoidance DNA repair and recombination mechanisms Genomic instability origins DNA damage checkpoint signaling Cancer-related genomic alterations She pioneered investigations into ribonucleotide incorporation in DNA, elucidating how RNase H2, topoisomerases, and helicases prevent mutagenesis. Her laboratory employs Saccharomyces cerevisiae to dissect evolutionarily conserved mechanisms relevant to human disease. Analysis of her 81 publications reveals consistent emphasis on ribonucleotide-induced genomic stress, with recent work (2021-2025) expanding into rDNA topology, recombination dynamics, and the dual nature of ribonucleotide lesions. These studies integrate molecular biology, biochemistry, and genetics to address fundamental questions in genome integrity.

Julien Duxinمشاهده پروفایل

دانشیار

• Genome Maintenance
• DNA Repair
• Mechanisms of DNA-Protein Crosslink Repair
• +۳ مورد دیگر

Julien Duxin is an Associate Professor and group leader at the Novo Nordisk Foundation Center for Protein Research (CPR), affiliated with the Faculty of Health and Medical Sciences at the University of Copenhagen, Denmark. He previously worked at Harvard Medical School (2012–2016) under Johannes C. Walter. Education: PhD in Biochemistry (2005–2011) from Washington University in St. Louis, advised by Sheila Stewart, and a BSc in Chemistry (2000–2004) from Missouri State University. His research focuses on genome maintenance and DNA repair , particularly mechanisms of DNA-protein crosslink (DPC) repair induced by chemotherapeutic agents. His lab developed the first in vitro system for DPC repair (2014) and investigates how repair processes integrate with DNA replication. Key collaborations involve proteins like SPRTN, RFWD3, and the proteasome. His publications (2012–2021) explore ubiquitin signaling , translesion synthesis , and replication-coupled proteolysis in DNA repair, with implications for cancer therapy. The lab's work bridges biochemistry , molecular biology , and clinical oncology , targeting novel chemotherapeutic strategies.

Daniel Semlowمشاهده پروفایل

استادیار

• DNA Replication
• DNA Repair
• Nucleic Acid Chemistry
• +۴ مورد دیگر

Daniel Semlow is an Assistant Professor of Biochemistry at the California Institute of Technology (Caltech) and a Ronald and JoAnne Willens Scholar. He earned his B.S. from the University of Illinois, Urbana (2005) and his Ph.D. from the University of Chicago (2015). He served as a Visiting Associate at Caltech from 2019–2020 before joining as a faculty member in 2020. His research focuses on DNA replication and repair mechanisms, particularly those involving nucleic acid chemistry and genome maintenance. Education: B.S. in Biochemistry, University of Illinois, Urbana (2005) Ph.D. in Biochemistry, University of Chicago (2015) The Semlow Lab employs biochemical, genetic, and analytical methods to investigate how cells tolerate and repair DNA damage during replication. They also develop tools to identify novel DNA lesions and elucidate their origins. These studies aim to advance understanding of DNA repair pathways and potentially inform therapeutic strategies for cancer and genetic disorders. His publications highlight research on DNA interstrand crosslink repair, spliceosome dynamics, and RNA ligase deoxyribozymes. Key themes include DNA damage response, RNA processing, and enzyme activity. Collaborations with researchers like James C. Walter and others underscore interdisciplinary approaches to genome stability. Scientific Awards: Ronald and JoAnne Willens Scholar (2021–) As an instructor, Semlow contributes to Caltech’s BMB/Bi/Ch 174 course on advanced topics in biochemistry and molecular biophysics (2021–2024). He emphasizes literature analysis and synthesis of biochemical research.

Nigel Brissettمشاهده پروفایل

مدرس ارشد

• Protein Biochemistry
• DNA Damage and Repair
• Structural Biology
• +۳ مورد دیگر

Nigel Brissett is a Senior Lecturer at the University of Brighton's School of Applied Sciences, affiliated with the Centre for Lifelong Health. His research focuses on protein biochemistry, DNA damage response mechanisms, and fetal alcohol spectrum disorder (FASD). He holds a PhD from the University of London (1996) and a combined Biochemistry/Chemistry degree from Aston University (1991). Research interests include structural biology of protein-DNA interactions, prokaryotic DNA repair enzymes, and FASD's molecular effects. He applies biochemical approaches to study prenatal alcohol exposure's impact on skeletal development and metabolic processes. Nigel teaches biochemistry and metabolic pathways, emphasizing research-integrated pedagogy and student engagement. Previous roles include postdoctoral research at the University of Sussex (1997-2005) and the Genome Damage and Stability Centre (2005-2019). He is a Biochemical Society Local Ambassador and holds a Postgraduate Certificate in Learning and Teaching in Higher Education.

