جست‌وجوی استاد و پژوهشگر

Matthias Mannمشاهده پروفایل

استاد

• Mass Spectrometry
• Proteomics
• Systems Biology
• +۶ مورد دیگر

Professor Matthias Mann is a world-leading scientist serving as Director of the Proteomics and Signal Transduction department at the Max Planck Institute of Biochemistry in Martinsried, Germany, and Director of the Proteomics department at the Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Denmark. With an h-index exceeding 277 and over 350,000 citations, he is recognized as the highest cited German researcher and one of the most influential scientists globally in proteomics. His educational background includes: Ph.D. in Chemical Engineering from Yale University (1988) Master's Degree in Physics from Georg August University Göttingen (1984) Bachelor's of Arts in Mathematics from Georg August University Göttingen (1982) Professor Mann's research focuses on advancing mass spectrometry-based proteomics to understand biological systems at the protein level. His work spans technological developments in mass spectrometry, bioinformatics and computational analysis, signal transduction and posttranslational modifications, and clinical proteomics applications for disease diagnosis and treatment. The Mann lab has pioneered groundbreaking methods like SILAC for quantitative proteomics and MaxQuant for proteome data analysis. Their vision is to translate proteomics knowledge into clinical practice for predictive, diagnostic, and preventive medicine, with recent work focusing on AI-guided platforms for analyzing proteomes from minimal tissue samples. Analysis of Professor Mann's recent publications reveals a strong trend toward clinical applications of proteomics, particularly in cancer research, metabolic diseases, and neurodegenerative disorders. His work increasingly integrates spatial proteomics, single-cell resolution techniques, and artificial intelligence approaches to uncover disease mechanisms and identify potential biomarkers, with a clear shift from basic technology development toward direct clinical applications and personalized medicine. Professor Mann has received numerous prestigious awards throughout his career: 2025: Elected member of the American National Academy of Sciences 2024: Dr. H.P. Heineken Award for Biochemistry and Biophysics 2023: Otto Warburg Medal 2019: Nominated member of the Bavarian Academy of Sciences 2013: Elected member of Leopoldina German National Academy of Sciences 2012: Körber European Science Award, Louis-Jeantet Foundation Prize for Medicine, Ernst Schering Prize, and Leibniz Prize Professor Mann leads a highly collaborative research team involved in multiple international networks including the Bill & Melinda Gates Foundation, Michael J. Fox Foundation for Parkinson's Research, CLINSPECT-M, and Munich Heart Alliance. His lab has mentored numerous successful researchers, with several former postdocs receiving prestigious ERC Starting Grants. The Mann group has developed innovative clinical proteomics pipelines for analyzing archived tissue specimens and body fluids, aiming to identify protein markers for early detection of diseases such as diabetes and cancer. The Mann lab operates across two major research centers with state-of-the-art mass spectrometry facilities. Their Clinical Knowledge Graph platform integrates multi-omics data with extensive metadata, creating an ecosystem for machine learning applications in proteomics. Current research focuses on developing highly sensitive methods that can profile thousands of proteins from minimal cell samples, enabling the identification of critical disease-related proteins and supporting the development of individualized therapies.

Chang-Jun Liuمشاهده پروفایل

استاد مدعو

• Phenylpropanoid biosynthesis
• Lignin biosynthesis and modification
• Plant cell wall structure
• +۷ مورد دیگر

