جست‌وجوی استاد و پژوهشگر

Jan M. Deussingمشاهده پروفایل

پژوهشگر

• Cellular & Systems Neuroscience
• Behavioral & Cognitive Neuroscience
• Molecular & Developmental Neuroscience
• +۴ مورد دیگر

Dr. Jan M. Deussing is a Research Group Leader at the Max Planck Institute of Psychiatry in Munich, Germany, where he heads the Molecular Neurogenetics research group. He is a regular member of MCN and GSN with full faculty status, focusing on the intersection of genetics, neuroscience, and psychiatry. His work at the Core Unit Genetically Engineered Mouse Models (GEMMs) positions him at the forefront of translational research on stress-related neuropsychiatric disorders. Dr. Deussing's research program investigates how genetic risk factors interact with environmental stressors to influence the development of neuropsychiatric conditions. His laboratory employs sophisticated mouse models to dissect the epigenetic mechanisms and neural circuits underlying disorders like bipolar disorder, depression, and anxiety. Recent work has focused on corticotropin-releasing hormone (CRH) systems, FKBP51 protein function, P2X7 receptors, and genetic variants associated with bipolar disorder. A September 2024 press release highlighted his team's successful decoding of a risk gene for bipolar disorder, accompanied by an explanatory comic illustrating their findings. Analysis of Dr. Deussing's recent publications reveals a strong emphasis on molecular mechanisms of stress response, with particular focus on CRH signaling pathways, FKBP51 co-chaperone function, and genetic determinants of bipolar disorder. His work spans from basic molecular neuroscience to translational applications, with increasing attention to sex-specific effects in stress susceptibility and resilience. The research employs cutting-edge techniques including genetically engineered mouse models, multi-omics approaches, and deep behavioral phenotyping. Dr. Deussing mentors several graduate students including Simon Chang, Lidia Urbina Treviño, and Clemens Ries, with former students like Laura Sotillos Elliott having completed their training under his supervision. His laboratory collaborates extensively with other research groups at the Max Planck Institute and internationally, particularly on projects involving neural circuit mapping and molecular mechanisms of psychiatric disorders. The Deussing Lab operates within the Molecular Neurogenetics department of the Max Planck Institute of Psychiatry, utilizing the Core Unit Genetically Engineered Mouse Models (GEMMs) to investigate stress-related neuropsychiatric disorders. The team employs a multidisciplinary approach combining molecular biology, behavioral neuroscience, and genetic engineering to unravel the complex interplay between genetic predisposition and environmental stressors in mental health conditions.

Leanne Stokesمشاهده پروفایل

دانشیار

• Pharmacology
• Immunology
• Ion Channel Biology
• +۵ مورد دیگر

Leanne Stokes is an Associate Professor in Pharmacology at the University of East Anglia, affiliated with the School of Chemistry, Pharmacy and Pharmacology. Her research focuses on ion channel biology, particularly purinergic P2X receptors, and their roles in immune signaling, inflammation, and chronic pain. Stokes completed her BSc and MRes at the University of Sheffield and Birmingham, followed by a PhD in Immunology at Birmingham. She has held postdoctoral roles at the University of Sheffield and Sydney, leading to prestigious fellowships at RMIT University and the University of Sydney. Her expertise includes drug discovery using natural products, spider venom, and traditional medicines. Key projects involve identifying modulators of P2X4 and P2X7 receptors, with applications in neuroinflammation and cancer. Stokes has secured funding from organizations like the Royal Society and Kuwait Government, and collaborates internationally on purinergic signaling research. She also contributes to educational initiatives like ReceptorCards for pharmacology teaching and public engagement through virtual reality projects. Her scientific awards include a Vice Chancellor’s Research Fellowship at RMIT University (2013-2015). Current research explores genetic polymorphisms in ion channels and novel drug design techniques using on-cell NMR methods. Stokes actively participates in academic networks such as the European Purines Conference and serves on editorial boards for journals like the British Journal of Pharmacology.

