جست‌وجوی استاد و پژوهشگر

• Glycobiology
• Chemical Biology
• Glycosylation
• +۵ مورد دیگر

Jennifer Kohler is an Associate Professor in the Department of Biochemistry at UT Southwestern Medical Center. She leads the Kohler Lab, which focuses on developing chemical biology tools to study glycosylation in biological systems. Her research has significant implications for understanding fundamental biology, cancer metastasis, and infectious diseases. Dr. Kohler completed her undergraduate degree in Chemistry at Bryn Mawr College. She earned her Ph.D. in the Chemistry Department at Yale University, where she studied the kinetics of protein-DNA interactions under Prof. Alanna Schepartz. From 2000-2004, she was an American Cancer Society postdoctoral fellow with Prof. Carolyn Bertozzi at the University of California, Berkeley. Dr. Kohler's research focuses on understanding the roles of glycoconjugates in biological systems. Her lab develops innovative chemical biology methods to address challenges in glycoscience, particularly through the creation of photocrosslinking sugar analogs that can be metabolically incorporated into cellular glycoconjugates. These tools enable the identification of transient glycan-mediated interactions that would otherwise be difficult to capture. Her work spans multiple areas including: Development of photocrosslinking reagents for sialic acid and GlcNAc Investigation of glycan-mediated host-pathogen interactions, particularly with cholera toxin Exploration of O-GlcNAc's role in nuclear transport Creation of methods to discover glycoprotein substrates of sialidases Understanding glycosylation in intestinal epithelial tissue Analysis of Dr. Kohler's recent publications (2021-2024) reveals a consistent focus on glycobiology with particular emphasis on sialic acid and O-GlcNAc modifications. Her work bridges chemical biology and disease mechanisms, with applications in infectious disease (particularly cholera), metabolism, and cancer. She frequently collaborates with other researchers worldwide and shares her innovative photocrosslinking reagents with the scientific community. Dr. Kohler was an American Cancer Society postdoctoral fellow during her time at UC Berkeley. While specific awards aren't detailed in the provided text, her sustained research program and numerous high-impact publications suggest recognition within her field. Dr. Kohler advises graduate students in the Biochemistry and Cell Regulation programs at UT Southwestern. Her research is supported by grants that enable her lab to develop and implement new tools for studying glycosylated molecules, with applications spanning fundamental biology, cancer metastasis, and infectious disease. She has mentored numerous students and postdoctoral fellows who have contributed to her extensive publication record. The Kohler Lab is dedicated to advancing glycoscience through innovative chemical biology approaches. The lab actively develops and shares photocrosslinking sugar analogs that have been adopted by research groups worldwide. Current research focuses on understanding glycosylation in intestinal epithelial tissue and its implications for host-pathogen interactions. The lab maintains strong collaborations with other research groups both within UT Southwestern and internationally.

• RNA Editing
• Alternative Splicing
• Transcriptomics
• +۷ مورد دیگر

Xinshu Xiao is a Professor in the Department of Integrative Biology and Physiology at the University of California Los Angeles, within the College of Letters and Science. She leads an active research laboratory focused on RNA biology and computational genomics, with significant contributions to understanding RNA editing, alternative splicing, and their roles in neurological disorders and cancer. Dr. Xiao earned her PhD in Health Sciences and Technology from the Massachusetts Institute of Technology in 2004. Her research career has been marked by continuous NIH funding and innovative methodological developments in transcriptome analysis. Her primary research interests center on RNA editing mechanisms, particularly A-to-I editing, and their implications in neurological disorders like schizophrenia and Alzheimer's disease, as well as cancer. She has developed several important computational tools for RNA analysis, including RASER, L-GIREMI, and dsRID. Her work bridges computational biology with molecular mechanisms, employing long-read RNA sequencing technologies to uncover novel aspects of RNA processing. Analysis of her recent publications reveals a strong focus on the intersection of RNA biology with neurological disorders, particularly schizophrenia and Alzheimer's disease, alongside significant work in cancer genomics. Her research increasingly incorporates long-read sequencing technologies to resolve complex aspects of RNA processing that were previously inaccessible with short-read approaches. Dr. Xiao currently serves as Principal Investigator on multiple NIH grants, including R01AG078950, R01CA262686, R01AG075206, and R01MH123177, demonstrating sustained funding success across multiple research domains. Her laboratory, the Xiao Lab, maintains active collaborations across multiple disciplines and institutions, as evidenced by her extensive publication record with diverse co-authors spanning computational biology, neuroscience, and cancer research fields.

