جست‌وجوی استاد و پژوهشگر

Anja Noheمشاهده پروفایل

دانشیار

• Cell Biology
• Medical Imaging
• Stem Cell Biology
• +۵ مورد دیگر

Anja Nohe is an Associate Professor in the Department of Biological Sciences at the University of Delaware's College of Arts & Sciences. Her roles include leading research initiatives focused on musculoskeletal disorders, stem cell biology, and advanced imaging techniques. She holds a Diplom from the University of Würzburg (Germany), a Ph.D. from the Theodor Boveri Institute (University of Würzburg), and completed postdoctoral training at the University of Western Ontario (Canada). Her research emphasizes developing novel delivery systems for proteins/nanoparticles, advanced imaging tools like FICS (Family of Image Correlation Spectroscopy), and studying stem cell differentiation mechanisms. Current projects target osteoporosis and osteoarthritis, including the development of therapeutic peptides (e.g., CK2.3) to enhance bone formation and inhibit osteoclastogenesis. Her lab uses mouse models, human cell cultures, and bioreactors to investigate molecular dynamics in bone and cartilage. Key research areas include: BMP receptor signaling and its role in bone homeostasis Peptide-mediated osteogenesis and cartilage repair Age-related bone density decline and its signaling pathways Her team collaborates on grants focused on translational therapies for musculoskeletal diseases. Lab facilities include advanced microscopy and cell culture setups at the DBI building.

• Computational Chemistry
• Medicinal Chemistry
• Ligand-Gated Ion Channels
• +۶ مورد دیگر

Associate Professor Thomas Balle is affiliated with the University of Sydney's School of Pharmacy, Department of Pharmaceutical Sciences. He previously worked at the University of Copenhagen, leading projects on structural approaches to ligand-gated ion channel drug discovery. His research focuses on computational and medicinal chemistry, particularly ligand-gated ion channels, drug design, and radioligand development for brain imaging. Education: MSc Eng, PhD (industrial setting at H. Lundbeck A/S). He trained as a medicinal chemist and contributed to CNS drug design and biomarker development for PET imaging. Research interests include ion channel structure-function relationships, fragment-based drug design, and PET radioligand development. Recent articles explore NMDA receptor mutations, P2X7 receptor structures, and GABA A receptor roles in anaesthesia and pain. He leads grants on TB drug candidates, GABA A receptor analgesics, and ion channel drug discovery consortia. Advises students Prisca AKPABIO and Dongsheng WU. Collaborates with academic and biotech partners. Member of The Centre for Drug Discovery Innovation.

• Multiple Sclerosis
• Neuroimmunology
• PET Imaging
• +۳ مورد دیگر

Laura Airas is a faculty member at Yale School of Medicine, focusing on neuroimmunology and multiple sclerosis research. Her work bridges clinical neuroscience with advanced imaging techniques , particularly PET imaging of neuroinflammatory markers like TSPO and P2X7 receptors. Dr. Airas's research spans neurodegenerative mechanisms , biomarker development , and therapeutic monitoring in MS. Recent publications demonstrate expertise in multimodal diagnostics , combining in vivo imaging with metabolomic profiling to improve disease prognosis. Scientific contributions include: Developing TSPO-PET as a predictive tool for MS progression Identifying CHI3L1 as a biomarker for brain volume loss Advancing understanding of microglial activation patterns in neurodegenerative diseases Participating in international consensus on smouldering MS definitions She maintains active collaborations across neurology , immunology , and radiological sciences disciplines at Yale.

Francesco Di Virgilioمشاهده پروفایل

استاد بالینی

• Inflammation
• Neuroinflammation
• Cytokines
• +۵ مورد دیگر

Francesco Di Virgilio is a Clinical Professor at the University of Ferrara , affiliated with the Medical School and Department of Morphology, Surgery and Experimental Medicine. He has held leadership roles including Deputy Rector for Research, Dean for Education, and Departmental Chairman. Medical Doctor (MD) from University of Padova (1979) His research spans Inflammation , Neuroinflammation , Purinergic receptors , and Cancer immunology , focusing on P2X7 receptor mechanisms, cell death pathways , and immunometabolism . He has contributed to understanding apoptosis and necrosis in disease and ATP signaling . Notable awards include membership in the European Academy of Tumor Immunology (2016) and Faculty of 1000 (2012). He serves on editorial boards for journals like Inflammation , Purinergic Signalling , and American Journal of Physiology-Cell Physiology . Scientific Awards : Member of the European Academy of Tumor Immunology (2016), Member of Faculty of 1000 (2012) His 239 PubMed-indexed articles and 4 international patents highlight his work on innate immunity , metabolic disorders , and cancer .

