جست‌وجوی استاد و پژوهشگر

Zhishan Wangمشاهده پروفایل

استاد پژوهشی

• Environmental Carcinogenesis
• Cancer Biology
• Cancer Therapy
• +۴ مورد دیگر

Zhishan Wang, MD, PhD is a Research Professor in the Department of Pathology at Stony Brook University's Renaissance School of Medicine . His work focuses on environmental carcinogenesis , particularly mechanisms of cancer biology and cancer therapy , with a specialization in metal-induced carcinogenicity. Research Interests: Environmental Carcinogenesis Epigenetic and Epitranscriptomic Mechanisms Tumor Microenvironment Remodeling Metal Toxicity Pathobiology Non-Coding RNA Regulatory Networks Scientific Contributions: Analysis of 15 recent publications reveals expertise in: Metal-Induced Oncogenic Pathways (e.g., NF-κB activation, Hedgehog signaling) RNA Modification Dynamics (m6A, lncRNA-splicing interactions) Stem Cell Plasticity in Carcinogenesis Multi-Carcinogen Synergy Mechanisms Epigenetic-Genotoxic Interplay Transcriptomic Reprogramming by Toxicants

Silvi Rouskinمشاهده پروفایل

استادیار

• RNA structure
• Gene regulation
• Alternative splicing
• +۴ مورد دیگر

Dr. Silvi Rouskin serves as Assistant Professor in the Department of Microbiology at Harvard Medical School (Harvard University), where she leads groundbreaking research on RNA structural biology. Her work bridges computational biology, biochemistry, and single-molecule modeling to decode RNA's role in cellular processes and disease mechanisms. Her primary research focuses on RNA structure formation and its impact on gene regulation , alternative splicing , and viral pathogenesis . By pioneering tools like DMS-MaPseq and the DREEM algorithm, her lab detects multiple RNA conformations at single-nucleotide resolution in living cells. Current investigations target human, bacterial, and viral RNA structures to develop machine-learning prediction models for therapeutic applications in cancer and infectious diseases. Dr. Rouskin's publication record centers on RNA structural dynamics, exemplified by her 2020 HIV study revealing how alternative RNA configurations regulate viral gene activity. This work underpins her broader mission to build a comprehensive RNA structure database for accelerating drug target discovery. Her scientific accolades include: Pew Biomedical Scholar (2024) Vilcek Prize for Creative Promise in Biomedical Science (2021) Dr. Rouskin actively mentors the next generation of scientists, having guided at least one PhD candidate (Phil) to completion. Her lab currently supports undergraduate researchers including Tammy and Stuti (studying tau alternative splicing) and Sherry (investigating SMN1/SMN2 structures), reflecting her commitment to hands-on training in RNA biology. The Rouskin Lab operates at the Harvard Medical School campus (77 Avenue Louis Pasteur, NRB 930, Boston), combining wet-lab experimentation with computational innovation to advance structural RNA biology.

R. Glen Uhrigمشاهده پروفایل

دانشیار

• Plant Functional Genomics
• Quantitative Proteomics
• Post-Translational Modifications
• +۴ مورد دیگر

R. Glen Uhrig, PhD, is an Associate Professor of Plant Biology at the University of Alberta within the Department of Biological Sciences, Faculty of Science. His research focuses on plant functional genomics and proteomics, particularly examining diurnal regulation of cellular processes via quantitative proteomics in Arabidopsis thaliana and agriculturally relevant crops. The Uhrig Lab investigates post-translational modifications (PTMs) such as phosphorylation and acetylation to understand plant adaptation to environmental changes. Educationally, he holds a B.Sc.H. (2005) and M.Sc. (2008) from Queen’s University, followed by a Ph.D. from the University of Calgary (2013). His postdoctoral training at the Swiss Federal Institute of Technology (2017) furthered his expertise in plant systems biology. R. Glen Uhrig teaches courses including BIOL 343/543 (Macromolecular Characterization Techniques) and BOT 380 (Drug Plants), emphasizing hands-on proteomics and plant biotechnology. His awards include the ASTech Award (2022), NSERC Post-Doctoral Award (2015–2017), and the Marie Curie Plant Fellowship (2013–2015). His work bridges fundamental research with applications in agri-food production and crop resilience. Key research themes include: 1) Diurnal regulation of plant proteomes and PTMs, 2) Molecular mechanisms of plant immunity and stress responses, and 3) Leveraging proteomics to enhance crop productivity. The lab employs cutting-edge tools like quantitative mass spectrometry and multi-omics integration to address these questions.

