جست‌وجوی استاد و پژوهشگر

Andrew Macdonaldمشاهده پروفایل

استاد

• Oncogenic viruses
• cell biology
• virology
• +۱ مورد دیگر

Professor Andrew Macdonald is a leading expert in tumour virology at the University of Leeds, holding the position of Professor of Tumour Virology in the School of Molecular and Cellular Biology and serving as Pro-Dean for Research and Innovation in the Faculty of Biological Sciences. His work focuses on understanding how DNA tumour viruses, such as human papillomaviruses (HPV) and polyomaviruses, contribute to cancer and identifying novel therapeutic strategies. He has held roles including Head of the School of Molecular and Cellular Biology (2020–2023) and has been recognized for his research on viral mechanisms and their clinical implications. Education: BSc, University of Leeds PhD in Molecular Biology, University of Leeds (2001) Research Interests: His research integrates virology, oncology, and cell biology to study viral replication, host-pathogen interactions, and antiviral therapies. Key areas include HPV-induced cervical cancer, BK polyomavirus in kidney disease, and the role of cellular signaling pathways in viral persistence. His lab emphasizes interdisciplinary collaboration with clinicians and industry to translate findings into clinical applications. Funding & Grants: Recent funding highlights include a boost for radiotherapy research in Leeds (2024) and studies on BK nephropathy in transplantation (2023). His work has been featured in outlets like the BBC and Yorkshire Post. Labs & Teams: He leads the Macdonald Lab, a well-funded group with state-of-the-art molecular and cellular facilities. The lab fosters a supportive environment for staff and students, emphasizing career development and publication.

Xuming Zhangمشاهده پروفایل

استاد

• Molecular Biology
• Virology
• Coronavirus Pathogenesis
• +۵ مورد دیگر

Xuming Zhang is a Professor in the Department of Microbiology and Immunology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. He holds a Ph.D. from Justus-Liebig University of Giessen, Germany, with postdoctoral training at Louisiana State University and the University of Southern California School of Medicine. His research focuses on understanding molecular mechanisms of coronavirus pathogenesis, particularly using murine coronavirus (MHV) as a model to study multiple sclerosis and neurodegenerative diseases. Key interests include viral RNA persistence in central nervous system (CNS) cells, viral-induced apoptosis in oligodendrocytes, and regulation of viral RNA synthesis through cellular signaling pathways such as MEK/ERK. His lab also explores antiviral drug discovery and development of viral vectors for vaccine applications. Recent work highlights studies on resveratrol's antiviral effects via sirtuins, identification of anti-coronavirus compounds, and analysis of coronavirus stability on food surfaces. His research bridges molecular virology, neuroimmunology, and host-pathogen interactions, with implications for developing therapies against viral CNS infections. Dr. Zhang's laboratory investigates cellular gene regulation during coronavirus infection, including over 200 differentially expressed genes identified via microarray analysis. Current efforts focus on mechanisms linking viral persistence to oligodendrocyte dysfunction and the role of transcription factors like Egr-1 in viral replication.

• Non-coding RNA research
• Computational Biology
• Genomics
• +۳ مورد دیگر

Sam Griffiths-Jones is a Professor of Computational Biology at the University of Manchester, affiliated with the Division of Evolution, Infection and Genomics within the Faculty of Life Sciences and Faculty of Biology, Medicine and Health. His research focuses on non-coding RNA (ncRNA) structure, function, and evolution, leveraging computational methods and databases such as Rfam and miRBase. He holds a PhD in Chemistry from the University of Nottingham (2000) and has held academic positions since 2007, including roles at the Wellcome Trust Sanger Institute. Research interests include ncRNA gene identification, microRNA regulation, and comparative genomics. Key contributions include curating miRBase and expanding Rfam to include viral and metagenomic families. His work bridges computational tools and biological insights, addressing questions about RNA diversity and evolutionary mechanisms. Education: BSc (Biochemistry) and PhD (Chemistry) from the University of Nottingham Labs/Teams: Leads a group focused on RNA computational biology and collaborates with global teams on Rfam/miRBase development Grants/Impacts: Impacts include tool development for microRNA research and pharmaceutical applications Teaching roles include Academic Admissions Officer for biosciences programs and courses in bioinformatics and genomics. Recent publications (2020-2025) highlight advancements in RNA sequencing, database resources, and functional studies in diverse organisms.

