جست‌وجوی استاد و پژوهشگر

Vladimir Katanaevمشاهده پروفایل

استاد

• Wnt Signaling Pathway
• Cancer Biology
• GPCR Signaling Mechanisms
• +۳ مورد دیگر

Prof. Vladimir Katanaev is a Full Professor at the University of Geneva's Faculty of Medicine, affiliated with the Department of Cellular Physiology and Metabolism and the Centre for Translational Research in Onco-haematology. His research focuses on oncogenic signaling pathways, particularly the Wnt signaling pathway's role in cancer and developmental biology. He combines fundamental and translational research to develop anti-cancer therapies, including Wnt inhibitors and novel drug candidates. His work also extends to G protein-coupled receptor (GPCR) signaling mechanisms and biomimetic nanocoatings inspired by biological structures. Educated at Krasnoyarsk and Moscow State Universities, he completed his PhD at the University of Fribourg (Switzerland) and a postdoc at Columbia University (USA). Key roles include leading a research group at the University of Konstanz (2005–2011) and joining the University of Lausanne as an associate professor before moving to UNIGE in 2018. His lab investigates Wnt pathway inhibitors, GNAO1-related encephalopathies, and synthetic applications of biological nanocoatings. Research highlights include identifying natural product-based anticancer agents, developing personalized therapies for genetic disorders, and exploring light-interacting nanomaterials. Collaborators include postdoctoral fellows and scientific collaborators like Jana Valnohova and Gonzalo Solis. His work bridges basic science and clinical translation, aiming to advance oncology and neurology treatments.

Jamie Spanglerمشاهده پروفایل

دانشیار

• Structural Immunology
• Protein Engineering
• Therapeutic Antibody Discovery
• +۳ مورد دیگر

Jamie Spangler, PhD, is an Associate Professor at Johns Hopkins University, holding joint appointments in Biomedical Engineering, Chemical & Biomolecular Engineering, Oncology, Ophthalmology, and Molecular Microbiology & Immunology. She leads the Spangler Lab, focused on engineering proteins to advance therapies for cancer, autoimmune disorders, and infectious diseases. Her work integrates structural biophysics, biomolecular engineering, and translational immunology to develop innovative protein-based treatments. Education : PhD in Biological Engineering, MIT (2011) BS in Biomedical Engineering, Johns Hopkins University (2006) Research Interests : Her lab engineers antibodies and cytokines to manipulate immune responses. Key areas include: Designing IL-2/IL-15 mimetics for T cell modulation Bispecific antibodies targeting VEGF pathways for ocular diseases Orally bioavailable Th17 antagonists Protein degradation platforms using endocytosis-inducing proteins Nanoparticle delivery systems for regulatory T cell expansion Awards : William R. Brody Faculty Scholar Award (Johns Hopkins) Melanoma Research Alliance Pilot Award (2024) Early Career Contributions Recognition (2025) Advancing Therapeutics : Dr. Spangler's lab collaborates with industry and clinical partners to translate engineered proteins into therapies. Recent work includes: CD25-biased IL-2 immunocytokines for cancer immunotherapy Anti-AML CAR-NK cell affinity optimization VEGF-A/C bispecific decoys for neovascular eye diseases Labs & Affiliations : Affiliated with the Translational Tissue Engineering Center and multiple interdisciplinary initiatives at Johns Hopkins. Her lab emphasizes cross-disciplinary approaches bridging engineering, immunology, and clinical medicine.