Alisha Jonesمشاهده پروفایل

استادیار

• RNA Structural Dynamics
• Long Noncoding RNAs (lncRNAs)
• Protein-RNA Interactions
• +۴ مورد دیگر

Alisha Jones is an Assistant Professor of Chemistry at New York University, affiliated with the Department of Chemistry within the College of Arts & Science. She holds a Ph.D. in Chemistry from the University of Washington and dual Bachelor’s degrees in Chemistry and Zoology from Miami University of Ohio. Her research focuses on RNA structural dynamics, particularly the role of long noncoding RNAs (lncRNAs) in gene regulation and disease mechanisms. Dr. Jones employs a combination of biochemical, biophysical, and computational approaches to study RNA structure and function, including chemical probing, molecular dynamics simulations, and machine learning. Her group investigates how structural conformations of lncRNAs influence their biological roles, such as regulating gene expression through conformational changes. They also explore therapeutic strategies to target these RNA structures in diseases like cancer and viral infections. Notable projects include studying the Xist lncRNA’s A-repeats, SARS-CoV-2 methylation complexes, and the functional core of the lncRNA Cyrano. Publications highlight her work on RNA structure probing techniques, cooperativity effects in chemical experiments, and the interplay between RNA dynamics and biological function. Her lab, the Jonesy Research Group, emphasizes interdisciplinary approaches and hosts outreach initiatives to promote RNA science. Dr. Jones is based at NYU’s Silver Center, and her contact information includes aj3863@nyu.edu.

• RNA Biology
• Genomics
• Transcriptomics
• +۵ مورد دیگر

Dr. Athma A Pai is an Associate Professor at UMass Chan Medical School, holding primary appointments in the RNA Therapeutics Institute and the T.H. Chan School of Medicine. She maintains extensive secondary appointments across multiple departments including Genomics and Computational Biology, Systems Biology, and several graduate programs at the Morningside Graduate School of Biomedical Sciences, reflecting the highly interdisciplinary nature of her work. Education: BS in Biochemistry/Anthropology from University of Pennsylvania PhD in Human Genetics from University of Chicago Postdoctoral training in RNA Genomics from MIT Dr. Pai's research program centers on RNA biology with particular emphasis on RNA processing, splicing mechanisms, and the regulation of gene expression. Her work investigates how environmental factors influence RNA processing through biochemical, molecular, and genetic mechanisms. She employs cutting-edge genomic and transcriptomic approaches to study alternative polyadenylation, mRNA transcript initiation and termination, and the spatial organization of RNA processing events within cells. Her research has significant implications for understanding fundamental gene regulation mechanisms and their roles in disease processes. Analysis of Dr. Pai's recent publications reveals a strong focus on developing high-resolution profiling methods for understanding transcriptional and translational regulation. Her work increasingly integrates computational approaches with experimental biology to investigate how RNA processing events are coordinated across the transcriptome. A notable trend is her exploration of how RNA processing contributes to inflammatory responses and cellular defense mechanisms, with implications for therapeutic development. Dr. Pai actively mentors students through multiple graduate programs at UMass Chan Medical School, including Biochemistry and Molecular Biotechnology, Biophysical Chemical and Computational Biology, Interdisciplinary Graduate Program, MD/PhD Program, RNA Therapeutics and Biology Program, and Systems Computational and Quantitative Biology. She maintains an active laboratory (Pai Lab) that welcomes postdoctoral researchers interested in RNA biology. Her laboratory website provides additional information about ongoing research projects and opportunities for collaboration and training, and she maintains a professional presence through her Twitter account (@athmapai).