Yunmeng Liuمشاهده پروفایل

استادیار

• Metabolic Syndromes
• Diabetes Pathogenesis
• Cardiovascular Disease
• +۶ مورد دیگر

Yunmeng Liu, Ph.D., is an Assistant Professor in the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. Her research focuses on metabolic syndromes, particularly diabetes-linked cardiovascular complications and hypertension. She leads studies on immune cell contributions to hypertension pathogenesis using advanced techniques like radio-biotelemetry and 3D microscopy. Liu’s work integrates immunology, endocrinology, and molecular biology to develop therapeutic strategies. Education & Training: Ph.D. in Pharmacology, New York Medical College (2013) Postdoctoral Training at UAMS Rusch Laboratory (2019) Research Interests: Exploring how diabetes exacerbates cardiovascular disease and hypertension through metabolic reprogramming. Current projects investigate T cell interactions in kidney and heart tissues, immune pathways (e.g., IFNγ-PDL1), and cellular mechanisms driving salt-sensitive hypertension. Collaborations span immunology and physiology fields. Grants: Sturgis Foundation Grant (2024–2024): $50K, PI for 'Diabetes promotes hypertension via metabolic reprogramming' NIH R01 HL146713 (2024–2029): Major contributor to 'T cell homing to the kidney' Labs/Teams: Leads a multidisciplinary lab using cutting-edge tools like Seahorse assays and multi-color flow cytometry. Collaborates with the Rusch laboratory and immunology experts at UAMS.

Noah Marcusمشاهده پروفایل

دانشیار

• Cardiovascular Disease
• Sleep Apnea
• Autonomic Regulation
• +۳ مورد دیگر

Noah Marcus is an Associate Professor in the Department of Physiology and Pharmacology at Des Moines University Medicine and Health Sciences. He holds additional roles in the Doctor of Osteopathic Medicine Program, Master of Science in Biomedical Sciences Program, and Ph.D. in Biomedical Sciences Program. His expertise spans autonomic regulation, cardiopulmonary physiology, cardiovascular disease, and sleep apnea. Dr. Marcus earned his Ph.D. from the University of Wisconsin-Madison (2010), followed by a post-doctoral fellowship at the University of Nebraska Medical Center (2010–2015). His research focuses on cardio-renal dysfunction in heart failure, sex steroid hormones in sleep apnea, and therapeutic interventions like remote ischemic conditioning. Research Interests: His work examines mechanisms underlying chemoreflex dysfunction in heart failure, autonomic dysregulation in sleep disorders, and cardio-renal interactions. Key areas include glomerular hyperfiltration, hepatic microcirculation, and neuroinflammatory pathways. Publications highlight advancements in understanding chronic intermittent hypoxia effects, medullary astrocyte signaling, and therapeutic strategies for long-COVID cardiovascular complications. His studies often utilize rodent models to explore novel treatment avenues. Grants and advising details are not explicitly listed in the provided text.

Keisuke Itoمشاهده پروفایل

استاد

• Hematopoietic Stem Cell Biology
• Hematological Malignancies
• Stem Cell Metabolism
• +۴ مورد دیگر

Keisuke Ito, M.D., Ph.D., is a Professor in the Departments of Cell Biology, Medicine, and Oncology (Medical Oncology) at Albert Einstein College of Medicine. He also serves as Director of Scientific Resources of the Stem Cell Institute. His research focuses on hematopoietic stem cell (HSC) biology, including self-renewal, differentiation, and their roles in myelodysplastic syndrome (MDS) and sickle cell disease. Key areas include mitochondrial metabolism, epigenetic regulation, and bone marrow microenvironment dynamics. Dr. Ito's work integrates live imaging and single-cell approaches to study HSC fate and leukocyte behavior in disease models. He leads initiatives in metabolic control of HSCs and therapeutic strategies targeting cellular energetics. Notable contributions include discoveries on TET proteins' roles in hematopoiesis and mitochondrial NADPH-cholesterol pathways in extracellular vesicle biogenesis. He has organized major symposia, including the Paul S. Frenette Memorial Symposium and the Einstein Stem Cell Institute Retreats. His research is supported by NIH grants focusing on HSC metabolism and LLS-funded studies on mitochondrial alterations in MDS. Dr. Ito also directs the Single Cell Genomics Core and contributes to the NYTrainKUHR training program. His publications span high-impact journals like Nature, Cell, and Science, with a focus on translating stem cell biology into clinical therapies.

