جست‌وجوی استاد و پژوهشگر

Britt Adamsonمشاهده پروفایل

دانشیار

• Stress Response Networks
• DNA Damage Response
• Genome Editing
• +۳ مورد دیگر

Britt Adamson is an Associate Professor in the Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics at Princeton University, where she serves as Director of the Undergraduate Program in Quantitative and Computational Biology. Her lab investigates molecular networks in human cells with focus on stress response mechanisms and genome editing technologies. She received her B.S. in Biology from the Massachusetts Institute of Technology (2005) and Ph.D. in Genetics and Genomics from Harvard University (2012), followed by postdoctoral training at UCSF under Jonathan Weissman supported by a Damon Runyon Cancer Research Foundation Fellowship. Adamson's research centers on how cells organize stress response networks during DNA damage and endoplasmic reticulum stress, developing CRISPR-based functional genomics and single-cell sequencing tools to map molecular behaviors. Her work bridges fundamental cell biology with therapeutic applications in genome editing. Analysis of her 15 most recent publications reveals dominant themes in precision genome editing (prime/base editing optimization) and systematic dissection of DNA repair pathways through combinatorial CRISPR screening. Her lab consistently integrates computational approaches with high-resolution experimental techniques to uncover context-dependent cellular behaviors. Her scientific recognitions include: Damon Runyon Cancer Research Foundation Postdoctoral Fellowship Princeton IP Accelerator Award (2025) STAT Who to Know: 10 Scientists leading a new generation of gene editors (2024) Adamson actively mentors eight graduate students (including alumni Ann Cirincione and Jun Hussmann) and two postdocs, with research funded through institutional awards and collaborative grants. Her lab's technological developments have enabled projects spanning virology, immunology, and developmental biology. The Adamson Lab operates within Princeton's Lewis-Sigler Institute for Integrative Genomics, fostering an interdisciplinary environment that merges cell biology, genomics, and computational science. Current projects focus on improving prime editing efficiency and understanding stress response adaptation in disease contexts.

• Stem Cell Biology
• Genetic Engineering
• Epigenetics
• +۵ مورد دیگر

Konstantinos Anastassiadis is a Professor at the Center for Molecular and Cellular Bioengineering (CMCB) of Dresden University of Technology , leading the Stem Cell Engineering group at the Biotechnology Center (BIOTEC) . His research focuses on unraveling molecular pathways regulating stem cell self-renewal and lineage commitment, with a strong emphasis on genetic engineering tool development and epigenetic mechanisms during cellular reprogramming. The lab utilizes mouse and human embryonic stem cells, neural stem cells, mesenchymal stromal cells, and induced pluripotent stem cells (iPSCs) in their investigations. Core Research Areas: Molecular regulation of stem cell fate Epigenetic mechanisms (e.g., UTX/UTY histone demethylases) Genetic engineering tool development (Flp, Dre, Vika recombinases, CRISPR protocols) Conditional immortalization systems for rare cell expansion Publications highlight his contributions to understanding: Role of histone methyltransferases (MLL1, MLL2, Setd1b) in hematopoiesis and cancer Epigenetic regulation during mouse development and spermatogenesis Genetic tools for protein tagging, transposon-mediated BAC transgenesis Interactions between stem cells and niche microenvironments Transcriptional and mechanical markers during reprogramming Collaborations span immunology , developmental biology , and bioinformatics . The lab actively participates in teaching activities at CMCB and maintains a focus on translational applications of stem cell research.

John A. Copland, IIIمشاهده پروفایل

استاد

• Cancer Biology
• Molecular Carcinogenesis
• Translational Research
• +۳ مورد دیگر

Dr. John A. Copland III is a Professor of Cancer Biology and Biochemistry & Molecular Biology at Mayo Clinic in Jacksonville, Florida. He leads the Cancer Biology and Translational Research Laboratory, focusing on molecular mechanisms of carcinogenesis, tumor progression, and development of targeted cancer therapies. Education: PhD in Physiology & Endocrinology (Medical College of Georgia), MS in Endocrinology (Medical College of Georgia), BS in Chemistry (Columbus College), with postdoctoral training at University of Texas Medical Branch. Research interests center on: Identifying tumor suppressor genes (e.g., RhoB, TBR3, GATA3) and oncogenes (e.g., FOXO3a, SCD1, NPTX2). Developing patient-derived xenografts and live cell models for personalized medicine. Designing SCD1 inhibitors via in silico modeling for clinical trials. Recent publications highlight his work on SCD1 inhibition in leukemia and thyroid cancer ImmunoPET imaging of thyroid tumors CRISPR-identified drug synergies in cholangiocarcinoma Patient-specific combination therapies using xenograft models

