جست‌وجوی استاد و پژوهشگر

Michael J. Ragusaمشاهده پروفایل

دانشیار

• Structural Biology
• Biochemical Reconstitution
• Autophagy
• +۵ مورد دیگر

Michael J. Ragusa is an Associate Professor of Chemistry at the Department of Chemistry, College of Arts and Sciences, Dartmouth College , specializing in molecular mechanisms of selective autophagy . His research integrates structural biology , biochemical reconstitution , and cell biology to understand how cells degrade toxic components like damaged organelles. Education: B.S. in Chemistry from Siena College, Ph.D. in Biochemistry from Brown University His work focuses on autophagy , particularly the role of Atg proteins in membrane tethering and cargo selection. His lab has published extensively on mitophagy , ALFY , and Atg11 , linking defects in these pathways to cancer , neurodegeneration , and infectious diseases . Recent studies highlight mechanisms of vesicle clustering and dimerization-dependent membrane interactions . Dr. Ragusa teaches courses such as CHEM 5: General Chemistry , CHEM 42: Biological Chemistry II , and CHEM 95.05: Protein Crystallography . His lab employs techniques like X-ray crystallography , NMR spectroscopy , and membrane reconstitution to dissect protein-lipid interactions.

• Plant Developmental Biology
• Epigenetics
• Plant Genetics
• +۵ مورد دیگر

Ueli Grossniklaus is an Ordinary Professor at the University of Zurich within the Faculty of Mathematical and Natural Sciences , affiliated with the Department of Plant and Microbiology . His work focuses on plant developmental biology, particularly epigenetic and genetic mechanisms governing reproduction and adaptation. Key Courses: Epigenetics, Plant Biology Workshop, Group Seminars on Current Research Laboratory Techniques: Advanced methods in plant cell mechanics, transcriptomics, and genome editing Research Interests span plant epigenetics, reproductive biology, and the interplay between environmental stress and genetic regulation. He investigates: Mechanistic control of gametogenesis and fertilization Epigenetic contributions to plant adaptation Evolutionary implications of asexual reproduction Biophysical forces in plant cell growth Publication Trends (2025–2018) reveal expertise in: Arabidopsis and fern model systems Epigenetic regulation (DNA methylation, histone dynamics) Apomixis and hybrid seed failure mechanisms Biomechanics of pollen tubes and carnivorous plants Genome editing tools (CRISPR) and long-read sequencing Scientific Collaborations include interdisciplinary projects on: Microfluidic devices for plant cell analysis Gene drive ecology and ethics 3D imaging of plant reproductive structures Advising and Grants focus on mentoring through research internships in developmental biology, genetics, and systems biology. His lab engages in: Epigenetic response to environmental stress Cell wall mechanics in reproduction Computational modeling of plant growth Laboratory Teams integrate plant biologists, bioengineers, and computational scientists to study: Mechanistic gene regulation Evolutionary developmental biology Microrobotics for cellular force measurement

Peter Chienمشاهده پروفایل

استاد مدعو

• Regulated Proteolysis
• Protein Quality Control
• Bacterial Cell Cycle Regulation
• +۴ مورد دیگر

Peter Chien is an Adjunct Professor in the Department of Biochemistry and Molecular Biology at the University of Massachusetts Amherst. His research focuses on regulated protein degradation and quality control in bacteria, with a particular emphasis on mechanisms governing proteolysis during the bacterial cell cycle. PhD, University of California, San Francisco Postdoctoral Training, Massachusetts Institute of Technology The Chien Lab employs interdisciplinary approaches including biochemistry, structural biology, and cell biology to study proteolytic mechanisms in Caulobacter crescentus. Their work explores how AAA+ proteases like ClpXP and Lon recognize substrates with precision and how this impacts cellular regulatory networks. Recent research trends from the lab include investigations into Lon protease modulation , DNA damage responses , protein homeostasis under stress , and genetic regulators of proteostasis . Studies often integrate structural analysis with functional assays to uncover molecular principles of protease specificity. The lab is affiliated with multiple graduate programs, including the Molecular and Cellular Biology (MCB) program, Chemistry-Biology Interface Program, Biotechnology Training Program, and the Institute for Applied Life Sciences at UMass Amherst.