• Biomaterials Engineering
• Nanotechnology
• Tissue Engineering
• +۳ مورد دیگر

Kaushal Rege is a Professor at Arizona State University (ASU), serving as the Director of the School for Engineering of Matter, Transport and Energy. He is affiliated with the Biodesign Center for Biomaterials Innovation and Translation and the Biodesign Center for Sustainable Macromolecular Materials and Manufacturing. Rege holds graduate faculty roles in Chemical Engineering, Biomedical Engineering, Biological Design, Materials Science and Engineering, and the School of Molecular Sciences. He earned his Ph.D. in Chemical Engineering from Rensselaer Polytechnic Institute and conducted postdoctoral work at Massachusetts General Hospital and Harvard Medical School. His research focuses on developing biomaterials and nanomaterials for tissue repair, therapeutic delivery, and wound healing, particularly leveraging photothermal nanomaterials and polymer-based systems. Notable contributions include laser-activated sealants for skin and intestinal repair, and smart materials for military defense applications. Rege has secured funding from NIH, NSF, and Mayo Clinic, and has been recognized with the AIMBE Fellowship (2017), American Society of Photobiology New Investigator Award (2014), and DoD Young Investigator Award. Rege’s research portfolio includes over 150 peer-reviewed articles and spans collaborations across engineering, medicine, and biology. His lab actively develops materials for clinical translation, including radiation-responsive nanosensors and hydrogel platforms for cancer dormancy modeling. Current projects emphasize temporal delivery systems, inflammasome modulation in diabetic wounds, and exosome-based drug resistance studies.

• Genetics
• Cardiovascular Development
• Hypertension
• +۳ مورد دیگر

Lingjuan Hong is an Associate Research Scientist in the Department of Genetics at Yale School of Medicine. She holds a PhD from Zhejiang University (2015). Her research focuses on genetic mechanisms underlying cardiovascular development, hypertension, and neurovascular injury, with a particular emphasis on transcription factors and signaling pathways. Key research interests include the role of PRDM6 in heart development and hypertension pathogenesis, GPR124 in vascular inflammation and repair, and the molecular basis of leukocyte-endothelial interactions in neurovascular disorders. Her work integrates systems biology approaches with experimental models to explore gene regulation in disease contexts. Recent studies highlight discoveries such as PRDM6's role as a master regulator of renin-producing cells and its link to hypertension, as well as GPR124's contributions to pericyte migration during ischemic injury. These findings bridge basic science and translational medicine. Publications span topics from CRISPR-based DNA repair optimization to neuroprotective drug design for Alzheimer’s disease. Hong collaborates across disciplines, leveraging genetic, pharmacological, and imaging tools to address complex biological questions.

Seiko Ikezuمشاهده پروفایل

استادیار

• Neuroscience
• Alzheimer's Disease
• Autistic Spectrum Disorders
• +۱۲ مورد دیگر

