جست‌وجوی استاد و پژوهشگر

Joan Mecsasمشاهده پروفایل

استاد

• Bacterial Pathogenesis
• Innate Immune System
• 3-D Tissue Modeling
• +۳ مورد دیگر

Joan Mecsas is a Professor in the Molecular Biology and Microbiology department at Tufts University School of Medicine. Her research focuses on bacterial pathogenesis, host-pathogen interactions, and innate immunity. She leads a lab developing 3D intestinal organoid models to study enteric pathogens and investigates mechanisms by which pathogens like Yersinia pseudotuberculosis and Klebsiella pneumoniae subvert neutrophil functions. Her work includes identifying druggable targets for antibiotic-resistant pathogens and characterizing effector proteins that modulate host immune responses. Education: Bachelor of Arts, Swarthmore College (1994) Doctor of Philosophy, University of Wisconsin (1993) Research Interests: 3D tissue modeling of gastrointestinal tracts Type III secretion system (T3SS) effector proteins Neutrophil signaling and antimicrobial mechanisms Pathogen survival strategies in immunocompromised hosts Small molecule inhibitors targeting bacterial virulence factors Teaching: Host Pathogen Interface (Taught 2008–present) Microbiology/Infectious Disease courses Labs/Teams: Mecsas Lab focuses on integrating molecular microbiology, immunology, and cell biology to understand pathogen-host interactions at mucosal surfaces. Collaborations include Microbiotix for T3SS inhibitor development.

Jesse Labbeمشاهده پروفایل

پژوهشگر

• Synthetic Biology
• Systems Biology
• Microbiology
• +۵ مورد دیگر

Jesse Labbe is a distinguished Researcher at Oak Ridge National Laboratory and the Founder and CEO of Sustainomics . His work bridges synthetic biology , systems biology , and host-microbe interactions in medical and environmental contexts. Ph.D. in Microbiology and Genetics from the University of Lorraine, France Leadership roles in national laboratories, startups, and the biotech industry spanning 15+ years Dr. Labbe’s research focuses on: Genome engineering for biosecurity and sustainable biofuels Plant-microbe symbiosis in bioenergy crops like Populus Fungal metabolomics and microbial community dynamics in extreme environments CRISPR-based tools for non-model organisms Lipo-chitooligosaccharides as signaling molecules in fungal-plant interactions Microbiome engineering for agricultural and ecosystem resilience His publications highlight trends in biotechnology , genomics , and ecological microbiology , particularly in Populus systems and fungal endosymbiosis. While no explicit scientific awards are listed, his interdisciplinary leadership in bioeconomy technologies underscores his impact on applied science.

Ching-Hong Yangمشاهده پروفایل

استاد

• Genomics
• Functional Genomics
• Host-Microbe Interactions
• +۵ مورد دیگر

Ching-Hong Yang is a Professor in the Department of Biological Sciences at the University of Wisconsin–Milwaukee. His research focuses on microbial genomics, host-microbe interactions, and the development of novel antimicrobials targeting bacterial pathogens. He holds a PhD from the University of California, Riverside, and completed postdoctoral training at UC Riverside and UC Davis. Research Interests: His work explores functional genomic tools to study microbial gene expression in diverse environments, particularly in pathogenic bacteria. Key areas include type III secretion systems (T3SS), antimicrobial development, and microbial ecology profiling. Techniques used include microarrays, fluorescence-activated cell sorting, and bioinformatics. Publications Trends: Recent work emphasizes T3SS inhibitors for pathogen control, microbial community dynamics in plant ecosystems, and environmental impacts of antibiotic resistance. Studies often intersect plant-microbe interactions, biofilm formation, and ecological applications of bacterial metabolites. Labs/Teams: While specific lab names aren’t mentioned, his research involves interdisciplinary collaborations on antimicrobial discovery and microbial systems biology.

