جست‌وجوی استاد و پژوهشگر

Gary Brennanمشاهده پروفایل

استادیار

• Epigenetics
• RNA Biology
• Epilepsy
• +۲ مورد دیگر

Dr. Gary Brennan is an Assistant Professor at the School of Biomolecular and Biomedical Science, University College Dublin, and a member of the Conway Institute. He is a Funded Investigator at the FutureNeuro Research Center and has held affiliations with institutions including the Royal College of Surgeons in Ireland (RCSI) and the University of California-Irvine. His research focuses on the molecular mechanisms of epilepsy, particularly epigenetic and epitranscriptomic regulation, RNA modifications, and neuroinflammatory pathways. Education: PhD in Physiology & Medical Physics from RCSI (2015) Postdoctoral Training: University of California-Irvine (2012-2015) under Prof. Tallie Z. Baram; RCSI (2016-2018) under Prof. David Henshall His research program addresses three critical challenges: (1) understanding molecular reprogramming after brain insults, (2) developing RNA-based therapies targeting epigenetic processes, and (3) identifying peripheral biomarkers for epilepsy prediction. Key contributions include studies on microRNA regulation of seizure networks, m6A RNA methylation in temporal lobe epilepsy, and systemic delivery of antagomirs timed with blood-brain barrier disruption. His work has been published in journals like Nature Reviews Neurology , JCI Insight , and Molecular Brain . Recent funding includes grants from Science Foundation Ireland (SFI), Health Research Board (HRB), and the European Union. He has received awards such as the CURE Taking Flight Award and Marie Curie Fellowship. Dr. Brennan also supervises PhD students and coordinates modules on CNS diseases and multicellular systems.

• Cancer Biology
• Hematopoietic Malignancies
• Extracellular Vesicles
• +۶ مورد دیگر

Margaret McGee is an Associate Professor at the School of Biomolecular and Biomedical Science , University College Dublin , with a research focus on cancer biology and extracellular vesicle signaling. Her work spans hematological malignancies, bone marrow microenvironment interactions, and mitotic regulatory mechanisms. She coordinates major modules including Genetic Basis of Disease and Regulation of Gene Expression . BSc University of Reading Dip Applied Science Dublin Institute of Technology PhD Biochemistry Trinity College Dublin Her research explores extracellular vesicle-mediated communication in cancer progression, cyclophilin A's role in mitotic exit, and preclinical biotherapeutic development. Current collaborations with Vejle Hospital Denmark and Mater Hospital Dublin investigate EV-based liquid biopsies for therapy response prediction. Notably, she co-authored the foundational MISEV2023 guidelines for extracellular vesicle research. Scientific contributions include: Wellcome Trust ISSF Mid Career Fellow (2017) Conway Institute Fellow (2007) IRCSET Fellowship (2003) She leads the EU Twinflag consortium for EV-based biomarker development in joint disorders and chairs the SBBS Research, Innovation and Impact Committee (2020-2024). Her lab has trained numerous researchers who now hold prominent positions in academia and industry.

Chad Slawsonمشاهده پروفایل

استاد

• O-GlcNAcylation
• Mitochondrial Biology
• Cancer Metabolism
• +۴ مورد دیگر

Chad Slawson is Professor in the Department of Biochemistry and Molecular Biology at the University of Kansas Medical Center . His research focuses on O-GlcNAcylation , a dynamic post-translational modification that regulates cellular processes such as nutrient sensing, stress response, and mitochondrial function. Dr. Slawson's laboratory has made significant contributions to understanding how O-GlcNAc modifies proteins in the Mitochondria Nucleus Cytoplasm to affect disease mechanisms including cancer and Alzheimer's. His work has been funded by major organizations including National Institutes of Health (NIH) Midwest Cancer Alliance Patton Trust and he maintains active professional affiliations with American Society for Biochemistry and Molecular Biology (ASBMB) American Chemical Society (ACS) Recent publication trends show Dr. Slawson's expanding impact across Neurodegenerative disease mechanisms Cancer metabolism Immunometabolism Transcriptional regulation Mitochondrial stress response Metabolic disease pathways His laboratory has developed novel CRISPR-based tools for studying O-GlcNAc regulation at genomic cis-regulatory elements, advancing epigenetic research methodologies.