Owen Skinnerمشاهده پروفایل

استادیار

• Mass Spectrometry
• Proteomics
• Metabolomics
• +۶ مورد دیگر

Owen Skinner is an Assistant Professor in the Department of Chemistry and Chemical Biology at Northeastern University, affiliated with the Barnett Institute of Chemical and Biological Analysis. He leads the Skinner Lab, which specializes in high-resolution mass spectrometry to study protein-metabolite interactions in health and disease. Skinner earned his Ph.D. from Northwestern University and conducted postdoctoral research at Massachusetts General Hospital. His research focuses on thiol redox regulation, vitamin cofactor metabolism, and oxidative phosphorylation dynamics. Education: Ph.D. in Chemistry (Northwestern University), Postdoctoral Fellowship in Analytical Chemistry (Massachusetts General Hospital). Research interests include proteomics, metabolomics, mitochondrial dysfunction, and metabolic signaling. The lab actively recruits graduate students, undergraduates, and postdoctoral researchers across Northeastern's scientific community. Affiliations: Barnett Institute, College of Science Lab Members: PhD students Yifan Liu, Michael Xiao, Angela Rojas-Merchan; Undergraduates Helena Rittenhouse, Ridha Shah; High School collaborator Helen Loango Techniques: Native mass spectrometry, proteomics, metabolomics, redox biology Publications span mitochondrial metabolism, metabolic biomarkers in septic shock, and enzyme engineering. The lab emphasizes interdisciplinary collaboration and supports students through Northeastern's experiential learning programs.

Brenda Schulmanمشاهده پروفایل

استاد

• Structural biology
• Ubiquitin-proteasome system
• Ubiquitin-like proteins
• +۵ مورد دیگر

Brenda Schulman is a Professor and Director of the Molecular Machines and Signaling Pathways department at the Max Planck Institute of Biochemistry in Martinsried, Germany. She also holds an honorary professorship at the Technical University of Munich's Department of Chemistry and serves as Adjunct Faculty at St. Jude Children's Research Hospital in Memphis, TN, USA. Her research focuses on understanding how ubiquitin and ubiquitin-like proteins regulate cellular processes through protein modification. Dr. Schulman's research interests center on structural biology of the ubiquitin-proteasome system and ubiquitin-like proteins. Her work has shown that hundreds of dynamic multiprotein complexes are transiently converted into different conformations by specialized regulatory factors that control ubiquitin and ubiquitin-like proteins, thereby monitoring virtually all processes in cell biology. She combines biochemical reconstitution, structural analysis, enzymology, protein design, cell biology, and genetics to understand how these molecular machines function. Her research has significant implications for understanding diseases such as cancer, neurodegenerative disorders, and viral infections where defects in ubiquitin pathways are implicated. Her extensive publication record demonstrates expertise in ubiquitin signaling, protein degradation mechanisms, structural biology of E3 ligases, and molecular machines. Her work spans from fundamental mechanisms of ubiquitin chain formation to therapeutic applications in targeted protein degradation. Among her numerous scientific accolades are the Feldberg Prize for Anglo-German Scientific Exchange (2025), ERC Advanced Grant (2023), Louis-Jeantet Prize for Medicine (2023), Gottfried Wilhelm Leibniz Prize (2019), and election to the National Academy of Sciences (2014). She has also received the Dorothy Crowfoot Hodgkin Award from The Protein Society and has been an Investigator of the Howard Hughes Medical Institute. Dr. Schulman leads an active research group that has produced numerous high-impact publications in top journals including Nature, Cell, and Nature Structural & Molecular Biology. Her team has made significant contributions to understanding the structural mechanisms of ubiquitin transfer, E3 ligase specificity, and the role of ubiquitin in cellular quality control pathways. Current research in her lab focuses on deciphering the ubiquitin code and developing novel approaches for targeted protein degradation.