Seiko Ikezu, M.D., is an Assistant Professor of Neuroscience and Associate Consultant II-Research at Mayo Clinic in Jacksonville, Florida. She is a core member of the Molecular Neurotherapeutics Laboratory led by Dr. Tsuneya Ikezu, where she conducts pioneering research on Alzheimer’s disease and autistic spectrum disorders. Education: MD, Gunma University BS in Arts and Sciences, Gunma University Residency in Internal Medicine, University of Tokyo Medical Center and Kosei-Nenkin Hospital Clinical Fellowship in Endocrinology, University of Tokyo Medical Center Clinical Research Fellowship in Endocrinology, University of Tokyo Medical Center Research Fellowship in Neuroscience, Cleveland Clinic Foundation Observership in multiple specialties, University of Nebraska Medical Center Research Interests: Dr. Ikezu's research focuses on understanding and targeting molecular mechanisms in neurodegenerative and neurodevelopmental disorders. Her primary interests include: • Developing antisense oligonucleotides (ASOs) against TTBK1 to slow Alzheimer’s progression by reducing tau phosphorylation. • Targeting microglial tumor susceptibility gene 101 (TSG101) to inhibit extracellular vesicle-mediated spread of pathological tau. • Investigating microglial dysfunction in autism, particularly how maternal immune activation leads to lasting microglial changes and cognitive impairments. Her work leverages human iPSC-derived neurons, mouse models, and advanced proteomic techniques to uncover disease mechanisms and identify therapeutic targets. Research Trends: Her recent publications highlight a strong emphasis on extracellular vesicles as carriers of pathological proteins in Alzheimer’s disease, microglial activation, and novel therapeutic strategies using ASOs and genetic models. There is a consistent focus on tau propagation, neuroinflammation, and biomarker discovery using cutting-edge imaging and isolation techniques. Scientific Awards: Alzheimer's Disease Center Career Development Award, Boston University (2018–2019) Research Topic Editor, Frontiers in Aging Neuroscience (2022) Advising and Grants: Dr. Ikezu serves as Principal Investigator (PI) on a National Institute on Aging-funded project targeting TSG101 for Alzheimer’s therapy, demonstrating her leadership in securing competitive research funding. She collaborates with Ionis Pharmaceuticals and Mayo Clinic researchers, including Dr. Debabrata Mukhopadhyay. While specific advisees are not listed, her role in a major research lab suggests active mentorship of trainees and junior scientists. Labs and Teams: She is a key member of the Molecular Neurotherapeutics Laboratory at Mayo Clinic, which focuses on tauopathies, microglia, extracellular vesicles, and iPSC-based disease models. The lab employs advanced techniques including cryoelectron microscopy, CRISPR editing, and single-particle analysis to study neurodegeneration and develop biotherapeutics.

• Neurology
• Stroke Research
• Neuroimmunology
• +۵ مورد دیگر

Dr. Tim Ullrich Magnus is an Associate Professor in the Department of Neurology at the University Medical Center Hamburg-Eppendorf, affiliated with the University of Hamburg. His research focuses on the intersection of neurology, immunology, and stroke pathophysiology, with particular emphasis on neuroinflammation, brain injury mechanisms, and potential therapeutic interventions. Dr. Magnus's research primarily investigates: Neuroimmunological aspects of stroke and brain injury Role of extracellular vesicles in neuroprotection and recovery Purinergic signaling pathways in neurological disorders Microglial and immune cell responses following CNS injury Novel diagnostic and therapeutic approaches for stroke and neurodegenerative conditions Analysis of Dr. Magnus's recent publications (2023-2025) reveals several key trends: Extensive work on extracellular vesicles as therapeutic vehicles and biomarkers Investigation of purinergic signaling pathways (particularly P2X7 receptors) in stroke Development of nanobody-based therapeutic approaches for neurological conditions Examination of sex-specific differences in neuroinflammatory responses Collaborative registry studies on neurological complications of vasculitis Dr. Magnus participates in significant research initiatives including the Hamburg Center of Neuroscience (HCNS) and the Neuro-Immune-Network Hamburg. His work involves multi-center collaborations across Germany and internationally, particularly in stroke research and neuroimmunology.