• Genomics
• Transcriptomics
• Bioinformatics
• +۶ مورد دیگر

Mingming Lu is a Research Fellow in the Department of Neurology at Yale University's Yale School of Medicine. Their work focuses on genomic and transcriptomic research, with a particular emphasis on bioinformatics, disease associations, and aging biology. Current research includes developing databases for genomic analysis and exploring epigenetic mechanisms in health and disease. Research interests span endogenous retroviruses, transcriptome-wide association studies (TWAS), and the role of m6A RNA modifications in aging. Lu has contributed to initiatives like the HervD Atlas and TWAS Atlas, which aim to curate genomic data for disease research. Their work also involves cancer genomics, including tumor variant identification and single-cell expression mapping in cancer. No scientific awards are listed. Advising no formal trainees is recorded, though their research collaborations may involve team-based projects. Lu is affiliated with the National Genomics Data Center in China and contributes to genomic database development, reflecting their role in bridging computational methods with biological discovery.

Brian D. Robinsonمشاهده پروفایل

استاد

• Genitourinary Pathology
• Molecular Pathogenesis of Prostate Cancer
• Precision Oncology
• +۷ مورد دیگر

Brian D. Robinson, M.D., is a Professor of Pathology and Laboratory Medicine and Professor of Pathology in Urology at Weill Cornell Medical College . As a board-certified anatomic pathologist with subspecialty expertise in Genitourinary Pathology , his work bridges clinical diagnostics, molecular mechanisms, and precision oncology in prostate, bladder, and kidney cancers. Education: M.D., Weill Cornell Medical College (2006) B.A., Washington University in St. Louis (2002) His research focuses on: Androgen receptor signaling and its role in prostate carcinogenesis SPOP mutations as drivers of prostate tumorigenesis Single-cell genomics to study tumor heterogeneity Digital pathology for biomarker development Epigenetic mechanisms in advanced prostate cancer Recent publications highlight computational pathology approaches, tumor microenvironment dynamics, and molecular diagnostics for urothelial and prostate cancers. He serves on expert panels for prostate and bladder cancer classification and co-authored Archives of Pathology & Laboratory Medicine guidelines. Honors include the Paul Peter Rosen Clinical Service Award (2020) and multiple teaching awards. He directs Anatomic Pathology for his department and contributes to medical education at Weill Cornell.

Michael Jenningsمشاهده پروفایل

استاد

• Membrane Biology
• Ion Transport
• Red Blood Cell Physiology
• +۳ مورد دیگر

Michael Jennings is a Professor in the Department of Physiology and Cell Biology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. After stepping down as Department Chair in July 2020, he continues as a part-time faculty member focusing on teaching, curriculum development, and educational administration while collaborating on research projects. His educational background is highlighted by a Ph.D. from Harvard University. Ph.D., Harvard University Dr. Jennings' research centers on membrane transport proteins, particularly anion exchangers (Band 3/AE1) and cation-chloride cotransporters, with emphasis on molecular mechanisms and human disease connections. His work spans from fundamental biophysics of transport to disease implications including diastrophic dysplasia, corneal clouding, and bone metabolism disorders. Recent investigations have expanded into iron transport pathways and their physiological consequences. Analysis of his 2015-2025 publications reveals a dominant focus on ion transport kinetics, with increasing attention to disease pathophysiology. Key themes include molecular characterization of anion exchange mechanisms, regulatory pathways of cotransporters, and physiological impacts of transporter dysfunction in conditions like osteoporosis and corneal edema, demonstrating consistent evolution from basic science to translational applications. His research program has been continuously supported by NIH funding, including a 30-year R01 grant (GM026861) on AE1, a 10-year R01 (HL037479) on K+/Cl- cotransport, and an R21 grant on SLC4A11. Dr. Jennings leads the Jennings Lab, which has produced seminal contributions to membrane transport physiology through innovative experimental approaches and collaborative investigations into transporter-disease relationships.