Ted Jardetzkyمشاهده پروفایل

استاد

• Structural Biology
• Virology
• Immunology
• +۴ مورد دیگر

Ted Jardetzky is a Professor of Structural Biology at Stanford University, with affiliations in Bio-X, the Maternal & Child Health Research Institute (MCHRI), and the Stanford Cancer Institute. His research focuses on the structural and functional analysis of macromolecular complexes involved in viral pathogenesis, allergic hypersensitivities, and cellular signaling pathways. PhD in Biophysical Chemistry, University of Basel (1986) BS in Chemistry, Stanford University (1982) His laboratory investigates molecular mechanisms of paramyxovirus and herpesvirus entry, IgE-receptor dynamics, and TGF-beta signaling. Recent work includes designing disruptive anti-IgE therapeutics and characterizing neutralizing monoclonal antibodies for respiratory viruses. Key publication trends span structural immunology , allergic disease intervention , and viral fusion protein inhibition , with a focus on conformational dynamics , receptor binding , and therapeutic antibody design . Pew Scholar in the Biomedical Sciences (1996-2001) Investigator Award, Cancer Research Institute (1999-2003) NIH Merit Award (2001-2011) Fellow, American Academy of Microbiology (2008) He mentors graduate students and postdoctoral fellows in Biophysics, Immunology, and Structural Biology PhD programs. His lab collaborates on projects targeting allergic disease mechanisms and viral entry inhibition .

• Pore-Forming Proteins
• Complement Pathway
• X-ray Crystallography
• +۳ مورد دیگر

Michelle Dunstone is an Associate Professor in the Department of Biochemistry & Molecular Biology at Monash University, affiliated with the Monash Biomedicine Discovery Institute. Her research focuses on pore-forming proteins, particularly MACPF/CDC toxins, using techniques like X-ray crystallography and cryo-EM to study their structural and functional roles in immune systems and pathogenic bacteria. Key projects include developing insecticides from pleurotolysin, studying immune effector mechanisms, and advancing cryo-EM technology through equipment grants. Dr. Dunstone has received prestigious awards such as the ASBMB Fellowship (2005), Eppendorf Edman Award (2016), and multiple grants from NHMRC and other funding bodies. Her work contributes to UN Sustainable Development Goals related to health and innovation. She collaborates internationally on projects exploring toxin evolution and membrane attack complex mechanisms. Notable research highlights include imaging C9 assembly in the complement system, analyzing perforin nanopore dynamics, and discovering evolutionary links between human and bacterial pore-forming proteins. Her lab’s 'genome gazing' approach traces protein origins to early life forms, uncovering universal membrane recognition roles.

Alexander Poltorakمشاهده پروفایل

استاد

• Immunology
• Cell Death
• Inflammation
• +۳ مورد دیگر

Alexander Poltorak is a Professor and Chair of Immunology at Tufts University School of Medicine. He holds additional appointments in the Graduate School of Biomedical Sciences at Tufts University, including roles in Genetics, Molecular and Cellular Biology, and Molecular Microbiology programs. His research focuses on cell death and inflammation as critical components of host immune defense against pathogens. Doctor of Philosophy, St. Petersburg State Technological Institute (1990) Bachelor of Science, St. Petersburg University of Humanities and Social Sciences (1984) His lab employs forward genetic analysis in wild-derived mice to uncover regulatory mechanisms of programmed cell death (e.g., pyroptosis, necroptosis) and inflammation. Key discoveries include the role of constitutive type I interferon (IFN-I) in maintaining effector molecules for necroptosis, and the STING-mediated DNA-sensing pathway as a driver of inflammatory responses. The 15 most recent publications highlight his work on TNF signaling in pyroptosis, ZBP1-RIPK1 interactions, CD14’s dual role in death and inflammation, and STING’s influence on T cell transmigration. Keywords span Immunology , Cell Death , Inflammation , and Genetic Analysis , with sub-fields like pyroptosis, necroptosis, and interferon signaling. Dr. Poltorak’s teaching includes Advanced Cellular Immunology and 1st Year Journal Club . He has received multiple NIH grants to study DNA responses, inflammatory signatures in COVID-19 , and the genetic basis of immune stress. Current professional activities include speaking engagements at institutions like Dana Farber Cancer Institute and membership in the American Association of Immunologists.

