جست‌وجوی استاد و پژوهشگر

• Autophagy
• Mitophagy
• Retinal Degeneration
• +۷ مورد دیگر

Patricia Boya is a Full Professor in the Department of Medicine at the University of Fribourg, within the Faculty of Mathematics, Natural Sciences and Medicine. She is a leading researcher in autophagy, mitophagy, and lysosomal biology, with a focus on retinal and neurodegenerative diseases. Her research interests center on the molecular mechanisms of autophagy and mitophagy, particularly their roles in retinal health, aging, neurodegeneration, and cell death. She investigates how mitochondrial dynamics, lysosomal function, and autophagic flux contribute to diseases such as retinitis pigmentosa, glaucoma, ALS, and Parkinson’s. Her work combines molecular biology, cell imaging, and preclinical models to uncover therapeutic targets. The analysis of her recent publications reveals a strong focus on mitophagy regulation, neuroinflammation (especially via the cGAS/STING pathway), and the development of neuroprotective compounds. She has contributed to high-impact reviews and guidelines in autophagy research, and her work spans fundamental mechanisms to translational applications. She is actively involved in scientific leadership, including the "Women in Autophagy" initiative to promote gender equity in science and the "DRIVE" international PhD training program in autophagy. Dr. Boya has published over 150 articles in top journals including Nature , Nature Communications , Autophagy , and Cell Death & Disease . Her work is highly collaborative, involving interdisciplinary teams across Europe. She leads a research group focused on cellular recycling mechanisms and their implications for vision and aging, contributing significantly to the understanding of autophagy in health and disease.

• Peroxisome Biology
• Protein-Protein Interactions
• Structural Biology
• +۵ مورد دیگر

Dr. Stefan Gaussmann serves as a Researcher within the Department of Biology at ETH Zurich, affiliated with the Professorship for Biomolecular NMR. His work focuses on elucidating molecular mechanisms of peroxisomal protein import through structural and biophysical approaches, with significant contributions to understanding PEX protein interactions and peroxisome biogenesis. His research spans Peroxisome Biology, Protein-Protein Interactions, and Structural Biology, leveraging NMR spectroscopy to investigate conformational dynamics of peroxins like PEX5, PEX13, and PEX14. Current interests include phase separation phenomena (e.g., SMNDC1 perturbation), glycosome biogenesis in trypanosomatid parasites, and development of novel tools for protein interaction analysis such as modular nanoparticle sensors and sortase-based ubiquitin engineering. Analysis of his 12 publications (2019-2025) reveals consistent emphasis on molecular recognition motifs in peroxisomal import machinery, with recent expansion into pharmacological targeting of phase-separated proteins and parasite-specific peroxin interactions. His work bridges fundamental structural biology with therapeutic applications for peroxisome-related disorders. As part of ETH Zurich's Biomolecular NMR group, Dr. Gaussmann contributes to a collaborative research environment focused on advanced biophysical characterization of biomolecular systems, utilizing facilities at the Hönggerberg campus.

• Cardiac Calcium Signaling
• Mitochondrial Calcium Dynamics
• Cardiac Arrhythmias
• +۴ مورد دیگر