Henning Urlaubمشاهده پروفایل

استاد

• Mass Spectrometry
• Proteomics
• Protein Interactions
• +۷ مورد دیگر

Prof. Henning Urlaub is a Professor at the Faculty of Medicine at Georg August University Göttingen and Group Leader of the Bioanalytical Mass Spectrometry Group at the Max Planck Institute for Multidisciplinary Sciences (formerly Max Planck Institute for Biophysical Chemistry). His roles include leading a research group focusing on proteomics and clinical biochemistry at the University Medical Center Göttingen (UMG). He holds dual affiliations in both academic and clinical research sectors. He earned his Ph.D. in biochemistry from the Free University of Berlin (1993–1996) and conducted postdoctoral research at institutions including the Max Delbrück Center for Molecular Medicine (Berlin) and the Philipps University of Marburg. His career includes leadership roles since 2010 in both the Max Planck Institute and UMG. Research Interests : Dr. Urlaub’s work centers on modern mass spectrometry applications for analyzing proteins, post-translational modifications, and protein interactions. Key projects include: Quantitative analysis of synaptic proteins under stimulation Protein cross-linking studies in B cells and other systems Method development for protein-RNA/DNA interactions Structural elucidation of large complexes via CX-MS and cryo-EM His group operates as a core proteomics facility for the Max Planck Institute and collaborates with external institutions like the University Hospital Frankfurt. They also maintain a clinical proteomics branch at the UMG’s Institute for Clinical Chemistry. Collaborations & Infrastructure : The group provides proteomics services to researchers across disciplines, emphasizing translational and clinical applications. Their instrumentation includes advanced mass spectrometry platforms (e.g., ESI, MALDI) for high-throughput proteomic analysis.

Tobin Sosnickمشاهده پروفایل

استاد

• Protein Folding
• Biophysics
• Molecular Dynamics
• +۵ مورد دیگر

Prof. Tobin Sosnick is a Professor and Chair of the Department of Biochemistry and Molecular Biology at the University of Chicago, affiliated with the Pritzker School of Molecular Engineering and the Institute for Biophysical Dynamics. He holds a PhD in Applied Physics from Harvard University (1989) and a B.A. in Physics from UC San Diego. His research focuses on protein folding mechanisms, biophysical dynamics, and membrane protein behavior, employing advanced techniques like SAXS, HDX-MS, and molecular simulations. He leads the Graduate Program in Biophysical Sciences and has pioneered studies on disordered proteins and allosteric regulation. Notable contributions include elucidating the '70% Rule' for folding transition states and developing optogenetic tools for actin imaging. Recognized as a 2024 AAAS Fellow and contributor to the 2023 Lasker Award-winning AlphaFold project, his work bridges physics, chemistry, and biology. Affiliations: Chair, Department of Biochemistry and Molecular Biology; Senior Fellow, Computation Institute; Founding Member, Institute for Biophysical Dynamics. Collaborations span structural biology, computational biophysics, and cellular engineering. Research Highlights: Protein Folding Dynamics: Transition state topology, cooperativity, and downhill folding. Disordered Proteins: Conformational ensembles, solvent effects, and phase separation. Molecular Tools: Optogenetic systems (e.g., LILAC) and HDX-MS for membrane protein analysis. Grants & Awards: 2024 AAAS Fellow, 2023 Lasker Award contributor, multiple NIH grants for protein dynamics research. His lab has produced over 200 peer-reviewed publications. Labs & Teams: The Sosnick Group integrates experimental and computational approaches, with ongoing projects on riboswitches, stress granule formation, and prestin electromotility mechanisms in hearing.

Genhong Chengمشاهده پروفایل

استاد

• Virology
• Immunology
• Innate Immunity
• +۴ مورد دیگر

Genhong Cheng is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics (MIMG) at the University of California Los Angeles (UCLA). His research focuses on understanding the molecular mechanisms of host-pathogen interactions, particularly in viral infections such as Zika virus, SARS-CoV-2, and influenza. Dr. Cheng has made significant contributions to the field of innate immunity, especially in interferon signaling pathways and NF-kappaB regulation. Dr. Cheng's research interests span across virology, immunology, and molecular biology. He has extensively studied how viruses interact with host immune responses, with a particular focus on interferon signaling pathways. His work has revealed critical mechanisms by which viruses evade host defenses and how host cells mount effective antiviral responses. Key areas of investigation include: NF-kappaB signaling in immune responses Interferon-stimulated gene functions Host metabolic changes during viral infection Mechanisms of viral replication and evasion Development of broad-spectrum antiviral strategies Analysis of Dr. Cheng's recent publications reveals a strong focus on emerging viral threats, including SARS-CoV-2 and monkeypox virus. His research consistently explores how host metabolic pathways intersect with immune responses to viral infection. A notable theme is the identification of host factors that can be targeted for broad-spectrum antiviral therapies, particularly those involving lipid metabolism and interferon-stimulated genes. Recent work has emphasized translational applications of basic discoveries in viral pathogenesis. Dr. Cheng's laboratory has been instrumental in advancing our understanding of host-pathogen interactions at the molecular level. His team employs a multidisciplinary approach combining virology, immunology, molecular biology, and systems biology to unravel complex host-virus relationships. Current research directions include exploring novel antiviral strategies targeting host factors that are essential for viral replication.

