جست‌وجوی استاد و پژوهشگر

Matthias Mannمشاهده پروفایل

استاد

• Mass Spectrometry
• Proteomics
• Systems Biology
• +۶ مورد دیگر

Professor Matthias Mann is a world-leading scientist serving as Director of the Proteomics and Signal Transduction department at the Max Planck Institute of Biochemistry in Martinsried, Germany, and Director of the Proteomics department at the Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Denmark. With an h-index exceeding 277 and over 350,000 citations, he is recognized as the highest cited German researcher and one of the most influential scientists globally in proteomics. His educational background includes: Ph.D. in Chemical Engineering from Yale University (1988) Master's Degree in Physics from Georg August University Göttingen (1984) Bachelor's of Arts in Mathematics from Georg August University Göttingen (1982) Professor Mann's research focuses on advancing mass spectrometry-based proteomics to understand biological systems at the protein level. His work spans technological developments in mass spectrometry, bioinformatics and computational analysis, signal transduction and posttranslational modifications, and clinical proteomics applications for disease diagnosis and treatment. The Mann lab has pioneered groundbreaking methods like SILAC for quantitative proteomics and MaxQuant for proteome data analysis. Their vision is to translate proteomics knowledge into clinical practice for predictive, diagnostic, and preventive medicine, with recent work focusing on AI-guided platforms for analyzing proteomes from minimal tissue samples. Analysis of Professor Mann's recent publications reveals a strong trend toward clinical applications of proteomics, particularly in cancer research, metabolic diseases, and neurodegenerative disorders. His work increasingly integrates spatial proteomics, single-cell resolution techniques, and artificial intelligence approaches to uncover disease mechanisms and identify potential biomarkers, with a clear shift from basic technology development toward direct clinical applications and personalized medicine. Professor Mann has received numerous prestigious awards throughout his career: 2025: Elected member of the American National Academy of Sciences 2024: Dr. H.P. Heineken Award for Biochemistry and Biophysics 2023: Otto Warburg Medal 2019: Nominated member of the Bavarian Academy of Sciences 2013: Elected member of Leopoldina German National Academy of Sciences 2012: Körber European Science Award, Louis-Jeantet Foundation Prize for Medicine, Ernst Schering Prize, and Leibniz Prize Professor Mann leads a highly collaborative research team involved in multiple international networks including the Bill & Melinda Gates Foundation, Michael J. Fox Foundation for Parkinson's Research, CLINSPECT-M, and Munich Heart Alliance. His lab has mentored numerous successful researchers, with several former postdocs receiving prestigious ERC Starting Grants. The Mann group has developed innovative clinical proteomics pipelines for analyzing archived tissue specimens and body fluids, aiming to identify protein markers for early detection of diseases such as diabetes and cancer. The Mann lab operates across two major research centers with state-of-the-art mass spectrometry facilities. Their Clinical Knowledge Graph platform integrates multi-omics data with extensive metadata, creating an ecosystem for machine learning applications in proteomics. Current research focuses on developing highly sensitive methods that can profile thousands of proteins from minimal cell samples, enabling the identification of critical disease-related proteins and supporting the development of individualized therapies.

Rotem Karniمشاهده پروفایل

دانشیار

• Alternative RNA Splicing
• RNA Biology
• Cancer Therapy
• +۴ مورد دیگر

Rotem Karni, PhD, is an Associate Professor of Genetics at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He leads a research lab focused on understanding how alternative RNA splicing contributes to cancer and genetic diseases, with a strong emphasis on translating these findings into RNA-based therapies. Karni's lab develops decoy oligonucleotides, small molecules, and splice-switching technologies to modulate splicing factors and enhance immunotherapy. Education BSc in Biological Chemistry from The Hebrew University of Jerusalem (1997) PhD in Biological Chemistry from The Hebrew University of Jerusalem, Israel (2002) Postdoctoral Fellowship at Cold Spring Harbor Laboratory, NY (2002-2007) Karni's research explores the deregulation of alternative splicing in oncogenesis, particularly how splicing factors like RBFOX2 and S6K1 influence metastasis, DNA repair, and immune checkpoint modulation. His team investigates m6A RNA modifications for stabilizing mutant genes, with applications in Duchenne Muscular Dystrophy and pancreatic cancer. The lab's work is commercialized through biotech companies: SKIP Therapeutics, Andlit Therapeutics, and RNAble. Selected Research Trends RNA mis-splicing and neoantigen generation (2025) Splicing factor inhibition for tumor suppression (2023) Metastatic splicing signatures in pancreatic cancer (2023) Immune checkpoint splicing in cancer immunotherapy (2021) m6A modulation for mRNA stabilization (2023) Advising & Collaborations Karni has mentored numerous PhD and postdoctoral researchers, many of whom now hold leadership roles in academia, biotech, and medical institutions globally. His lab collaborates extensively on projects involving RNA innovation, including partnerships with the Institute for RNA Innovation. Contact Department of Genetics & Institute for RNA Innovation, One uCity Square, Room 4018, Philadelphia, PA 19104 Phone: 215-898-5072 Email: Rotem.Karni@Upenn.edu