Vickery Trinkaus-Randallمشاهده پروفایل

استاد

• Purinoreceptors
• EGFR receptors
• Confocal imaging
• +۶ مورد دیگر

Vickery Trinkaus-Randall is a Professor in the Department of Biochemistry at Boston University. Her research focuses on cellular responses to injury, particularly in corneal wound healing and diabetic complications. University: Boston University Department: Biochemistry Email: vickery@bu.edu Her lab investigates corneal injury responses using pre-Type II diabetic models, emphasizing purinergic signaling , EGFR receptor dynamics , and pannexin protein roles . Key methods include confocal imaging , live calcium mobilization tracking , and MATLAB-based analysis of cytoskeletal changes. Recent publications reveal research trends in corneal biomechanics (substrate stiffness effects), hypoxia-induced matrix remodeling , and diabetic corneal innervation changes . Collaborative studies span respiratory allergy mechanisms and endothelial cell mechanotransduction . Scientific Awards: Educator of the Year 2025 Her work integrates in vitro , organ culture , and in vivo models to study soluble factor signaling and cell polarity regulation during wound repair. The lab employs advanced imaging technologies and quantitative analysis to explore these processes.

• Medicinal Chemistry
• Organic Chemistry
• Drug Discovery
• +۷ مورد دیگر

Richard Bujaroski is a Research Fellow in Medicinal Chemistry at Monash University, actively contributing to interdisciplinary research in drug discovery and molecular pharmacology. His work spans tuberculosis, antifungal agents, ion channel modulation, and kinase-related neurological disorders. Research Interests: His expertise lies in medicinal and organic chemistry , with a strong focus on drug discovery for infectious and neurological diseases. He investigates bioisosteres for tuberculosis, amiloride analogs for antifungal and ion channel applications, and kinase targets in cerebral cavernous malformations. His research integrates synthetic chemistry with biological evaluation. The recent publications (2022–2024) reflect a trend toward developing targeted inhibitors for specific biological pathways, including dual-target antibacterials, ASIC inhibitors for neurological conditions, and P2X7 receptor antagonists for inflammation. His work is highly collaborative, often involving teams from pharmacology, microbiology, and neuroscience disciplines. Scientific Contributions: While no formal awards are listed, his research has been published in reputable journals such as Cell Chemical Biology , Frontiers in Cellular and Infection Microbiology , and Biomolecules , with several papers receiving citations and attention on academic platforms. Advising and Grants: There is no public information on students advised or grants led by Dr. Bujaroski. However, his active publication record suggests strong involvement in funded research projects, likely under senior investigators like M. J. Kelso. His role as a Research Fellow indicates he is a key contributor to collaborative grants in medicinal chemistry and drug development. Labs and Teams: He is part of a research network at Monash University focused on medicinal chemistry and drug discovery, particularly within the group led by Professor Martin J. Kelso. His collaborations extend to experts in microbiology, electrophysiology, and molecular biology, indicating integration into a multidisciplinary research environment.

Markus Sperandioمشاهده پروفایل

استاد

• Inflammation
• Neutrophil Recruitment
• Glycobiology
• +۳ مورد دیگر

Markus Sperandio is a Professor at the Biomedical Center Munich , Ludwig-Maximilians-Universität München (LMU Munich). His research focuses on neutrophil recruitment during inflammation and its molecular regulation, with a particular interest in fetal immune ontogeny , glyco-structures , and circadian rhythms in immunity . Email: markus.sperandio@med.uni-muenchen.de Research Interests : His work explores how sialylation, alarmins (e.g., S100A8/A9), and ion channels (e.g., KV1.3, TRPM7) modulate leukocyte trafficking. Recent projects investigate the interplay between circadian clocks and inflammatory responses, as well as pathways like the non-canonical NF-κB pathway in fetal development. Article Trends : His publications emphasize neutrophil adhesion , selectin ligands , and magnesium-dependent signaling in inflammation. Contributions span in vivo models of sepsis, murine fetal immunity, and nanoparticle-induced pulmonary inflammation. Grants & Collaborations : Dr. Sperandio leads projects within collaborative networks like TRR 359 PILOT and TRR 332 - Neutrophils , funded by institutions such as the German Research Foundation (DFG) .

