جست‌وجوی استاد و پژوهشگر

Ning Zhangمشاهده پروفایل

استادیار

• Plant Defense Mechanisms
• Genome Editing Technologies
• Crop Improvement
• +۳ مورد دیگر

Ning Zhang is an Assistant Professor in the Biology Department at James Madison University (JMU), joining in 2024. Her research focuses on enhancing crop resilience through molecular and biochemical studies of plant defense mechanisms against bacterial pathogens, alongside developing genome editing technologies for trait improvement. She holds a PhD in Horticulture and Crop Science from The Ohio State University (2016), an MS in Silviculture from Zhejiang Agriculture and Forestry University (2011), and a BS in Landscape Architecture from Shandong Agricultural University (2008). Research Interests: Dr. Zhang's lab investigates plant immunity pathways, CRISPR/Cas9 genome editing applications, and engineering crops for disease resistance. Her work integrates molecular biology, genetics, and biochemistry to tackle challenges posed by climate change and biotic/abiotic stresses. Recent Trends in Publications: Her articles concentrate on MAPK signaling pathways, NLR protein interactions, PP2C phosphatase regulation, and bacterial effector mechanisms in tomato and other crops. Key themes include immune system activation, pathogen recognition diversity, and transgenic plant development. Lab Information: The Zhang Lab at JMU is part of the Department of Biology, focusing on plant biotechnology solutions for agricultural sustainability. They collaborate on projects involving CRISPR-based gene editing and stress tolerance research.

Knut Drescherمشاهده پروفایل

دانشیار

• Bacterial Biofilms
• Microbial Multicellularity
• Biophysics
• +۵ مورد دیگر

Prof. Knut Drescher is an Associate Professor at the Biozentrum, University of Basel , leading a research group focused on bacterial biofilms , swarming , and microbial multicellularity . Previously, he served as a Professor of Biophysics and Max Planck Research Group Leader at Philipps-Universität Marburg (2015-2021) and conducted postdoctoral research at Princeton University. Research Interests: Physical and biological mechanisms of biofilm formation Cell-cell interactions in microbial communities Antibiotic resistance in biofilms Hydrodynamics of bacterial swarms Evolution of cooperation in multispecies biofilms Development of bioimaging software (BiofilmQ, BacStalk) Scientific Awards: 2023: SNSF Consolidator Grant 2019: Heinz Maier-Leibnitz Prize (DFG), VAAM Research Prize, IUPAP Young Scientist Prize 2016: ERC Starting Grant Advising & Grants: Advises PhD and Master's students in microbiology, biophysics, and bioinformatics Secured major grants from ERC , HFSP , and DFG

Patricia Championمشاهده پروفایل

استاد

• Molecular Genetics
• Mycobacterial Pathogenesis
• Bacterial Genetics
• +۷ مورد دیگر

Patricia Champion is a Professor in the Department of Biological Sciences at the University of Notre Dame, where she holds the title of Notre Dame Collegiate Professor. Her research is centered on the molecular mechanisms of mycobacterial pathogenesis, with a focus on protein transport and virulence. She is affiliated with the Eck Institute for Global Health and the Center for Rare and Neglected Diseases. PhD in Molecular Biology, Princeton University (2003) B.S. in Biological Sciences, Carnegie Mellon University (1998) Her research interests lie in understanding how pathogenic mycobacteria, including Mycobacterium tuberculosis and M. marinum , cause disease through targeted protein secretion, particularly via the Type VII (ESX-1) secretion system. She investigates how secreted proteins function as effectors and regulate gene expression, and how post-translational modifications like acetylation influence virulence. Her lab employs an interdisciplinary approach combining genetics, molecular biology, proteomics, and transcriptomics. The recent publications highlight a strong focus on ESX-1-mediated secretion, identification of novel substrates, regulatory mechanisms (e.g., WhiB6, EspM), and post-translational modifications. The work spans fundamental bacterial physiology to host-pathogen interactions, contributing to the broader goal of identifying targets for anti-virulence therapeutics against tuberculosis. Her scientific recognition includes being named a Notre Dame Collegiate Professor, a distinguished honor reflecting her scholarly excellence. Dr. Champion leads an active research laboratory committed to fostering an inclusive and respectful environment, emphasizing core values such as integrity, teamwork, and excellence. Her lab's work is supported by ongoing research grants, though specific funding sources are not detailed in the text. The Champion Lab operates within the Department of Biological Sciences and collaborates with key institutes at Notre Dame focused on global and neglected diseases.