• Cell Signaling
• Cancer Biology
• Neurodegenerative Diseases
• +۳ مورد دیگر

Dr. Cathy Tournier is a Senior Lecturer in the Division of Cancer Sciences at the University of Manchester. Her research focuses on mitogen-activated protein kinase (MAPK) signaling pathways in cancer and neurodegenerative diseases. She holds a PhD in Endocrinology and has held post-doctoral fellowships from institutions including the Howard Hughes Medical Institute and the Lister Institute of Preventive Medicine. Education: BSc (Biochemistry), University of Montpellier, France (1990) MSc (Biochemistry), University of Montpellier, France (1991) PhD (Endocrinology and Cellular/Molecular Interactions), University of Paris XI, France (1996) Research Interests: Tournier’s laboratory investigates MAPK signaling pathways in cancer development and neurological disorders. Key topics include ERK5 and JNK signaling in cell survival, apoptosis, and inflammation-driven carcinogenesis. Collaborations include mouse model development for studying cancer progression and macrophage activation in tumors. Awards: She has received prestigious fellowships such as the Lister Institute Senior Research Fellowship (2001–2006) and Howard Hughes Medical Institute Research Associate (1998–2000). Teaching and Advising: Teaches Cell Signalling (BIOL31441) and supervises dissertation students. Active in undergraduate mentoring and project supervision. Labs/Teams: Her work aligns with research beacons like Dementia@Manchester and the Manchester Cancer Research Centre, focusing on translational signal transduction research.

Angela Steinauerمشاهده پروفایل

عضو هیئت علمی

• Biomolecular Engineering
• Nanomedicine
• Drug Delivery Systems
• +۳ مورد دیگر

Angela Steinauer is a Tenure Track Assistant Professor at the École Polytechnique Fédérale de Lausanne (EPFL), Switzerland, leading the Laboratory of Biomolecular Engineering and Nanomedicine (LIBN). She holds academic affiliations within the School of Basic Sciences (SB), specifically in the Institute of Chemical Sciences and Engineering (ISIC) and the Section of Chemistry and Chemical Engineering (SCGC). Her roles include teaching advanced chemistry courses, nanobiotechnology, and supervising doctoral students in the Chemical Biology program. She is also a member of the doctoral program committee for Chemistry and Chemical Engineering. Dr. Steinauer's research focuses on biomolecular engineering and nanomedicine, emphasizing protein engineering, drug delivery systems, and endosomal escape mechanisms. Her work integrates chemical synthesis, biophysical techniques, and molecular biology to develop innovative therapeutic carriers. Key educational milestones include a Ph.D. in Chemical Biology from Yale University (2018) and a B.Sc./M.Sc. in Chemistry from the University of Zurich (2007–2012). Her teaching responsibilities include courses such as Advanced General Chemistry I , Nanobiotechnology , and Chemical Biology Seminar Series . She actively supervises five doctoral students, fostering interdisciplinary research in biomolecular innovation. Her recent publications highlight advancements in peptide delivery mechanisms, protein cage assembly, and stimulus-responsive nanocarriers, reflecting her commitment to bridging fundamental research with translational applications in medicine and biotechnology.

