جست‌وجوی استاد و پژوهشگر

Cameron A. Myhrvoldمشاهده پروفایل

استادیار

• CRISPR-based technologies
• Viral RNA studies
• Host-pathogen interactions
• +۷ مورد دیگر

Cameron A. Myhrvold is an Assistant Professor of Molecular Biology at Princeton University, leading the Myhrvold Lab. His research focuses on CRISPR-based technologies to study viral and host RNA, with applications in detecting and combating RNA viruses like SARS-CoV-2. He specializes in developing Cas13-based tools for multiplexed nucleic acid detection, host-pathogen interaction analysis, and RNA perturbation. Education: A.B. in Molecular Biology from Princeton University (undergraduate), Ph.D. in Systems Biology from Harvard University. His postdoctoral work at Harvard involved pioneering CRISPR-Cas13 technologies, leading to innovations like CARMEN, CARVER, and SHINE. Research interests include: CRISPR-based RNA editing, quantitative nucleic acid detection, systems biology of viral infections, and translating technologies for global health. His lab emphasizes deploying diagnostics in resource-limited settings and studying viral dynamics across diverse tissues and infection conditions. Notable achievements: Named NEBEC Emerging Young Investigator. His work has advanced field-deployable viral diagnostics and multiplexed RNA analysis tools. Collaborates with institutions like the Broad Institute and the CDC on pandemic response initiatives. Current projects include developing quantitative CARMEN variants for gene expression analysis, high-throughput screening of Cas13-virus interactions, and applying CRISPR tools to study influenza and SARS-CoV-2 in animal models.

Adele Murrellمشاهده پروفایل

استاد

• Epigenetics
• Genomic Imprinting
• DNA Methylation
• +۶ مورد دیگر

Professor Adele Murrell is a Professor of Epigenetics in the Department of Life Sciences at the University of Bath's Faculty of Science. She serves as Co-Director of the Centre for Therapeutic Innovation and is affiliated with both the Centre for Mathematical Biology and the Centre for Bioengineering & Biomedical Technologies (CBio). She is currently accepting doctoral students and maintains an active research program with multiple ongoing projects. Her research focuses on understanding how cells establish and maintain their specific identities through epigenetic mechanisms. Her work centers on epigenetic barriers and cell identity, genomic imprinting as a model epigenetic system, long-range epigenetic silencing in cancer, and epigenetic reprogramming during metastasis. She investigates how higher-order chromatin structure and epigenetic modifications shape the genome within the nucleus to constitute cell identity and provide memory of developmental origins. Her current work examines colon cancer and liver metastasis, focusing on changes in DNA methylation and its demethylation intermediates such as 5-hydroxymethylcytosine. Analysis of Professor Murrell's recent publications reveals a strong focus on DNA hydroxymethylation patterns in cancer progression, particularly in colorectal cancer metastasis. Her work bridges molecular epigenetics with clinical applications, exploring how epigenetic changes during metastasis could be targeted to prevent cancer spread. She has developed novel techniques for detecting epigenetic modifications and has made significant contributions to understanding allele-specific chromatin domains and genomic imprinting mechanisms. Professor Murrell leads multiple research projects including 'Two stages of genome wide 5-hydroxymethylcytosine (5hmC) reprogramming during colorectal carcinogenesis and liver metastasis' funded by the MRC until February 2024, and 'Modelling the fits and starts of how genes burst into expression' funded by The Leverhulme Trust until June 2024. She was also a Co-Investigator on the 'Multi User High-Content Confocal Microscope' project funded by the Biotechnology and Biological Sciences Research Council. Her laboratory work connects with UN Sustainable Development Goals, particularly those related to health and well-being. Her fingerprint analysis shows strong activity in Epigenetics (100%), DNA Methylation (94%), Allele research (73%), Methylation studies (69%), Genomic Imprinting (60%), CTCF research (56%), Promoter Region analysis (44%), and Differentially Methylated Regions (34%).