Huazhong Shiمشاهده پروفایل

استاد

• Biochemistry
• Molecular Biology
• Gene Editing
• +۳ مورد دیگر

Dr. Huazhong Shi is a Professor in the Department of Chemistry and Biochemistry at Texas Tech University. His research focuses on molecular biology, biochemistry, and plant stress response mechanisms, with a particular emphasis on gene editing for crop improvement, herbicide resistance development, and computational simulations of protein-small molecule interactions. Ph.D., Wuhan University, China, 1995 Research Associate, University of Arizona, 1999-2001 Research Associate, University of California, 2001-2003 Research Associate, Purdue University, 2003-2004 Dr. Shi’s research explores gene editing strategies to enhance crop traits such as clonal seed production, haploid induction, and herbicide resistance. His lab also investigates molecular dynamics simulations to understand enzyme-herbicide interactions and stress-inducible gene regulation. Key projects include engineering salt-tolerant crops via Na+/H+ antiporter optimization and elucidating the roles of SHI genes in stress response pathways. The 15 most recent publications highlight advancements in gene editing for hybrid vigor preservation, directed evolution of herbicide-resistant enzymes, and computational modeling of stress tolerance mechanisms. These works span disciplines including plant biotechnology, environmental toxicology, and agricultural sustainability, with subfields such as RNA splicing, redox biology, and nutrient-stress interactions. Dr. Shi’s lab includes graduate students Yihui Yuan, Hongjia Qian, Amna Aqdas, Karthik Kalvakuntla, and Shoumik Kundu, alongside research associate Dr. Jianfei Guo. His work contributes to global food security through biotechnological innovations in crop resilience to environmental stresses.

Debra Lynn Silverمشاهده پروفایل

استاد

• Developmental Neurobiology
• RNA Biology
• Cortical Evolution
• +۶ مورد دیگر

Debra Lynn Silver is a Professor at Duke University in the Departments of Molecular Genetics and Microbiology, Cell Biology, and Neurobiology. She is affiliated with the Duke Regeneration Center, Duke Initiative for Science & Society, Duke Cancer Institute, and Duke Institute for Brain Sciences. Education: Ph.D., Johns Hopkins University (2003) Postdoctoral Fellowship, National Institutes of Health (2003-2010) B.S., Tufts University (1993) Her research focuses on developmental neurobiology , RNA biology , and human cortical evolution , exploring genetic mechanisms in neurodevelopmental disorders and brain evolution. Recent studies investigate DDX3X mutations in autism, EIF4A3 in neurogenesis, and human-specific enhancers regulating cortical development. Publications highlight her work on mRNA stability, RNA-binding proteins, and species-specific neurodevelopmental features. Grants include NIH funding for DDX3X pathology and cortical RNA localization studies (2018-present).

Li Songمشاهده پروفایل

استادیار

• Computational Immunology
• Bioinformatics
• Genomics
• +۳ مورد دیگر

Li Song is an Assistant Professor at the Department of Biomedical Data Science within the Geisel School of Medicine at Dartmouth College . He earned his Ph.D. in Computer Science (2018) and a Master's in Applied Mathematics and Statistics from Johns Hopkins University , advised by Liliana Florea. He completed postdoctoral training in the labs of X. Shirley Liu and Heng Li at the Data Science Department of Dana-Farber Cancer Institute . Education Ph.D. in Computer Science (Johns Hopkins University, 2018) M.S. in Applied Mathematics and Statistics (Johns Hopkins University) Research Focus : Designing algorithms for next-generation sequencing data analysis in immunology and microbiology. Key projects include: TRUST4 - De novo assembly of T-cell/B-cell receptors from RNA-seq T1K - Genotyping of polymorphic HLA/KIR genes Centrifuger - Compressed microbial genome classification Chromap - Ultrafast chromatin profiling data processing Recent Publications demonstrate expertise in computational immunogenetics, metagenomic analysis, and chromatin profiling workflows. The 2024 Genome Biology paper on Centrifuger received a Best Paper Award at RECOMB2024 . Training & Recruitment : The Song Lab actively seeks postdocs and graduate students through the Quantitative Biomedical Sciences program and Department of Computer Science at Dartmouth.