• DNA Repair Mechanisms
• Molecular Biology
• Archaea Genomics
• +۳ مورد دیگر

Roles and Affiliations: Mariarosaria De Falco is a Researcher at the Institute of Biosciences and BioResources (IBBR-CNR) in the Naples Division, part of the National Research Council of Italy. She specializes in enzymology, DNA replication, and DNA repair mechanisms in Archaea. Research Interests: Her work focuses on molecular mechanisms of DNA replication and recombinational repair in Archaea, particularly Sulfolobus solfataricus . She also explores human enzymes and genomic stability. Her lab develops isothermal amplification systems for rapid diagnostics of infections and CRISPR-Cas-based biosensing technologies. Publications Overview: Recent work includes advancements in room-temperature LAMP technology, CRISPR diagnostics, and insights into DNA repair pathways in Archaea. Her studies highlight the coordination of SSB and NurA/HerA complexes in DNA end resection and the role of extremophilic enzymes in biotechnology. Lab Activities: Hosts Master’s students for research in DNA repair in extremophiles and diagnostic tool development. Collaborates on projects integrating nucleic acid amplification with biosensors for point-of-care applications.

Weilong Haoمشاهده پروفایل

دانشیار

• Bioinformatics
• Comparative Genomics
• Evolution
• +۴ مورد دیگر

Weilong Hao is an Associate Professor in the Department of Biological Sciences at Wayne State University, affiliated with the College of Liberal Arts and Sciences. His research focuses on understanding dynamic genomic changes and their functional consequences using comparative genomics, next-generation sequencing, and bioinformatics. Key areas include genome structure evolution, mutation mechanisms, and mitochondrial genetics. Education: Ph.D. in Bioinformatics from McMaster University, with a Certificate in Effective College Instruction (2018). Awards include an NSERC Postdoctoral Fellowship and NSF grant #1838291. Research Interests: Comparative genomics of yeast, bacteria, and plants Mechanisms of mutation and genome plasticity Evolutionary dynamics of AT-rich genomes Horizontal gene transfer and recombination Recent Work Trends: Publications emphasize genomic mechanisms in yeast mitochondria, antibiotic resistance in urban environments, and evolutionary transitions in fungi. Themes include mutation bias, recombination-driven genome evolution, and functional genomic innovations. Grants & Awards: Active NSF funding supports pathogen genome research. Teaching includes courses in evolution (BIO2700) and bioinformatics (BIO5280/BIO7280). Labs/Teams: Directs the Hao Lab (haolab.wayne.edu), focusing on integrative genomic approaches to evolutionary biology and microbial genomics.

