Narendra P. Singh

Narendra P. Singh is a Research Professor in the Department of Pathology, Microbiology & Immunology at the School of Medicine, University of South Carolina, Columbia. His work lies at the intersection of immunology, toxicology, and therapeutic development.

Research Interests: His research centers on the molecular mechanisms by which environmental toxicants like TCDD (dioxin) cause immunosuppression through activation of the aryl hydrocarbon receptor (AhR), leading to T-cell apoptosis and thymic atrophy. He also explores the anti-inflammatory and immunomodulatory potential of resveratrol in autoimmune diseases such as multiple sclerosis, lupus, and diabetes. His lab investigates how resveratrol activates AhR and estrogen receptors to induce apoptosis in pathogenic T cells.

Publication Trends: Analysis of his recent publications reveals a consistent focus on immune regulation through apoptosis, particularly via Fas/FasL signaling. His work spans autoimmune disease models, cancer immunotherapy using engineered cell surfaces (e.g., ProtEx™), and xenotransplantation immunobiology. There is a strong emphasis on translational applications, including novel therapeutic strategies and biomolecular engineering for immune modulation.

• Scientific Awards:
• Best Paper of the Year Award, Society of Toxicology (2007)

Advising and Grants: While specific students or grant details are not listed, his extensive publication record with recurring collaborators (e.g., Haval Shirwan, Mitzi Nagarkatti) suggests active mentorship and sustained research funding. His work on CD80-decorated tumor cells and FasL-based immunomodulation indicates involvement in innovative, potentially grant-funded projects in immunotherapy.

Labs and Teams: Although the name of his lab is not specified, the repeated mention of 'my lab' indicates an active research group focused on molecular immunology and immunotherapeutic development within the Department of Pathology, Microbiology & Immunology.