Bei Beiمشاهده پروفایل

دانشیار

• Sleep Disorders
• Circadian Rhythm
• Clinical Psychology
• +۵ مورد دیگر

Dr. Bei Bei is an Associate Professor at the School of Psychological Sciences, Monash University, and an NHMRC Emerging Leadership (EL2) Fellow. She leads the Behavioural Sleep Medicine service, research, and training at Monash University Healthy Sleep Clinic, focusing on individual differences in sleep-wake behaviors, sleep-mental health relationships, and community dissemination of evidence-based sleep interventions. Doctor of Psychology (Clinical), University of Melbourne PhD, University of Melbourne Her research spans six major areas: Sleep-wake circadian rhythm disorders Cognitive Behavioral Therapy for Insomnia (CBT-I) Psychological/behavioral aspects of sleep Sleep-mental health interactions (mood, anxiety) Adolescent sleep patterns and wellbeing Perinatal/postpartum sleep interventions for women Recent publications (2024-2025) address: Insomnia treatment mechanisms in depression comorbidity Neurodevelopmental impacts of circadian factors Pregnancy-related insomnia risk identification Adolescent sleep facilitators/barriers Integrated models for youth depression and sleep across continents She also contributes to: Antifungal drug tolerance mechanisms RNA polyadenylation dynamics Mitochondrial RNA stability in cancer 3' UTR splice variants in rare diseases Awarded the NHMRC Emerging Leadership (EL2) Fellowship and Early Career Research Grant , Dr. Bei serves on editorial boards for Sleep Medicine Reviews, Sleep, and Behavioral Sleep Medicine journals.

Pabitra Sahooمشاهده پروفایل

استادیار

• Molecular & Cellular Neuroscience
• Localized Protein Synthesis
• Stress Granules
• +۸ مورد دیگر

Pabitra Sahoo is an Assistant Professor in the Department of Biological Sciences at Rutgers University, leading a research group focused on axonal mRNA dynamics and stress granule biology. His work bridges molecular neuroscience and regenerative medicine with direct implications for neural repair mechanisms. His educational background includes: B.S. from Utkal University, India (2005) M.S. from University of Hyderabad, India (2007) Ph.D. from National Centre for Cell Science, University of Pune (2013) Postdoctoral fellowship at Twiss Lab, University of South Carolina (2023) Dr. Sahoo's research centers on stress granules in axons and their dual role in physiological mRNA storage and pathological inhibition of nerve regeneration. His lab investigates how localized protein synthesis mechanisms govern neural repair, neurodevelopment, and neurodegenerative processes through cutting-edge approaches in spatial transcriptomics and axonal biology. Key discoveries include the identification of G3BP1 as a critical regulator of axonal mRNA translation and the demonstration that stress granules exist under normal physiological conditions in neurons. Analysis of his 2021-2025 publications reveals a dominant focus on stress granule disassembly mechanisms (particularly involving G3BP1), RNA-binding protein functions in axonal mRNA stability, and therapeutic targeting of these pathways for nerve regeneration. His work consistently connects fundamental molecular mechanisms to applications in spinal cord injury, peripheral nerve repair, and neurodegenerative conditions like ALS. The Sahoo Lab operates as a collaborative team of "curiosity driven, fun, and coffee loving scientists" investigating how mRNA storage granules respond to neuronal signals. Current projects specifically examine stress granule dynamics in neuronal development models and their dysfunction in neurodevelopmental disorders (e.g., Down syndrome) and neurodegenerative diseases, with therapeutic strategies emerging from multiple patent filings.