Chang-Jun Liu is a Senior Scientist in the Plant Science Group of the Biology Department at Brookhaven National Laboratory, where he has conducted research on plant phenylpropanoid biosynthesis and lignin metabolism since joining in 2005. He also holds an Adjunct Professor position in the Biochemistry & Cell Biology Department at Stony Brook University and serves as Associate Editor for Plant Cell & Environment (2024-present) and Frontiers in Plant Sciences (2015-present). Dr. Liu's educational background includes: Ph.D. in Plant Biochemistry and Molecular Biology from the Shanghai Institute of Plant Physiology, Chinese Academy of Science (1999) Dr. Liu's research integrates approaches from biochemistry, molecular genetics, biophysics, protein engineering, metabolic engineering, and synthetic biology to investigate phenylpropanoid and lignin biosynthesis in plants. His laboratory addresses fundamental questions about how lignin and related compounds are synthesized and incorporated into cell walls, how regulatory networks govern metabolic activity, and how lignification influences cell wall structure and function. A central aim of his research is optimizing plant feedstocks for efficient lignocellulosic biomass utilization. Analysis of Dr. Liu's publication record reveals a consistent trajectory from fundamental biochemical mechanisms to applied bioenergy solutions. His recent work focuses on cytochrome b5 diversity, electron transfer mechanisms in phenolic biosynthesis, and metabolic engineering approaches to modify lignin composition. This research spans from evolutionary studies of lignin biosynthesis across plant lineages to practical applications in bioenergy crop improvement. Dr. Liu has received recognition for his contributions to science, including: Brookhaven National Laboratory Science and Technology Award (2018) Dr. Liu serves as Editorial Board Member for the Journal of Biological Chemistry (2020-present), PNAS Nexus (2024-present), and Plant Physiology Journal (2025-). He is Scientific Lead at the Joint BioEnergy Institute, Feedstocks Division, Lawrence Berkeley National Laboratory, and Project Lead at the Center for Bioenergy Innovation, Oak Ridge National Laboratory. His research is funded by the U.S. Department of Energy through multiple Bioenergy Research Centers. Dr. Liu leads a research group at Brookhaven National Laboratory focused on elucidating the posttranslational regulation and macromolecular organization of lignin biosynthesis, with applications toward developing designer lignins and reducing biomass recalcitrance for sustainable biofuel production. His work addresses the critical challenge of lignin's dual nature: while it impedes enzymatic access to polysaccharides in biofuel production, it also represents the most abundant renewable source of aromatic carbon for high-value bioproducts.

Kathrin Langمشاهده پروفایل

استاد

• Chemical Biology
• Protein Engineering
• Genetic Code Expansion
• +۳ مورد دیگر

Kathrin Lang is a Full Professor at the Department of Chemistry and Applied Biosciences, ETH Zurich, and Head of the Organic Chemistry Laboratory. Her research focuses on chemical biology, particularly the development of tools for genetic code expansion to incorporate non-canonical amino acids into proteins and advance bioorthogonal chemistries for studying biological processes. Keywords: Genetic Code Expansion, Bioorthogonal Chemistry, Protein Engineering, Ubiquitylation Networks, Post-Translational Modifications. Lang’s work emphasizes proximity-triggered crosslinking reactions, bioorthogonal labeling, and in vivo chemistries to address challenges in protein interaction mapping and structural elucidation. Her group’s recent publications highlight methodologies for dual protein labeling, deciphering ubiquitin code, and enhancing cycloaddition reactivity. Current projects include exploring cyclopropene-fused dibenzocyclooctynes for improved labeling and investigating methylated lysine as a conformational regulator in Hsp90. Funding sources include the ERC (Ubl-tool), DFG (SFB1035, SPP1926), and ETH Zurich. She contributes to education through courses like Genetic Code Expansion for Studying Posttranslational Modifications and Chemical Biology and Synthetic Biochemistry . Collaborative efforts span structural biology, microbiology, and synthetic biochemistry, with applications in ubiquitin research and cellular imaging.

Mei Hongمشاهده پروفایل

استاد

• Solid-State NMR Spectroscopy
• Membrane Proteins
• Amyloid Proteins
• +۳ مورد دیگر

Mei Hong is the David A. Leighty Professor of Chemistry at the Massachusetts Institute of Technology (MIT), where she leads the Hong group. Her research focuses on developing and applying high-resolution solid-state NMR spectroscopy to study the structure and dynamics of biological macromolecules, particularly membrane proteins, amyloid proteins, and plant cell walls. Her work integrates advanced NMR techniques with biophysical and biochemical studies to elucidate mechanisms underlying ion transport, protein misfolding in neurodegenerative diseases, and plant cell wall architecture. Her research interests span viral ion channels (e.g., influenza M2, SARS-CoV-2 E protein), amyloid proteins (e.g., tau in Alzheimer’s disease), and plant cell wall polysaccharides. She pioneered techniques like 19F-based NMR distance measurements and multidimensional correlation NMR to study structural and dynamic heterogeneity in biomolecules. Her lab’s contributions include defining the structure of the SARS-CoV-2 envelope protein, elucidating tau fibril conformations, and revealing the single-network model of plant primary cell walls. Collaborations with medicinal chemists, electrophysiologists, and molecular dynamics experts enhance her interdisciplinary approach.