Vahe Bandarianمشاهده پروفایل

استاد

• Natural Product Biosynthesis
• Radical SAM Enzymology
• RNA Modification
• +۳ مورد دیگر

Vahe Bandarian is a Professor in the Department of Chemistry at the University of Utah, where he has been since 2015. He previously served as Associate Chair for Undergraduate Studies (2019-2021) and is currently Associate Dean for Student Affairs in the College of Science. His research focuses on radical SAM enzymes and their roles in natural product biosynthesis and RNA modification. B.S., California State University-Los Angeles (1992) Ph.D., University of Wisconsin-Madison (1998) NIH Postdoctoral Fellow, University of Michigan (2003-2009) Assistant/Associate Professor, University of Arizona (2009-2015) His work explores enzymatic transformations in bacterial gene clusters, particularly radical-mediated reactions in peptide-based natural products and tRNA hypermodification . By combining structural biology and biochemical assays, his lab uncovers novel mechanisms for drug discovery applications. Recent publications highlight his expertise in radical SAM chemistry, including studies on binuclear copper states , intermolecular electron transfer , and predictable peptide crosslinking . His funding includes continuous NIH support since 2015. Fellow, American Chemical Society (2023) Fellow, AAAS (2023) Fellow, ASBMB (2022) Distinguished Research Award, University of Utah (2021) Bandarian has served on multiple NIH review panels and editorial boards, including the Journal of Biological Chemistry (2013-2023). His leadership roles in academic service include co-chairing Gordon Conferences and mentoring junior faculty through ASBMB workshops.

Bin Z. HEمشاهده پروفایل

دانشیار

• Evolution of Stress Responses
• Gene Regulatory Networks
• Fungal Pathogenesis
• +۵ مورد دیگر

Dr. Bin Z. HE is an Associate Professor in the Department of Biology at the University of Iowa, College of Liberal Arts and Sciences. His research focuses on the evolution of gene regulatory networks in stress response mechanisms, particularly in pathogenic yeast species like Candida glabrata and Candida auris . Using interdisciplinary approaches combining genomics, bioinformatics, and molecular evolution, he investigates how transcription factors and their regulatory networks adapt to environmental changes, with implications for understanding microbial pathogenicity and host-microbe interactions. His work addresses fundamental questions about regulatory network divergence, protein sequence evolution, and adaptive selection signatures in both coding and non-coding regions. Key methodologies include RNA-seq, ChIP-seq, phylogenetic analysis, and functional assays. While no specific student advisorship details appear in the text, his lab actively explores stress response evolution through collaborative research platforms and open science initiatives. The research has significant biomedical relevance, offering insights into fungal infection mechanisms and potential therapeutic strategies. His recent publications highlight evolutionary patterns in transcription factor interactions, adhesin family expansions, and stress response network rewiring across yeast pathogens. Publications span topics from molecular mechanisms in TORC1 signaling to computational resources for primate gene evolution analysis.