Andrew Bassettمشاهده پروفایل

پژوهشگر

• Genome Engineering
• Neurodegenerative Diseases
• Stem Cell Research
• +۵ مورد دیگر

Dr. Andrew Bassett serves as Head of the Cellular and Gene Editing Research group at the Wellcome Sanger Institute, where he develops cutting-edge genome engineering techniques using human pluripotent stem cells to investigate neurodegenerative diseases including Alzheimer's and Parkinson's. His work focuses on scaling genetic screening approaches and improving CRISPR specificity for modeling complex disease mechanisms. His academic training includes: PhD at the MRC Laboratory of Molecular Biology (MRC-LMB) with Andrew Travers on chromatin remodelling in heterochromatin formation Postdoctoral research with David Baulcombe at the University of Cambridge studying small RNA roles in chromatin modification Additional postdoctoral work with Chris Ponting at the MRC Functional Genomics Unit (MRC-FGU) in Oxford, where he pioneered CRISPR applications in Drosophila Bassett's research program centers on developing advanced genome engineering methodologies for precise modulation of gene expression networks during development and neurodegeneration. His group specializes in creating complex editing events (SNPs, paired knockouts, enhancer perturbations) within iPSC-derived models, with particular emphasis on epigenetic regulation and transcriptional control. Current projects integrate single-cell 'omics and phenotypic assays to decode genetic causes of neurodegenerative disorders through the OpenTargets consortium. Analysis of his 15 most recent publications reveals dominant trends in CRISPR technology development (35%), neurodegenerative disease modeling (30%), and single-cell functional genomics (25%). His work consistently bridges methodological innovation with disease mechanism studies, increasingly incorporating multi-omics approaches and expanding into cancer immunology and infectious disease applications since 2022. As group leader, Bassett mentors postdoctoral researchers and PhD students while securing major funding for genome engineering initiatives. His team operates within the Sanger Institute's Cellular Operations division and maintains critical partnerships with the OpenTargets consortium for therapeutic target validation. The laboratory specializes in high-throughput screening platforms using iPSC-derived neural and microglial models, with recent methodological advances including scSNV-seq and ONE-STEP tagging systems that significantly enhance precision genome editing capabilities.

Ramanujan Hegdeمشاهده پروفایل

استاد

• Cell Biology
• Molecular Biology
• Membrane Proteins
• +۳ مورد دیگر

Ramanujan Hegde serves as a Professor and Group Leader at the MRC Laboratory of Molecular Biology (LMB), University of Cambridge, where he directs research on membrane protein biosynthesis and cellular quality control mechanisms. His work examines how membrane proteins are accurately targeted to organelles, inserted into lipid bilayers, folded, and assembled into functional complexes, with emphasis on the cellular pathways that eliminate defective proteins to prevent disease. Professor Hegde's research program focuses on fundamental questions in cell biology: How do cells ensure precise membrane protein localization? What molecular machinery governs protein insertion and folding? How do quality control systems detect and degrade misfolded proteins? His investigations reveal that biosynthetic failures are common, triggering degradation pathways linked to diseases like neurodegeneration. Key research areas include: Intramembrane chaperone mechanisms for multipass membrane proteins Orphan subunit recognition during complex assembly Ribosome-associated mRNA degradation in autoregulation Proteasome assembly quality control ER membrane protein complex functions Molecular basis of protein aggregation diseases His 2017-2023 publications in Cell, Nature, and Science demonstrate consistent innovation in protein quality control, with landmark discoveries including UBE2O's role in orphan subunit degradation, the EMC as a transmembrane domain insertase, and TTC5-mediated tubulin autoregulation. These works bridge basic cell biology with disease mechanisms through rigorous biochemical and structural approaches. Professor Hegde mentors a research team of 11 scientists: Christine Desroches Altamirano Zhong Yan Gan Dino Janssen Ryan Judy Jennifer Miao Elizabeth Miller Tim Stevens Julia Toplak Huping Wang Haoxi Wu Eszter Zavodszky His laboratory operates within the MRC LMB's world-class infrastructure, utilizing advanced techniques in biochemistry, structural biology, and cell imaging. Supported by Medical Research Council funding, the group maintains strong collaborations across Cambridge and internationally to dissect protein biogenesis pathways with implications for therapeutic development in protein-misfolding disorders.