Joanna Chiuمشاهده پروفایل

استاد

• Molecular Genetics
• Animal Behavior
• Circadian and Seasonal Biology
• +۳ مورد دیگر

Joanna Chiu is a Professor and Chair in the Department of Entomology at the University of California, Davis, affiliated with the College of Agricultural and Environmental Sciences and the UC Davis Genome Center. She holds a B.A. in Biology and Music from Mount Holyoke College and a Ph.D. in Molecular Genetics from New York University. Her research focuses on molecular mechanisms underlying animal behavior, circadian rhythms, seasonal biology, and insect genomics, with applications in pest management and agricultural science. Key research interests include understanding how circadian clocks integrate environmental cues like temperature and light to regulate physiology and behavior, particularly in insects. Her work involves molecular genetics, transcriptomics, and genomic tools to study pest species such as Drosophila suzukii and Tuta absoluta, addressing challenges like pesticide resistance and invasive species control. She has developed diagnostic tools (e.g., RPA-Cas12a assays) and software (e.g., CRUMB app) for analyzing insect behavior and genetics. Recent publications highlight studies on circadian temperature compensation, seasonal adaptation in insects, and the molecular basis of pest resistance. Her lab’s collaborations span entomology, genomics, and computational biology, with implications for sustainable agriculture and chronobiology. Grants and funding support her work on pest genomics, circadian mechanisms, and translational applications in pest control. Joanna Chiu mentors students and researchers in entomology, biochemistry, and genetics through UC Davis graduate groups (ENT, BMCDB, IGG, ABGG). Her lab actively contributes to genome assembly projects for agricultural pests and explores novel strategies for integrated pest management using molecular and genetic approaches.

Ole Nørregaard Jensenمشاهده پروفایل

استاد

• Mass Spectrometry
• Proteomics
• Posttranslational Modification
• +۹ مورد دیگر

Ole Nørregaard Jensen is a Professor in Biomedical Mass Spectrometry and Systems Biology at the Department of Biochemistry and Molecular Biology, University of Southern Denmark . His research integrates advanced mass spectrometry, proteomics, and bioinformatics to study chromatin biology, post-translational modifications, and cellular signaling networks. He is actively involved in major research initiatives funded by Novo Nordisk Foundation and Lundbeck Foundation. His research interests include Mass Spectrometry, Proteomics, Posttranslational Modification, Histone Biology, Chromatin Biology, Bioinformatics, Systems Biology, Lipidomics, and Protein Chemistry . He employs cutting-edge techniques such as tandem mass spectrometry and ion mobility spectrometry to analyze protein isomers and dynamic modifications. His work has significant implications for understanding gene regulation, DNA replication, and disease mechanisms. His recent publications demonstrate a strong trend in chromatin dynamics, epigenetics, and integrated omics approaches , combining proteomics with transcriptomics and lipidomics to unravel complex biological systems. His research spans from fundamental molecular mechanisms to translational applications in biomedicine and food science. He has been recognized with several prestigious awards: MCP Lectureship Award Juan Pablo Albar Proteomics Pioneer Award 2019 EliteForsk 2009 prize Knight Order of Dannebrog (Ridder af Dannebrogordenen) Jensen is deeply involved in academic service, including peer review for journals like Nature Communications and Molecular and Cellular Proteomics , organizing conferences, and supervising students. He teaches courses such as Biomedical Mass Spectrometry - Principles and Applications and coordinates the Computational Biomedicine international Master’s program. He leads multiple active research projects, including PLATO and INTEGRA, focusing on health data, imaging, and protein networks. He is a key member of a vibrant research environment in biomedical mass spectrometry at SDU, contributing to both national and international scientific collaborations. His lab is at the forefront of developing and applying novel mass spectrometry methodologies for systems biology.

• Biophysics
• Cellular Biophysics
• Dynamic Self-Organization in Living Matter
• +۵ مورد دیگر

Matthias Weiss is a Professor of Experimental Physics at the University of Bayreuth since 2010. Previously, he held roles including BIOMS Junior Group Leader at the German Cancer Research Center (2004–2010) and postdoc positions at EMBL Heidelberg and the MEMPHYS-Center in Denmark. He studied physics at Frankfurt and Heidelberg, earning a Diploma (1997) and PhD in quantum chaos (2000). His research bridges physics and biology, focusing on dynamic self-organization in living systems. Key areas include transport processes, organelle formation, embryogenesis, and parasite-host interactions. Techniques include advanced light microscopy and computational modeling. His work spans projects like the physics of Giardia adhesion and Trypanosoma motility, funded under SPP 2332 PoP. Notable publications explore anomalous diffusion in nuclei, ER network dynamics, and microtubule roles in Trypanosoma. Collaborations involve institutions like DKFZ, EMBL, and the University of Würzburg. He leads the Experimental Physics I department at Bayreuth and advises on biophysical methodologies.