Magnar Bjøråsمشاهده پروفایل

پژوهشگر

• DNA Repair Mechanisms
• Epitranscriptomics
• Gene Expression Regulation
• +۳ مورد دیگر

Magnar Bjørås is a Researcher at the Department of Microbiology , University of Oslo. His work spans interdisciplinary research at the intersection of molecular biology, DNA repair, and microbiology, with a particular focus on bacterial pathogenesis and host-virus interactions. Key research themes: DNA repair enzymes, epitranscriptomic modifications, and gene expression dynamics Active collaborations with teams across Norway and international institutions Developed novel methodologies for nucleic acid extraction and antimicrobial peptide design Recent publications highlight his expertise in: DNA glycosylase functions in neurogenesis and metabolic diseases Combinatorial antiviral therapies against coronaviruses and enteroviruses Epigenetic mechanisms in immunodeficiency and cancer His group employs cutting-edge approaches in: Redox biology and oxidative stress responses Computational analysis of regulatory mutations Nanotechnology for biomedical applications

Thomas Preissمشاهده پروفایل

استاد

• RNA Biology
• Gene Regulation
• Cancer Biology
• +۳ مورد دیگر

Thomas Preiss is a Professor of RNA Biology at the John Curtin School of Medical Research (JCSMR), Australian National University (ANU), and serves as Director of the Shine-Dalgarno Centre for RNA Innovation and the National Therapeutic mRNA Platform. He holds a Ph.D. from the University of Newcastle upon Tyne and has extensive postdoctoral experience at the European Molecular Biology Laboratory (EMBL). His research focuses on RNA-level gene regulation, particularly in eukaryotes, with applications to cancer and cardiac biology. Key affiliations include the Division of Genome Sciences and Cancer and leadership roles in collaborative research groups. Education Bachelor of Chemistry (1986-1991), Philipps-Universität, Marburg (Germany), and University of Bristol (UK) Ph.D. (1992-1995), University of Newcastle upon Tyne (UK) Habilitation in Biochemistry (1995-2002), EMBL, Heidelberg (Germany) Research Interests His group investigates RNA processing, modification, and interactions, with a focus on translational control mechanisms. Projects include studying RNA methylation (e.g., m5C and m6A), ribosome dynamics, and the role of RNA dysregulation in diseases like cancer. Techniques employed range from classical molecular biology to cutting-edge 'omics approaches. Publications Recent work highlights advancements in RNA modification profiling, translational control, and therapeutic mRNA applications. Key themes include the interplay between RNA modifications and translation efficiency, as well as the development of novel sequencing methods for studying ribosome interactions. Labs & Teams He leads the Preiss Group - RNA Biology and collaborates with the Shirokikh and Hannan groups on protein biosynthesis, translational control, and cancer therapeutics. The National Therapeutic mRNA Platform under his direction advances mRNA-based therapies.

Roberto Bonasioمشاهده پروفایل

استاد

• Epigenetics
• Chromatin Biology
• Noncoding RNA
• +۶ مورد دیگر

Roberto Bonasio, Ph.D., is a Professor of Cell and Developmental Biology at the Perelman School of Medicine , University of Pennsylvania. He serves as Core Faculty at the Penn Epigenetics Institute and Member of the Institute for Regenerative Medicine. Research Interests : The Bonasio Lab explores epigenetic gene regulation in brain function, focusing on noncoding RNAs , chromatin biochemistry , and gene-behavior relationships . His work spans traditional (mice) and non-traditional models (ants, fruit flies, planarians). Recent Articles highlight studies on neuropeptide-driven caste behavior in ants, RNA-binding chromatin complexes , and methodological innovations like ligation-independent RNA sequencing. Students : Roberto mentors PhD candidates in the Cell and Molecular Biology (CAMB) and Biochemistry and Molecular Biophysics (BMB) graduate groups, including Johnny Doherty, Segovia Garcia, Lauren Reich, and Julia Tasca. Labs & Teams : The lab integrates epigenetics, genomics, and neurobiology , with expertise in single-cell RNA sequencing , protein-RNA interaction mapping , and R-loop analysis . Key collaborators include Penn researchers and international institutions.