Sachdev Sidhuمشاهده پروفایل

استاد پژوهشی

• Synthetic Antibodies
• Protein Engineering
• Biotechnology
• +۵ مورد دیگر

Sachdev Sidhu is a Research Professor and Entrepreneur in Residence at the University of Waterloo. His research focuses on synthetic antibodies, protein engineering, and biotechnological applications. He leads efforts in developing novel therapeutic antibodies, engineered protein systems, and molecular tools for biomedical research. His work spans cancer therapy, viral infection countermeasures, and regenerative medicine. Sidhu is also involved in translational research, bridging academic discoveries with commercial applications through entrepreneurial ventures. Key research interests include synthetic antibody libraries, CAR T-cell engineering, ubiquitin-based therapeutics, and phage display technologies. He has contributed to advancements in targeted therapies for glioblastoma, leukemia, and ocular diseases. His team develops innovative methods for protein design, such as engineered ubiquitin variants and modular antibody architectures. Publications highlight breakthroughs in antibody-based treatments, including synNotch CAR T cells for glioblastoma and neutralizing antibodies against SARS-CoV-2. His work integrates structural biology, molecular biology, and computational approaches to address complex biomedical challenges. Sidhu collaborates with industry partners to advance technologies into clinical and commercial settings.

Urs Jenalمشاهده پروفایل

استاد

• Bacterial Signal Transduction
• Microbiology
• Antibiotic Resistance
• +۵ مورد دیگر

Professor Urs Jenal is a Full Professor at the Biozentrum of the University of Basel, Switzerland, where he has led research on bacterial signal transduction since 2008. His laboratory investigates the molecular mechanisms of bacterial persistence and antibiotic resistance, with particular focus on pathogens causing chronic infections in humans. Previously, he served as Associate Professor (2002-2008) and Assistant Professor (1996-2002) at the same institution, and completed postdoctoral training at Stanford University and ETH Zurich. Education 2000: Habilitation and VENIA DOCENDI in Microbiology, University of Basel 1987-1991: PhD in Molecular Microbiology, ETH Zurich (supervisor: Prof. T. Leisinger) 1982-1986: Studies of Experimental Biology, ETH Zurich 1977-1981: Gymnasium with Matura Type C, Chur Research Focus Prof. Jenal's research centers on understanding how bacterial pathogens persist in the human body despite antibiotic treatments. His laboratory investigates cyclic nucleotides, particularly c-di-GMP, as signaling molecules that control bacterial biofilm formation, virulence, and antibiotic tolerance. His team studies pathogenic Escherichia coli causing recurrent urinary tract infections and Pseudomonas aeruginosa causing long-term lung infections in cystic fibrosis patients. Recent work has revealed how "sleeping" bacteria survive antibiotic treatments and how pathogens breach respiratory epithelia through goblet cell invasion. Scientific Recognition 2014: Elected member of the European Academy of Microbiology (EAM) 2013: ERC Advanced Investigator Award 2012: Elected member of the European Molecular Biology Organization (EMBO) 2011: Elected member of the American Academy of Microbiology (AAM) Mentorship and Collaborations Prof. Jenal has mentored numerous PhD students and postdocs, many receiving awards for their research. His laboratory is part of the NCCR AntiResist initiative focused on developing novel approaches against antibiotic resistance. He collaborates extensively with clinical researchers and has developed innovative models, including human mini-lungs, to investigate pathogen-host interactions. His recent publications demonstrate how understanding bacterial persistence mechanisms can lead to new therapeutic strategies against chronic infections.

Ralph Hückelhovenمشاهده پروفایل

استاد

• Plant Pathology
• Molecular Biology
• Plant Immunity
• +۳ مورد دیگر

Prof. Ralph Hückelhoven is a Professor of Phytopathology at the Technical University of Munich (TUM), affiliated with the TUM School of Life Sciences. His research focuses on the molecular and biological mechanisms underlying plant diseases, particularly plant immunity, pathogen exploitation of signal transduction, and host-pathogen interactions. He leads the Chair of Phytopathology at TUM since 2006, following academic roles at universities of Kiel and Hohenheim. Education: PhD (1999) and habilitation in molecular phytopathology (2005) from Justus Liebig University Giessen, after a biology degree at RWTH Aachen University. Awards: Julius Kühn Prize (2004) and leadership of a DFG Junior Research Group (2002-2006). His research spans plant immunity at cellular and molecular levels, including studies on receptor kinases (e.g., MIK2, LORE), RAC GTPases (e.g., RACB), and metabolomics-driven insights into pathogen resistance. He has published over 100 peer-reviewed articles, examining topics like fungal toxins, volatile signaling, and crop disease management. Key publications include work on Arabidopsis immune receptors, barley powdery mildew susceptibility factors, and Fusarium head blight resistance. Research integrates genetics, proteomics, and metabolomics to advance disease-resistant crop development. His lab investigates host-pathogen interactions across scales—from molecular signaling to field epidemiology—contributing to sustainable agricultural strategies against plant pathogens.