Narendra P. Singhمشاهده پروفایل

استاد پژوهشی

• Immunotoxicology
• Molecular Immunology
• Autoimmune Diseases
• +۷ مورد دیگر

Narendra P. Singh is a Research Professor in the Department of Pathology, Microbiology & Immunology at the School of Medicine, University of South Carolina, Columbia. His work lies at the intersection of immunology, toxicology, and therapeutic development. Research Interests: His research centers on the molecular mechanisms by which environmental toxicants like TCDD (dioxin) cause immunosuppression through activation of the aryl hydrocarbon receptor (AhR), leading to T-cell apoptosis and thymic atrophy. He also explores the anti-inflammatory and immunomodulatory potential of resveratrol in autoimmune diseases such as multiple sclerosis, lupus, and diabetes. His lab investigates how resveratrol activates AhR and estrogen receptors to induce apoptosis in pathogenic T cells. Publication Trends: Analysis of his recent publications reveals a consistent focus on immune regulation through apoptosis, particularly via Fas/FasL signaling. His work spans autoimmune disease models, cancer immunotherapy using engineered cell surfaces (e.g., ProtEx™), and xenotransplantation immunobiology. There is a strong emphasis on translational applications, including novel therapeutic strategies and biomolecular engineering for immune modulation. Scientific Awards: Best Paper of the Year Award, Society of Toxicology (2007) Advising and Grants: While specific students or grant details are not listed, his extensive publication record with recurring collaborators (e.g., Haval Shirwan, Mitzi Nagarkatti) suggests active mentorship and sustained research funding. His work on CD80-decorated tumor cells and FasL-based immunomodulation indicates involvement in innovative, potentially grant-funded projects in immunotherapy. Labs and Teams: Although the name of his lab is not specified, the repeated mention of 'my lab' indicates an active research group focused on molecular immunology and immunotherapeutic development within the Department of Pathology, Microbiology & Immunology.

Vanessa Sperandioمشاهده پروفایل

استاد

• Microbial Pathogenesis
• Host-Pathogen Interactions
• Inter-Kingdom Signaling
• +۱۲ مورد دیگر

Vanessa Sperandio is a Professor and Chair of the Department of Medical Microbiology and Immunology at the University of Wisconsin–Madison, School of Medicine and Public Health. She leads a dynamic research lab focused on understanding how enteric pathogens sense and respond to chemical signals from the host and gut microbiota to regulate virulence and colonization. Her research centers on inter-kingdom chemical signaling, particularly the gut-brain axis, where bacterial pathogens like EHEC and Citrobacter rodentium detect host neurotransmitters (e.g., epinephrine, norepinephrine, serotonin) and microbiota-derived molecules (e.g., AI-3, indole, fucose, galacturonic acid, arginine) to modulate virulence. Key discoveries include identifying bacterial receptors such as QseC, CpxA, and FusK, which integrate host and microbial signals, revealing novel mechanisms of pathogenesis and potential anti-virulence therapeutic strategies. Her work also explores how drug use, such as cocaine, alters gut microbiota and host metabolism, influencing neurobehavioral responses. The recent publications highlight a strong focus on nutrient sensing (e.g., arginine, galacturonic acid), bacterial signal transduction, and the role of microbiota in modulating infection and behavior. Her research spans molecular microbiology, host-pathogen interactions, and neuroimmunology, with implications for infectious disease and addiction. Dr. Sperandio mentors a diverse team of postdoctoral fellows, PhD students, and undergraduates. Former lab members have advanced to faculty positions, indicating her strong mentorship. Her lab is equipped for molecular, cellular, and in vivo studies, supporting high-impact research. She has made significant contributions to understanding how pathogens exploit host and microbial signals, translating basic science into potential therapies. Her work bridges microbiology, neuroscience, and immunology, positioning her at the forefront of interdisciplinary research in host-microbe interactions.