Ulrike Kutayمشاهده پروفایل

استاد

• Nuclear envelope structure and biogenesis
• Nucleo-cytoplasmic transport
• Metazoan ribosome biogenesis
• +۳ مورد دیگر

Ulrike Kutay is a Full Professor of Biochemistry at ETH Zurich, Switzerland, with a research focus on nuclear biology and dynamics. Her work investigates nuclear envelope structure/function, ribosome biogenesis, and nucleo-cytoplasmic transport. Diploma in Biochemistry (Free University Berlin, 1992) PhD in Natural Sciences (Humboldt University Berlin, 1996) Research interests center on nuclear compartmentalization, including mitotic nuclear envelope breakdown and reassembly, ribosome assembly pathways, and the molecular mechanisms governing nuclear transport. Her lab explores how nuclear dysfunction contributes to diseases like ribosomopathies and cancer. Recent publications highlight her work on SUN/KASH proteins in nuclear envelope dynamics, ribosome biogenesis steps, and nuclear pore complex regulation. Collaborations with groups like the Spahn lab in Berlin underscore her interdisciplinary approach. EMBO Member (2010) Leopoldina Member (2012) ERC Advanced Grant (2012) As a mentor, she has supervised PhD students including Chiara and Roja. She actively participates in editorial boards, grant review panels (e.g., ERC, DFG), and institutional leadership roles at ETH Zurich and the Biochemistry Center Heidelberg. The Kutay Group at ETH Zurich combines proteomics, functional analyses, and structural studies to unravel nuclear processes, fostering a collaborative environment with recent achievements in mitotic nuclear disassembly and ribosome maturation research.

Paul J. Galardyمشاهده پروفایل

دانشیار

• Cancer Biology
• Ubiquitin-Proteasome System
• Pediatric Oncology
• +۵ مورد دیگر

Paul J. Galardy, M.D. is an Associate Professor of Pediatrics and Assistant Professor of Biochemistry and Molecular Biology at Mayo Clinic in Rochester, Minnesota. He serves as Chair of the Division of Pediatric Hematology/Oncology within the Department of Pediatric and Adolescent Medicine and holds a joint appointment in the Department of Biochemistry and Molecular Biology. His academic training includes: M.D. and Sc.D. from Boston University School of Medicine (1997) Residency and Chief Resident in Pediatrics at Massachusetts General Hospital (2000) Fellowship in Pediatric Hematology/Oncology at Children's Hospital, Dana Farber Cancer Institute (2004) Postdoctoral Research Fellowship under Hidde Ploegh at Whitehead Institute for Biomedical Research Dr. Galardy's research program investigates the ubiquitin-proteasome system in cancer pathogenesis, with dual focus on UCH-L1 in B-cell malignancies (including Burkitt lymphoma) and USP44 in chromosome segregation. His laboratory demonstrated UCH-L1's oncogenic role in driving B-cell cancers and lung tumors using transgenic models, while establishing USP44 as a critical tumor suppressor whose loss causes aneuploidy and increased cancer susceptibility, particularly in lung adenocarcinoma. His team employs RNA interference, protein biochemistry, live-cell imaging, and genetically engineered mouse models to elucidate de-ubiquitinating enzyme mechanisms and therapeutic potential. His research is funded by the National Cancer Institute, American Society of Hematology, Howard Hughes Medical Institute, and other organizations seeking novel childhood cancer therapies that improve cure rates while reducing treatment toxicities. Scientific recognition includes: Physician Scientist Early Career Award, Howard Hughes Medical Institute (2007) Basic Science Faculty Scholar, American Society of Hematology (2007) Best Poster Award at Third International Symposium on Non-Hodgkin's Lymphoma (2009) Dana-Farber Harvard Cancer Institute Fellowships (2005) HHMI/NIH Research Scholar (1993) Dr. Galardy maintains active clinical practice in pediatric hematology/oncology specializing in leukemia and lymphoma. He leads the Division of Pediatric Hematology/Oncology and contributes to the Mayo Clinic Comprehensive Cancer Center and Children's Research Center, where his laboratory operates within the Cancer Cell Genomics, Signalling, and Metastasis Program.