Liron Boyman is an Adjunct Assistant Professor in the Department of Pharmacology and Physiology at the University of Maryland School of Medicine, where he maintains active research affiliations with the BioMET-Center for Biomedical Engineering and Technology in Baltimore, MD. His academic journey includes: B.Sc. in Medical and Life Sciences from Tel Aviv University School of Medicine and Faculty of Life Sciences, Israel (2004) Ph.D. in Physiology and Pharmacology from Tel Aviv University School of Medicine, Israel (2010) Postdoctoral Fellowship at BioMET-Center for Biomedical Engineering and Technology, University of Maryland (2010-2015) Dr. Boyman's research centers on cardiac calcium signaling mechanisms, with groundbreaking contributions to understanding mitochondrial calcium dynamics in cardiac cells. He pioneered novel imaging technologies for high-resolution calcium measurements, including genetically targeted mitochondrial probes and oxygen microsensors for ischemia studies. His work bridges fundamental discoveries in excitation-contraction coupling with pathophysiological implications for heart failure and arrhythmias. Analysis of his 15 most recent publications (2023-2025) reveals expanding research frontiers beyond cardiac physiology into cancer metastasis mechanisms and organelle crosstalk. Key trends include calcium-dependent tumor dissemination via P2Y2 signaling, lysosomal calcium's role in arrhythmias, and mitochondrial-peroxisome interactions mediated by MARCH5. His work consistently integrates advanced imaging with molecular physiology across cardiac, metabolic, and oncological contexts. His scientific recognition includes: Ph.D. Stipend Award from Dr. Miriam and Sheldon G. Edelson Foundation (2004-2010) Katzir-Katchalsky Award for Student Travel Fellowships (2008) Shtacher Award for Research Excellence (2009) American Heart Association Scientist Development Grant (2014) Dr. Boyman has secured significant competitive funding as Principal Investigator on an AHA grant investigating mitochondrial calcium signaling in heart disease (2015-2019), and as collaborator on NIH-funded projects including sepsis research (2018-2021) and xenotransplantation studies (2020-2025). His laboratory maintains extensive collaborative networks for implementing novel imaging tools across multiple disease models. He operates within the BioMET-Center for Biomedical Engineering and Technology, leveraging its infrastructure for developing cutting-edge cellular imaging methodologies and investigating calcium dynamics in cardiac and non-cardiac systems.

Tom A. Rapoportمشاهده پروفایل

استاد

• Protein Transport Across Membranes
• ERAD (Endoplasmic Reticulum-Associated Degradation)
• Membrane Biology
• +۵ مورد دیگر

Tom A. Rapoport is the Don W. Fawcett Professor of Cell Biology at Harvard Medical School (HMS), where he has been a faculty member since 1995. He holds a Ph.D. in Biochemistry from Humboldt University (East Berlin) and a Habilitation in enzymology. His research focuses on mechanisms of protein transport across membranes, ER-associated degradation (ERAD), and membrane morphology regulation. Rapoport is a Howard Hughes Medical Institute (HHMI) Investigator and leads the Rapoport Lab, which employs biochemical and structural techniques like X-ray crystallography and cryo-EM. Education: Ph.D. in Biochemistry, Humboldt University, East Berlin (1980s) Habilitation in Enzymology, Humboldt University (post-Ph.D.) Research Interests: Rapoport's work centers on understanding how proteins are transported across membranes, particularly in the endoplasmic reticulum (ER), and how misfolded proteins are degraded via ERAD. His lab also investigates ER tubule formation and peroxisomal protein import. Recent projects include studies on lung surfactant proteins and their role in lamellar body formation. Awards: Howard Hughes Medical Institute Investigator (1997–present) Grants & Funding: R01HL150520 (NIH): Function and application of lung surfactant proteins (2020–2025) R01GM052586 (NIH): Protein Transport Across Membranes (1995–2027) Labs/Teams: The Rapoport Lab collaborates extensively, using interdisciplinary approaches to solve structural and mechanistic questions in membrane biology. Key techniques include cell-free reconstitution assays and cryo-EM.