Huaiying Zhangمشاهده پروفایل

استادیار

• Biomolecular Condensates
• Cancer Biology
• Cellular Functions
• +۳ مورد دیگر

Huaiying Zhang is an Assistant Professor in the Department of Biological Sciences at Carnegie Mellon University, part of the Mellon College of Science. His research focuses on the role of biomolecular condensates in cellular functions and cancer progression, particularly investigating phase transitions in telomere maintenance and cancer cell immortality. He holds a Ph.D. from McGill University and completed postdoctoral research at Dartmouth College, Princeton University, and the University of Pennsylvania. Research interests include engineering synthetic organelles, developing optogenetic tools to manipulate phase separation in live cells, and targeting phase transitions for cancer therapy. His work bridges biophysics, cell biology, and synthetic biology to address fundamental questions in nuclear organization and disease mechanisms. Education: Ph.D., McGill University Postdoctoral Fellowships: Dartmouth College, Princeton University, University of Pennsylvania Publications highlight advances in understanding telomere clustering in cancer cells, nuclear body formation, and applications of phase separation in therapeutic strategies. Collaborative projects emphasize interdisciplinary approaches, combining experimental and theoretical methods. Lab activities focus on biomolecular condensates' material properties, their roles in genomic processes, and translational applications in cancer treatment. The lab actively seeks students and researchers interested in cellular biophysics and disease biology.

Sonia Navas-Martinمشاهده پروفایل

استاد

• Innate Immunity
• Neuroimmunology
• Neuroinflammation
• +۸ مورد دیگر

Sonia Navas-Martin is a Professor in the Department of Microbiology & Immunology at Drexel University College of Medicine. She holds a PhD from Universidad Autónoma de Madrid (1997). Her research focuses on innate immunity mechanisms during viral infections and neurodegenerative diseases, with emphasis on CNS pathologies and cellular senescence. Education: PhD in Microbiology & Immunology, Universidad Autónoma de Madrid (1997) Research Interests: Dr. Navas-Martin investigates how innate immune pathways contribute to immunopathology in viral infections (e.g., coronaviruses), neuroinflammation, and neurodegenerative diseases like Alzheimer’s. Her work combines molecular biology, immunology, and animal models to identify therapeutic targets. Key areas include: Microglial responses to viral pathogens Role of non-coding RNAs (e.g., miRNAs) in immune regulation Cellular senescence in HIV-associated neurocognitive disorders Cross-talk between TLR signaling and viral replication Publications: Her recent work includes studies on SARS-CoV-2 antiviral strategies, microglial antiviral mechanisms, and HIV-HCV co-infection dynamics. The articles reflect a focus on innate immunity modulation, viral pathogenesis, and translational therapies. Awards: Curator, American Society for Microbiology’s COVID-19 Research Registry Grants & Mentorship: She oversees an NIH-funded neuroimmunology graduate position and mentors students in scientific excellence. Her lab is known for collaborative, open research environments fostering innovation. Labs & Teams: Active in the Institute for Molecular Medicine & Infectious Disease at Drexel, collaborating on coronavirus immunology and SARS-CoV-2 therapeutic development. Her research integrates virology, immunology, and neurobiology to address critical gaps in understanding viral CNS pathogenesis.

Anupama Chembathمشاهده پروفایل

پژوهشگر

• Protein Engineering
• Molecular Biology
• Genetic Mutagenesis
• +۳ مورد دیگر

Anupama Chembath is a Post-Doctoral Research Associate at Aston University's School of Biosciences within the College of Health and Life Sciences. Her research focuses on protein engineering, molecular biology, and genetic mutagenesis, with notable contributions to armadillo repeat proteins and saturation mutagenesis techniques. She has collaborated internationally on projects such as PRe-ART (Predictive Reagent Antibody Replacement Technology) and applied non-degenerate mutagenesis methods to alpha-helical repeat proteins. Her work bridges biochemical and genetic approaches to understand protein function and structure, including studies on circadian rhythms in plants and yeast pseudohyphal growth mechanisms. Recent advancements include modular binder technologies leveraging next-generation sequencing (NGS) and high-resolution selection in yeast. Award recognition details are not explicitly stated in the provided texts. Her research trends emphasize precision engineering, structural biology, and applications in biotechnology, with publications spanning from 2009 to 2024. Collaborative efforts highlight interdisciplinary approaches to protein design and functional analysis.