• Biomedical Engineering
• Nanotechnology
• Tumor Therapy
• +۴ مورد دیگر

Liu Hongmei is a Researcher and Master's Supervisor at Southern University of Science and Technology's Department of Biomedical Engineering. Holding a Ph.D. from the Chinese Academy of Sciences, she specializes in micro-nano robotics and tissue engineering for tumor therapy, with over 66 publications and 12 patents. Her work bridges biomedical engineering and nanotechnology for precision cancer treatments. B.S., Biological Sciences, Harbin Normal University (2005) M.S., Botany, Northeast Agricultural University (2008) Ph.D., Biochemical Engineering, Chinese Academy of Sciences (2015) Her research focuses on biomaterials engineering , nanoparticle drug delivery , and microenvironment-responsive hydrogels . Key areas include glioma therapy, traumatic brain injury recovery, and intervertebral disc degeneration treatments. Recent work explores pH/ROS/inflammation-triggered hydrogels and bioengineered bacteria for disease modulation. Article trends show a strong emphasis on nanoparticle design (2014-2025) for glioma, hydrogel development (2017-2025) for tissue repair, and biomimetic material synthesis (2023-2025) inspired by spider silk and meniscus structures. Sub-fields span pyroptosis inhibition, epigenetic reprogramming, and microbiome engineering. Jiangsu Science and Technology Award (2020) Jiangsu Medical Science and Technology Award (2020) Jiangsu Educational Science Research Award (2021) Chinese Medical Doctor Association's Outstanding Young Scientist (2018) Liu has supervised numerous projects including National Natural Science Foundation of China grants, Jiangsu Province Key R&D Program funding, and Shenzhen City General Projects. She holds 12 Chinese invention patents and collaborates with institutions like the UNESCO Centre for Higher Education Innovation.

Zahoor Shahمشاهده پروفایل

استاد

• Neuroprotection
• Stroke Research
• Cerebrovascular Diseases
• +۳ مورد دیگر

Zahoor Shah, Ph.D. , is a Professor and Vice Chair in the Department of Medicinal and Biological Chemistry at the College of Pharmacy and Pharmaceutical Sciences , The University of Toledo . He serves as Associate Dean for Graduate Education and Research and Program Director . Dr. Shah obtained his doctorate in Toxicology from Hamdard University (New Delhi, India) and completed postdoctoral training at the University of Louisville (2005) and Johns Hopkins University (2007). 2005: Postdoctoral Fellow, University of Louisville 2007: Postdoctoral Fellow, Johns Hopkins University 2009: Instructor, Johns Hopkins University Dr. Shah’s research focuses on identifying molecular targets and developing drugs for ischemic and hemorrhagic brain injuries . Key areas include: Neuroprotective agents targeting oxidative stress and inflammation Role of Nrf2/HO1 pathway in stroke recovery Mechanistic studies of cofilin signaling in neuroinflammation Preclinical models of stroke (t-MCAO, pMCAO, BCCAO) and zebrafish Alzheimer’s models Development of ROS-sensitive nitric oxide synthase inhibitors Patents in oxidative stress-related therapies His 15 most recent articles (2022–2024) emphasize: Therapeutic targeting of cofilin and neuroinflammation in stroke and neurodegenerative diseases Interplay between gut microbiota and cognitive decline Preclinical validation of anti-inflammatory agents (e.g., triazole-pyrimidine hybrids) Impact of metabolic factors (diabetes, hyperglycemia) on brain injury outcomes Dr. Shah has received major grants including NINDS R01 (2020–2025) and NIA R01 (2018–2023), and holds patents for neuroprotective compositions (US Patent 10,590,119; provisional applications D2018-11 and D2019-35). He has published over 83 peer-reviewed articles and mentored numerous graduate and undergraduate students.

Lukas Edward Dowمشاهده پروفایل

استاد

• Cancer Biology
• Genetics
• Molecular Biology
• +۵ مورد دیگر

Lukas Edward Dow is a Professor of Biochemistry and Biophysics at Weill Cornell Medical College (2025-present) and holds a secondary appointment in Medicine. His research spans genetic and non-genetic resistance mechanisms in KRAS-driven cancers, WNT signaling, and CRISPR-based cancer modeling. Ph.D. and B.Sc. from University of Melbourne Focus on CRC, pancreatic, breast, and prostate cancers Research interests include genetic resistance mechanisms , CRISPR applications , WNT pathway dependencies , and tumor microenvironment dynamics . Key publications reveal trends in mutant-specific therapies , epithelial plasticity , and precision genome editing . Current research projects funded by National Cancer Institute and Department of Defense investigate KRAS allelic imbalance, R-Spondin sensitization, and WNT pathway alterations. External collaborations include scientific advisory roles at Mirimus, Inc. and consulting at Revolution Medicines, Inc. His lab develops genetically engineered mouse models and organoid systems for studying cancer progression, with emphasis on metastasis , drug resistance , and epigenetic adaptations . The work has significant implications for improving cancer therapies through context-dependent targeting .