Alexander Hoffmannمشاهده پروفایل

استاد

• NFκB signaling
• IRF signaling
• Innate immunity
• +۶ مورد دیگر

Professor Alexander Hoffmann at the Department of Microbiology, Immunology & Molecular Genetics at University of California Los Angeles is a leading systems immunologist focusing on the dynamic regulation of immune signaling networks. His work integrates experimental approaches (biochemistry, molecular biology, live-cell imaging, next-gen sequencing) with computational modeling to decode how immune cells like macrophages and B-cells make stimulus-specific decisions. Education: BA in Physics from Cambridge University (1988), PhD in Biochemistry of TFIID from Rockefeller University (1994), Postdoc in HIV latency control at MIT (1998), and Postdoc in NFκB systems immunology at Caltech (2003). His research uncovers how NFκB and IRF signaling systems govern immune cell responses through temporal dynamics and network architecture. Current projects explore macrophage stimulus specificity , B-cell antibody response regulation , and hematopoietic aging mechanisms , supported by NIH grants as Principal Investigator. Recent publications focus on single-cell signaling fidelity , dynamic gene regulatory logic , and computational approaches to immune modeling . His 15 most recent articles (2024-2025) reveal a strong emphasis on signaling dynamics , immune training , and multi-scale modeling . Scientific Awards: UCLA Undergraduate Research Mentor Award (2023) Thomas M Asher Endowed Chair in Microbiology (2014–present) Hellman Fellow (2007–2008) Ellison Medical Foundation Scholar in Aging Research (2005–2009) Multiple graduate and postdoctoral fellowships He mentors through the Bruins in Genomics program and leads interdisciplinary research at the QCBio Institute , bridging biochemistry , mathematical modeling , and computational biology to understand immune decision-making.

Paul Marshallمشاهده پروفایل

پژوهشگر

• Neuroscience
• Epigenetics
• RNA Biology
• +۳ مورد دیگر

Dr. Paul Marshall is a Researcher at the Queensland Brain Institute, The University of Queensland, supported by an NSERC Scholarship. His work focuses on neuroepigenetic mechanisms underlying learning and memory, with expertise in RNA biology, DNA structure dynamics, and fear extinction processes. He completed his PhD in 2020 at the Queensland Brain Institute, exploring dynamic DNA structure states and their role in memory. His research integrates cutting-edge technologies to study noncoding RNAs, epigenetic modifications (e.g., m6A, Z-DNA), and their impact on synaptic plasticity and cognitive functions. Key contributions include identifying the role of DNA G-quadruplex in transcriptional control, the function of long noncoding RNAs in fear extinction, and mechanisms linking RNA editing (via ADAR1) to memory consolidation. His findings bridge molecular biology with behavioral neuroscience, advancing understanding of how genetic and epigenetic factors influence cognitive processes. Publications highlight collaborations with Timothy Bredy and others, emphasizing interdisciplinary approaches to unravel neural mechanisms. No awards are explicitly listed, but his work is recognized in high-impact journals like Nature Neuroscience and Cell Reports .

Sabrina Leslieمشاهده پروفایل

دانشیار

• Single-Molecule Biophysics
• Biomedical Imaging
• Nanotechnology
• +۳ مورد دیگر

Sabrina Leslie is an Associate Professor at the University of British Columbia (UBC) in the Michael Smith Laboratories and Department of Physics. Her research focuses on developing single-molecule microscopy tools to study biomolecular interactions in biologically relevant environments. She leads the Leslie Lab, which bridges physics, engineering, and biology to advance genetic medicines and vaccines. Education BSc (Honours Physics and Mathematics), University of British Columbia (2002) PhD in Optical and Atomic Physics, UC Berkeley (2008) Postdoctoral Fellowship, Harvard University (2009–2011) Research Interests Dr. Leslie pioneers the Convex Lens-induced Confinement (CLiC) imaging platform to visualize single molecules (DNA, RNA, proteins) and lipid nanoparticles in realistic cellular conditions. Her lab investigates nucleic acid dynamics, nanoparticle formulation for drug delivery, and single-cell analysis. Applications include improving mRNA vaccines and oligonucleotide therapeutics. Key Awards Member of Royal Society of Canada’s College of New Scholars (2020) NSERC Accelerator Award (2017–2020) Young Investigator Award, Canadian Biophysical Society (2019) Advising & Collaborations Her lab has trained over 50 students and postdocs. Collaborators include industry partners in biotechnology and nanotechnology. She co-founded ScopeSys to commercialize CLiC technology. Labs & Teams Based at UBC’s Michael Smith Laboratories, the Leslie Lab integrates interdisciplinary expertise. Ongoing projects include lipid nanoparticle characterization, single-molecule RNA studies, and CLiC-based diagnostics.