Zhipeng Luمشاهده پروفایل

دانشیار

• RNA biology
• RNA structures
• RNA machines
• +۷ مورد دیگر

Zhipeng Lu is currently an Associate Professor of Pharmacology and Pharmaceutical Sciences at the University of Southern California (USC) School of Pharmacy. His research focuses on understanding RNA molecules and their structural complexity as a second layer of genetic instructions beyond protein encoding. He directs the Lu Lab at USC, which develops and applies novel technologies to investigate RNA structures, interactions, chemical modifications, and functions in cellular processes and animal development. Dr. Lu's research interests center on "RNA machines" in living cells, with particular emphasis on how RNA molecules fold into structures and form intermolecular interactions to execute genetic instructions. His work spans multiple dimensions of RNA biology, including RNA structure-function relationships, RNA-protein interactions, RNA modifications, and the role of RNA in human diseases such as genetic disorders and viral infections. The lab combines computational, chemical, and biological approaches to elucidate fundamental mechanisms of RNA machines, with the ultimate goal of developing new understanding and therapies targeting human diseases. Analysis of Dr. Lu's publication history reveals a strong trajectory in RNA structure and interaction mapping technologies. His work has evolved from foundational studies on RNA processing and modification to developing innovative high-throughput methods like PARIS and RISE for analyzing RNA interactomes. Recent publications focus on specific RNA systems like XIST and snoRNAs, demonstrating how his lab has moved from method development to applying these tools to solve longstanding biological questions in epigenetics and RNA therapeutics. Dr. Lu has received numerous prestigious awards recognizing his contributions to RNA research: NHGRI K99/R00 NIH Pathway to Independence Award (2017-2022) RNA Society Scaringe Award (2017) Stanford University Jump Start Award for Excellence in Research (2016-2017) Damon Runyon-Sohn Fellowship (2015-2017) His research is supported by multiple funding sources from organizations including the National Institutes of Health and other foundations. The Lu Lab is actively recruiting PhD students and postdoctoral researchers to work on several cutting-edge directions including RNA structures, interaction networks, RNA modification mechanisms, and their roles in development and disease. The lab integrates biological, chemical, and computational approaches to advance RNA biology and push forward RNA medicine. The Lu Lab at USC is a dynamic research environment focused on "RNA machines" with recent highlights including solving aspects of the orphan snoRNA problem and discovering snoRNAs that control eMet tRNA activity. The lab's vision emphasizes creative exploration of RNA biology, with researchers encouraged to pursue innovative ideas much like "wild animals running in the African savannah." Current research directions include analysis of RNA structures, interaction networks, RNA modification mechanisms, and their roles in development and disease, with applications to genetic disorders, cancers, and viral infections.

Mansoureh Eghbaliمشاهده پروفایل

استاد

• Pulmonary Hypertension
• Myocardial Ischemia-Reperfusion Injury
• Sex Differences in Cardiovascular Disease
• +۳ مورد دیگر

Mansoureh Eghbali, PhD, is a Professor in the Department of Anesthesiology at the David Geffen School of Medicine, University of California, Los Angeles. Her research program investigates molecular mechanisms of cardiovascular and pulmonary diseases with emphasis on sex-specific pathophysiology. She leads an active NIH-funded laboratory focused on pulmonary hypertension, myocardial ischemia-reperfusion injury, and the role of RNA-binding proteins in vascular remodeling. Her research integrates multiomics approaches to explore: Sex chromosome influences (Y-gene Uty) in pulmonary vascular protection MicroRNA regulation of cardiac fibrosis and calcification (e.g., miR-129-5p/Asporin axis) Gut-heart-lung interactions in diet-induced pulmonary hypertension Endothelial subpopulations (TM4SF1+) in disease progression Analysis of her recent publications reveals strong emphasis on: Integrative multiomics in vascular diseases Sex differences in drug responses Novel therapeutic targeting of RNA-binding proteins Cross-organ communication in cardiopulmonary pathologies She directs multiple NIH grants including: R01HL159865: Role of Chromosome Y gene, Uty (2021-2025) R01HL147586: Role of miR125 in pulmonary hypertension (2019-2023) R01HL129051: Role of miR193 in oxidized lipid-induced PH (2016-2021) R01HL131182: Epigenetic regulation by X chromosome (2016-2021)

Lu Chengمشاهده پروفایل

استاد مهمان

• Genomics
• Bioinformatics
• Microbial Genetics
• +۳ مورد دیگر

Lu Cheng is a Visiting Professor in the Department of Computer Science at the University of Helsinki, affiliated with the Vehtari Aki Professorship. He holds a Doctor of Philosophy in Natural Sciences from the University of Helsinki (2013). His research focuses on computational genomics, bioinformatics, and microbial genetics, with emphasis on DNA sequence analysis, nanopore sequencing technologies, and systems biology. He leads projects on alternative splicing in cancer and the impact of microbiota on human health. Notable contributions include the NanoBaseLib benchmark dataset and methods for RNA modification analysis. His work addresses UN Sustainable Development Goals related to good health and innovations in data science. Education: Doctor of Philosophy in Natural Sciences (2013), University of Helsinki; Doctoral degree in Natural Sciences (2013), University of Helsinki. Research Interests: Genomics, computational biology, microbial ecology, RNA sequencing technologies, and bioinformatics tool development. His projects explore bacterial population dynamics, host-pathogen interactions, and applications of machine learning in genomics. Advising: Supervises doctoral researchers including Guangzhao Cheng and Chengbo Fu. Active in grants such as the Academy of Finland Research Fellowship (2023-2025). Labs/Teams: Leads research groups focused on single-cell genomics and computational methods for biological systems.