Albert Erivesمشاهده پروفایل

دانشیار

• Regulatory Genomics
• Evolutionary Genomics
• Evolution of Metazoa
• +۶ مورد دیگر

Albert Erives is an Associate Professor in the Department of Biology at the University of Iowa , specializing in regulatory genomics, evolutionary genomics, and the evolution of metazoans. His research focuses on decoding gene regulatory logic in DNA sequences, particularly during animal embryogenesis, using comparative genomics to identify regulatory modules driving phylogenetic transitions. PhD from University of California, Berkeley His work spans eukaryotic gene regulation, integrating biochemistry, molecular genetics, and computational biology to uncover principles of organismal evolution. Recent studies include viral nucleosome structure, Notch signaling pathway evolution, and enhancer organization in model organisms like Drosophila and Ciona . Notable scientific awards include the NSF CAREER Award (2012, 2010) . He actively seeks graduate students and postdoctoral researchers for his laboratory, which utilizes core facilities such as the Carver Center for Genomics.

• Entomology
• Biological Control
• Biopesticides
• +۴ مورد دیگر

Michele Ricupero is an Assistant Professor (RTD-B) in the Department of Agriculture Food and Environment (Di3A) at the University of Catania, specializing in Applied Entomology. His research focuses on sustainable pest control in protected crops using biological methods and biopesticides, with emphasis on ecotoxicology of natural enemies. Education includes a B.S. and M.S. in Agricultural Sciences (with honors), Ph.D. in Agricultural Sciences, and professional certification as an Agronomist. He conducted international research at institutions including INRA (France), University of Minnesota (USA), and Universidad de Talca (Chile) through Erasmus+ grants. Research interests center on: Biological control of horticultural pests (especially tomatoes) Molecular identification of insects Transcriptomics of plant-insect defenses Bioinsecticide development and ecotoxicology His publications demonstrate strong focus on sustainable pest management, with recent works analyzing non-target effects of pesticides, essential oil formulations, and invasive species dynamics. Awards include: Top Reviewer in Multidisciplinary, Plant & Animal Science (Clarivate, 2019) He advises graduate theses on topics like RNA interference in Lepidoptera and bioinsecticide efficacy. Research funded through PRIN projects, ENI Italy-Tunisia programmes, and Agritech Center. Leads activities in the Biocontrol Lab and serves on the Board of the Italian Entomological Society. Editorial roles include Annals of Applied Biology and guest editorships for Agronomy and Frontiers in Agronomy.

• Pharmacology
• Cholesterol Metabolism
• Alzheimer's Disease
• +۵ مورد دیگر

Bianca Papotti is a fixed-term Researcher at the Department of Food and Pharmaceutical Sciences, University of Parma. Her academic career spans interdisciplinary research in Pharmacology Cholesterol Metabolism Neurodegenerative Diseases Cardiovascular Pathology Immunometabolism . She teaches courses including Experimental Pharmacology and Food Toxicology. Her research focuses on the role of PCSK9 and cholesterol efflux in Alzheimer's Disease Atherosclerosis Rheumatoid Arthritis Lipoprotein Biology Inflammatory Disease Drug Development . Key trends in her publications (3 in 2025, 12 in 2024) reveal strong emphasis on PCSK9 inhibition mechanisms, cholesterol-immune crosstalk in rheumatoid arthritis, and fasting interventions in lipid-related pathologies. Her work has explored PCSK9's neuroinflammatory effects ABCA1/ABCG1 transporter dynamics Macrophage cholesterol loading Natural compound screening HDL dysfunction in diabetes Covid-19 lipid interactions .

