Gary Perdew

Dr. Gary Perdew is the John T. And Paige S. Smith Professor in the Department of Veterinary and Biomedical Sciences at Pennsylvania State University's College of Agricultural Sciences. His research focuses on the molecular mechanisms of toxicity, particularly dioxin-mediated signal transduction and the role of the Aryl Hydrocarbon Receptor (AhR) in regulating cellular homeostasis. Notably, his work explores how environmental pollutants like dioxins disrupt metabolic and microbial systems, with implications for long-term health effects. He leads the Health and the Environment Seed Grant Committee at the Institute of Energy and Environment.

• Research Themes: Environmental toxicology, receptor signaling, pollutant metabolism, gut microbiome interactions.
• Affiliations: Institute of Energy and Environment, Metabolomics Core Facility.

Key research interests include AhR's role in pollutant-induced toxicity, microbiota-derived ligands, and dietary modulation of receptor activity. Recent studies highlight early-life exposure effects on gut health and the discovery of natural AhR modulators in foods like mushrooms.

His articles frequently address AhR signaling pathways, dioxin toxicity, and translational applications in environmental health. He has contributed to WHO guidelines for toxic equivalence factors and led high-impact studies on pollutant-induced metabolic dysfunction.

• Awards: None explicitly listed, but his leadership roles and prolific publications reflect significant recognition in the field.
• Grants & Advising: Leads seed grant programs but no explicit student advisees listed. Collaborates widely with teams like the Metabolomics Core Facility and international AHR Meeting committees.

Current lab activities include investigating gut-lung axis signaling, microbial metabolite effects on AhR, and developing AhR-based therapies for metabolic and inflammatory disorders.