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

Ron Drorمشاهده پروفایل

استاد

• Computational Biology
• Machine Learning
• Molecular Dynamics Simulation
• +۶ مورد دیگر

Ron Dror is the Cheriton Family Professor of Computer Science at the Stanford Artificial Intelligence Lab , with courtesy appointments in Structural Biology and Molecular & Cellular Physiology . He also holds affiliations with Bio-X, the Institute for Human-Centered Artificial Intelligence (HAI), the Institute for Computational and Mathematical Engineering (ICME), Sarafan ChEM-H, and the Wu Tsai Neurosciences Institute. Education: PhD in Electrical Engineering and Computer Science, MIT MPhil in Biological Sciences, University of Cambridge (Churchill Scholar) BS in Mathematics and Electrical & Computer Engineering, Rice University (summa cum laude) Ron leads a multidisciplinary research group that combines molecular simulation and machine learning to study biomolecular structure, dynamics, and function. His work focuses on developing computational methods to accelerate drug discovery by predicting molecular interactions and designing more effective therapeutics. Current projects include the PENSA software library for analyzing biomolecular ensembles and FRAME framework for structure-based ligand design. His research has produced groundbreaking work on G-protein-coupled receptors (GPCRs) , RNA structure prediction , and mitochondrial transport mechanisms . Key publications highlight applications of geometric deep learning and molecular dynamics simulations in structural biology. Scientific Awards: Cheriton Family Professorship (2023) Two Gordon Bell Prizes (2014, 2009) Best Paper Awards at NeurIPS (2021), IPDPS (2013), SC11 (2011), SC09 (2009), SC06 (2006) Science Magazine Top 10 Breakthrough (2010) Fulbright Scholarship , NSF Fellowship , DoD Fellowship , Whitaker Foundation Fellowship Ron has advised numerous doctoral and master’s students including EJ Fine , Masha Karelina , and Briana Sobecks . His lab collaborates with experimentalists across academia and industry, applying computational methods to diverse biomedical problems such as RNA structure prediction , GPCR signaling , and mitochondrial metabolism .

• Biochemistry
• Protein Chemistry
• Post-translational Modifications
• +۵ مورد دیگر