John Aitchisonمشاهده پروفایل

استاد مدعو

• Systems Biology
• Cell Biology
• Systems Cell Biology
• +۷ مورد دیگر

John Aitchison is an Adjunct Professor affiliated with the Institute for Systems Biology and the Center for Infectious Disease Research in Seattle, Washington. He holds a Ph.D. from McMaster University and leads a research program in systems cell biology, focusing on the integration of molecular, genomic, and computational approaches to understand cellular complexity. Adjunct Professor, Institute for Systems Biology, Seattle Ph.D., McMaster University Dr. Aitchison’s research centers on systems cell biology, with key interests in nucleocytoplasmic transport, peroxisome biogenesis, and host-pathogen interactions. His lab employs functional genomics, proteomics, and computational modeling to dissect the molecular mechanisms underlying cellular organization and responses to environmental stimuli. He collaborates extensively with the Rachubinski and Wozniak laboratories at the University of Alberta. His recent publications reflect a strong focus on systems-level analyses of cellular processes, including gene regulation, chromatin dynamics, and immune responses to infection. Trends in his work include the development of integrative models to predict cellular behavior and the study of organelle dynamics in health and disease. CIHR Scholar AHFMR Scholar Dr. Aitchison has mentored numerous postdoctoral fellows and research scientists, including Fred Mast, Song Li, and Thurston Herricks. His lab has received support from various funding agencies, enabling large-scale proteomic and genomic studies. He also contributes to scientific discourse through editorial roles, as seen in his commentary on MBoC. His laboratory operates at the intersection of experimental and computational biology, developing and applying high-throughput technologies to address fundamental questions in cell biology and infectious disease.

• Mass Spectrometry
• Metabolomics
• Lipidomics
• +۵ مورد دیگر

Zheng-Jiang Zhu is a Professor at the Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, within the Interdisciplinary Research Center on Biology and Chemistry (IRCBC) . Since 2013, he has led a research program focused on advanced mass-spectrometry technologies and their application to metabolomics, lipidomics, and systems biology. Education and Training PhD in Chemistry, University of Massachusetts Amherst, 2006–2011 BS in Chemistry, Nanjing University, 2002–2006 Post-doctoral Research Associate, Scripps Research Institute, 2011–2013 Research Interests Professor Zhu’s research integrates cutting-edge mass spectrometry , ion mobility spectrometry , and bioinformatics to address fundamental questions in metabolism , aging , and neurodegeneration . His group develops novel analytical workflows, software tools, and databases that enable high-throughput, high-coverage profiling of metabolites and lipids in complex biological systems. Specific areas of focus include: Stable-isotope tracing metabolomics for mapping metabolic fluxes across tissues Lipid transport and remodeling at subcellular resolution Machine-learning-assisted metabolite annotation and structural elucidation Biomarker discovery for early cancer diagnosis and aging interventions Scientific Output & Impact Over the past decade, Zhu has authored more than 78 peer-reviewed publications in leading journals such as Nature Communications , Analytical Chemistry , Science Advances , and Nature Chemistry . His 2025 papers alone address tissue-specific fatty-acid biosynthesis, AI-driven metabolite annotation, organellar lipid trafficking, and the anti-aging role of citrulline in macrophages. These works collectively advance both technological frontiers and biological understanding, positioning his laboratory at the forefront of integrated multi-omics research. Software & Databases AllCCS2 – A curated atlas of collision cross-section values for small molecules Met4DX – A unified data-processing platform for multidimensional untargeted metabolomics LipidIMMS Analyzer – Integrative tools for ion-mobility-based lipidomics MetFlow – Interactive workflow for metabolomics data cleaning and differential analysis Collaborations & Funding Zhu’s research is supported by multiple national grants and extensive collaborations with clinicians and industry partners. His group routinely engages in peer review for over 20 high-impact journals, reflecting the community’s recognition of his expertise in analytical chemistry and systems biology.

Geoffrey Wasteneysمشاهده پروفایل

استاد

• Plant Cell Biology
• Microtubule Dynamics
• Cellulose Biosynthesis
• +۶ مورد دیگر