Donald Rioمشاهده پروفایل

استاد

• Nucleic Acid Transactions
• Transposable Elements
• RNA Binding Proteins
• +۳ مورد دیگر

Donald Rio holds the Richard and Rhoda Goldman Distinguished Chair in the Biological Sciences and is a Professor of Biochemistry, Biophysics, and Structural Biology. He is affiliated with the Division of Biochemistry and Molecular Biology and the Center for Integrative Genetics. His lab focuses on nucleic acid transactions, including transposable element mobilization (P elements) and RNA binding protein mechanisms controlling alternative splicing. Research highlights include studies on THAP9 proteins in humans/zebrafish, cryo-EM structural analysis of transposase-DNA complexes, and splicing regulation in neurodegenerative diseases like ALS and Parkinson’s. His work combines biochemical, genetic, and computational approaches, including the development of the Junction Usage Model (JUM) for splicing analysis. Research interests span transposition mechanisms linked to HIV integration, immune system recombination, and evolutionary genome dynamics. His team investigates how RNA binding proteins like hnRNPA1 influence splicing in disease contexts, with projects involving CRISPR-based models and patient RNA-seq data analysis. Collaborations include studies on splicing accuracy across tissues and age, and the impact of splicing defects in neurodegenerative disorders. Key awards include the Goldman Chair. His lab’s contributions bridge fundamental molecular mechanisms with translational applications in genetic disease modeling and drug discovery. Recent work focuses on isogenic stem cell models (iSCORE-PD) for Parkinson’s research and structural biology insights into transposase function. Grants and projects involve NIH funding for ALS splicing studies and collaborations with institutions like the Buck Institute. His lab actively publishes in top journals such as Genome Research , PNAS , and Nature , with a strong emphasis on cryo-EM and bioinformatic methods.

Ross Thyerمشاهده پروفایل

استادیار

• Synthetic Biology
• Protein Engineering
• Genetic Code Expansion
• +۶ مورد دیگر

Ross Thyer is an Assistant Professor in the Department of Chemical and Biomolecular Engineering at Rice University. He holds a BSc (Hons) from the University of Western Australia and a PhD from the Harry Perkins Institute of Medical Research under Drs. Rackham and Filipovska. His postdoctoral training at the University of Texas at Austin with Prof. Andrew Ellington focused on engineered biosynthesis pathways and non-canonical amino acids. He co-founded GRO Biosciences, a Boston-based biotech startup, and leads the Thyer Lab at Rice. His research bridges synthetic biology, protein engineering, and molecular programming to address global challenges. Key areas include expanding genetic codes for therapeutics, engineering biosynthetic pathways via genetic circuitry, and developing microbial systems for environmental bioremediation. Core technologies include deep learning for protein design, modular DNA assembly, and high-throughput selections. The lab also develops tools like MutCompute for enzyme engineering and domesticates non-model bacteria for bioproduction. His work emphasizes technology innovation, with recent advances in selenocysteine incorporation, L-DOPA sensing systems, and actinobacteria toolkits. The Thyer Lab actively collaborates on biocatalyst development and translational applications in healthcare and industry.

Ralph Bockمشاهده پروفایل

استاد

• Plant Molecular Biology
• Chloroplast Biology
• Organelle Biotechnology
• +۷ مورد دیگر

Prof. Dr. Ralph Bock serves as Director of Department 3: Organelle Biology, Biotechnology and Molecular Ecophysiology at the Max Planck Institute of Molecular Plant Physiology in Potsdam, Germany, where he also leads the Organelle Biology and Biotechnology research group. Previously, he held positions as C4 Professor for Plant Biochemistry and Biotechnology at the University of Münster (2001-2004) and Group Leader at the Institute of Biology III, University of Freiburg (1996-2001). His academic credentials include: Habilitation: University of Freiburg, 1999 Doctorate: University of Freiburg, 1996 Diploma: University of Halle, 1993 Prof. Bock's research focuses on plant molecular biology with particular emphasis on chloroplast biology, organelle biotechnology, and molecular ecophysiology. His work spans genetic engineering of plastids, photosynthesis research, plant biotechnology applications, and understanding organelle-nucleus communication. He has made significant contributions to developing chloroplast transformation systems and applying them to molecular farming, metabolic engineering, and understanding fundamental processes in plant cell biology. His research has important implications for sustainable agriculture, bioenergy, and pharmaceutical production, particularly through the development of plant-based systems for producing vaccines and therapeutic proteins. Analysis of Prof. Bock's recent publications (2023-2025) reveals a strong focus on chloroplast biology, genetic engineering, and molecular farming applications. His work spans fundamental research on organelle genetics, photosynthesis, and stress responses, as well as applied research on using plant and algal systems for biopharmaceutical production. A notable trend is the increasing use of advanced genetic engineering techniques, including CRISPR-based approaches, to manipulate organelle genomes. His research also shows growing interest in algal systems as alternative expression platforms for molecular farming, particularly red algae like Porphyridium for producing viral antigens and glycoproteins.