Christian Friedrich Wilhelm Becker is a full Professor at the University of Vienna, holding a position within the Faculty of Chemistry and the Department of Biological Chemistry. His research profile shows extensive activity in protein chemistry and biochemistry, with particular focus on post-translational modifications and their implications in disease mechanisms. His work bridges chemical biology, biochemistry, and biomedical applications, contributing significantly to the academic and research landscape at one of Europe's oldest and most prestigious universities. Faculty of Chemistry, University of Vienna Department of Biological Chemistry Active research leader with numerous ongoing projects Significant publication record spanning multiple disciplines Professor Becker's research primarily focuses on protein chemistry, particularly post-translational modifications and their role in protein function and dysfunction. His work spans multiple interconnected areas including ubiquitination, protein aggregation, prion protein behavior, and biomimetic approaches to protein analysis. His research has significant implications for understanding neurodegenerative diseases and developing novel therapeutic approaches. The fingerprint analysis of his work shows strong connections to biochemistry, molecular biology, and chemistry, with particular emphasis on cysteine chemistry, glycosylation, and amino acid modifications. Analysis of Professor Becker's recent publications (2021-2025) reveals a consistent research trajectory focused on protein modification techniques and their biological implications. His work shows increasing sophistication in chemical biology approaches to study protein function, with particular emphasis on ubiquitination pathways and protein aggregation mechanisms. The integration of chemical synthesis methods with biological analysis represents a hallmark of his research approach. His publications span high-impact journals in biochemistry, chemical biology, and peptide science, demonstrating the interdisciplinary nature of his contributions. Professor Becker has received notable recognition for his research contributions, most prominently the Cathay Award in 2020. This award acknowledges his significant contributions to the field of protein chemistry and chemical biology. His work appears to have practical applications in therapeutic development, particularly in the areas of targeted protein degradation and immunotherapy, which likely contributed to this recognition. Cathay Award (2020) Professor Becker leads multiple significant research projects, including 'Targeted protein degradation - from small molecules to complex organelles' (2020-2024), 'Taktira: Development of an improved, low-side-effect and sustainable immunotherapy' (2019-2023), and 'Structure Zoom: Zooming in on protein functional sites with atomic resolution' (2018-2021). These projects demonstrate substantial grant funding and collaborative research efforts across multiple institutions. His active participation in 290 recorded activities through 2025 indicates a highly engaged research program with numerous collaborators and trainees. Targeted protein degradation project (2020-2024) Taktira immunotherapy project (2019-2023) Structure Zoom project (2018-2021) Professor Becker's research environment includes a robust team of collaborators and junior researchers, as evidenced by the numerous co-authored publications and activities. His work intersects with multiple research groups studying protein function, modification, and therapeutic applications. The international collaboration network shown in his profile indicates significant engagement with researchers across multiple countries, creating a dynamic research ecosystem focused on advancing protein science and its biomedical applications.

Masato Katoمشاهده پروفایل

استاد

• Protein Phase Separation
• Low-Complexity Domains
• RNA Granule Biogenesis
• +۳ مورد دیگر

Masato Kato serves as Professor in the Department of Biochemistry at the University of Texas Southwestern Medical Center since 2020 and concurrently as Team Leader at Japan's National Institutes for Quantum and Radiological Science and Technology. His academic trajectory includes progressive appointments from Assistant Professor (2004-2014) to Associate Professor (2014-2020) at UT Southwestern, with prior postdoctoral training at Harvard Medical School and Nara Institute of Science and Technology. 2020-present: Professor, Department of Biochemistry, UT Southwestern 2020-present: Team Leader, National Institutes for Quantum and Radiological Science and Technology, Japan 2014-2020: Associate Professor, Department of Biochemistry, UT Southwestern 2010-2014: Assistant Professor, Department of Biochemistry and Internal Medicine, UT Southwestern 2004-2010: Assistant Professor, Department of Internal Medicine, UT Southwestern 1999-2004: Postdoctoral Fellow, Ellenberger Lab, Harvard Medical School 1998-1999: Postdoctoral Fellow, Hakoshima Lab, Nara Institute of Science and Technology Dr. Kato's research pioneers the biophysical characterization of protein phase separation, particularly focusing on low-complexity domains (LCDs) in neurodegenerative disease contexts. His work establishes fundamental mechanisms of biomolecular condensate formation, including hydrogel polymerization, liquid-solid transitions, and mutation-induced dysregulation in ALS/FTD. Key contributions demonstrate how C9orf72-encoded poly-dipeptides disrupt nucleocytoplasmic transport and how redox states regulate Ataxin-2 phase behavior, bridging structural biochemistry with pathological mechanisms. Analysis of his 22 publications reveals a cohesive research program centered on LCD-driven phase transitions. The most recent 15 articles (2012-2019) systematically investigate pathological aggregation in neurodegeneration, structural basis of condensate formation, and regulatory mechanisms like phosphorylation and oxidation. This body of work establishes LCDs as central players in both physiological RNA granule assembly and disease-associated solidification, with strong emphasis on C9orf72-related ALS/FTD mechanisms. Dr. Kato maintains active leadership within the McKnight Laboratory at UT Southwestern, where his team employs integrated approaches spanning structural biology, cell biology, and biophysics to dissect phase separation mechanisms. His collaborative network includes prominent neuroscience and biochemistry groups, with co-authorship on key studies in Cell, Science, and PNAS.