Geoffrey Wasteneys is a Professor in the Department of Botany at the University of British Columbia's Faculty of Science. He holds a Canada Research Chair Tier 1 in Plant Cell Biology and leads an active research laboratory focused on plant cell biology and development. His work bridges molecular biology, cell biology, and plant physiology to understand fundamental mechanisms of plant growth. Dr. Wasteneys received his B.Sc. in Biology from Carleton University in 1983 and his Ph.D. in Plant Cell Biology from the Australian National University in 1989. His early career included prestigious fellowships including the National Research Fellow (1988-91), Humboldt Fellow (1992-1993) at the University of Heidelberg, Queen Elizabeth II Fellow (1992-1998), and Fellow/Senior Fellow positions (1996-2004) at the Australian National University. Dr. Wasteneys' research primarily focuses on plant cell biology with emphasis on microtubule dynamics, cellulose biosynthesis, and plant cell wall formation . His laboratory investigates how microtubule arrays organize to guide cellulose deposition and influence plant cell shape and tissue mechanics. His work has significant implications for understanding plant growth, development, and responses to environmental stresses. Analysis of Dr. Wasteneys' recent publications reveals a consistent focus on microtubule-associated proteins (particularly CLASP), cellulose synthase complexes, and their roles in plant cell morphogenesis . His research spans from molecular mechanisms of protein function to whole-plant developmental processes, with particular attention to root development, cell wall biosynthesis, and plant responses to environmental cues. A notable trend in his recent work is the integration of advanced imaging techniques with genetic and molecular approaches to study dynamic cellular processes. Canada Research Chair Tier 1 in Plant Cell Biology National Research Fellow (1988-91) Australian National University Humboldt Fellow (1992-1993) University of Heidelberg Queen Elizabeth II Fellow (1992-1998) Australian National University Fellow/Senior Fellow (1996-2004) Australian National University Dr. Wasteneys actively mentors the next generation of plant scientists, currently supervising multiple PhD and MSc students in his laboratory. His research is supported by competitive grants including the Canada Research Chairs program. His laboratory provides training in advanced cell biological techniques, molecular genetics, and plant physiology, preparing students for diverse careers in academia and industry. The Wasteneys Lab at UBC serves as a hub for plant cell biology research, bringing together students and researchers to investigate fundamental questions about plant cell organization and function. The lab utilizes cutting-edge microscopy, molecular genetics, and biochemical approaches to unravel the mechanisms that drive plant development.

Anthea Letsouمشاهده پروفایل

استاد

• Developmental Biology
• Neurogenetics
• Molecular Genetics
• +۵ مورد دیگر

Anthea Letsou is a Professor of Human Genetics at the University of Utah, with a research focus on using Drosophila melanogaster to model human developmental and neurodegenerative diseases. Her work spans two primary areas: embryonic morphogenesis and neurometabolic disorders. Education: B.A., Harvard University; Ph.D., Yale University Research Interests: Dr. Letsou’s laboratory investigates the molecular mechanisms underlying dorsal closure during embryonic development, focusing on evolutionarily conserved pathways like JNK and Dpp signaling. She also develops Drosophila models for Adrenoleukodystrophy (ALD), a fatal neurodegenerative disorder caused by VLCFA accumulation, aiming to elucidate disease etiology and identify therapeutic targets. Publication Trends: Her research integrates genetic, biochemical, and pharmacological approaches in Drosophila , emphasizing conserved mechanisms relevant to human health. Key themes include signal transduction pathways, epithelial morphogenesis, lipid metabolism, and neurodegeneration. Lab Activities: Dr. Letsou’s lab employs double mutant studies to explore gene redundancy in VLCFA metabolism, characterizes dorsal closure dynamics, and screens for neuroprotective drugs using Drosophila models.

Regina Ensenauerمشاهده پروفایل

استاد

• Early origins of childhood obesity
• Fetal programming
• Nutrient-sensing mechanisms
• +۳ مورد دیگر

Regina Ensenauer is a Professor of Experimental Pediatrics and Metabolism at Heinrich Heine University Düsseldorf, affiliated with the University Children’s Hospital. Her research focuses on early-life origins of childhood obesity, fetal programming, and metabolic disease prevention. She leads the PEACHES cohort study investigating maternal obesity’s long-term effects on offspring. As an Anna Boyksen Fellow at the TUM Institute for Advanced Study, her work addresses preventive pediatrics. Her academic journey includes a medical degree from Heidelberg University, residency in Pediatrics at Freiburg, and postdoctoral training at the Mayo Clinic. Awards include the Friedrich-Linneweh Award (2012) and Mayo Alumni Scientific Award (2005). Her research spans metabolite profiling, placental metabolism, and nutritional interventions, with emphasis on translational strategies to combat obesity. Key publications address insulin resistance in maternal obesity, fatty acid metabolism in pregnancy, and neurodevelopmental impacts of dietary PUFAs. Her work integrates clinical, molecular, and epidemiological approaches to understand obesity’s developmental origins, aiming to inform preventive public health policies.