Michael Sattlerمشاهده پروفایل

استاد

• Biomolecular NMR Spectroscopy
• Structural Biology
• RNA Regulation
• +۷ مورد دیگر

Prof. Dr. Michael Sattler is a Full Professor of Biomolecular NMR at the Technical University of Munich (TUM) and Director of the Institute of Structural Biology at Helmholtz Zentrum München. He leads the Molecular Targets & Therapeutics Center and directs the Bavarian NMR Center. His research focuses on integrative structural biology, elucidating molecular mechanisms of biological pathways through advanced NMR techniques combined with cryo-EM, SAXS, and crystallography. Key areas include RNA regulation (alternative splicing, non-coding RNAs), disease mechanisms (e.g., spinal muscular atrophy), and structure-based drug discovery for cancer and infectious diseases. Education & Career PhD in Chemistry (1995) from Goethe University Frankfurt Postdoc at Abbott Laboratories (Chicago) and EMBL Heidelberg (Group Leader, 1997–2007) Full Professor at TUM since 2007 Director roles at Helmholtz Munich and Bavarian NMR Center since 2007 Research Highlights Prof. Sattler's work has revealed structural insights into RNA:protein interactions (e.g., SF1-RNA, U2AF), SMN Tudor domain recognition, and drug discovery strategies targeting Hsp90 and viral proteases. His lab pioneered integrative structural biology approaches and established high-end NMR facilities like the 1.2 GHz spectrometer. Awards & Recognition ERC Synergy Grant (2023) Leopoldina Membership (2017) EMBO Membership (2012) Erwin Schrödinger Prize (2020) Teaching & Leadership He teaches advanced courses in NMR spectroscopy, biochemistry, and structural biology at TUM. Leads EU Horizon-funded training networks (AEGIS, RNAct) and organizes international conferences on NMR and drug discovery.

Rachel O'Neillمشاهده پروفایل

استاد

• Genome Stability
• Retroelement Transcription
• Centromere Function
• +۵ مورد دیگر

Rachel O'Neill serves as a Board of Trustees Distinguished Professor in the Department of Molecular and Cell Biology at the University of Connecticut's College of Liberal Arts and Sciences. Her research bridges molecular genetics, cytogenetics, and computational genomics to investigate fundamental mechanisms of genome stability and evolution across diverse eukaryotic species. Her primary research interests focus on retroelement transcription, centromere function, chromosome evolution, and species-specific genomic adaptations. O'Neill's lab pioneers telomere-to-telomere (T2T) genome assembly methodologies using next-generation sequencing technologies, establishing non-traditional model organisms including marsupials, monotremes, birds, marine species, plants, and insects for comparative genome biology studies. Human Telomere-to-Telomere Consortium Primate T2T Consortium Gibbon T2T Consortium Earth Biogenomes Project Ruminant T2T Consortium Fly T2T Consortium Deep Ocean Genomes Project Antarctic Genomes Consortium Colossal Foundation UConn’s Biodiversity and Conservation Genomics program O'Neill's recent publications (2021-2025) demonstrate leadership in large-scale genomics initiatives, with significant contributions to understanding centromere biology, sex chromosome evolution, and conservation genomics. Her work spans marsupial mole genomics, ruminant chromosome evolution, and epigenetic regulation of X-chromosome inactivation, reflecting her lab's broad impact across evolutionary biology, conservation, and fundamental genome science. Her laboratory actively trains students through cohort-based programs including the RaMP Cohort and Biodiversity and Conservation Genomics Program, securing substantial collaborative funding through multi-institutional consortia. The lab maintains strong infrastructure for advanced genome assembly and epigenomic analysis, with particular expertise in challenging repetitive regions and non-model organism genomics.