Bob Beitle Jr.مشاهده پروفایل

استاد

• Biochemical Engineering
• Bioseparation
• Fermentation
• +۵ مورد دیگر

Dr. Bob Beitle Jr. is a Professor of Chemical Engineering and Senior Associate Vice Chancellor for Research and Innovation at the University of Arkansas. He joined the department in 1993, earned tenure in 1998, and was promoted to Full Professor in 2006. His research spans biochemical engineering , bioseparation , fermentation , and adaptive technology for the disabled , with significant work on protein purification, catalytic nanoparticles, and sustainable bioprocesses. Education: BS, MS, PhD in Chemical Engineering from the University of Pittsburgh (1987, 1991, 1993) Dr. Beitle's research combines experimental and computational approaches, focusing on peptide-directed nanoparticle synthesis and biocatalysis . His recent publications highlight advancements in MOF-based separations , CO2 capture materials , and viral detection platforms . He has secured grants like the CAREER Award and led projects in industrial partnerships and student development . Scientific contributions include multiple patents in bioseparation and software interfaces. Awards span decades: teaching honors (1988–2007) and mentorship recognition . He serves on the Cell and Molecular Biology Program Advisory Committee and the Executive Committee for the Biochemical Technology Division of ACS . Lab initiatives involve genomic data-driven affinity tail design and membrane-assisted fermentation systems .

• Synthetic Biology
• Enzyme Engineering
• Genetic Circuits
• +۳ مورد دیگر

Dr. Seung-gu Lee is a Principal Scientist and Director of the Synthetic Biology Institute at the Korea Research Institute of Bioscience and Biotechnology (KRIBB). He holds a Ph.D. in Biotechnology from KAIST and serves as the President of the Korean Society of Enzyme Engineering. His leadership extends to multiple national research initiatives focused on advancing synthetic biology infrastructure and applications. Dr. Lee is a leading expert in genetic circuits and enzyme engineering for synthetic biology. He pioneered the development of GESS (Genic Enzyme Screening System/Circuits) technology, which enables ultra-high-speed screening of trace enzyme activities at the single-cell level. His research focuses on applying intelligent genetic circuits to biosensors, metabolic control, and bioprocess development. He is actively integrating AI-based automated workflows with synthetic biology to revolutionize the speed and scale of biological research. His work spans multiple disciplines including enzyme engineering, genetic circuit design, metabolic engineering, and biofoundry development. Dr. Lee currently leads several major research initiatives including the Korea-North America Biofoundry Collaboration Global Joint Research Center, the development of core technologies for advanced synthetic biology, and the establishment of biofoundry infrastructure. His research team at KRIBB works at the intersection of synthetic biology, enzyme engineering, and AI-based automation to develop next-generation bio-manufacturing platforms. The lab has made significant contributions to genetic circuit design, biosensor development, and plastic biodegradation technologies.

Rudolf Amannمشاهده پروفایل

استاد

• Microbial ecology
• Marine carbon cycle
• Phytoplankton-bacterioplankton interactions
• +۲ مورد دیگر

Prof. Dr. Rudolf Amann serves as Managing Director at the Max Planck Institute for Marine Microbiology in Bremen, Germany, and leads the Department of Molecular Ecology. His work pioneers molecular methods for studying marine microorganisms, with a focus on fluorescence in situ hybridization (FISH) to identify and quantify microbial cells. Managing Director, Max Planck Institute for Marine Microbiology (since 2018) Department Head, Molecular Ecology Research Center, Bremen, Germany Research Interests: Marine microbial diversity and ecology Carbon cycle dynamics in coastal and deep-sea environments Phytoplankton-bacterioplankton interactions Microbial taxonomy and phylogenetics Single-cell identification techniques (FISH, CARD-FISH) Integration of metagenomics and proteomics Publication Trends: Recent work focuses on microbial interactions in extreme environments (hydrothermal vents, Arctic waters), carbohydrate cycling in oceanic systems, and ecological differentiation of bacterial populations through advanced imaging and omics technologies. Contact: ramann@mpi-bremen.de