• Molecular Pathology
• Toxicology
• Carcinogenesis
• +۴ مورد دیگر

Robert Sills is a Professor and Chief of the Comparative and Molecular Pathogenesis Branch at the National Institute of Environmental Health Sciences (NIEHS) . With a background in veterinary medicine and molecular biology, his research focuses on elucidating the molecular and cellular mechanisms of chemical-induced carcinogenesis in the liver, lung, and other organ systems. He also investigates the application of molecular pathology techniques to evaluate non-neoplastic tissue changes caused by environmental exposures. Research Interests Molecular pathology of chemical-induced diseases Development of animal models for toxicological studies Computational approaches to gene expression analysis Epigenetic and immune responses to environmental agents Key Trends in Recent Publications His recent work spans toxicology, molecular biology, and computational pathology , with specific emphasis on: Epidermal growth factor receptor (EGFR) signaling in hepatocarcinogenesis Transcriptomic profiling of chemically exposed tissues Epigenetic alterations in response to arsenic and endocrine disruptors Advances in laser microdissection and immunohistochemistry Mechanistic insights into oxidative stress and fibrosis Multi-omics integration for predictive toxicology Scientific Awards Fellow, International Academy of Toxicologic Pathology (IATP) Technological Contributions Sills has pioneered the use of laser capture microdissection and multi-omics data harmonization to improve precision in toxicological pathology. His team has developed standardized protocols for gene expression analysis in rodent models and epigenetic profiling of chemically induced lesions.

Renate Jansenمشاهده پروفایل

پژوهشگر

• Cell Biology
• Molecular Biology
• Biochemistry
• +۳ مورد دیگر

Dr. Renate Jansen is the Degree Programme Coordinator for BSc Biology at the Faculty of Science and Engineering , University of Groningen. Her research focuses on intracellular organelle biogenesis, protein targeting, and membrane dynamics in eukaryotic cells. Email: r.l.m.jansen@rug.nl Location: Cluster Biology — Cluster Support, Nijenborgh 7, Groningen, Room 5173.0257 Her work explores the molecular mechanisms of peroxisome and mitochondrial protein targeting, biogenesis pathways, and membrane protein functionality. Key contributions include studies on PEX14 overexpression effects, ABC transporter targeting signals, and comparative genomics of PEX proteins. Recent publications highlight her expertise in peroxisomal membrane protein targeting (2023), organelle cross-talk in human cells (2024), and foundational reviews on biogenesis factors like Pex3/Pex19 (2019, 2023). She collaborates with researchers on peroxisome-mitochondrion interactions and contributes to academic training in biology at the University of Groningen.

Michael Francis Wanglerمشاهده پروفایل

دانشیار

• Pediatric genetics
• Peroxisomal disorders
• Medical genetics
• +۴ مورد دیگر

Dr. Michael Francis Wangler is an Associate Professor at Baylor College of Medicine within the Graduate School of Biomedical Sciences and Department of Molecular & Human Genetics . His research focuses on pediatric genetics and peroxisomal disorders , using Drosophila models and genomics to study Mendelian disease mechanisms. Co-Director of Model Organisms Screening Center (MOSC) for Undiagnosed Diseases Network Active in clinical genetics at Texas Children's Hospital Research interests include: Deciphering molecular pathogenesis of rare diseases Genomics and metabolomics in peroxisome biogenesis disorders Functional validation of de novo variants Model organism applications in clinical genetics Recent publications highlight work on: DDX39B , RBBP5 , and DNMT3A variant-associated syndromes Biomarker discovery in peroxisomal diseases Neurodevelopmental disorder mechanisms via Drosophila Laboratory: Duncan Neurological Research Institute (Room DNRI-1050, Houston, TX)