Nozomu Yachieمشاهده پروفایل

استاد

• Genome Editing
• Cell Engineering
• Synthetic Biology
• +۲ مورد دیگر

Professor Nozomu Yachie directs research at UBC's School of Biomedical Engineering, focusing on cellular/molecular engineering and computational biology. His lab develops DNA event-recording technologies to trace molecular dynamics using genome editing and high-performance computing. Key innovations include CloneSelect for retrospective cell isolation and computational tools like FRACTAL for large-scale lineage reconstruction.

Sabrina Leslieمشاهده پروفایل

دانشیار

• Single-molecule biophysics
• Biotechnology
• Fluorescence microscopy
• +۵ مورد دیگر

Sabrina Leslie is an Associate Professor at the University of British Columbia (UBC), affiliated with the Michael Smith Laboratories, the Department of Physics & Astronomy, and the School of Biomedical Engineering. Her research focuses on single-molecule biophysics and imaging technologies, particularly the CLiC platform, to advance genetic medicines and vaccine development. She holds a BSc from UBC and a PhD from UC Berkeley, with postdoctoral training at Harvard University. Dr. Leslie’s work bridges physics, biology, and engineering, with contributions to nucleic acid interactions, nanoparticle dynamics, and therapeutic oligonucleotides. She has received numerous awards, including the Killam Accelerator Fellowship and membership in the Royal Society of Canada. Her lab actively collaborates with industry and academia, emphasizing commercialization through her spin-off company, ScopeSys. Education: BSc (Physics & Mathematics, UBC, 2002), PhD (Optical & Atomic Physics, UC Berkeley, 2008) Affiliations: Michael Smith Laboratories, Department of Physics & Astronomy, School of Biomedical Engineering Research Themes: Single-molecule imaging, lipid nanoparticles, DNA dynamics, therapeutic delivery systems Awards: Killam Fellowship, Young Investigator Award, NSERC Accelerator Award Grants: CFI Innovation Fund, NSERC Accelerator Grant Her lab develops cutting-edge imaging tools like the CLiC platform to study biomolecules and nanomaterials in real-time, enabling advancements in diagnostics and therapeutics. Collaborations span academia and industry, with a focus on translating discoveries into clinical applications.

James W. Schneiderمشاهده پروفایل

استاد

• Biomaterials
• Medical Devices
• Bionanotechnology
• +۶ مورد دیگر

Dr. James W. Schneider is a Professor of Chemical Engineering and Courtesy Faculty in Biomedical Engineering at Carnegie Mellon University. He holds a B.S. in Chemical Engineering from the University of Wisconsin (1992) and a Ph.D. from the University of Minnesota (1998), followed by postdoctoral research at the Naval Research Laboratory. His research focuses on self-assembly principles in biomaterials, particularly amphiphilic molecules for applications in DNA/RNA detection, medical device development, and biomanufacturing process monitoring. Key contributions include micelle-based DNA electrophoresis and PNA amphiphile technologies for nucleic acid quantitation. Research interests span bionanotechnology, medical devices, and biomaterials with emphasis on programmable materials for diagnostic tools. Notable awards include the NSF CAREER Award (2001) and Beckman Young Investigator Award (2002), and he is a Fellow of the American Institute for Medical and Biological Engineering (2014). Current work includes collaborations with the Center for Nucleic Acids Science and Technology (CNAST) on PNA-based viral contaminant detection systems and surfactant studies in nonpolar liquids. His lab develops bioinspired materials for applications in biomanufacturing, drug delivery, and rapid diagnostic technologies.