Daan van Aaltenمشاهده پروفایل

استاد

• Protein O-GlcNAcylation
• Intellectual Disability
• Structural Biology
• +۵ مورد دیگر

Daan van Aalten is a Professor at Aarhus University, affiliated with the Department of Molecular Biology and Genetics - Neurobiology within the Faculty of Natural Sciences. His research focuses on protein O-GlcNAcylation, a critical posttranslational modification linked to intellectual disability (OGT-CDG). He leads studies using model systems (mESCs, Drosophila, mice) to dissect molecular mechanisms underlying OGT-CDG phenotypes. Notable contributions include defining OGT-CDG as a congenital disorder of glycosylation and identifying therapeutic targets. He has secured major grants, including a Novo Nordisk Foundation Laureate Grant (DKK 50M) and a Villum Investigator Grant (DKK 40M), supporting work on protein modifications and fungal pathogenesis. Key research areas include enzymology, structural biology, and neurobiology. His lab explores O-GlcNAc signaling dynamics, fungal cell wall synthesis, and genetic disorders. Recent studies highlight neurodevelopmental defects in mouse models and human stem cell systems. Collaborative projects with international teams advance drug discovery for fungal pathogens and intellectual disability syndromes. Publications span molecular mechanisms of OGT mutations, enzyme inhibitors, and structural biology. Awards include recognition for his transformative work in glycobiology and neurodevelopment. His lab actively engages in training scientists and welcomes inquiries about OGT-CDG studies via ogtcdg@au.dk.

Tim Baldenspergerمشاهده پروفایل

پژوهشگر

• Biochemistry
• Neuroscience
• Cell Biology
• +۴ مورد دیگر

Tim Baldensperger is a researcher affiliated with the Faculty of Chemistry and the Institute of Biological Chemistry. His work focuses on protein modifications, oxidative stress, and neurodegenerative diseases, contributing to the understanding of post-translational mechanisms in pathological conditions. University: Not explicitly stated Department: Institute of Biological Chemistry Research interests include: Lipofuscin and age-related cellular dysfunction Oxidative stress-induced protein modifications Molecular mechanisms of protein aggregation Neurodegenerative disease pathways His recent publications (2024-2025) explore posttranslational modifications in α-synuclein aggregation, lipofuscin's role in neurodegeneration, and non-enzymatic protein alterations in disease contexts. Collaborations span neuroscience and chemical biology domains, emphasizing cross-disciplinary SDG-aligned research. Key activities include presenting at conferences on topics like: Parkinson's disease mechanisms Lysosomal dysfunction in aging cells Glycation effects on protein aggregation

Karin Sauerمشاهده پروفایل

استاد

• Biofilm Development
• Antimicrobial Resistance
• Microbiology
• +۳ مورد دیگر

Karin Sauer is a Distinguished Professor in the Department of Biological Sciences at Binghamton University. Her research focuses on understanding biofilm formation and resistance in Pseudomonas aeruginosa , with an emphasis on regulatory mechanisms and signaling pathways. She leads the Sauer Lab, part of the Biofilm Group and the Binghamton Biofilm Research Center (BBRC). Dr. Sauer holds a PhD from the Max Planck Institute for Terrestrial Microbiology and MS/BS degrees from Philipps University of Marburg. Her work addresses how biofilms develop antimicrobial resistance, particularly through posttranslational modifications and gene expression changes. Research interests include biofilm dispersion mechanisms, cyclic di-GMP signaling, and the development of strategies to combat biofilm-associated infections. Notable achievements include identifying the role of cis-2-decenoic acid in biofilm dispersion and advancing understanding of biofilm drug tolerance. Dr. Sauer has been recognized as a SUNY Distinguished Professor and a Fellow of the American Academy of Microbiology. Her lab collaborates with other research groups and has trained numerous graduate students and postdoctoral researchers. Key contributions include studies on biofilm matrix dynamics, bacterial communication, and translational approaches to biofilm eradication, such as enzyme-based therapies and surface engineering.