• Ribosome biogenesis
• Molecular Biology
• Genetics
• +۵ مورد دیگر

Dr. Dieter Kressler is a Senior Researcher at the Department of Biology , Faculty of Science and Medicine , University of Fribourg. Holding a PhD and serving as head of the proteomics platform , his work focuses on the molecular mechanisms of eukaryotic ribosome biogenesis. Email: dieter.kressler@unifr.ch ORCID: 0000-0003-4855-3563 Contact: +41 26 300 8645 Location: PER 05 building, Fribourg Research Interests include: Dedicated chaperones for ribosomal proteins Co-translational regulation of ribosomal protein expression Ubiquitin signaling in ribosome assembly RNA helicase roles in pre-ribosomal particles Structural dynamics of ribosome maturation Stress response coupling to translational control His 15 most recent publications (2025-2016) reveal a consistent focus on ribosome biogenesis, with key articles in eLife , Nature Communications , and Nucleic Acids Research . Research spans from thermal avoidance circuits in C. elegans to ubiquitin fusion mechanisms in yeast ribosomes , integrating structural biology, genetics, and biochemical approaches.

Han-Jou Chenمشاهده پروفایل

مدرس

• Neuroscience
• Molecular Biology
• Cell Biology
• +۳ مورد دیگر

Dr. Han-Jou Chen is a Lecturer in Neuroscience at the Department of Biology, University of York. Their research investigates the molecular mechanisms underlying protein aggregation in neurodegenerative diseases such as ALS, Alzheimer’s, and Parkinson’s, with a focus on chaperone response systems and RNA-protein interactions. Current projects include exploring cell-specific responses to TDP-43 pathology and developing small molecule activators of the HSF1 pathway for therapeutic applications. Education: PhD in VAPB mutation studies (Imperial College London), MSc in Molecular Medicine (National Taiwan University), Postdoc in TDP-43 pathogenesis (King's College London) Research interests center on protein homeostasis in neuronal cells, particularly how dysregulation of the heat shock protein (HSP) network and RNA binding contributes to TDP-43 aggregation. Their work combines cellular models, CRISPR editing, and collaborations with biophysicists for drug screening. Recent publications highlight their dual focus on understanding TDP-43 pathology and developing chaperone-targeted therapies. They actively supervise PhD students through cell-based projects and maintain collaborations with European networks focused on ALS treatment. As an educator, Dr. Chen teaches advanced neuroscience and genetics courses, emphasizing critical thinking and translational research approaches. Their tutorials encourage deep exploration of neuroscience topics through paper discussions and evidence-based essay writing.

Donald F. Huntمشاهده پروفایل

استاد

• Analytical Biochemistry
• Mass Spectrometry
• Proteomics
• +۵ مورد دیگر

Donald F. Hunt is Professor of Chemistry at the University of Virginia, College of Arts and Sciences, where he leads a research program that pioneers ultra-sensitive mass spectrometry methods for protein characterization and immunopeptidomics. Research Focus: Development of nanoflow HPLC-microelectrospray ionization techniques coupled to ion-trap and Fourier-transform mass spectrometers. Structural analysis of proteins and post-translational modifications at femtomole/attomole sensitivity. Discovery of peptide antigens presented via MHC molecules on cancerous or infected cells for vaccine development. Large-scale differential proteomics to compare healthy vs diseased states, drug treatments, and secreted proteins. Identification of phosphoproteins, protein-protein and protein-DNA interactions. Recent Publications: All five 2017 papers leverage advanced mass-spectrometry workflows to dissect antigen presentation, MHC-peptide specificity, phosphorylation-dependent antigens, and high-resolution intact protein fragmentation. Laboratory & Facilities: The Hunt laboratory occupies Room 188B in the Chemistry Building at the University of Virginia, equipped with state-of-the-art ion-trap and FT-ICR mass spectrometers optimized for nano-LC-ESI-MS/MS analyses.