Bianca Schrulمشاهده پروفایل

استاد

• Lipid Droplets
• Lipid Metabolism
• Cell Biology
• +۴ مورد دیگر

Prof. Dr. Bianca Schrul leads the Group for Medical Biochemistry & Molecular Biology at Saarland University's Center for Molecular Signaling (PZMS) in Homburg, Germany. Her research focuses on lipid droplet biogenesis, protein targeting to lipid droplets, and cross-organelle communication in lipid metabolism. Principal Investigator at Saarland University PhD/MSc/MD students under her supervision Lipid droplet research via biochemical and cell biological methods Research Interests: • Molecular mechanisms of lipid droplet protein targeting • Physicochemical membrane properties in organelle biogenesis • ER-to-lipid droplet communication • Pathological lipid metabolism in metabolic diseases Methodologies: • In vitro reconstitution experiments • CRISPR/Cas9 and RNAi • Quantitative proteomics/lipidomics • Advanced fluorescence microscopy Publications Trends: Her 15 most recent articles (2010–2024) cover lipid droplet biogenesis, peroxisome-lipid droplet crosstalk, protein targeting dynamics, and implications in Alzheimer's disease and metabolic disorders like obesity/diabetes. Collaborations: Integrates with molecular dynamics simulations, microfluidics, and EPR spectroscopy experts for interdisciplinary research.

Sigrun Reumannمشاهده پروفایل

استاد

• Plant Biochemistry
• Peroxisome Biology
• Proteomics
• +۴ مورد دیگر

Prof. Dr. Sigrun Reumann is a full Professor at the University of Hamburg , where she serves as Managing Director of the Research Unit Plant Biochemistry and Infection Biology within the Department of Biology, Faculty of Mathematics, Computer Science and Natural Sciences. Her research focuses on plant peroxisomes, protein targeting mechanisms, and their roles in stress response and metabolic pathways. Education and Career Habilitation in Biochemistry, University of Göttingen (2007) Doctorate, University of Göttingen (1996-1999) Postdoctoral Fellow, University of Michigan (1996-1999) Research Interests Sigrun Reumann’s work bridges biochemistry and computational biology. She investigates peroxisomal targeting signals (PTS1/PTS2), organelle proteomics, vitamin K1 biosynthesis, and cross-talk between peroxisomes, mitochondria, and chloroplasts during photorespiration. Her team also explores autophagy in plant cells and stress-induced metabolic adaptations. Publication Trends Her recent articles (2010-2015) emphasize PredPlantPTS1 bioinformatics tools, novel peroxisomal signal discovery, and proteomic analysis of Arabidopsis and spinach leaf peroxisomes. Studies integrate machine learning with experimental validation to map organelle function and metabolic pathways. Leadership She leads the Research Unit Plant Biochemistry and Infection Biology and has held academic positions at the University of Stavanger (2008-2014) and University of Göttingen (2001-2006).

Nancy Bravermanمشاهده پروفایل

دانشیار

• Peroxisomal Disorders
• Zellweger Spectrum Disorder
• Inborn Errors of Metabolism
• +۷ مورد دیگر

Nancy Braverman is an Associate Professor at McGill University , with appointments in the Departments of Human Genetics , Pediatrics , and Medicine . Her research focuses on inherited peroxisomal disorders , particularly the Zellweger Spectrum Disorder , using mouse models and clinical trials to explore disease mechanisms and therapeutic interventions. Education : BSc from Cornell University, Master in Human Genetics from Sarah Lawrence College, MD from Tulane University, Pediatric residency at Yale-New Haven Hospital, Fellowship in Clinical and Biochemical Genetics at Johns Hopkins. Contact : Email nancy.braverman@mcgill.ca , Phone: 514 934 1934.23404 Her work investigates how peroxisomal enzyme defects cause multi-systemic diseases affecting the nervous system, eyes, hearing, bones, liver, kidney, and adrenal glands . By engineering mouse models , her lab studies disease progression and develops drugs/therapies for improved patient outcomes. She leads a patient registry to document disease variability. Recent publications highlight advancements in gene therapy for retinal function , variant curation standards via ClinGen panels, metabolomic biomarkers , and diagnostic modalities for peroxisomal disorders. Her articles emphasize translational approaches bridging biochemical research and clinical applications .