Silvia Santosمشاهده پروفایل

پژوهشگر

• Developmental Biology
• Cell Biology
• Cell Cycle & Chromosomes
• +۳ مورد دیگر

Silvia Santos is a Group Leader at the Francis Crick Institute, leading the Quantitative Stem Cell Biology Lab since January 2018. Her research focuses on understanding cell decision-making during transitions, specifically cell division and differentiation in early development using human embryonic stem cells. She combines experimental techniques with theoretical approaches, including advanced microscopy, genomics, and computational modeling. Education and Career: PhD in Molecular and Cell Biology from EMBL-Heidelberg (2008), followed by postdoctoral training at Stanford University (2009-2014). She held an MRC Career Development Award at Imperial College London (2014-2017) before joining the Crick. Her work emphasizes interdisciplinary methods to study cellular processes in health and disease. Research Interests: Spatial-temporal control in cell decisions, stem cell differentiation, cell cycle regulation, and modeling embryonic development. She advocates for women in science and mentorship programs for early-career researchers. Key Achievements: Recipient of Marie Curie E-Star, EMBO, and HFSP fellowships. Recognized with the BioModels’ Model of the Year 2023 for contributions to systems biology. Her lab develops models like gastruloids to study embryonic development. Grants and Mentorship: Supported by MRC and other grants. Committed to fostering excellence in training and mentorship, previously chairing mentorship initiatives at Imperial College London. Labs and Teams: Quantitative Stem Cell Biology Lab at the Crick, collaborating with interdisciplinary teams on projects involving proteomics, genomics, and high-throughput screening.

Jacques Archambaultمشاهده پروفایل

استاد

• Human Papillomavirus (HPV)
• Polyomavirus
• Viral DNA Replication
• +۴ مورد دیگر

Dr. Jacques Archambault is a Professor in the Department of Microbiology and Immunology at McGill University , and an associate member of the Division of Experimental Medicine since 2016. His research focuses on the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), with an emphasis on their replication mechanisms as episomes in host cells. The Archambault laboratory employs functional genomics, proteomics, and chemical biology approaches to identify cellular pathways exploited by these viruses and develop high-throughput assays for screening small molecule inhibitors of viral replication. Analysis of his recent publications reveals a strong focus on HPV and HPyV replication machinery, including studies on the E1 helicase, UAF1-USP1 interactions, and structural characterization of viral proteins involved in DNA replication. His work bridges virology, oncology, and drug discovery, particularly targeting oncogenic HPV types implicated in anogenital and oropharyngeal cancers, as well as HPyVs like BKPyV and JCPyV that cause pathologies in immunosuppressed patients. Current efforts in the lab aim to elucidate the molecular mechanisms by which HPVs and HPyVs replicate their genomes and to develop antiviral therapies targeting these processes. Techniques such as fluorescence anisotropy, NMR spectroscopy, and crystallography are frequently employed to study protein-DNA and protein-protein interactions critical to viral replication.

Cathy Wuمشاهده پروفایل

استاد

• Computational Biology
• Bioinformatics
• Data Science
• +۸ مورد دیگر

Cathy Wu is a distinguished academic holding the Unidel Edward G. Jefferson Chair in Engineering and Computer Science at the University of Delaware. She serves as Director of the Center for Bioinformatics & Computational Biology (CBCB), Data Science Institute (DSI), and Protein Information Resource (PIR). Her roles include professorships in the Departments of Computer & Information Sciences and Biological Sciences. Education: BS in Plant Pathology (National Taiwan University, 1978), MS and PhD in Plant Pathology (Purdue University, 1982–1984), and a second MS in Computer Science (University of Texas at Tyler, 1989). She completed postdoctoral training in Molecular Biology at Michigan State University (1985–1986). Research interests focus on computational biology, bioinformatics, and data science with emphasis on protein informatics, biological text mining, ontology development, gene-disease-drug networks, and machine learning applications. She leads initiatives in integrating FAIR principles into biological databases like UniProt and InterPro. Her work bridges computational methods with biomedical challenges, including cancer genomics, epigenetic regulation, and proteomic analyses. She has spearheaded educational programs such as the Online Graduate Certificates in Applied Bioinformatics and Biomedical Informatics and Data Science. Her contributions include over 290 peer-reviewed publications (48,000+ citations, h-index 71) and authored/co-authored four books on bioinformatics. She directs multidisciplinary research teams and collaborates internationally on projects like the HALO study on ovarian cancer genetics. Awards and recognition are implied through her leadership roles and academic appointments, though specific prizes are not listed here. Her grants and funding support large-scale initiatives in bioinformatics infrastructure and translational research.