• Single Cell Genomics
• Transcription Factors
• Chromatin Complexes
• +۴ مورد دیگر

Xi Chen is an Assistant Professor at the Department of Biology, Southern University of Science and Technology (SUSTech), since 2019. He previously worked as a Senior Staff Scientist at the Wellcome Sanger Institute (2016–2019) and Postdoctoral Fellow at the European Bioinformatics Institute (2013–2016). His academic journey includes a PhD in Life Sciences (2009–2012) and BSc in Experimental Medicine (2005–2009) from the University of Manchester and Peking University Health Science Center respectively. Education: PhD, Life Sciences, University of Manchester (2009–2012) BSc, Experimental Medicine, Peking University Health Science Center (2005–2009) Research Interests focus on: Developing single-cell epigenetic and transcriptomic sequencing technologies Epigenetic and bioinformatic analysis of genomic data Using T cells and stem cells as models to study transcription factors and chromatin complexes in cell fate determination and memory Recent Publications highlight his work in single-cell genomics (2018–2019), with methodological advances like rapid chromatin accessibility profiling and insights into T helper cell CRISPR screens, embryonic stem cell differentiation, and innate immunity variability. His publications span high-impact journals including Cell , Nature , and Nucleic Acids Research . Labs & Collaborations: Xi Chen leads the xichenlab.com , a hub for single-cell genomics research. The lab recruits postdocs and research assistants for both computational (dry lab) and experimental (wet lab) roles, emphasizing interdisciplinary collaboration and access to SUSTech's supercomputing resources.

• Stem Cell Biology
• Respiratory Biology
• Toxicology
• +۳ مورد دیگر

Dr. Oliver Brookes is a Research Fellow at Queen Mary University of London's School of Engineering and Materials Science, supervised by Prof David Lee in Engineering Building 147. His work bridges biomedical engineering and toxicology through advanced in vitro model development. Primary research foci include: Stem Cell Biology : Biomechanical properties of embryonic stem cells and pericyte differentiation from mesenchymal stem cells Respiratory Modeling : Co-culture systems for alveolar/bronchial epithelium and nanoparticle interaction studies Nanotoxicology : Pulmonary surfactant effects on nanoparticle uptake and xenobiotic exposure mechanisms His 2017-2023 publications demonstrate evolving expertise in 3D respiratory barrier models, with increasing emphasis on repeated exposure scenarios and secretome dynamics. Key methodological trends include integration of biomechanical analysis with stem cell models and translation of co-culture systems for toxicity screening. Brookes currently leads an Innovate UK-funded project (£34,996 BBSRC ICURe Explore grant; Oct 2024-Jan 2025) focused on commercializing respiratory barrier models. He collaborates within Prof Lee's biomaterials research group and cross-institutional toxicology networks to advance preclinical testing platforms.

• Proteomics
• Mass Spectrometry
• Cancer Biology
• +۵ مورد دیگر

Dr. K.E. Stecker serves as an Assistant Professor in the Biomolecular Mass Spectrometry and Proteomics (BMSP) group within the Faculty of Science at Utrecht University. Her research focuses on applying innovative mass spectrometry approaches to understand protein regulation in cancer, with particular emphasis on tumor-immune cell interactions. Dr. Stecker's research interests span several interconnected areas of molecular and cellular biology. She investigates protein signaling in immuno-oncology, exploring how tumor cells interact with immune cells and how these interactions can be leveraged for therapeutic benefit. Her work on protein regulation in cytokine-mediated cell death provides insights into fundamental mechanisms of cell survival and death pathways. Additionally, she develops innovative mass spectrometry methods to study protein post-translational modifications, which are crucial for understanding cellular signaling networks. Her recent publications reveal a strong trajectory from plant proteomics during her PhD to cancer-focused research during her postdoc and faculty position. The work shows increasing emphasis on translational applications, particularly in immuno-oncology and breast cancer research. Her group employs advanced proteomics and phosphoproteomics techniques to study protein dynamics in cellular systems, with particular focus on microtubule regulation, DNA damage response, and tumor-immune interactions. Scientific Recognition: National Science Foundation Graduate Research Fellowship (awarded during PhD work) Dr. Stecker leads an active research group that applies cutting-edge mass spectrometry approaches to address fundamental questions in cancer biology. Her work bridges basic science and clinical applications, particularly through collaborations with clinical researchers studying treatment resistance in breast cancer. The group has developed specialized techniques for phosphoproteomics sample preparation and analysis that have been widely adopted in the field. Her laboratory focuses on understanding protein regulation in cancer, with particular expertise in studying protein signaling networks that govern tumor-immune cell interactions. The group combines biochemical, proteomic, and cell biological approaches to investigate how post-translational modifications regulate protein function in cancer contexts.