David K. Cortezمشاهده پروفایل

استاد

• DNA Damage Response
• Genome Integrity
• DNA Repair
• +۷ مورد دیگر

David K. Cortez is Professor of Biochemistry and Chair of the Department of Biochemistry at Vanderbilt University School of Medicine. He also holds the Richard N. Armstrong Ph.D. Chair for Innovation in Biochemistry and serves as Associate Director for Basic Science Research at the Vanderbilt-Ingram Cancer Center. His research is centered on genome maintenance, DNA damage response, and replication stress mechanisms. Institution: Vanderbilt University School: School of Medicine Department: Department of Biochemistry Leadership: Chair of Biochemistry, Associate Director (Basic Science), VICC Contact: david.cortez@vanderbilt.edu | 615-322-8547 | 613 Light Hall, Nashville, TN Dr. Cortez's research focuses on understanding how cells maintain genome integrity during DNA replication and in response to DNA damage. His work integrates genetics, biochemistry, cell biology, proteomics, and structural biology to dissect mechanisms involving ATR kinase signaling, replication fork remodeling, BRCA-related pathways, abasic site repair, and proteolysis . These processes are crucial for preventing cancer, developmental disorders, and aging. The 15 most recent publications highlight a consistent focus on DNA damage signaling, replication fork dynamics, and repair mechanisms . Key themes include the use of iPOND for proteomic mapping , fork regression and protection , ATR-mediated checkpoint control , and therapeutic targeting of DNA repair pathways in cancer. Subfields span molecular oncology, signal transduction, and structural enzymology. Scientific recognition includes: Richard N. Armstrong Ph.D. Chair for Innovation in Biochemistry Dr. Cortez leads an active research program with ongoing postdoctoral recruitment, indicating strong grant support and mentoring activity. His lab is embedded in multiple interdisciplinary centers, including the Genome Maintenance Program (Vanderbilt-Ingram Cancer Center), Vanderbilt Institute of Chemical Biology, and Center in Molecular Toxicology , reflecting broad collaborative and funding networks. He advises graduate and postdoctoral researchers in molecular cancer biology and DNA repair. Future work continues to explore therapeutic vulnerabilities in DNA repair-deficient cancers. The Cortez Lab maintains a strong presence in both basic and translational research, with ongoing projects aimed at identifying novel repair proteins, characterizing fork protection mechanisms, and developing cancer therapies targeting the DNA damage response. The lab utilizes cutting-edge techniques such as genetic screens, iPOND, structural biology, and preclinical models.

• Structural Biology
• Epigenetics
• Molecular Biology
• +۴ مورد دیگر

Dr. Hongda Huang is an Associate Professor in the Department of Biology at Southern University of Science and Technology (SUSTech) in Shenzhen, China. He joined SUSTech in 2017 after completing his postdoctoral training at Memorial Sloan-Kettering Cancer Center in New York. His academic career spans structural biology and epigenetic research, with a focus on understanding molecular mechanisms of genome regulation. Education: PhD in Structural Biology (2004-2010), University of Science & Technology of China BS in Biological Sciences (2000-2004), University of Science & Technology of China Dr. Huang's research primarily focuses on epigenetic regulation of the eukaryotic genome through structural biology and biochemistry techniques. His work examines DNA methylation (including DNA methyltransferases, demethylases and reader modules), histone modifications (methylation, acetylation, phosphorylation, ubiquitination), chromatin remodeling, histone variants (particularly H2A and H3), and histone chaperones. These epigenetic mechanisms influence gene transcription, DNA replication, DNA repair, and cell development, with dysfunctions potentially leading to human diseases including cancer. Dr. Huang's publication record demonstrates consistent contributions to structural biology, particularly in determining the molecular structures of protein complexes involved in epigenetic regulation, DNA repair, and chromosome dynamics. His work frequently appears in high-impact journals including Nature, Nature Structural & Molecular Biology, and Cell Research, showing expertise in X-ray crystallography and NMR spectroscopy techniques applied to understand fundamental biological processes at the molecular level. As an active research professor at SUSTech's School of Life Sciences, Dr. Huang maintains a laboratory focused on epigenetics and structural biology. His collaborative publications with international researchers indicate integration into global scientific networks and suggest successful funding for his research program. His work has particular relevance for understanding disease mechanisms and potentially developing therapeutic approaches targeting epigenetic regulators.

• Epigenetics
• Molecular Biology
• Chromatin Dynamics
• +۳ مورد دیگر

Marek Adamus is a Researcher at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, working within the Montoya Group. His research focuses on fundamental molecular mechanisms governing epigenetic inheritance and DNA replication processes. Research Interests Adamus specializes in chromatin dynamics during DNA replication, particularly how parental histones are recycled to maintain epigenetic memory across cell divisions. His work bridges structural biology and epigenetics, investigating protein complexes that ensure faithful transmission of epigenetic information. Key methodologies include biochemical reconstitution and structural analysis of replication machinery. Scientific Output His 2024 Cell publication demonstrates how the fork protection complex facilitates histone recycling, revealing critical links between replication fork stability and epigenetic inheritance. This high-impact work shows significant interdisciplinary reach across molecular biology and epigenetics fields. Collaborations & Infrastructure Adamus operates within the Montoya Group at CPR, leveraging the center's advanced proteomics and structural biology facilities. His research involves international collaborations evidenced by multi-institutional authorship, supported by infrastructure from the Novo Nordisk Foundation.