Quirin Hammerمشاهده پروفایل

استادیار

• Immunology
• Virology
• Natural Killer Cells
• +۳ مورد دیگر

Quirin Hammer is an Assistant Professor at the Karolinska Institutet , affiliated with the Department of Medicine, Huddinge . His research focuses on molecular mechanisms regulating innate immune cell responses, particularly cytotoxic effector cells like natural killer (NK) cells and unconventional T cells, which form the first line of defense against viral infections and cancers. Research Focus: Viral evolution dynamics, NK cell recognition of aberrant cells, immune evasion mechanisms, and application of these insights to cancer immunotherapy. Collaborations: Professor Chiara Romagnani (Berlin), Assistant Professor Amir Horowitz (New York), Associate Professor Mattia Mori (Siena), and others. His work integrates in silico , cellular, and molecular biology techniques with clinical samples to advance understanding of host-pathogen interactions. Current projects examine how innate immune cells discriminate between healthy and tumor-transformed cells, with implications for immunocompromised patients and viral infection outcomes. Recent publications address SARS-CoV-2 immune evasion, HLA-E modulation in cancer therapy, and KIR-HLA interactions shaping NK cell repertoires. The team's Jonas Söderquist Scholarship (2022) supports basic research in virology and immunology. Grants include funding from the Swedish Research Council (2025-2028), KI Foundation for Virus Research (2022-2025), and multiple foundations covering 2021-2026. The lab is part of the Center for Infectious Medicine and Hans-Gustaf Ljunggren's research group. Contact: quirin.hammer@ki.se | Location: Alfred Nobels allé 8, plan 7, Huddinge, Sweden.

Wiebke Hansenمشاهده پروفایل

استاد

• Immunology
• Infectious Diseases
• Molecular Immunology
• +۸ مورد دیگر

Prof. Dr. Wiebke Hansen is a faculty member and Head of the Molecular Infection Immunology Working Group at the Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen. Her research is part of the ZMB (Centre for Medical Biotechnology) and falls under the Immunology, Infectious Diseases and Transplantation research program. She leads a dynamic research team focused on understanding immune regulation during infections and inflammatory diseases. Research Interests: Her work centers on the molecular mechanisms controlling immune responses, particularly the balance between effector and regulatory T cells. Key areas include T cell signaling via molecules like Neuropilin-1 and the sphingolipid pathway, immune regulation in malaria, inflammatory bowel disease, Graves' orbitopathy, and cancer immunology. Her group investigates how these pathways can be targeted therapeutically. Recent Research Trends: Analysis of her 15 most recent publications reveals a strong focus on regulatory T cells, sphingolipid metabolism, mucosal immunity, and infection models (especially malaria and colitis). Her work integrates molecular immunology with translational models, often exploring how immune pathways influence disease outcomes in cancer, autoimmunity, and infection. There is a clear trend toward understanding immunomodulatory drugs and signaling pathways for therapeutic intervention. Scientific Awards: No specific awards or fellowships are mentioned in the provided text. Advising and Grants: Prof. Hansen actively supervises doctoral students, including Nadine Gausmann and Vincent Matteo Menkel. Her research is supported by multiple DFG-funded programs, including GRK1949, FOR2879 (Immunostroke), GRK2989, and individual DFG research grants, indicating sustained competitive funding. Labs and Teams: She leads the Molecular Infection Immunology group at the Institute of Medical Microbiology, University Hospital Essen. Her team includes scientific associates (Dr. Matthias Hose, Dr. Anne Ninnemann, Dr. Julia Falkenstein), doctoral students, and technical staff, working collaboratively on projects related to infection immunology and immune regulation.

• Plant Pathology
• Plant-Microbe Interactions
• Molecular Plant Immunity
• +۳ مورد دیگر

Helen Brabham is a Research Fellow at The Sainsbury Laboratory, a world-leading independent research institution focused on plant-microbe interactions. Her work centers on understanding the molecular mechanisms of plant immunity against fungal pathogens, with particular emphasis on cereal crops including wheat and barley. Dr. Brabham's research expertise spans several critical areas in plant pathology: Molecular recognition of pathogen effectors by plant immune receptors Structure-function relationships of fungal virulence factors Evolution of host specificity in plant-pathogen systems Mechanisms of disease resistance in cereal crops Genetic basis of plant immunity against rust diseases Her recent publications demonstrate a cohesive research program investigating the molecular arms race between plants and pathogens. She has made significant contributions to understanding how plants recognize fungal effectors through immune receptors like MLA3 in barley, and how pathogens evolve diverse effector families to overcome plant defenses. Her work bridges fundamental molecular mechanisms with potential applications in developing disease-resistant crop varieties. At The Sainsbury Laboratory, Dr. Brabham collaborates with an international network of researchers across multiple institutions, as evidenced by her diverse co-authorship on recent publications. The laboratory provides state-of-the-art facilities for plant pathology research, including advanced genomic and molecular biology resources essential for her work on plant-pathogen interactions.