Pål Falnesمشاهده پروفایل

استاد

• Biochemistry
• Molecular Biology
• Protein Methylation
• +۵ مورد دیگر

Pål Falnes is a Professor at the University of Oslo , affiliated with the Department of Biochemistry and Molecular Biology . His research focuses on protein methylation, particularly in mitochondrial contexts and its implications for RNA/DNA repair mechanisms. Active in studying seven-β-strand (METTL) methyltransferases and their roles in lysine methylation. Investigates mitochondrial enzymatic activity , including ATP synthase and citrate synthase regulation. Research Interests : Dr. Falnes specializes in post-translational modifications , particularly lysine and histidine methylation. His work bridges protein-RNA interactions , translation dynamics , and mitochondrial metabolism , with recent studies on METTL family members like METTL13, METTL18, and FAM173B. Article Trends : Publications highlight METTL methyltransferases in human proteomics, mitochondrial respiration regulation, and DNA/RNA repair via AlkB proteins. Key themes include chronic pain mechanisms , ribosome biogenesis , and sequence-specific enzymatic methylation . Research Groups : He leads the Biological Methylation - Falnes group and contributes to the Center for Computational Inference in Evolutionary Life Science (CELS) .

R. Gary Sawersمشاهده پروفایل

استاد

• Microbial metabolism
• Anaerobic physiology
• Hydrogen and formate metabolism
• +۲ مورد دیگر

Professor R. Gary Sawers leads the Microbiology division at the Institute of Biology, Martin Luther University Halle-Wittenberg. His research spans three decades, focusing on microbial formate/hydrogen metabolism and Streptomyces physiology at the aerobic-anaerobic interface. Key contributions include elucidating glycyl radical enzyme mechanisms and nitrate respiration in actinomycetes. Research Themes: Microbial formate metabolism, hydrogen production, Streptomyces dormancy, and respiratory nitrate reductases Key Techniques: Molecular genetics, protein biochemistry, structural analysis, microbial physiology Recent Publications (2020-2025) reveal his group's work on: Formate channel (FocA) function in pH homeostasis and metabolite transport [NiFe] hydrogenase maturation and cofactor biosynthesis Streptomyces spore survival mechanisms under anaerobic stress Redox regulation of hydrogen metabolism in enterobacteria Group Members include PhD students Christopher Erdmann and Sissy Schnabel, along with postdocs Dr. Dörte Falke, Dr. Marco Fischer, Dr. Michelle Kammel, and Dr. Anne Oertel. Technical support is provided by Claudia Hammerschmidt, Antje Krippner, and Stefan Schwoch.

Alicia K. Byrdمشاهده پروفایل

استادیار

• DNA Damage Response
• Helicase Enzymes
• G-quadruplex Structures
• +۳ مورد دیگر

Alicia K. Byrd serves as an Assistant Professor in the Department of Biochemistry and Molecular Biology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. She also holds an Associate Member position at the Winthrop P. Rockefeller Cancer Institute. Her research focuses on DNA damage response mechanisms, particularly the role of helicase enzymes in maintaining genomic stability. Dr. Byrd's research interests center on DNA repair pathways and genomic instability. Her laboratory investigates how helicases resolve secondary DNA structures like G-quadruplexes, which can cause chromosomal rearrangements leading to cancer or Fragile X Syndrome. Using biophysical, biochemical, and cellular techniques—including single-molecule kinetics, proteomics, and genomics—her team examines enzyme mechanisms both individually and within multi-protein complexes, with emphasis on post-translational modifications. Her publication analysis reveals strong specialization in G-quadruplex biology and helicase function across diverse systems from bacteriophage to human enzymes. Key trends include methodological innovations in DNA unwinding assays, structural analyses of helicase-DNA interactions, and exploration of helicase roles in replication fork dynamics. The research demonstrates consistent focus on fundamental mechanisms of DNA repair enzymes with translational implications for cancer and genetic disorders. Dr. Byrd leads an active research program in the Biomedical Research Center (B408), utilizing advanced techniques to study DNA-protein interactions. Her laboratory maintains collaborative relationships across multiple institutions as evidenced by co-authorship patterns in publications.