Hongjun Songمشاهده پروفایل

استاد

• Neural Stem Cell Regulation
• Adult Hippocampal Neurogenesis
• Neuroepigenetics
• +۵ مورد دیگر

Hongjun Song serves as Perelman Professor of Neuroscience at the University of Pennsylvania's Perelman School of Medicine within the Department of Neuroscience. His laboratory maintains dual appointments with the Department of Neuroscience and is affiliated with multiple graduate groups including Biochemistry and Molecular Biophysics, Cell and Molecular Biology, and Neuroscience. Research Expertise: Dr. Song's laboratory investigates two core areas: (1) neural stem cell regulation and neurogenesis in developing and adult mammalian brains, and (2) epigenetic and epitranscriptomic mechanisms in the nervous system. His work explores how dysfunction in these processes contributes to brain disorders. Key methodologies include single-cell genetic approaches, high-throughput sequencing (RNA-seq, ChIP-seq, Bisulfite-seq, ATAC-seq), and single-cell RNA-seq bioinformatics pipelines. Publication Trends: Recent work (2024-2025) demonstrates expansion into organoid modeling of neurodevelopmental disorders, glioblastoma, and Alzheimer's disease, with emphasis on epitranscriptomic regulation (m6A methylation), cross-species neurogenesis comparisons, and therapeutic targeting of epigenetic mechanisms. His publications consistently bridge molecular mechanisms with circuit-level functional outcomes. Landis Award for Outstanding Mentorship (2022) - Recognized for purposeful, individualized mentoring extending beyond science to trainees' personal lives National Academy of Medicine (2020) - Elected for contributions to neuroscience AAAS Fellow (2022) - Elected alongside seven other Penn faculty Mentoring Impact: Dr. Song's laboratory has trained over 50 researchers including 30+ PhD students and postdocs, many now leading independent labs at institutions like UCSF, Mount Sinai, and KAIST. His mentoring philosophy emphasizes helping trainees develop independent research projects they can own, with lab culture fostering collaboration across diverse backgrounds while maintaining scientific rigor. Trainees credit him with supporting career paths aligned with individual interests and skills. Research Infrastructure: The lab maintains cutting-edge capabilities in single-cell analysis, neural organoid modeling, and epigenetic/epitranscriptomic profiling, with recent focus on human-specific neurogenic mechanisms and therapeutic applications for brain disorders.

Samie R Jaffreyمشاهده پروفایل

استاد

• RNA Epitranscriptomics
• RNA Methylation
• Stress Granule Biology
• +۴ مورد دیگر

Dr. Samie R Jaffrey is the Greenberg-Starr Professor of Pharmacology at Weill Cornell Medical College since 2016, with a focus on RNA modifications and epitranscriptomics. His research spans molecular biology, cancer mechanisms, and neurogenetics. RNA Methylation Dynamics RNA Aptamer Engineering Neuronal mRNA Regulation His work addresses critical questions in mRNA stability, stress granule formation, and RNA-based therapeutics. Recent publications highlight mechanisms of m6A-dependent degradation and tRNA modification impacts on metastasis. Dr. Jaffrey's lab develops innovative RNA imaging tools like Pepper and Broccoli tags, enabling live-cell visualization of RNA processes. Collaborations with biotech partners (Lucerna, Chimerna) translate these discoveries into clinical applications.

Ehsan Pashay Ahiمشاهده پروفایل

پژوهشگر

• Genetics
• Developmental biology
• Physiology
• +۹ مورد دیگر

Ehsan Pashay Ahi is a Postdoctoral Researcher at the University of Helsinki within the Faculty of Biological and Environmental Sciences and Organismal and Evolutionary Biology Research Programme . Holding a PhD in Biology from the University of Iceland, his research bridges Genetics, Developmental Biology, Physiology, Ecology, and Evolutionary Biology . PhD, Biology, University of Iceland, Reykjavik His work focuses on: Evolutionary developmental biology (Evo-Devo) Epigenetic regulation (m6A RNA modification) Gene co-expression networks in fish Hippo signaling pathway evolution Environmental adaptation mechanisms Phenotypic diversity in cichlids Recent publications (2023-2025) examine: Sex-specific maturation timing in Atlantic salmon Carotenoid-based color evolution Environmental RNA research beyond mRNA Leptin signaling in zebrafish reproduction Scientific contributions include: European Research Council (ERC) funded project (2023-2027) on life-history genes in fishes Collaborative studies with teams across Finland, Austria, and Iceland Research trends highlight cross-disciplinary integration of: Transcriptomics Epigenetics Gene regulatory networks Comparative physiology Ecological adaptation Developmental pathway evolution