J. Christopher Loveمشاهده پروفایل

استاد

• Nano-based drugs
• Precision medicine
• Immunology
• +۳ مورد دیگر

J. Christopher Love is the Raymond A. (1921) and Helen E. St. Laurent Professor of Chemical Engineering at MIT, with affiliations to the Koch Institute for Integrative Cancer Research, Broad Institute, and Ragon Institute. He earned a BS in Chemistry from the University of Virginia and a PhD in Physical Chemistry from Harvard University under George Whitesides, followed by postdoctoral work under Hidde Ploegh at Harvard Medical School. His research focuses on single-cell analysis, precision medicine, and biomanufacturing. The Love Lab develops technologies for drug discovery, vaccine development, and equitable biologic medicine production. Notable successes include pioneering single-cell analysis platforms, advancing metastatic cancer diagnostics via liquid biopsies, and engineering yeast-based vaccine manufacturing. Recent articles highlight innovations in liquid biopsy sensitivity, AI-driven ECG diagnostics, and CAR T-cell therapies. Awards include the Keck Young Scholar (2009), Dana Scholar (2009), and Camille Dreyfus Teacher-Scholar. He co-founded OneCyte, HoneyComb, and Sunflower Therapeutics, and advises multiple biotech companies. His lab emphasizes translational research, integrating chemical and biological engineering principles to address global healthcare challenges. Current work explores manufacturability-by-design for vaccines, tumor immunology, and mucosal vaccine delivery systems.

• Genetic Engineering
• Microbial Biotechnology
• Bioenergy
• +۴ مورد دیگر

Sarah D'Adamo is an Associate Professor in Bio Process Engineering at Wageningen University & Research. Her research focuses on genetic engineering of microalgae, particularly Nannochloropsis species, to enhance lipid production, carotenoid synthesis, and selenium accumulation. She explores metabolic pathways, biotechnological applications, and sustainable biomass production. Expertise: Genetic engineering tools, lipid metabolism, microalgal biotechnology. Key Projects: Includes metabolic modeling, CRISPR-Cas systems, and industrial applications of microalgae. Her work bridges fundamental biology with industrial biotechnology, addressing challenges in biofuel production and nutrient optimization.

• Immunology
• Lipid Metabolism
• Infectious Diseases
• +۳ مورد دیگر

Dijin Xu is an Associate Research Scientist in the Department of Microbial Pathogenesis at Yale School of Medicine, Yale University. His research focuses on lipid metabolism, immunology, and molecular mechanisms underlying metabolic disorders and host-pathogen interactions. He holds a PhD from Tsinghua University (2016). Education: PhD in Microbiology, Tsinghua University, 2016 Research Interests: Dr. Xu’s work spans immunology (e.g., B cell biology and somatic hypermutation), lipid metabolism (lipid droplet dynamics and adipose tissue homeostasis), and virology (antiviral defense mechanisms against SARS-CoV-2). His studies integrate cellular biology, molecular genetics, and biochemical approaches to understand disease processes. Publications Overview: His recent work explores mechanisms of lipid droplet regulation, metabolic disorder prevention, and immune system function. Notable contributions include studies on Rab GTPases in lipid storage and ELOF1’s role in antibody diversification. Labs & Affiliations: He is affiliated with the West Campus Integrative Science & Technology Center at Yale University, focusing on interdisciplinary research in cellular and molecular biology.

• Systems Biology
• Cancer Research
• Drug Resistance
• +۷ مورد دیگر

Sampsa Hautaniemi is a Professor at the Department of Biochemistry and Developmental Biology within the Faculty of Medicine at the University of Helsinki. He serves as Principal Investigator of the Systems Biology of Drug Resistance in Cancer research group and holds docentship in the Faculty of Medicine. Professor Hautaniemi actively supervises doctoral students across multiple programs including the Doctoral Programme in Biomedicine, Doctoral Programme in Clinical Research, and Doctoral Programme in Integrative Life Science. His research focuses on systems biology approaches to understand drug resistance mechanisms in cancer, particularly ovarian cancer. His work integrates computational biology, genomics, epigenetics, and bioinformatics to develop precision medicine approaches for cancer treatment. His laboratory develops innovative computational methods and experimental models including patient-derived organoids to study tumor evolution, identify therapeutic targets, and predict treatment responses. Analysis of his recent publications reveals a strong emphasis on understanding tumor heterogeneity, clonal evolution during therapy, and the development of computational tools for cancer genomics. His work spans multiple disciplines including cancer biology, computational biology, immunology, and precision medicine, with a particular focus on high-grade serous ovarian cancer as a model system. Scientific Awards: The Anders Jahre Medical Prize to young medical scientists (2014) for outstanding research on systems biology and cancer The Finnish Medical Foundation 50-years jubileum award (2010) Professor Hautaniemi has supervised numerous doctoral students and early-career researchers, contributing significantly to cancer research education. His research is supported by multiple active projects including the DECIDER project (Clinical Decision via Integrating Multiple Data Levels to Overcome Chemotherapy Resistance in High-Grade Serous Ovarian Cancer) funded until 2026, as well as projects from the Academy of Finland, Cancer Foundation, and industry partners like Orion Corporation. His laboratory maintains a patient-derived organoid biobank for high-grade serous ovarian cancer and develops computational tools like Jellyfish for visualizing tumor evolution.