• Neurodegeneration
• Autophagy
• Polyamine metabolism
• +۵ مورد دیگر

Rong Zhai is a Professor in the Department of Neurology at the University of Chicago. She has an active research program focused on neurodegeneration, autophagy, polyamine metabolism, and microRNA-mediated neuroprotection. Education: PhD in Neurobiology – University of Alabama at Birmingham Postdoctoral Fellowship in Neurogenetics – Baylor College of Medicine Research Interests: Dr. Zhai’s work centers on understanding molecular mechanisms underlying neurodegenerative diseases using Drosophila models. Her research spans autophagy regulation, polyamine biosynthesis, microRNA-mediated post-transcriptional control, and NAD+ metabolism. She has made significant contributions to understanding how metabolic imbalances and protein aggregation contribute to diseases such as Alzheimer’s, Huntington’s, and rare genetic neuropathies. Scientific Impact: Her recent publications demonstrate a strong focus on translational neuroscience, particularly in developing therapeutic strategies for rare genetic disorders like Snyder-Robinson syndrome and hereditary neuropathies. She has consistently published in high-impact journals such as Nature Genetics , PNAS , Cell Death & Disease , and EMBO Molecular Medicine . Funding: Dr. Zhai has been continuously funded by the NIH since 2008, holding multiple R01, R21, R33, and RF1 grants as Principal Investigator. Her current projects focus on polyamine imbalance in neurotoxicity and microRNA regulation of neuroprotective pathways.

HASSAN Bassemمشاهده پروفایل

استاد پژوهشی

• Neuroscience
• Developmental Genetics
• Neurogenesis
• +۵ مورد دیگر

Dr. HASSAN Bassem is a Research Professor and Principal Investigator leading the Brain Development team at Inserm, affiliated with the Paris Brain Institute (Institut du Cerveau). He holds a PhD in Molecular Genetics from Ohio State University (1996) and a Bachelor of Science in Biology from the American University of Beirut (1989). His research explores how genomic networks instruct neural development, bridging cell fate specification and neuronal wiring using Drosophila models. Research Focus His work addresses: 1) Gene regulation in neural cell development, 2) Mechanisms of brain wiring specificity/robustness, 3) Roles of disease-associated genes (e.g., FMRP) in axon growth, and 4) Development of computational/genetic tools for neural mapping. Key themes include neurogenesis plasticity, behavioral individuality origins, and tumor suppression links. Publication Trends Recent articles (2013–2020) emphasize Drosophila -based studies of neural circuitry, behavioral genetics, and molecular regulators of neurodevelopment. Methodological innovations in conditional mutagenesis and temporal control of gene activity are recurring highlights. Leadership He directs the BrainDev team, focusing on interdisciplinary approaches to decode brain self-organization. The lab prioritizes tool development for genetic/neuronal network analysis.

Judy Davieمشاهده پروفایل

دانشیار

• Gene Regulatory Mechanisms
• Cytokine Signaling Pathways
• Myogenesis
• +۷ مورد دیگر

Judy Davie is an Associate Professor at Southern Illinois University Carbondale in the Department of Biochemistry and Molecular Biology. Her research focuses on gene regulation during skeletal muscle development, cytokine signaling, and epigenetic mechanisms in rhabdomyosarcoma. PhD in Molecular Biology (University of California, Berkeley, 1998) Postdoctoral Fellowship (MD Anderson Cancer Center) Research Highlights : Dr. Davie's lab investigates the role of myogenic regulatory factors (MRFs) like myogenin in muscle cell differentiation. Key work explores how CIITA and IFN-γ signaling disrupt myogenesis and contribute to muscle repair and diseases such as muscular dystrophy. Her team also studies epigenetic silencing in rhabdomyosarcoma, identifying therapeutic targets for pediatric cancer. Publication Trends : Her recent work spans gene regulatory networks, cytokine signaling, epigenetic modifications, and transcriptional defects in cancer. Themes connect muscle biology, transcriptional machinery, and immune-related gene expression. Scientific Awards : American Cancer Society Postdoctoral Fellowship Contact : Email: jdavie@siumed.edu Phone: (618) 453-5002