Casey N. Cookمشاهده پروفایل

دانشیار

• Neurodegenerative Diseases
• Alzheimer's Disease
• Tauopathy
• +۱۲ مورد دیگر

Dr. Casey N. Cook is an Associate Professor of Neuroscience at Mayo Clinic in Jacksonville, Florida, where she leads the Comparative Pathogenesis of Alzheimer's Disease and Related Disorders Laboratory. Her research is dedicated to uncovering the molecular mechanisms underlying neurodegenerative diseases, with a strong focus on tauopathies, TDP-43 proteinopathies, and white matter abnormalities. Her research interests include: Pathogenic mechanisms in tau aggregation and toxicity TDP-43 pathology in Alzheimer’s disease, frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS) Role of oligodendrocytes and myelination defects in neurodegeneration Utilization of animal and cellular models to validate findings in human tissue Dr. Cook’s recent publications reflect a strong trend in structural and molecular neuroscience, particularly in protein aggregation diseases. Her work leverages cryo-EM, transgenic models, and human biofluid/tissue analysis to identify therapeutic targets and biomarkers. She is actively involved in high-impact collaborative research across neurodegenerative disorders. Her scientific contributions are supported by multiple NIH grants, including those from the National Institute on Aging and the National Institute of Neurological Disorders and Stroke. Notable projects include: Investigating tau and ApoE4-mediated alterations in oligodendrocyte progenitor cells Impact of T cells on the CNS during aging and Alzheimer’s disease Mechanistic insights into the A152T risk variant and tauopathy Manipulating tau's posttranslational modifications to block disease progression Dr. Cook collaborates extensively with leading researchers at Mayo Clinic, including Dr. Petrucelli, Dr. Dickson, and Dr. Kang. Her laboratory is part of Mayo Clinic’s robust neuroscience research ecosystem, contributing to both discovery and translational efforts in neurodegenerative diseases.

Steven Berginkمشاهده پروفایل

دانشیار

• DNA Repair
• Protein Quality Control
• Neurodegeneration
• +۵ مورد دیگر

Steven Bergink is an Associate Professor at the University of Groningen, holding positions at both University College Groningen (Department of Mathematics and Natural Sciences) and the Medical Faculty (Department of Cell Biology). His research group focuses on the intersection of DNA repair mechanisms, protein quality control systems, and neurodegenerative processes. Dr. Bergink received his master's degree in molecular biology from the University of Groningen, followed by a PhD at ErasmusMC in Rotterdam under Jan Hoeijmakers, where he studied DNA repair regulation through ubiquitin family posttranslational modifications. He continued this research focus during his postdoctoral work at the Max Planck Institute of Biochemistry in Munich with Stefan Jentsch. DNA Damage (100%) Protein Aggregation (97%) Quality Control (95%) Ubiquitin (89%) Polyglutamine (88%) DNA Repair (84%) His recent publications demonstrate a strong focus on the relationship between DNA damage, protein homeostasis, and neurodegenerative conditions. The research spans from fundamental molecular mechanisms of protein quality control to clinical implications in conditions like glioblastoma and ataxias. His work often involves chaperone systems, DNA repair pathways, and their connections to neurological disorders. Understanding the cause of ataxia in the DNA repair deficiency syndrome Ataxia Telangiectasia: a possible link between DNA damage and proteostasis (2013) Dr. Bergink has supervised multiple research projects as indicated by the 3 supervised works documented in his profile. His research has attracted attention from both academic and public spheres, with media coverage of his work on ataxias. He maintains active collaborations across multiple institutions as evidenced by his research network.

Tracy Rosebrockمشاهده پروفایل

استادیار

• Microbiology
• Plant Pathology
• Immunology
• +۴ مورد دیگر

Tracy Rosebrock serves as Assistant Professor of Biology at Stonehill College, where she was honored with the 2022 Louise F. Hegarty Award for Excellence in Teaching. Her teaching excellence is characterized by compassionate mentorship, challenging yet supportive pedagogy, and an open-door policy that has made her a trusted advisor. Students consistently praise her ability to simplify complex biological concepts while inspiring academic excellence and fostering a positive learning environment. Professor Rosebrock's research spans two critical areas of pathogen-host interactions: tuberculosis immunology and plant-microbe dynamics. Her tuberculosis work investigates macrophage signaling pathways, antibiotic resistance mechanisms in mycobacteria, and antibody-mediated immune responses. In plant pathology, she examines ubiquitin-mediated immune regulation, bacterial effector proteins that suppress host defenses, and viral disease emergence. This dual focus demonstrates her interdisciplinary approach to understanding fundamental biological defense mechanisms across kingdoms. Her publication record from 2002-2019 reveals consistent contributions to understanding host-pathogen conflicts, with recent work emphasizing immune signaling in tuberculosis control and ubiquitin pathways in plant immunity. These research trajectories highlight her commitment to addressing both human health challenges and agricultural security through molecular investigation. Scientific Recognition: Louise F. Hegarty Award for Excellence in Teaching (2022) - Stonehill College's highest teaching honor, awarded for transformative student impact and pedagogical excellence As an academic advisor, Professor Rosebrock maintains an exceptionally supportive relationship with students, described as "a listening ear, a shoulder to cry on, and a mentor." Her teaching philosophy integrates Aristotle's principle that "educating the mind without educating the heart is no education at all," creating classrooms where students feel empowered to reach their highest potential. While specific research grants aren't detailed in available materials, her sustained publication output indicates active research programs in microbiological and plant pathological systems.