• Molecular Genetics
• Plant Breeding
• Biotechnology
• +۷ مورد دیگر

Fredy Altpeter is a Professor of Molecular Genetics and Biotechnology at the University of Florida's Institute of Food and Agricultural Sciences (IFAS) within the Agronomy department. With over two decades of service at UF since joining as faculty in December 2001, he was promoted to Associate Professor in 2008 and to Full Professor in 2012. His appointment consists of 80% research dedicated to crop improvement and 20% teaching responsibilities. Dr. Altpeter's educational background includes a Dipl. Ing. Agr. degree (MS equivalent) in Crop Science from the University of Hohenheim in Germany (1990) and a PhD equivalent (Dr. sc. agr.) in Plant Breeding & Biotechnology from the same institution (1994). Prior to his faculty position, he completed postdoctoral research at UF (1994-1997) and served as Group Leader of a crop biotechnology team at the Plant Genome Resource Center of the IPK Gatersleben, Germany (1997-2001). His research integrates translational genomics, molecular physiology, and metabolic engineering for crop improvement, with a focus on precision genome editing, synthetic biology, and molecular dissection of regulatory networks. He specializes in transforming grasses and sugarcane using gene editing to enhance production of value-added products, particularly for biofuel applications. His work has pioneered targeted genome editing in sugarcane, including both targeted co-mutagenesis of more than 100 genes and precision nucleotide substitutions. Dr. Altpeter's publications reveal a strong focus on developing oil-producing sugarcane varieties, improving photosynthesis efficiency, and enhancing stress tolerance in bioenergy crops. His research has led to significant advancements in converting sugarcane into an oil-producing crop, a milestone that helped establish the Bioenergy Science Center funded with $115M by DOE. 2020 SIVB Distinguished Scientist Award University of Florida Research Foundation Professorship (2013, 2018) SIVB Fellow (2018) University of Florida-IFAS High Impact Publication award (2014) Dr. Altpeter has mentored more than 18 graduate students and supervised 25 postdoctoral research associates while at UF, in addition to training numerous undergraduates and visiting scientists. His students have won more than 40 awards, including several from SIVB. He has authored over 60 peer-reviewed journal articles in high-impact journals including Nature Biotechnology, Plant Cell, and Plant Biotechnology Journal, as well as 13 book chapters. He has been awarded two patents and filed four more in crop biotechnology. His laboratory focuses on re-designing photosynthesis, plant architecture, and stress response pathways to enhance productivity of commercially important grasses, while developing metabolic engineering approaches for high biomass crops like sugarcane or energycane to drive the emerging bioeconomy through next-generation biofuels and chemicals.

• Pulmonary Fibrosis
• Lung Aging
• Single-Cell Profiling
• +۳ مورد دیگر

Taylor Adams is a Researcher at the Yale School of Medicine's Internal Medicine Department, affiliated with the Kaminski Lab. Their work focuses on pulmonary fibrosis mechanisms, lung aging, and single-cell profiling, with a particular emphasis on epigenetic and immunological pathways. Adams collaborates closely with senior investigators like Naftali Kaminski, contributing to studies on fibrogenesis, drug development, and cellular dynamics in lung diseases. Research interests include understanding how epigenetic changes, microRNA regulation, and immune-cell interactions drive fibrotic processes. Recent work explores novel biomarkers for disease progression and non-invasive diagnostic methods. Adams' publications highlight advancements in spatial transcriptomics, somatic mutation analysis in aging lungs, and the role of GPR87 and CD103+ dendritic cells in fibrosis. Key contributions include identifying aberrant basaloid cells in IPF and developing computational tools like SDePER for deconvolving spatial transcriptomic data. Their lab's interdisciplinary approach integrates genomics, bioinformatics, and experimental models to translate findings into therapeutic strategies.

Denina Simmonsمشاهده پروفایل

دانشیار

• Aquatic Toxicology
• Bioinformatics
• Proteomics
• +۳ مورد دیگر

Denina Simmons is an Associate Professor and Canada Research Chair (Tier II) at Ontario Tech University's Faculty of Science, affiliated with the Applied Biosciences (Graduate) and Biology (Undergraduate) departments. Her research focuses on Aquatic Toxicology , particularly using proteomics and metabolomics to non-lethally monitor aquatic wildlife health. She holds a PhD in Environmental and Life Sciences from Trent University (2009), an MSc in Watershed Ecosystems (Trent University, 2005), and a BSc in Applied Chemical and Biological Sciences (Ryerson University, 2000). Her work bridges bioinformatics and ecotoxicology , addressing human impacts on aquatic ecosystems through omics technologies. Recent projects include studying pharmaceutical bioaccumulation in fish, pesticide effects on bats, and lithium's physiological disruption in trout. She has delivered over 20 invited lectures since 2013, including at the University of Toronto and Environment Canada. Key awards include NSERC Post-doctoral and Doctoral Fellowships. Her research has produced over 30 peer-reviewed articles, emphasizing interdisciplinary approaches to environmental health challenges. She teaches BIOL 4020: Introduction to Environmental Toxicology and BIOL 4030: Advanced Topics in Environmental Toxicology .