George-Lucian Moldovanمشاهده پروفایل

استاد

• DNA Damage Tolerance
• Genomic Instability
• DNA Repair
• +۳ مورد دیگر

George-Lucian Moldovan is a Professor at the Department of Molecular and Precision Medicine, Penn State College of Medicine, and a member of the Penn State Cancer Institute. His research focuses on elucidating the molecular mechanisms of DNA lesion replication in human cells, particularly in the context of genomic stability and cancer prevention. Affiliation: Penn State College of Medicine, Hershey, PA Academic Rank: Professor Research Interests include: Genomic Instability DNA Damage and Repair Replication Stress Translesion Synthesis Role of PARP Proteins in Radioresistance Bisphenol A (BPA) Environmental Impacts Scientific Awards : Outstanding Early-Stage Investigator (2015) Outstanding Research Publication (2021) Dean's Award for Excellence in Teaching (2019, 2022) Outstanding Collaborative Research Team (2020) His grants and projects include studies on DNA damage tolerance pathways (NIGMS, 2015-2026), PCNA-PARI pathway in cancer (U.S. Army and CDMRP), and PARP14/RAD18-mediated repair mechanisms (NIEHS). His work contributes to UN Sustainable Development Goals related to health and well-being.

• DNA Replication
• Cryo-Electron Microscopy
• Single-Molecule Biophysics
• +۲ مورد دیگر

Jacob Lewis is Senior Lecturer of Cell and Molecular Biology at University of Wollongong's School of Chemistry and Molecular Bioscience. An NHMRC Investigator and ARC DECRA Fellow, he leads research on DNA replication dynamics using cryo-EM and single-molecule biophysics. His work challenges textbook models of replication machinery through structural studies of origin activation and replisome heterogeneity. Current projects investigate mitochondrial DNA replication and replication fork stalling mechanisms relevant to cancer therapeutics. Lewis maintains collaborations with international institutions including the Francis Crick Institute and holds continuous fellowship support since 2019. His research combines biochemical reconstitution with advanced imaging to analyze nucleic acid-protein interactions.

• Structural Biology
• Medical Molecular Engineering
• DNA Replication
• +۳ مورد دیگر

Zhi-Qiang Xu is a Research Fellow at the University of Wollongong, affiliated with the Faculty of Science, Medicine and Health and the School of Chemistry and Molecular Bioscience. He holds a PhD from the University of Sydney (2006). His research focuses on structural biology, including macromolecular modeling and medical molecular engineering of nucleic acids and proteins. Xu specializes in studying DNA replication mechanisms, protein dynamics, and bacterial molecular processes using advanced techniques like single-molecule visualization. His research outputs from 2021 to 2024 highlight investigations into DNA replication fork dynamics, helicase functions, and transcription-repair coupling mechanisms. Xu is available to supervise Master’s and PhD students in these areas. No scientific awards are explicitly listed in the provided information.

Elizabeth Thrallمشاهده پروفایل

استادیار

• Biophysical Chemistry
• DNA Replication
• Translesion Synthesis
• +۳ مورد دیگر

Elizabeth Thrall is an Assistant Professor in the Department of Chemistry at Fordham University, located within the College of Arts and Sciences. She is affiliated with the JMH 628/630 laboratory and holds office in JMH 632. Her research focuses on biophysical chemistry, particularly DNA replication mechanisms, translesion synthesis, and enzymatic interactions in organisms like Bacillus subtilis . She employs advanced techniques such as single-molecule imaging to study replication fork dynamics and TLS pathway regulation. Additionally, she develops machine learning-based approaches for undergraduate chemistry education, enhancing hypothesis-driven experimentation and functional group identification in spectroscopy. Her research interests include the roles of DNA damage tolerance factors, clamp-protein interactions, and replication stalling. Key findings involve the coordination of replicative polymerases with sliding clamps and the constitutive role of translesion polymerases in replication machinery. She also explores the compartmentalization of replication forks and the activation of single-stranded DNA-binding proteins during stress. Her publications highlight contributions to understanding TLS pathway choice, enzymatic gatekeeping, and methodological standards for DNA repair studies. Her work bridges fundamental biochemistry with pedagogical innovations, integrating computational tools into laboratory curricula. She leads a research lab focused on single-molecule visualization and bacterial DNA repair mechanisms.