Chiu Ping Chengمشاهده پروفایل

استاد

• Molecular Biology
• Plant-Microbe Interactions
• Bacterial Pathogenesis
• +۵ مورد دیگر

Chiu Ping Cheng is a Professor in the Department of Biology at the University of Minnesota, USA, specializing in Molecular Biology and Plant-Microbe Interactions . With over two decades of research on Ralstonia solanacearum and its interactions with solanaceous crops, Dr. Cheng has pioneered studies on plant defense mechanisms against bacterial wilt, regulatory gene functions, and biocontrol agent applications. Current research: Plant-pathogen interactions Special techniques: Genomic screening, bacteriophage-derived proteins Key pathogens: Ralstonia solanacearum, Pectobacterium carotovorum His recent publications (2024) explore tomato cultivar resistance variation , NADPH oxidase-effector interactions , and phenylpropanoid metabolism in wild mungbean . Though no formal scientific awards are listed, his work has been featured in leading journals like Plant Cell & Environment and New Phytologist . Dr. Cheng operates from the Life Science Building R942 laboratory.

Oliver Seitzمشاهده پروفایل

استاد

• Chemical protein synthesis
• DNA/RNA-templated reactions
• Bioorganic synthesis
• +۶ مورد دیگر

Prof. Oliver Seitz leads the Bioorganic Synthesis research group at the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Humboldt University of Berlin. His lab focuses on cutting-edge chemical biology approaches for protein/nucleic acid interrogation, with recent work advancing DNA/RNA-programmed assemblies for cellular imaging and therapeutic applications. Research spans chemical protein synthesis, glycoprotein/phosphoprotein engineering, and nucleic acid-templated reactions. Key innovations include Forced Intercalation (FIT) probes for wash-free RNA imaging, loss-of-affinity principles for catalytic efficiency, and peptide-PNA conjugates for targeted cellular delivery. The group actively develops tools for live-cell protein labeling and biomolecular spatial screening. Recent publications (2021-2024) emphasize fluorescence-based detection systems, catalytic templated reactions, and therapeutic peptide synthesis. Trends show increasing sophistication in multi-dye probes, glycan engineering, and RNA-triggered pro-drug activation. Scientific awards include: Max Bergmann Award (2019) Prof. Seitz actively advises doctoral students, with recent graduates Marvin Björn Stutz (2023, magna cum laude ), Dino Gluhacevic von Krüchten (2023, summa cum laude ), and Sophie Schöllkopf (2023, magna cum laude ). Current PhD candidates include Ekaterina Kazakova (glycoprotein synthesis), Alina Herfort (phosphoproteins), and Lina-Marie Beck (peptide-nucleic acid conjugates), with postdocs like Dr. Mandana Oloub (viscosity sensors). The Bioorganic Synthesis lab operates within Berlin's vibrant chemical research ecosystem, utilizing specialized techniques for chemical protein synthesis and nucleic acid detection. Recent team growth reflects ongoing projects in RNA imaging, catalytic templated reactions, and therapeutic conjugate development, supported by open positions for new researchers.

Scott C. Garmanمشاهده پروفایل

استاد

• Structural Biology
• Glycoproteins
• Lysosomal Storage Diseases
• +۲ مورد دیگر

Scott Garman is Professor of Biochemistry at UMass Amherst, focusing on structural biology of glycoproteins in human diseases. PhD from Harvard University. Research areas: Lysosomal enzyme mechanisms in storage diseases (Fabry, Schindler); Malaria surface protein structures; Antibody-receptor interactions. Utilizes X-ray crystallography to study enzyme mutations causing disease. Key findings: Determined structures of α-galactosidase (Fabry disease) and α-NAGAL (Schindler disease), revealing molecular bases for enzyme dysfunction. Developed models for enzyme trafficking and substrate processing. Laboratory: Investigates protein folding diseases and develops therapeutic strategies. Collaborates on malaria vaccine development and antibody engineering.