Elemir Simkoمشاهده پروفایل

استاد

• Honey bee health
• Agricultural sustainability
• Comparative pathology
• +۳ مورد دیگر

Dr. Elemir Simko is a Professor in the Department of Veterinary Pathology at the University of Saskatchewan, affiliated with Prairie Diagnostic Services. He holds a DVM from the University of Belgrade (Yugoslavia) and a DVSc from the University of Guelph, and is a Diplomate of the American College of Veterinary Pathologists. Since 1998, he has coordinated core anatomic pathology courses at both undergraduate and graduate levels. His research focuses on honey bee health, agricultural sustainability, comparative pathology, and innate immunity. Recent work includes studies on honey bee pathogen dynamics, pesticide impacts, and equine septic arthritis diagnostics using biomarkers. He collaborates extensively with researchers on investigative pathology and contributes to diagnostic services. Education: DVM (University of Belgrade), DVSc (University of Guelph), ACVP Diplomate Key Research Themes: Honey bee health, infectious disease pathogenesis, antimicrobial resistance, and diagnostic pathology Collaborations: Prairie Diagnostic Services, multiple veterinary and agricultural researchers Dr. Simko’s publications span veterinary pathology, honey bee health, and equine medicine. His recent articles highlight advancements in diagnostic techniques for septic arthritis in horses and interventions to mitigate honey bee colony threats. He has no listed awards but maintains active roles in teaching and applied research.

Joonhyuk Suhمشاهده پروفایل

استادیار

• Food Science
• Analytical Chemistry
• Metabolomics
• +۵ مورد دیگر

Joonhyuk Suh is an Assistant Professor in the Department of Food Science & Technology at the University of Georgia's College of Agricultural & Environmental Sciences. His research focuses on applying analytical chemistry and metabolomics/flavoromics to enhance food flavor, quality, and safety. Research Interests : Multidisciplinary food chemistry analysis Metabolite and flavor profiling Nut and fruit quality evaluation Dairy product flavor chemistry Food safety biomarkers Recent Publication Trends (2025-2022) show expertise in: Metabolomic evaluation of agricultural products Flavor chemistry in tropical fruits and nuts Food processing safety and contaminant analysis Plant-based food characterization Microbiome and nutritional interventions

Wael M. Rabehمشاهده پروفایل

دانشیار

• Protein Structures
• Enzymology
• Structural Biology
• +۶ مورد دیگر

Dr. Wael M. Rabeh is an Associate Professor of Chemistry at New York University Abu Dhabi (NYUAD), affiliated with the Division of Science. He holds a PhD in Biochemistry from the University of Oklahoma and conducted postdoctoral research at the Structural Genomic Consortium (University of Toronto) and McGill University. His research focuses on protein structure-function relationships, particularly in disease-relevant proteins such as CFTR (cystic fibrosis transmembrane conductance regulator) and human Hexokinase 2, leveraging X-ray crystallography and biophysical techniques. Key areas include cystic fibrosis mechanisms, cancer metabolism, drug discovery, and bioluminescence. Dr. Rabeh’s work has contributed to understanding CFTR misfolding and functional correction, as well as the role of Hexokinase 2 in tumor growth. His lab collaborates internationally (e.g., with McGill University) and has secured funding from institutions like Al Jalila Foundation, Terry Fox Research Foundation, and NYUAD. He teaches courses in biochemistry and structural biology, emphasizing hands-on experimental approaches. Notable research highlights include the discovery of a dual-step correction mechanism for the ∆F508 CFTR mutation and structural studies of antiviral drugs like Tamiflu. His lab’s bioluminescence research aims to elucidate color-producing mechanisms in luciferases. Dr. Rabeh actively contributes to structural biology education through innovative laboratory curricula and public engagement.