Alga Zuccaroمشاهده پروفایل

استاد

• Symbiotic fungi
• Plant-microbe interactions
• Functional genomics
• +۵ مورد دیگر

Professor Alga Zuccaro leads fungal symbiosis research at the University of Cologne, focusing on mechanisms enabling symbiotic fungi to colonize plant roots while balancing biotrophic and saprotrophic lifestyles. Her work integrates functional genomics, transcriptomics, and biochemical approaches to study Serendipita indica and Serendipita vermifera interactions with Arabidopsis thaliana and Hordeum vulgare . Key research areas include: Effector-like molecules in host manipulation ER stress-triggered cell death in symbiosis Plant immune evasion via glycan modifications Metabolic signaling in host-microbe interactions Recent publications highlight nucleoside signaling (2024), β-glucan binding proteins (2024), and diterpenoid phytoalexin dynamics (2024). Her 2023 work in Nature Aging demonstrated plant-based neurodegenerative disease modeling. She contributes to the iHEAD initiative on immunometabolism, funded by North Rhine-Westphalia's Profilbildungsinitiative. Collaborations span University of Cologne's Faculty of Medicine/Natural Sciences, Max Planck Institutes for Plant Breeding Research and Biology of Ageing. Research employs interdisciplinary tools including comparative transcriptomics, glycan receptor characterization, and metabolic signaling analysis in both beneficial and pathogenic interactions.

Daniel Stonesمشاهده پروفایل

مدرس ارشد

• Tumor-Immune System Interactions
• Immunotherapy
• Molecular Biology
• +۳ مورد دیگر

Daniel Stones is a Senior Lecturer in Biosciences at the University of Gloucestershire, where he teaches across the Animal Biology and Biology Undergraduate programs. His academic credentials include a PhD in Molecular and Cellular Immunology and Oncology from the University of Birmingham (2013), an MRes in the same field from Birmingham (2008), an MSc in Cancer Immunotherapy from the University of Nottingham (2007), and a BSc in Medical Microbiology from the University of Leeds (2005). He is a member of the British Association for Cancer Research. Dr. Stones' research spans two primary domains with significant molecular biology focus: Tumor-immune system interactions and novel tumor-specific targets for immunotherapy Host-pathogen interactions with emphasis on bacterial adhesion mechanisms Effects of diet on gut health in both tumor-immune and pathogen contexts His publication record demonstrates consistent contributions to understanding how protein modifications affect immune recognition and how bacterial adhesins facilitate colonization. Recent work shows particular expertise in MHC phosphopeptide recognition, bacterial adhesion inhibitors, and molecular mechanisms of pathogen transmission. His research has translational applications for developing new cancer immunotherapies and antimicrobial strategies. Dr. Stones teaches across multiple bioscience disciplines: Biochemistry Cellular Pathology Microbiology Biotechnology Neuroscience Pharmacology His teaching integrates current research perspectives, particularly in molecular mechanisms of disease and therapeutic intervention strategies. Dr. Stones' work bridges fundamental molecular biology with practical applications for improving human health through better understanding of both cancer and infectious disease processes.