Arthur Leskمشاهده پروفایل

استاد

• Bioinformatics
• Genomics
• Protein Structure
• +۳ مورد دیگر

Arthur Lesk is a Professor of Biochemistry and Molecular Biology at Pennsylvania State University since 2003. Previously, he held roles including faculty member at the clinical school of the University of Cambridge (1990–2003), group leader at the European Molecular Biology Laboratory (1987–1990), and professor of chemistry at Fairleigh Dickinson University (1971–1987). He earned a B.A. from Harvard University (1961), Ph.D. from Princeton University (1966), and M.Sc. from the University of Cambridge (1999). His research focuses on bioinformatics, genomics, protein structure, and molecular biology. He has authored 189 scientific articles, 10 books, and has an h-index of 61. Notable works include Protein Science (2021) and Introduction to Bioinformatics (2019). Lesk chairs CODATA’s Biological Macromolecules Task Group and is a Fellow of the AAAS and Royal Society of Biology. He maintains active teaching and research roles, delivering lectures globally. His contributions include advancing protein structure databases and computational methods for molecular biology. Lesk is a Life Member of Clare Hall, Cambridge, and has held visiting positions at universities in New Zealand, Australia, and Europe.

James Shorterمشاهده پروفایل

استاد

• Protein Folding and Proteostasis
• Neurodegenerative Diseases
• Prion and Amyloid Biology
• +۷ مورد دیگر

James Shorter is a Professor of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania. He is affiliated with multiple prestigious institutes, including the Institute on Aging (IOA), the Institute for Translational Medicine and Therapeutics (ITMAT), the Penn Center for AIDS Research (CFAR), the Chemistry-Biology Interface (CBI), and the Penn Institute for RNA Innovation. He mentors several training programs such as the Penn Summer Undergraduate Internship Program (SUIP), PennPREP, and the Translational Research Immersion Program (TRIP), and serves as a Primary Trainer at the Center for Neurodegenerative Research (CNDR). Ph.D. in Cell Biology, University of London, 2000 M.A. in Biology, University of Oxford, 1995 Dr. Shorter’s research focuses on protein homeostasis, particularly the mechanisms of protein disaggregation and the role of prion-like domains in neurodegenerative diseases such as ALS, Alzheimer’s, Parkinson’s, and frontotemporal lobar degeneration. His lab investigates the Hsp104 disaggregase from yeast and has engineered variants to combat human proteinopathies. They also identified the mammalian disaggregase system (Hsp110/Hsp70/Hsp40) and explore how small molecules and nuclear import receptors can reverse pathological phase transitions of RNA-binding proteins like TDP-43 and FUS. His work bridges structural biology, genetics, and translational neuroscience. His recent publications highlight trends in targeting TDP-43 and FUS proteinopathies, engineering Hsp104 for selective detoxification, understanding mitochondrial disaggregases like Skd3, and modulating phase transitions with nuclear import receptors. His research spans from fundamental mechanisms of protein folding to therapeutic development for neurodegenerative diseases. Faculty Member, Institute on Aging (IOA) Faculty Member, Institute for Translational Medicine and Therapeutics (ITMAT) Mentor, Penn Summer Undergraduate Internship Program (SUIP) Primary Trainer, Center for Neurodegenerative Research (CNDR) Faculty Member, Penn Center for AIDS Research (CFAR) Member, Penn Institute for RNA Innovation Mentor, Translational Research Immersion Program (TRIP) Dr. Shorter advises numerous graduate students and postdoctoral researchers through the Biochemistry and Molecular Biophysics, Pharmacology, Neuroscience, and Cell and Molecular Biology graduate groups. His lab receives funding from NIH and other sources to support research on protein disaggregation, phase separation, and neurodegenerative disease mechanisms. He has trained many scientists now active in academia and biotech. His lab, located in Stellar-Chance Laboratories, operates at the intersection of biochemistry, cell biology, and translational medicine, with active projects on Hsp104 engineering, mitochondrial proteostasis, and the role of RNA-binding proteins in disease. The lab collaborates widely across Penn and with international partners to advance understanding and treatment of protein misfolding disorders.