Rolf Brekkenمشاهده پروفایل

استاد

• Tumor Microenvironment
• Extracellular Matrix (ECM)
• Angiogenesis
• +۹ مورد دیگر

Dr. Rolf Brekken is a Professor at UT Southwestern Medical Center, where he serves as the Effie Marie Cain Research Scholar in Angiogenesis Research and Principal Investigator in the Hamon Center for Therapeutic Oncology Research. His laboratory investigates tumor-host interactions with a particular emphasis on extracellular matrix (ECM) and angiogenesis, focusing on pancreatic, breast, and lung tumors. Dr. Brekken received his Bachelor of Arts degree from Luther College in Decorah, Iowa and his PhD from UT Southwestern Graduate School of Biomedical Sciences. His graduate research focused on Vascular Endothelial Growth Factor (VEGF) as a target for therapy of solid tumors. He completed postdoctoral training in the Department of Vascular Biology at the Hope Heart Institute in Seattle, Washington. Dr. Brekken's research interests center on the tumor microenvironment, particularly pathways that drive epithelial plasticity and immune suppression. His laboratory studies how angiogenesis and ECM remodeling are key components of the metastatic cascade, with current projects focused on the function of matricellular proteins (e.g., SPARC and fibulin-5) as regulators of ECM remodeling and angiogenesis. Another major area of study is the development and evaluation of novel cancer therapies with a focus on anti-angiogenic strategies. Analysis of Dr. Brekken's recent publications (2017-2018) reveals a consistent focus on pancreatic cancer biology, particularly examining the tumor microenvironment, ECM remodeling, and angiogenesis. His work frequently investigates specific molecular targets including Axl receptor, discoidin domain receptors, and phosphatidylserine, with applications in both diagnostic approaches and therapeutic interventions. A notable trend is the exploration of combination therapies and mechanisms of resistance to anti-angiogenic treatments. Effie Marie Cain Research Scholar in Angiogenesis Research Dr. Brekken leads the Brekken Laboratory located in the Hamon Center for Therapeutic Oncology Research, where his team conducts robust modeling of pancreatic and breast cancer. His research has significant implications for understanding resistance mechanisms to anti-VEGF therapy and hypoxia-induced tumor progression. The laboratory's work spans from basic molecular mechanisms to preclinical therapeutic applications, with strong translational potential.

• Plant Genetics
• Crop Biodiversity
• Breeding Informatics
• +۵ مورد دیگر

Karl Schmid is a W3 Professor of Crop Plant Biodiversity and Breeding Informatics at the University of Hohenheim's Institute of Plant Breeding, Seed Science and Population Genetics within the College of Agricultural Sciences. His research integrates evolutionary genetics, population genomics, and machine learning to address agricultural challenges. Ph.D. in Biology, University of Munich (1996) Postdoctoral Research, Cornell University (1997-1999) Emmy-Noether Research Group, Max Planck Institute of Chemical Ecology (2000-2006) Group Leader, Leibniz Institute of Plant Genetics (2006-2008) Professor of Genetics, Swedish Agricultural University (2008) His research focuses on crop biodiversity conservation, evolutionary genetics of plant pathogens, and breeding informatics applications. Current work leverages deep learning for phenotyping (quinoa panicles, barley genomics) and analyzes pathogen evolution (Exserohilum turcicum in maize). His team actively develops computational tools like GGoutlieR for geo-genetic pattern detection. Recent publications demonstrate strong trends in applying AI to agricultural genomics, particularly in quinoa improvement and pathogen surveillance. His group leads the EU H2020 INVITE project on molecular markers in plant variety protection and organizes international symposia like the 2024 Quinoa Symposium at Hohenheim. Head of Crop Biodiversity and Breeding Informatics Group Principal Investigator, EU H2020 INVITE project Organizer, International Quinoa Symposium 2024

Daan van Aaltenمشاهده پروفایل

استاد

• Protein O-GlcNAcylation
• Intellectual Disability
• Structural Biology
• +۵ مورد دیگر

Daan van Aalten is a Professor at Aarhus University, affiliated with the Department of Molecular Biology and Genetics - Neurobiology within the Faculty of Natural Sciences. His research focuses on protein O-GlcNAcylation, a critical posttranslational modification linked to intellectual disability (OGT-CDG). He leads studies using model systems (mESCs, Drosophila, mice) to dissect molecular mechanisms underlying OGT-CDG phenotypes. Notable contributions include defining OGT-CDG as a congenital disorder of glycosylation and identifying therapeutic targets. He has secured major grants, including a Novo Nordisk Foundation Laureate Grant (DKK 50M) and a Villum Investigator Grant (DKK 40M), supporting work on protein modifications and fungal pathogenesis. Key research areas include enzymology, structural biology, and neurobiology. His lab explores O-GlcNAc signaling dynamics, fungal cell wall synthesis, and genetic disorders. Recent studies highlight neurodevelopmental defects in mouse models and human stem cell systems. Collaborative projects with international teams advance drug discovery for fungal pathogens and intellectual disability syndromes. Publications span molecular mechanisms of OGT mutations, enzyme inhibitors, and structural biology. Awards include recognition for his transformative work in glycobiology and neurodevelopment. His lab actively engages in training scientists and welcomes inquiries about OGT-CDG studies via ogtcdg@au.dk.