Scott Baileyمشاهده پروفایل

استاد

• CRISPR-Cas
• Structural Biology
• Protein-Nucleic Acid Interaction
• +۵ مورد دیگر

Scott Bailey, PhD, is a Professor in the Department of Biochemistry and Molecular Biology at Johns Hopkins University, with joint affiliations in the School of Medicine and the Bloomberg School of Public Health. His research focuses on the structural and mechanistic basis of CRISPR-Cas systems and protein-nucleic acid interactions. Education: BSc, University of Sheffield, 1998 PhD, University of Sheffield, 2002 Dr. Bailey’s research centers on understanding how molecular machines recognize and modify nucleic acids, with an emphasis on CRISPR-mediated immunity. Using X-ray crystallography, his lab determines high-resolution structures of CRISPR complexes at various functional stages to derive mechanistic models. These models are tested through mutagenesis and biochemical assays to link structure with function. His work has elucidated mechanisms of Cas9, Type III-B, and Type V systems, contributing significantly to the field of genome editing. Recent publications highlight advancements in Cas9 engineering, genome imaging techniques, and the structural basis of CRISPR targeting. His research has broad implications for biotechnology and therapeutic development. Trends across his articles show a sustained focus on CRISPR mechanisms, structural biology, and nucleic acid biochemistry, with increasing applications in proteomics and imaging. Scientific Awards: Johns Hopkins Presidents Frontier Award - Winner (February 2016) Johns Hopkins Presidents Frontier Award - Finalist (January 2015) Shikani/El Hibri Prize for Discovery and Innovation - JHSPH (February 2015) Ho-Ching Yang Memorial Faculty Award - JHSPH (May 2010) Dr. Bailey advises graduate students and postdoctoral researchers in the Molecular Biophysics and Biochemistry programs. His lab has been supported by competitive grants, including the Johns Hopkins Discovery Awards (2020). He teaches advanced courses in molecular biology and gene editing, contributing to both PhD and Master’s level training. The Bailey Lab is an active research group that integrates structural biology, biochemistry, and molecular genetics to dissect CRISPR mechanisms. The team includes PhD students, postdoctoral fellows, and research staff who collaborate on projects spanning structural determination, functional assays, and novel method development.

Mohamed Salemمشاهده پروفایل

دانشیار

• Aquaculture
• Genomics
• Muscle Biology
• +۵ مورد دیگر

Mohamed (Moh) Salem is an Associate Professor in the Department of Animal & Avian Sciences at the University of Maryland's College of Agriculture and Natural Resources. His research focuses on omics approaches to enhance muscle growth and aquaculture production, leveraging genomics, transcriptomics, and bioinformatics to address genetic and environmental influences on fish phenotypes. Education: Ph.D. in Genetics (West Virginia University, 2004); M.S. in Zoology (Zagazig University, Egypt, 1995). Research Interests: Omics-driven strategies for improving aquaculture efficiency, muscle biology in fish, and epigenetic regulation of genetic traits. Key projects include genome assembly of rainbow trout, molecular biomarkers for fillet quality, and microbiome impacts on growth and stress resilience. Professional Roles: Chair of USDA National Animal Genome Research Program (2017), Co-chair of NRSP-8 grant proposal (2017–2018), and Associate Editor for BMC Genomics and Marine Biotechnology Journal. Grants: Principal investigator on USDA/AFRI-funded projects targeting genomic selection, microbiome modulation, and rainbow trout genome annotation. Collaborates with USAID/NAS on next-generation aquaculture breeding methods. Labs/Teams: Leads a multidisciplinary team integrating functional genomics, bioinformatics, and aquaculture engineering to advance sustainable fish production systems.