Julia Kamenzمشاهده پروفایل

استادیار

• Cell cycle regulation
• Cell division
• Biochemistry
• +۷ مورد دیگر

Dr. Julia Kamenz is an Assistant Professor (Rosalind Franklin fellow) at the University of Groningen's Faculty of Science and Engineering, where she leads research in the Molecular Systems Biology group within the Groningen Biomolecular Sciences and Biotechnology Institute (GBB). Her work focuses on understanding the molecular mechanisms that regulate cell cycle progression and cell division. Dr. Kamenz received her undergraduate training in Biochemistry at the University of Tuebingen, completed her PhD at the Friedrich Miescher Laboratory of the Max Planck Society under Dr. Silke Hauf (defended February 2015 with highest honors), and conducted postdoctoral research at Stanford University with Prof. James E. Ferrell. Her PhD work was supported by a Boehringer Ingelheim Fonds fellowship, and her postdoc was funded by a German Research Foundation (DFG) Postdoctoral Fellowship. Her research expertise spans cell cycle regulation and dynamics, post-translational modifications, Xenopus laevis model systems, and live cell microscopy. Dr. Kamenz investigates how kinases and phosphatases intricately regulate cell proliferation and division, with particular interest in the molecular mechanisms that ensure faithful chromosome segregation during mitosis. Her recent work has revealed novel insights into mitotic checkpoint signaling, particularly in early embryonic development where these checkpoints appear to function differently than in somatic cells. Dr. Kamenz's publication record demonstrates a strong focus on the dynamics of cell cycle transitions, with recent papers appearing in high-impact journals including Nature, The Journal of Biological Chemistry, and The Journal of Cell Biology. Her research integrates experimental biochemistry, live-cell imaging, and computational modeling approaches to understand complex regulatory networks. ERC Starting Grant (November 2022) NWO Vidi Grant (July 2021) Mansour Postdoctoral Travel Award (2019) Dr. Kamenz has secured significant research funding including an ERC Starting Grant (€1.5 million) and an NWO XS grant (€50,000) for her project "What limits mitotic checkpoint signaling in the early embryo?" Her research contributes to understanding fundamental biological processes with implications for developmental biology and cancer research. She collaborates extensively within the University of Groningen and with international partners, particularly in the areas of cell cycle research and biophysical approaches to biological problems. Dr. Kamenz leads a research group focused on cell cycle regulation within the Molecular Systems Biology division of the Groningen Biomolecular Sciences and Biotechnology Institute. Her lab combines biochemical approaches using Xenopus egg extracts with live-cell imaging and computational modeling to dissect the molecular mechanisms controlling cell division.

Shawn Gomezمشاهده پروفایل

استاد

• Systems Biology
• Network Pharmacology
• Translational AI
• +۷ مورد دیگر

Dr. Shawn Gomez is a Professor in the Lampe Joint Department of Biomedical Engineering at UNC-Chapel Hill and North Carolina State University and in the Department of Pharmacology at UNC-Chapel Hill. He serves as the Executive Director of FastTraCS, a component of the NC TraCS Institute funded through the NIH CTSA Program, and is a UNC Lineberger Comprehensive Cancer Center member. His educational background includes a PhD in Biomedical Engineering from Columbia University (1999), an MS in Aerospace Engineering Sciences from the University of Colorado, Boulder (1993), and a BS in Aerospace Engineering Sciences from the same institution (1990). He completed postdoctoral training in Bioinformatics and Computational Biology at the Judith P. Sulzberger Columbia Genome Center and Institut Pasteur in Paris. Dr. Gomez's research spans systems biology , network pharmacology , and translational AI , with a focus on understanding cell signaling architecture in human disease. His lab develops computational approaches for network pharmacology and targeted cancer therapies, along with machine learning methodologies to address clinical needs and enhance clinical decision making. The research integrates computational modeling with experimental approaches to improve diagnostic and therapeutic interventions. His recent publications reveal a strong focus on kinome research, particularly in pancreatic cancer and understudied kinases, with increasing integration of machine learning techniques for predicting clinical outcomes and kinase-substrate relationships. The work spans from fundamental systems biology to translational applications in cancer therapeutics and surgical outcomes prediction. Scientific Awards: Leadership Advanced Program, UNC-Chapel Hill 2017 Chancellor's Entrepreneurship Boot Camp 2015 ACCLAIM Scholar (Academic Career Leadership Academy in Medicine) 2013-2014 UNC Research Council Award 2011 Carl Storm URM Fellowship 2008 UNC Junior Faculty Development Award 2006 Florence Gould Scholar 2005 Pasteur Foundation Fellow 2002-2005 Dr. Gomez directs the Gomez Lab, which focuses on systems biology, network pharmacology, and translational AI. The lab maintains several key resources including Darkkinome.org, FAAS, and IAS servers for kinome research. His work bridges computational biology with clinical applications, particularly in cancer therapeutics and surgical outcomes prediction through machine learning approaches.