Anne Conibearمشاهده پروفایل

پژوهشگر ارشد

• Chemical Biology
• Protein Structure and Function
• Peptide Chemistry
• +۳ مورد دیگر

Dr. Anne Conibear is an Honorary Research Fellow at the School of Biomedical Sciences , University of Queensland . Her research focuses on understanding the role of post-translational modifications (PTMs) in regulating protein structure and function using chemical synthesis , NMR spectroscopy , and protein semi-synthesis techniques. PhD in Chemistry/Biochemistry, University of Queensland Postdoctoral fellowship in Vienna Current UQ Development Fellowship for independent research Her work leverages chemical biology tools to study PTMs like phosphorylation, sulfation, and palmitoylation, providing atomic-resolution insights into how cells dynamically respond to environmental cues. Recent publications highlight structural analysis of PTMs in Hsp90 , HMGN1 , and CD44 , alongside methodological advances in isotope labeling and ligation techniques . She has also contributed to venom peptide research and antimicrobial mechanisms . 2022: Australian Peptide Display Facility (ARC LIEF) 2020-2021: UQ Early Career Researcher Grant 2019-2022: CIL Research Grant 2019-2021: UQ Development Fellowship Dr. Conibear collaborates with industry partners like Syntab Therapeutics and CIL Research Program , while supervising research projects such as the 2024 Master Philosophy thesis on µ-Conotoxins . She actively participates in scientific outreach, including INDICAR cancer research initiatives .

Wei-Chen Changمشاهده پروفایل

دانشیار

• Enzymology
• Chemical Biology
• Natural Product Chemistry
• +۳ مورد دیگر

Wei-Chen Chang is an Associate Professor and the LORD Corporation Distinguished Scholar in the Department of Chemistry at NC State University. His research focuses on understanding enzymatic transformations in natural product biosynthesis, particularly those involving non-heme iron enzymes. He employs interdisciplinary methodologies including molecular biology, biochemical assays, and organic synthesis to explore reaction mechanisms and apply findings to drug discovery and chemo-enzymatic synthesis strategies. Education: Ph.D. Chemistry, University of Texas at Austin (2011) B.S. Chemistry, National Taiwan University (2003) Postdoctoral Research Fellow in Chemistry at Penn State University (2015) Research Interests: Chang’s lab investigates enzyme-catalyzed C-C and C-N bond formations, substrate selectivity in oxyfunctionalization reactions, and the mechanistic roles of iron-and 2-oxoglutarate-dependent oxygenases. Key projects include decoding the chemical logic behind unusual enzymatic reactions like isonitrile formation, cyclopropanation, and epoxidation, with a focus on their application in synthesizing therapeutically relevant molecules. Recent work highlights the discovery of novel enzymes and their roles in creating bioactive compounds such as antibiotics and anticancer agents. Recent Trends in Publications: His articles emphasize mechanistic studies of iron-dependent enzymes, particularly their ability to perform stereodivergent reactions and form non-canonical bonds. Key themes include substrate positioning effects, ferryl intermediate chemistry, and enzyme reprogramming for synthetic purposes. Contributions span diverse systems like Mycobacteria/Streptomyces biosynthesis, polyketide assembly, and lignan production, underscoring a focus on bridging enzymology with synthetic biology. Scientific Awards: 2020 ACS Academic Young Investigator Thomas Lord/LORD Corporation Distinguished Scholar Advising & Grants: Advises graduate students (e.g., Madison Davidson, Tzu-Yu Chen, Lide Cha) and postdoctoral researchers. Grants and funding support his lab’s exploration of enzyme mechanisms and applications in drug discovery. Labs & Teams: Chang leads the Chang Lab , a multidisciplinary group advancing enzymatic catalysis research. Collaborations span synthetic organic chemistry, biochemistry, and computational modeling to engineer novel enzymatic pathways and develop sustainable synthetic methods.