Ana Casañalمشاهده پروفایل

پژوهشگر

• Structural Biology
• Molecular Biology
• Biochemistry
• +۴ مورد دیگر

Ana Casañal is a Group Leader at the Structural Biology Center of Human Technopole in Milan, Italy (since 2021). Previously, she was a postdoctoral researcher and EMBO Long Term Fellow at the MRC Laboratory of Molecular Biology in Cambridge, UK (2014-2020). Her research focuses on structural biology of mRNA processing machinery and plant biochemical pathways, utilizing cryo-EM and biochemical approaches. Education: PhD in Biotechnology, University of Málaga, Spain (2014), with highest honors. Thesis: "The Fra allergens and their role in the control of flavonoid biosynthesis in strawberry plants" . Supervisors: Prof. V. Valpuesta and Dr. J.A. Márquez. Master in Advanced Biotechnology, University of Málaga-International University of Andalusia (2010). Bachelor's Degree in Biochemistry, University of Málaga (2008). Research Interests: Combines structural biology with molecular genetics to study RNA processing complexes and plant metabolic regulators. Specializes in cryo-EM to visualize molecular machines involved in mRNA maturation and plant defense mechanisms. Explores transcription factor networks controlling secondary metabolites in strawberries. Recognition: Received the FEBS Anniversary Prize (2019) for exceptional contributions to biochemistry and molecular biology. Recipient of the Brenner Postdoc Prize (2018) for outstanding research at the MRC-LMB. Holds multiple fellowships including EMBO-Marie Curie and MRC awards. Teaching: Guest lecturer in Structural Biology for the Biotechnology Master's Program at the University of Málaga since 2012. Regularly teaches courses on cryo-EM, protein structure analysis, and model building. Labs/Teams: Leads the Casañal Group at Human Technopole, focusing on integrating structural and functional studies of RNA-processing complexes in plants and eukaryotes.

Ivan Marazziمشاهده پروفایل

دانشیار

• Epigenetics
• Transcriptional Regulation
• NF-kappaB Signaling
• +۲ مورد دیگر

Ivan Marazzi is Associate Professor of Biological Chemistry at UC Irvine School of Medicine, leading the Center for Epigenetics & Metabolism. Research explores transcriptional regulation dynamics, NF-kappaB signaling, and chromatin organization in inflammation and host-virus interactions. Recent investigations focus on circadian control of immunity, DNA damage responses, and therapeutic targeting of inflammatory pathways. The lab employs molecular biology and genomics approaches to study transcriptional mechanisms in viral infections, cancer, and immune disorders.

Richard Kimberمشاهده پروفایل

پژوهشگر ارشد

• Environmental Geochemistry
• Nanotechnology
• Bioremediation
• +۳ مورد دیگر

Richard Kimber is a Research Fellow at the University of Manchester, holding the Dr Dame Kathleen Ollerenshaw Fellowship in Earth and Environmental Sciences. Previously, he served as a Junior Group Leader at the University of Vienna (2020–2023). His research focuses on two core areas: 1) the environmental fate of nucleic acids, examining how geochemistry influences DNA/RNA stability in contexts like ancient DNA preservation and wastewater epidemiology; and 2) microbial valorisation of metals, developing sustainable methods to convert waste metals into catalytic nanomaterials. His work aligns with UN Sustainable Development Goals related to sustainable production and responsible consumption (SDG 12) and climate action (SDG 13). Kimber earned his PhD in 2013 from the University of Manchester, focusing on the biogeochemical behavior of plutonium and americium in contaminated soils under supervisors Prof. J. Lloyd and Prof. F. Livens. Research Themes: Environmental nucleic acid stability and preservation mechanisms Microbial synthesis of biogenic nanoparticles for industrial applications Metal biorecovery from waste streams using microbial processes Geochemical controls on ancient DNA recovery in sediments Recent Article Trends: Recent work emphasizes nanoparticle synthesis optimization (e.g., Pd and Cu nanoparticles), mercury isotope fractionation studies, and biomolecule-mineral interactions in both terrestrial and extraterrestrial contexts. Over 20 peer-reviewed articles highlight his contributions to environmental geochemistry and sustainable nanotechnology.

Akhil Vaidyaمشاهده پروفایل

استاد

• Molecular Parasitology
• Antimalarial Drug Development
• Mitochondrial Biology
• +۲ مورد دیگر

Akhil Vaidya, PhD, is a Professor in the Department of Microbiology & Immunology at Drexel University College of Medicine, where he also serves as Director of the Center for Molecular Parasitology. He obtained his PhD from the University of Bombay in 1972. His research focuses on understanding the molecular functioning of malaria parasites to develop new antimalarial drugs, with particular emphasis on mitochondrial biology and parasite metabolism. His laboratory investigates essential mitochondrial processes in Plasmodium parasites including electron transport chain function, ATP synthase assembly, and pyrimidine biosynthesis pathways. These studies have led to discoveries of novel drug targets and mechanisms of existing antimalarials like atovaquone/proguanil (Malarone). Dr. Vaidya collaborates internationally on drug discovery projects with Medicines for Malaria Venture, including development of pyrazoleamide compounds that disrupt parasite sodium homeostasis. Research publications demonstrate consistent focus on molecular parasitology, mitochondrial function in apicomplexans, antimalarial drug mechanisms, and parasite metabolism. Recent work explores mitochondrial ribosomal proteins, metabolic roles of endosymbiotic organelles, and transcriptional regulation in Plasmodium. Honors & Awards: Provost Award for Outstanding Scholarly Productivity - Career (2024) Award for Excellence in Basic Science Mentoring (2023) He leads a research team including staff scientists Joanne Morrisey, Michael Mather, and Sudipta Das, and advises graduate students April Pershing, Ming Yang, Lindsay Pomykala, and Suyash Bhatnagar. His work is supported by grants from the NIH and Medicines for Malaria Venture.