• Matrix Metalloproteases
• Biophysics
• Enzymology
• +۴ مورد دیگر

Susanta Sarkar is a Research Professor at Arizona State University's School of Molecular Sciences, affiliated with the Tempe campus. His email is Susanta.Sarkar@asu.edu. He holds a NIH R01 GM145210 grant as the sole PI ($1.1 million), focusing on MMP1's role in collagen degradation. His research integrates biophysics, enzyme dynamics, and drug development to target matrix metalloproteases (MMPs) in diseases like cancer and neurodegeneration. He employs single-molecule techniques to study enzyme-substrate interactions, aiming to develop precision therapies with minimal side effects. Education : Ph.D. in Physics, University of Oregon (2006) M.S. in Physical Sciences, Indian Institute of Science (2000) Postdoctoral Associate, Cornell University (2008), NIH Research Fellow (2013) Research Interests : MMPs' role in human health, single-molecule biophysics, allosteric modulation, and drug screening for Parkinson’s/Alzheimer’s. His work bridges fundamental biology and translational medicine, funded by NIH. Publications : Recent work includes substrate-specific MMP dynamics, alpha-synuclein interactions, and biofilm inhibition. His 2020 Biophysical Journal study was cover-selected and F1000-recommended. Over 15 publications since 2016 address enzyme activity, thermodynamics, and imaging. Grants & Awards : NIH R01 GM145210 (2022-2026), $2.25 million in total funding. Recognized for innovative methodologies in single-molecule studies. Advising & Training : Supervised 54 trainees, including 3 PhDs securing >$1.5M in grants post-graduation. Emphasizes financial literacy alongside science, with students averaging $30K+ retirement savings. Service : Served on 12 NSF/NIH panels, reviewer for 20+ journals including Nature Communications and Biophysical Journal. Labs/Teams : Integrates personal finance education in group meetings to boost focus and career readiness. Lab focuses on MMPs, antimicrobial biopolymers, and fluorescent nanodiamond imaging.

Vincent Archambaultمشاهده پروفایل

استاد

• Cell Biology
• Molecular Biology
• Cancer Research
• +۵ مورد دیگر

Professor Vincent Archambault holds a full professorship at the University of Montreal's Faculty of Medicine, Department of Biochemistry and Molecular Medicine, and leads the Cell Cycle Regulation Research Unit at the Institute for Research in Immunology and Cancer (IRIC). His work focuses on molecular mechanisms regulating the cell division cycle, particularly in Drosophila models, with implications for cancer research. Education: B.Sc. in Biochemistry, Université de Montréal (1999) Ph.D. in Cell Cycle Studies, Rockefeller University (2004) Postdoctoral training at University of Cambridge (2004–2009) Research Interests: Cell cycle control, mitotic regulation, cancer biology, protein kinases (e.g., Polo, Greatwall), phosphatase networks (PP2A), and Drosophila model systems. His research identifies therapeutic targets for cancer by studying disruptions in cell cycle pathways. Key contributions include co-discovering Greatwall kinase and its role in mitotic regulation. Over 50 peer-reviewed articles highlight his work on nuclear reassembly, cytokinesis, and phosphatase-kinase interactions. Awards: Maud Menten New Principal Investigator Award (2009) GE Healthcare New Scientist Award (2015) Human Frontier Science Program Fellowship (2005–2009) Grants: Over 15 projects funded by CIHR, CRSNG, and others, totaling millions in research support. Labs/Teams: Leads the IRIC Cell Cycle Regulation Unit, collaborating with teams like Sylvain Meloche and Jean-Claude Labbé.