Jamie Spangler

Jamie Spangler, PhD, is an Associate Professor at Johns Hopkins University, holding joint appointments in Biomedical Engineering, Chemical & Biomolecular Engineering, Oncology, Ophthalmology, and Molecular Microbiology & Immunology. She leads the Spangler Lab, focused on engineering proteins to advance therapies for cancer, autoimmune disorders, and infectious diseases. Her work integrates structural biophysics, biomolecular engineering, and translational immunology to develop innovative protein-based treatments.

Education:

• PhD in Biological Engineering, MIT (2011)
• BS in Biomedical Engineering, Johns Hopkins University (2006)

Research Interests:
Her lab engineers antibodies and cytokines to manipulate immune responses. Key areas include:

• Designing IL-2/IL-15 mimetics for T cell modulation
• Bispecific antibodies targeting VEGF pathways for ocular diseases
• Orally bioavailable Th17 antagonists
• Protein degradation platforms using endocytosis-inducing proteins
• Nanoparticle delivery systems for regulatory T cell expansion

Awards:

• William R. Brody Faculty Scholar Award (Johns Hopkins)
• Melanoma Research Alliance Pilot Award (2024)
• Early Career Contributions Recognition (2025)

Advancing Therapeutics:
Dr. Spangler's lab collaborates with industry and clinical partners to translate engineered proteins into therapies. Recent work includes:

• CD25-biased IL-2 immunocytokines for cancer immunotherapy
• Anti-AML CAR-NK cell affinity optimization
• VEGF-A/C bispecific decoys for neovascular eye diseases

Labs & Affiliations:
Affiliated with the Translational Tissue Engineering Center and multiple interdisciplinary initiatives at Johns Hopkins. Her lab emphasizes cross-disciplinary approaches bridging engineering, immunology, and clinical medicine.