Michael J. Ragusaمشاهده پروفایل

دانشیار

• Structural Biology
• Biochemical Reconstitution
• Autophagy
• +۵ مورد دیگر

Michael J. Ragusa is an Associate Professor of Chemistry at the Department of Chemistry, College of Arts and Sciences, Dartmouth College , specializing in molecular mechanisms of selective autophagy . His research integrates structural biology , biochemical reconstitution , and cell biology to understand how cells degrade toxic components like damaged organelles. Education: B.S. in Chemistry from Siena College, Ph.D. in Biochemistry from Brown University His work focuses on autophagy , particularly the role of Atg proteins in membrane tethering and cargo selection. His lab has published extensively on mitophagy , ALFY , and Atg11 , linking defects in these pathways to cancer , neurodegeneration , and infectious diseases . Recent studies highlight mechanisms of vesicle clustering and dimerization-dependent membrane interactions . Dr. Ragusa teaches courses such as CHEM 5: General Chemistry , CHEM 42: Biological Chemistry II , and CHEM 95.05: Protein Crystallography . His lab employs techniques like X-ray crystallography , NMR spectroscopy , and membrane reconstitution to dissect protein-lipid interactions.

Dario Alessiمشاهده پروفایل

استاد

• Protein Phosphorylation
• Ubiquitylation Pathways
• Parkinson's Disease
• +۳ مورد دیگر

Professor Dario Alessi is a leading academic at the University of Dundee's School of Life Sciences, serving as the Director of the MRC Protein Phosphorylation Unit (MRC PPU) and Professor of Signal Transduction. He earned his BSc (1988) and PhD (1991) from the University of Birmingham. His research focuses on protein phosphorylation and ubiquitylation pathways, particularly the LRRK2 kinase pathway linked to Parkinson's disease. He has made groundbreaking contributions to understanding LRRK2's role in neurodegeneration, including its interaction with Rab proteins and scaffolding molecules like RILPL1. School of Life Sciences, University of Dundee MRC PPU Director since 2012 Signal Transduction Therapy Unit Director His work combines molecular biology, biochemistry, and collaborative industry partnerships to advance therapeutic strategies for Parkinson's disease. Key research areas include LRRK2 activation mechanisms, Rab protein phosphorylation, and lysosomal dysfunction. Alessi has trained over 30 graduate students and 40 postdocs, many now in academic and industry leadership roles. Notable awards include the EMBO Gold Medal (2005), the Robert A. Pritzker Prize for Leadership in Parkinson’s Research (2023), and an OBE (2023) for contributions to medical science. His lab promotes open science, sharing reagents and protocols globally through platforms like MRC Pure Agents and LRRK2.bio. Current projects include investigating novel mitochondrial and organelle biology in Parkinson’s, developing biomarkers, and advancing LRRK2 inhibitors through clinical trials. Collaborations span the Michael J. Fox Foundation, Aligning Science Across Parkinson’s, and the UK Dementia Research Initiative.

Hans H. Wandallمشاهده پروفایل

استاد

• Glycobiology
• Tissue Homeostasis
• Cancer Biology
• +۵ مورد دیگر

Hans H. Wandall is Professor and Deputy Head of Department at the University of Copenhagen's Department of Cellular and Molecular Medicine, Faculty of Health Sciences. He serves as Group Leader and Vice-Director of the Copenhagen Center for Glycomics. His educational background includes a PhD in Glycobiology (2004), medical licensure (2001), and MD from University of Copenhagen (1999). Research focuses on glycobiology using gene editing and tissue models to understand glycan functions in: Tissue development and cancer biology Host-virus interactions (HSV-1, Ebola) Stem cell regulation and regenerative medicine Glycan-based therapeutic development Recent publications demonstrate interdisciplinary approaches combining glycoproteomics, virology, and cancer biology, with emphasis on O-glycosylation mechanisms and viral pathogenesis. Awards & Recognition: ERC Consolidator Grant (2017) Lundbeck Foundation Ascending Investigator (2019) Sapere Aude Research Leader Award (2012) Young Scientist Award (2003) Leads multiple funded projects from Lundbeck Foundation, Novo Nordisk Foundation, and Danish National Research Foundation. Supervises doctoral candidates and postdoctoral researchers while directing the GlycoMedicine research group. Founded biotech ventures including GO-Therapeutics and Hemab ApS.