Forest M. Whiteمشاهده پروفایل

استاد

• Metastasis
• Precision Medicine
• Immunology & Immunotherapy
• +۷ مورد دیگر

Professor Forest M. White is a faculty member at MIT's Department of Biological Engineering , where he holds the Ned C. and Janet Bemis Rice Professorship . He is affiliated with the Koch Institute for Integrative Cancer Research and the MIT Center for Precision Cancer Medicine . His research focuses on systems biology and computational modeling of signaling networks in cancer, particularly at the tumor-immune interface . Education: B.S. in Chemistry (Framingham State College, 1993), Ph.D. in Analytical Chemistry (Florida State University, 1997) Professional Journey: Postdoc at University of Virginia, Research Scientist at MDS Proteomics, Assistant Professor at MIT (2003), Mitsui Career Development Professor (2005-2008) White employs high-resolution mass spectrometry to analyze protein phosphorylation and antigen presentation in cancer models, complementing genomic/transcriptomic approaches. His lab has identified chronic stress response enzymes linking high-fat diets to metabolic dysfunction and discovered resistance mechanisms in cancer therapies through phosphoproteomics . Scientific Awards: Mitsui Career Development Professorship (2005-2008) Ruth and Joel Spira Award for Excellence in Teaching (2010) Fellowship from the Ludwig Center at MIT The White Lab actively recruits trainees (undergraduates, graduates, postdocs) through programs like MSRP , CSB , and HST . His work is supported by grants from Break Through Cancer and Ludwig Center , with collaborations spanning Cima Lab , Swanson Biotechnology Center , and MIT Koch Institute .

Mehmet Koyutürkمشاهده پروفایل

استاد

• Systems Biology
• Computational Genomics
• Network Biology
• +۴ مورد دیگر

Mehmet Koyutürk serves as the Andrew R. Jennings Professor in the Department of Computer and Data Sciences at Case Western Reserve University's Case School of Engineering, with additional affiliation as a Member of the Cancer Genomics and Epigenomics Program at the Case Comprehensive Cancer Center. His computational research bridges algorithm development with biological applications, focusing on network-structured data analysis to address complex biomedical challenges. Dr. Koyutürk earned his Ph.D. in Computer Science from Purdue University following B.S. and M.S. degrees in Electrical Engineering and Computer Engineering from Bilkent University. His primary research domains include high-throughput biological data analysis, systems/network biology methodologies, data mining algorithms, and scientific computing optimization, with particular emphasis on phosphorylation networks, genomic interactions, and multi-omics integration. Recent publication trends reveal expanding applications of his network science expertise into Alzheimer's disease phosphoproteomics, bipolar disorder biomarker discovery, and intimate partner violence analysis, while maintaining core contributions to graph neural networks and biological link prediction. His group actively develops open-source analytical tools like RokaiXplorer for phospho-proteomic data accessibility. Scientific Recognition Andrew R. Jennings Professorship Dr. Koyutürk leads multiple NIH-funded initiatives including R01-LM012980 for phosphoproteomics analysis, U01-CA198941 (BD2K program) for big network integration, and R01-LM011247 for GWAS enhancement, complemented by NSF CAREER Award CCF-0953195. He serves on the steering committee for CWRU's Systems Biology and Bioinformatics graduate programs and as Associate Editor for IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), with extensive collaboration through Mark Chance's Center for Proteomics and Bioinformatics. His laboratory specializes in developing scalable algorithms for biological network analysis, currently advancing projects on kinase-substrate association prediction, co-phosphorylation network characterization in cancer, and network-based approaches to intimate partner violence data mining, with strong emphasis on translating computational methods into biomedical insights through open-source software dissemination.