Alisa Pieknyمشاهده پروفایل

استاد

• Cell Biology
• Cancer Research
• Drug Discovery
• +۴ مورد دیگر

Alisa Piekny, PhD, is a Professor of Biology and Associate Dean of Research and Infrastructure at Concordia University's School of Health. Her research focuses on cytoskeleton regulation during cell division, migration, and polarity, particularly in cancer cells. She employs human cell cultures, iPSCs, and collaborative drug discovery approaches to advance anti-cancer therapies and nanotechnology-based diagnostic tools. Education: PhD (University of Calgary), Post-Doc (IMP Vienna and University of Chicago). Research interests include anillin protein dynamics, microtubule-actomyosin interactions, and nanoparticle-cell interactions. Her work bridges cell biology with translational medicine, emphasizing cytokinesis mechanisms and their hijacking in cancer. Recent publications highlight innovations in drug delivery systems, fluorescent nanoparticle imaging, and molecular tools for live-cell cytokinesis analysis. Collaborations span nanotechnology, cancer biology, and developmental biology, yielding insights into cell fate regulation and therapeutic targeting. Her research has been recognized through interdisciplinary projects at the interface of biology and materials science, with a focus on practical medical applications.

Guillaume Chanfreauمشاهده پروفایل

استاد

• RNA metabolism
• RNA splicing
• RNA decay pathways
• +۵ مورد دیگر

Guillaume Chanfreau is a Professor in the Department of Chemistry and Biochemistry within the College of Letters and Science at the University of California Los Angeles (UCLA). His research focuses on fundamental mechanisms of RNA metabolism, with particular emphasis on RNA splicing, decay pathways, and ribonuclease functions. His work spans molecular biology, biochemistry, and genetics, utilizing yeast as a primary model organism to investigate conserved RNA processing mechanisms. Professor Chanfreau's research interests center on understanding how RNA processing pathways regulate gene expression. His work examines transcription termination, RNA splicing fidelity, RNA decay mechanisms, and the role of ribonucleases in cellular RNA homeostasis. He investigates how these processes are interconnected and how they respond to cellular stress conditions. His laboratory has made significant contributions to understanding how RNA quality control mechanisms prevent the accumulation of aberrant transcripts and maintain cellular health. Analysis of Chanfreau's recent publications (2020-2025) reveals a strong focus on RNA splicing mechanisms, RNA decay pathways, and ribonuclease functions. His work frequently employs yeast genetics combined with advanced RNA sequencing techniques. A notable trend is the increasing use of long-read sequencing technologies to analyze RNA isoforms and decay intermediates. His research consistently bridges fundamental molecular mechanisms with potential implications for understanding human diseases related to RNA processing defects. Professor Chanfreau has been continuously funded by the National Institutes of Health, with his current grant R35GM130370 (2019-2023) titled 'The Control of Gene Expression by Eukaryotic Ribonucleases' and previous long-term funding through R01GM061518 (2000-2019). His research program has supported numerous graduate students and postdoctoral researchers who have contributed to his extensive publication record spanning over two decades.

Olga Vitekمشاهده پروفایل

استاد

• Statistical Science
• Machine Learning
• Mass Spectrometry
• +۵ مورد دیگر

Olga Vitek is a Professor at Northeastern University's Khoury College of Computer Sciences, with affiliated faculty status in the Department of Chemistry and Chemical Biology. Her research bridges statistical science and machine learning with mass spectrometry-based proteomics and systems biology, focusing on developing open-source software tools like MSstats and Cardinal for quantitative proteomic analyses and imaging. Education: PhD in Statistics (Purdue University), Postdoc at the Ruedi Aebersold Lab (Institute for Systems Biology) Leadership: Director of the Barnett Institute for Chemical and Biological Analysis Her work emphasizes: Statistical experimental design Signal detection in complex mass spectrometry data Causal inference in biomolecular networks Reproducible computational infrastructure Recent publications highlight advancements in quantitative proteomics , mass spectrometry imaging , and causal modeling , with applications spanning cancer research, immunology, and clinical diagnostics. Notable trends include deep learning integration for image analysis and open-source tool development for scalable, transparent workflows. Scientific accolades: Elected Fellow of the American Statistical Association 2021 Gilbert S. Omenn Computational Proteomics Award NSF CAREER award Chan-Zuckerberg Essential Open-source Software award Senior Member, International Society for Computational Biology