Lida Derevninaمشاهده پروفایل

پژوهشگر

• Plant Pathology
• Plant Immunity
• Molecular Plant Pathology
• +۳ مورد دیگر

Dr. Lida Derevnina is a leading researcher in plant-pathogen interactions and immune receptor networks at the University of Cambridge , affiliated with the School of Biological Sciences and the Department of Plant Sciences . She heads the Crop Pathogen Immunity Group at the Crop Science Centre , focusing on NLR (Nucleotide-binding and Leucine-Rich Repeat) immune receptor networks and pathogen effector functions to engineer durable crop resistance. Education: PhD in Plant Pathology and Phytopathology, University of Sydney (2008-2012) BSc in Agricultural Science, University of Sydney (2004-2007) Her research explores how pathogens evade plant immunity through effector proteins and how NLR networks can be bioengineered to counteract these mechanisms. This work bridges molecular biology, evolutionary genetics, and sustainable agriculture, with recent advances in resistosome activation models and effectorome characterization. Scientific awards include the Crop Science Centre Fellowship (2022) , Marie Skłodowska-Curie Individual Fellowship (2016) , and the Jeanie Borlaug Laube Women in Triticum Award (2012) . Her work has been published in top journals such as Science , Nature , and PLoS Biology . Dr. Derevnina is actively engaged in public outreach, including the Talking Biotech podcast and a YouTube video explaining plant immunity . Her laboratory collaborates on projects related to global food security and pathogen genomics.

Matthias Feigeمشاهده پروفایل

دانشیار

• Protein Biochemistry
• Cell Biology
• Immunology
• +۳ مورد دیگر

Matthias Feige is an Associate Professor of Cellular Protein Biochemistry at the Technical University of Munich (TUM). He leads the Focus Group for Cellular Protein Biochemistry, previously serving as a Rudolf Mößbauer Tenure Track Assistant Professor. His research focuses on understanding cellular proteome integrity, particularly in the secretory pathway, combining protein biochemistry and cell biology. Key interests include protein folding, quality control mechanisms, and their biomedical applications. Education & Career: PhD in Biochemistry (2009), TUM under Johannes Buchner Postdoctoral Fellowship at St. Jude Children’s Research Hospital (Memphis, USA) with Linda Hendershot Head of the Cellular Protein Biochemistry Lab at TUM since 2015 Research Interests: Feige’s work explores molecular mechanisms governing protein biogenesis, secretory pathway proteins, and their roles in immunity. His interdisciplinary approach targets fundamental biology and translational applications like protein engineering and therapy development. Scientific Contributions: His publications highlight advancements in cytokine assembly, ER quality control, and protein aggregation mechanisms. Notable recent work includes studies on KDELR3 signaling, helminth immune modulation, and engineered cytokines. Awards & Recognition: Leopoldina Fellowship (2011–2014) Fellow of the Daimler and Benz Foundation (2016) Rainer Rudolph Award (2012) Multiple honors from TUM and international institutions Labs & Teams: He directs a lab investigating protein biogenesis and proteostasis. Collaborations span biochemistry, immunology, and structural biology, with a focus on translational research.

Antonio Molina Fernándezمشاهده پروفایل

استاد

• Plant Innate Immunity
• Molecular Biology of Plant-Fungal Interactions
• Cell Wall-Mediated Disease Resistance
• +۳ مورد دیگر

Antonio Molina Fernández is a Professor at the Universidad Politécnica de Madrid , leading the Plant Innate Immunity and Resistance to Necrotrophic Fungi group at the Center for Plant Biotechnology and Genomics (CBGP) . His research focuses on understanding plant defense mechanisms against necrotrophic fungal pathogens, particularly using the Arabidopsis-Plectosphaerella cucumerina interaction as a model system. Key areas include molecular recognition of pathogens, cell wall integrity signaling, and fungal pathogenicity mechanisms. His group investigates how plants sense necrotrophic fungi through receptors like ERECTA and BAK1, regulatory pathways involving MAP kinases and G-proteins, and the role of secondary metabolites in immunity. They also study the genomic basis of fungal lifestyles (pathogenic vs. endophytic) and their interactions with host plants. Current projects include enhancing crop disease resistance via cell wall-derived signals, zinc-mediated immunity, and sustainable agricultural solutions through bioengineering. Molina has secured funding from multiple EU programs, including Horizon-CL6 and MCIN/AEI grants. Notable achievements include identifying the YODA kinase pathway for broad-spectrum resistance and demonstrating the role of cell wall DAMPs in immunity. His work bridges fundamental research with translational applications, aiming to develop biocontrol strategies and climate-resilient crops.