Stephen Leveneمشاهده پروفایل

استاد

• DNA topology
• protein-DNA interactions
• nucleic acid structure
• +۵ مورد دیگر

Stephen Levene is a Professor of Bioengineering at The University of Texas at Dallas (UT Dallas), affiliated with the Erik Jonsson School of Engineering and Computer Science. His research focuses on the physical and functional genomics of DNA structure, protein-DNA interactions, and DNA topology in biological systems. He holds a PhD from Yale University (1985) and an AB from Columbia University (1979). Levene’s laboratory investigates genome organization, chromatin dynamics, and the role of circular DNA (eccDNA) in health and disease. His work employs advanced biophysical techniques, including hydroxyl radical probing, gel electrophoresis, and single-molecule analysis. Key areas include DNA supercoiling, topoisomerase function, and the interplay between DNA structure and cellular processes. His research has led to innovations in DNA topology simplification, Cre recombination kinetics, and methodologies for analyzing circular DNA populations in organisms like C. elegans and humans. Levene’s lab also develops tools for genomic studies, such as shallow-learning models for DNA fragmentation analysis and unmasking hidden topological activities in recombination systems. Levene’s contributions span over 40 years, with publications addressing DNA looping, knotting, and the thermodynamics of nucleoprotein assemblies. His work bridges biophysics, molecular biology, and engineering, emphasizing interdisciplinary approaches to genomic challenges.

• Environmental Epidemiology
• Children's Environmental Health
• Molecular Epidemiology
• +۳ مورد دیگر

Margaret Karagas, PhD is the inaugural Department Chair and James W. Squires Professor of Epidemiology at the Geisel School of Medicine at Dartmouth College, with a secondary appointment as Professor of Community and Family Medicine. She also serves as Director of both the Children's Environmental Health and Disease Prevention Research Center and the Center for Molecular Epidemiology at Dartmouth. Her leadership extends to the NIH-funded Environmental Influences on Child Health Outcomes (ECHO) Program, which encompasses over 90,000 participants across the United States. Dr. Karagas earned her PhD from the University of Washington in 1990 and has established herself as a leading researcher in environmental epidemiology. She collaboratively developed an innovative cross-disciplinary postdoctoral and graduate program in Quantitative Biomedical Sciences (QBS) that integrates epidemiology, bioinformatics, and bistatistics. Her research focuses on interdisciplinary studies investigating environmental exposures, host factors, and biological mechanisms affecting health from infancy through adulthood, with particular emphasis on under-studied rural populations. Dr. Karagas employs high-dimensional analytic tools along with biomarkers and sensors to study the exposome, genetic susceptibility, and biological response. Her work has uncovered adverse cardiometabolic, neurodevelopmental, and immune-related health outcomes associated with drinking water contaminants, food-borne toxicants (including in infant first foods), and exposures from woodstoves. Analysis of her recent publications reveals a strong focus on environmental health impacts across the lifespan, with significant contributions to understanding how environmental exposures affect child development, chronic disease risk, and health disparities. Her work frequently employs advanced molecular and analytical techniques to assess environmental exposures and their biological consequences. Dr. Karagas serves on numerous prestigious international consensus panels and committees, including those for the United Nations, World Health Organization, International Agency for Research on Cancer, European Food Safety Authority, US National Institutes of Health, and National Academies of Science, Engineering and Medicine. As an academic leader, she has mentored diverse investigators at all career stages and established innovative training programs. Her research has directly contributed to practice and policy changes regarding environmental health threats. She maintains active collaborations across multiple centers at Dartmouth including the Dartmouth Toxic Metals Superfund Research Program and Dartmouth SYNERGY.