Zhi-Ping Fengمشاهده پروفایل

پژوهشگر

• Bioinformatics
• Genomics
• Proteomics
• +۳ مورد دیگر

Dr. Zhi-Ping Feng is a Bioinformatician at the John Curtin School of Medical Research (JCSMR), Australian National University (ANU). Her research focuses on integrating omics data with protein structure-function relationships to study interactions between macromolecules. She has expertise in analyzing genomic and transcriptomic data (e.g., RNA-Seq, ChIP-Seq) and protein structure determination via nuclear magnetic resonance (NMR) spectroscopy. Previously, she held a Senior Research Fellow position at the Walter and Eliza Hall Institute (WEHI) from 2009, working on quality control in omics research and genomic data analysis. Her postdoctoral work at WEHI (2002–2005) involved structural biology of malaria-related proteins, supported by an Australian Postdoctoral Fellowship. She holds a PhD in protein bioinformatics from China and a physics background from Peking University. Education: PhD in Protein Bioinformatics (China) Bachelor’s in Physics, Peking University Research Interests: Her work bridges computational biology and structural biology, with emphasis on: Intrinsically unstructured proteins (IUPs) and their applications in malaria proteomics Omics data integration for disease modeling (e.g., cancer, diabetes, neurodegeneration) Protein-protein interaction networks and structural bioinformatics Publications: Recent work spans cancer immunotherapy, miRNA regulation in retinal degeneration, and T cell biology, with contributions to understanding Wnt signaling in joint replacement complications and genetic fusions in pediatric brain tumors. Awards: Australian Postdoctoral Fellowship (2005) Grants/Teams: Currently affiliated with ANU Bioinformatics Consultancy, supporting translational medical research in immunology, cancer, and genomics. Labs/Teams: Collaborates with the JCSMR’s multidisciplinary teams focusing on biomedical informatics and translational research.

David A. Hoodمشاهده پروفایل

استاد

• Cell Physiology
• Mitochondrial Biology
• Skeletal Muscle Physiology
• +۹ مورد دیگر

David A. Hood is a Full Professor and former Canada Research Chair in Cell Physiology (2003–2024) at York University, affiliated with the School of Kinesiology and Health Science. He is the Founding Director of the Muscle Health Research Centre (MHRC) and supervises graduate students in the Biology Graduate Program. Research Interests: His research focuses on mitochondrial biogenesis, turnover, and function in skeletal muscle. He investigates how exercise, aging, and muscle disuse affect mitochondrial health, with a particular interest in mitophagy, lysosomal function, and cellular signaling. His work spans human, animal, and cellular models, integrating physiological, biochemical, and molecular biology approaches. Recent Publication Trends: Recent publications emphasize transcriptional regulation (e.g., TFEB, TFE3, ATF4, p53), organelle crosstalk (mitochondria-lysosome interactions), and the role of exercise as 'mitochondrial medicine.' His lab explores therapeutic interventions like mitochondrial transplantation and nutrient signaling in muscle health. Scientific Awards: Canada Research Chair in Cell Physiology (2003–2024) Finalist for a prestigious national award Advising and Grants: Dr. Hood actively mentors graduate students and postdoctoral fellows. He has secured significant funding, including a $1 million CIHR grant to study mitochondria and lysosomes in muscle. His lab fosters interdisciplinary collaboration and contributes to major reviews in the field. Labs and Teams: He leads the Hood Lab at York University and co-founded the Muscle Health Research Centre (MHRC), a multidisciplinary hub promoting research on muscle function, exercise, and aging. The MHRC facilitates collaboration across departments and institutions.