• Pancreatic Cancer Research
• Purinergic Signaling
• Ion Channel Physiology
• +۳ مورد دیگر

Nynne Christensen serves as a Special Consultant in the Department of Biology, specifically within the Cell Biology and Physiology section at the University of Copenhagen. Her research focuses on cellular signaling mechanisms with particular emphasis on pancreatic function and disease pathology. Position: Special Consultant Institution: University of Copenhagen Department: Department of Biology, Cell Biology and Physiology Research Focus: Pancreatic physiology, purinergic signaling, ion channel function Dr. Christensen's primary research interests span pancreatic cancer biology, purinergic signaling pathways, and ion channel physiology. Her work investigates how ATP signaling and various ion channels contribute to pancreatic cell function and dysfunction in disease states. She has made significant contributions to understanding the role of P2X7 receptors in pancreatic cancer progression and the therapeutic potential of targeting ion channels and ATP signaling pathways. Her research bridges fundamental cellular physiology with translational cancer research, exploring mechanisms that could lead to novel treatment approaches. Analysis of Dr. Christensen's publication record (2015-2024) reveals a consistent focus on pancreatic signaling mechanisms, with particular emphasis on ATP-mediated processes and ion channel function. Her work spans multiple research areas from basic cellular physiology to translational cancer research, demonstrating how fundamental cellular processes contribute to disease mechanisms. Recent publications highlight her investigation of drug repurposing strategies, particularly examining how existing medications like proton pump inhibitors might be leveraged for pancreatic cancer treatment through their effects on ion transport systems. Dr. Christensen maintains active research collaborations with multiple investigators, most notably with Ivana Novak, as evidenced by their frequent co-authorship across numerous publications. Her work has garnered attention in both academic circles and media outlets, with several publications receiving notable citations and news coverage. Her research demonstrates a strong translational focus, connecting basic physiological mechanisms with potential clinical applications in pancreatic disease treatment.

• Adipose Tissue Biology
• Metabolism
• Endocrinology
• +۳ مورد دیگر

Patricia Stephanie S Petersen is an academic researcher at the University of Copenhagen's Faculty of Health and Medical Sciences (SUND), working within the Gerhart-Hines Group. Her research focuses on adipose tissue biology, metabolism, and endocrinology with a particular emphasis on brown and white adipose tissue function. Her research interests span several critical areas in metabolic disease research. Dr. Petersen investigates the molecular mechanisms of thermogenesis, adipose tissue remodeling during browning, and gene regulation in obesity-related conditions. Her work frequently examines how dietary factors influence adipose tissue function and metabolic homeostasis, with implications for understanding and potentially treating metabolic disorders. Analysis of her publication record reveals a strong focus on molecular pathways in adipose tissue, particularly examining transcriptional regulation, signaling molecules, and cellular responses to environmental stimuli like cold exposure and high-fat diets. Her research consistently bridges basic molecular mechanisms with physiological outcomes in metabolic health. Dr. Petersen maintains active collaborations with researchers across multiple institutions, working closely with prominent scientists in the field including Emanuelli B, Gerhart-Hines Z, and Plucińska K. Her work has appeared in high-impact journals such as Molecular and Cellular Endocrinology, Molecular Metabolism, and FEBS Journal.

• Cancer Research
• Molecular Biology
• Cell Physiology
• +۳ مورد دیگر

Haoran Yu is a Postdoctoral Researcher in the Department of Biology at the University of Copenhagen, specializing in Cell Biology and Physiology with a focus on pancreatic cancer mechanisms. His core research interests include: Cancer Research Molecular Biology Cell Physiology Genetics Oncology Purinergic Signaling Dr. Yu's publication record demonstrates sustained investigation into P2X7 receptor polymorphisms and purinergic signaling pathways in pancreatic cancer. His 2024 work examines genetic variants' cellular impacts while the 2020 review synthesizes physiological mechanisms toward therapeutic development, reflecting a translational research trajectory bridging molecular oncology and clinical applications.