Richard I. Gregoryمشاهده پروفایل

استاد

• RNA regulation
• Stem cell biology
• MicroRNA biogenesis
• +۷ مورد دیگر

Richard I. Gregory, PhD is a Professor in the Department of Biological Chemistry and Molecular Pharmacology, and Department of Pediatrics at Harvard Medical School. He serves as the Stem Cell Biology Endowed Chair for Boston Children's Hospital Department of Pediatrics and is Co-Director of the HMS Initiative for RNA Medicine. His laboratory at Boston Children's Hospital focuses on RNA regulation mechanisms in stem cell pluripotency, development, cancer, and neurological diseases. Dr. Gregory's research program bridges RNA biochemistry/molecular biology and stem cell research, with a focus on the regulation of microRNAs (miRNAs), messenger RNAs (mRNAs), and long non-coding RNAs (lncRNAs). His lab has made significant contributions to identifying key molecular mechanisms of stem cell biology, including the regulation of let-7 miRNAs by the RNA-binding protein and pluripotency factor LIN28. His work spans several critical areas: RNA biogenesis & decay pathways in human disease RNA methylation in gene regulation and cancer (epitranscriptomics) MicroRNA stem cell biology Development of novel therapeutic approaches for cancer Dr. Gregory's laboratory has pioneered the field of epitranscriptomics and cancer, providing the first functional evidence linking RNA modifications with cancer development. His innovative research strategy addresses new, unexplored areas of RNA metabolism and disease, with a focus on developing small molecule inhibitors targeting RNA regulatory pathways as potential cancer therapies. The laboratory has published extensively in top journals including Nature, Cell, and Molecular Cell, with recent work focusing on m6A and m7G RNA modifications in cancer. His laboratory has received significant recognition: Stem Cell Biology Endowed Chair for Boston Children's Hospital Department of Pediatrics (2018) Dr. Gregory has mentored numerous postdoctoral fellows who have gone on to establish successful careers in academia and industry. His laboratory is supported by multiple grants from the National Institutes of Health, including the National Institute of General Medical Sciences (NIGMS), National Cancer Institute (NCI), and the National Institute of Mental Health (NIMH). The Gregory Laboratory continues to be at the forefront of RNA biology research with implications for understanding and treating cancer and degenerative diseases.

Andrea Tanzerمشاهده پروفایل

پژوهشگر

• RNA Biology
• Transcriptomics
• Non-Coding RNA
• +۴ مورد دیگر

Andrea Tanzer is a researcher at the Max Perutz Labs, Department of Biochemistry and Cell Biology. Her work focuses on RNA biology, particularly RNA structure and function, non-coding RNA, and bioinformatics tools for genomic analysis. She leads the RNALands project (2015–2019), developing methods for RNA folding landscape analysis. Her research contributes to understanding RNA editing mechanisms, epigenetic regulation, and host-pathogen interactions. Key research interests include RNA structure prediction, transcriptome-wide analyses, and the role of RNA modifications in gene regulation. Tanzer has presented on topics such as RNA bioinformatics, structureomics, and G-quadruplexes in RNA. Her work bridges computational methods and experimental biology, with applications in both fundamental science and biomedical diagnostics. Notable contributions include the RNAxplorer tool for RNA structure sampling and collaborations on the GENCODE project. Media highlights include coverage of her work on mouse genome applications for human diagnostics.