Qi Luمشاهده پروفایل

دانشیار

• Nanoparticle-Membrane Interactions
• Biomedical Applications of Nanoparticles
• EEG Analysis of Music Tuning Effects
• +۴ مورد دیگر

Dr. Qi Lu is an Associate Professor in the Department of Physics within the Division of Physics, Engineering, Mathematics, and Computer Science at Delaware State University. He holds a Ph.D. in Physics from Clemson University (2006), an M.S. in Physics from Clemson University (2002), and a B.S. in Applied Physics from Shanghai Jiao Tong University (1998). His research focuses on nanoparticle interactions with lipid membranes, optical imaging applications in biomedicine, and the effects of music tuning on brainwaves via EEG analysis. He has co-authored over 15 publications in peer-reviewed journals and contributed to multimodal deep learning and quantum confinement materials design projects. Dr. Lu's expertise spans imaging optics, machine learning, and grant writing. He has secured significant funding including a $431,935 DoD grant (2023-2025) as Co-PI for neuro-pain research and a $799,058 NSF grant (2021-2024) as Co-lead for soft matter and quantum design research. His work bridges nanotechnology with biological systems, particularly exploring how nanoparticles influence membrane structures and potential medical applications. Grants: DoD: Multimodal Deep-Learning for NeuroPain ($431,935, 2023-2025) NSF: SMaRT QD Materials Design ($799,058, 2021-2024) Labs/Teams: Collaborates with the Center of Excellence for Emerging Technologies and the Advanced Quantum Sensing Center at DSU.

Florian Krammerمشاهده پروفایل

استاد

• Vaccinology
• Influenza research
• Viral immunology
• +۳ مورد دیگر

Prof. Florian Krammer is a Professor of Vaccinology at the Department of Microbiology, Icahn School of Medicine at Mount Sinai. He serves as Principal Investigator of the Sinai-Emory Multi-Institutional Collaborative Influenza Vaccine Innovation Center (SEM-CIVIC) and his laboratory is part of the NIH-funded Centers for Excellence in Influenza Research and Surveillance (CEIRS). His work focuses on developing broadly protective vaccines against influenza and other emerging RNA viruses. University of Natural Resources and Life Sciences, Vienna (Advanced training in biotechnology and applied virology) Prof. Krammer's research centers on understanding broadly-reactive immune responses against surface glycoproteins of RNA viruses, with a primary focus on influenza viruses but also including coronaviruses, hantaviruses, and filoviruses. His laboratory investigates cross-reactive antibody responses toward viral surface glycoproteins with the goal of translating basic research into novel vaccines and therapeutics. A major focus has been the development of a universal influenza virus vaccine that would protect against a range of influenza virus subtypes by boosting antibodies to the highly conserved HA stalk domain. His work has progressed from successful animal model testing to human clinical trials. Prof. Krammer's extensive publication record includes over 100 papers, with recent research focusing on neuraminidase-based vaccines, chimeric hemagglutinin approaches, mucosal vaccine delivery, and cross-reactive antibody responses to emerging variants. His laboratory has generated a large panel of research reagents for influenza and other RNA viruses, including recombinant proteins and monoclonal antibodies. Endowed Professor of Vaccinology, Icahn School of Medicine at Mount Sinai (2019) Member of the Vaccine and Edward Jenner Vaccine Society Young Investigator Program (2014-2017) ESWI Young Scientist Travel Award and 'Young Scientist Co-Chair' (2014) Options for the Control of Influenza VIII Promising Investigator Scholarship (2013) As Principal Investigator of SEM-CIVIC, Prof. Krammer leads a major initiative aimed at developing improved seasonal and universal influenza virus vaccines that induce long-lasting protection against drifted seasonal, zoonotic, and future pandemic influenza viruses. His laboratory team includes numerous postdoctoral fellows, research scientists, and administrative staff working on various aspects of viral immunology and vaccine development. The Krammer laboratory collaborates with multiple institutions including BioBus, Inc. and the Wild Bird Fund, and participates in the New York City Virus Hunters program to engage the community in scientific research.