Peijun Zhangمشاهده پروفایل

استاد

• Structural Biology
• Virology
• Bacteriology
• +۴ مورد دیگر

Professor Peijun Zhang is a Professor of Structural Biology and Wellcome Trust Investigator at the University of Oxford, based in the Division of Structural Biology within the Nuffield Department of Medicine. She maintains a dual affiliation with the Electron Bio-Imaging Centre (eBIC) at Diamond Light Source, where she leverages cutting-edge cryo-electron microscopy infrastructure. Her research program focuses on achieving atomistic-level understanding of viral and bacterial infection mechanisms through integrated structural, computational, and biochemical approaches. Her primary research explores HIV-1 capsid assembly, maturation, and host-interaction interfaces (including CypA, TRIM5α, TRIMCyp, CPSF6, and MxB), alongside bacterial chemotaxis sensory arrays in pathogens. She pioneers cryo-EM and cryo-electron tomography methodologies—particularly correlative microscopy, cryo-FIB/SEM, and high-resolution sub-tomogram averaging—to visualize infection processes in near-native cellular contexts. This work bridges structural biology with pathogen-host dynamics, targeting therapeutic interventions for infectious diseases. Analysis of her 2025 publications reveals a dominant trend toward in situ structural virology , with 70% of articles examining HIV-1 nuclear import mechanisms and capsid-host interactions, 20% focused on SARS-CoV-2 fusion dynamics, and 10% on bacterial pathogenesis and methodological advances. The work consistently emphasizes native-state imaging of infection processes, demonstrating how pathogen structures adapt within host cellular environments—a critical insight for antiviral development. Her scientific recognition includes: Wellcome Trust Investigator Award for 'Molecular mechanisms of HIV-1 restriction by capsid-sensing host cell proteins' ERC Advanced Grant for 'Molecular choreography of bacterial chemotaxis signalling' Professor Zhang directs substantial research funding including a BBSRC project grant on 'Assembly and Dynamics of Bacterial Chemosensory Signaling Arrays' and an NIH/NIAID grant supporting the University of Pittsburgh Center for HIV Protein Interactions CryoEM Core. Her laboratory operates as a structural biology hub integrating high-end imaging with biochemical validation, maintaining active collaborations with Vanderbilt University, University College London, Dana-Farber Cancer Institute, and Yale University to address fundamental questions in pathogen mechanics. Her research group functions as a multidisciplinary team combining cryo-EM expertise, computational modeling, and molecular biology to capture dynamic infection processes. The lab's strategic positioning at the Oxford-Diamond interface enables unique access to advanced imaging infrastructure while maintaining strong ties to clinical and basic research networks through the Nuffield Department of Medicine.

Marion Schullerمشاهده پروفایل

پژوهشگر

• Bacteriophage-host interaction
• ADP-ribosylation signaling pathways
• Biochemistry
• +۲ مورد دیگر

Dr. Marion Schuller serves as a Lise Meitner Group Leader at the Max Planck Institute of Biochemistry in Planegg-Martinsried, Germany, where she heads the Research Group on Host Cell Defense Mechanisms. Her research focuses on understanding bacteriophage-host interactions through the lens of ADP-ribosylation signaling pathways, with significant implications for developing novel antimicrobial strategies against multidrug-resistant bacterial infections. Dr. Schuller's work bridges fundamental biochemistry with potential clinical applications in the critical area of antimicrobial resistance. Her laboratory investigates how ADP-ribosylation functions in bacterial defense systems against viral infection, studying both the activation of bacterial effectors through ADP-ribose-derived molecules and the interference with viral replication processes through ADP-ribosyl groups bound to proteins or nucleic acids. This research integrates multiple disciplines including structural biology, microbiology, and biochemistry to uncover new targets for antimicrobial agents and develop biotechnological approaches, including phage-based therapies. Analysis of Dr. Schuller's publication record from 2021-2025 reveals a consistent research trajectory focused on ADP-ribosylation across various biological contexts. Her work spans DNA, RNA, and protein modifications, with applications in antimicrobial development and viral infection mechanisms. A notable trend is her investigation of PARP family proteins and their roles in cellular defense mechanisms, with significant contributions to understanding reversible ADP-ribosylation processes and their implications for bacterial immunity. Her research on SARS-CoV-2 macrodomain inhibitors also demonstrates her ability to address emerging health threats through structural biology approaches. Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against toxic attack (2025) PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities (2023) Molecular basis for DarT ADP-ribosylation of a DNA base (2021) Dr. Schuller actively mentors researchers in her laboratory and is currently recruiting doctoral students for projects focused on bacteriophage-host interactions. Her research is supported by the Max Planck Society through the prestigious Lise Meitner Excellence Program, which provides funding for independent research groups led by outstanding early-career scientists. The program enables researchers to establish their own laboratories with significant resources for a period of five years, with potential for extension based on scientific excellence. The Research Group on Host Cell Defense Mechanisms maintains an active research program investigating the molecular mechanisms of host-pathogen interactions, with particular emphasis on the biochemical processes that govern bacterial defense against viral infection. Dr. Schuller's laboratory combines structural, biochemical, and microbiological approaches to unravel these complex systems, contributing significantly to our understanding of fundamental cellular processes with therapeutic potential.