Peter Westمشاهده پروفایل

پژوهشگر

• Immunology
• Respiratory Medicine
• Mast Cell Biology
• +۳ مورد دیگر

Peter West is a Researcher at the University of Manchester's Division of Immunology, Immunity to Infection and Respiratory Medicine. His work focuses on mast cell biology, airway nerves, and chronic respiratory diseases such as cough. He holds a PhD from the University of Sheffield (2009) and a Master of Biological Science in Genetics and Microbiology (2005). His research explores the interplay between immunological drivers and sensory systems in respiratory illnesses, with recent studies on mast cell heterogeneity, neuroimmunological pathways, and viral respiratory infections. He has collaborated internationally, including at Johns Hopkins University and Oregon Health Science University. Education: PhD (2009): Regulation of Toll-Like Receptor Signalling by Macrophage Migration Inhibitory Factor, University of Sheffield M BiolSci (2005): Genetics & Microbiology, University of Sheffield Research Interests: Mast cells, chronic cough mechanisms, airway nerve density, neuroimmunology, inflammatory signaling, and respiratory pathogen interactions. His work contributes to UN Sustainable Development Goals addressing health and well-being (SDG 3) through improved understanding of immune responses and respiratory disease pathogenesis. Awards: His PhD was funded by a British Heart Foundation studentship. Labs & Collaborations: Current projects involve in vitro airway cell culture systems under Prof Nikos Papadopoulos. Past collaborations include work with Dr Brendan Canning (Johns Hopkins) and Dr Jacky Smith/Prof Ashley Woodcock (University of Manchester).

Jan Deussingمشاهده پروفایل

استاد

• Neurogenetics
• Psychiatry
• Stress Physiology
• +۳ مورد دیگر

Dr. Jan Deussing is a Research Group Leader at the Max Planck Institute of Psychiatry in Munich, Germany, specializing in Molecular Neurogenetics . His work focuses on unraveling the genetic and epigenetic mechanisms underlying stress-related neuropsychiatric disorders , particularly through the lens of the corticotropin-releasing hormone (CRH) system , which he has extensively linked to mood and anxiety disorders. Research Themes : Genetic risk factors, environmental stress interactions, epigenetic regulation, and neural stress circuits. Key Techniques : Genetic mouse models (e.g., conditional knockouts), CRH system analysis, and neuroimaging (MEMRI, ultramicroscopy). His recent studies highlight CRH receptor signaling in anxiety, social behavior, and neurovascular adaptation, while also exploring novel targets like the P2X7 receptor and GDF15 for therapeutic intervention. Dr. Deussing's lab has developed inducible Cre-driver mouse strains to advance gene-function research in the brain and eye. Though no formal awards are listed, his 200+ publications and leadership in the field underscore significant contributions to translational psychiatry and stress biology.

• Chronic Pain Mechanisms
• Spinal Cord Circuits
• Neural Mechanisms of Pain
• +۳ مورد دیگر

Dr. Longzhen Cheng is an Associate Professor at the Department of Neuroscience, School of Life Sciences, Southern University of Science and Technology (SUSTech) in Shenzhen, China. She joined SUSTech as an Assistant Professor in February 2018 and was promoted to Associate Professor in June 2025. Prior to joining SUSTech, she served as an Associate Professor at Fudan University's Institute of Brain Science from 2016 to 2018, where she established her own laboratory as a member of the "Junior PI Plan." She completed her postdoctoral training at Harvard Medical School under Dr. Qiufu Ma from 2013 to 2016. Dr. Cheng received her Ph.D. in Neurobiology from Fudan University (2005-2009), where she studied synaptic transmission and plasticity in the spinal dorsal horn under Dr. Zhi-Qi Zhao. She earned her M.S. in Physiology (2002-2005) and B.S. in Clinical Medicine (1997-2002) from Wannan Medical College in Anhui, China. Her research focuses on the neural mechanisms underlying pain and opioid effects. Specifically, her laboratory investigates: Neural mechanisms underlying mechanical pain hypersensitivity Neural mechanisms underlying opioid-induced mechanical pain hypersensitivity and analgesic tolerance Spinal circuits for somatosensory information processing Gating mechanisms for chronic pain Synaptic plasticity of spinal dorsal horn neurons Dr. Cheng's research employs a multidisciplinary approach combining genetic tools, behavior tests, and electrophysiological recordings in the spinal cord. Her work has revealed important insights into spinal circuits involved in touch-evoked dynamic mechanical pain and mechanisms for chronic pain. Her publications in Cell (2014), Nature Neuroscience (2017), Science (2015), and Neuron (2024) demonstrate her significant contributions to understanding pain mechanisms at the circuit level. Dr. Cheng has received several honors and awards, including: Fudan University Excellent Plan (2013) Junior PI Plan from Institute of Brain Science, Fudan University (2016) Her research has been supported by grants focusing on pain mechanisms and neural circuits. She teaches courses in Animal Physiology and Advanced Animal Physiology at SUSTech. Dr. Cheng's laboratory has made significant contributions to understanding the neural basis of chronic pain, particularly in identifying spinal circuits for mechanical pain and itch, and exploring how opioids affect pain processing.

• Biology of Aging
• Inflammatory Signalling
• Immune-Mediated Inflammatory Conditions
• +۱۷ مورد دیگر

Amanda Mackenzie is a Professor and Head of Department in the Department of Life Sciences at the University of Bath , where she leads the Inflammatory Signalling Research Group and the Centre for Bioengineering & Biomedical Technologies (CBio) . She is actively involved in research, teaching, and supervision at both undergraduate and postgraduate levels. University: University of Bath School/Department: Department of Life Sciences Role: Head of Department, Principal Investigator Research Group: Inflammatory Signalling Research Group Email: A.Mackenzie@bath.ac.uk ORCID: 0000-0002-9935-418488 Her research focuses on the biology of aging , inflammatory signalling pathways , and mechanisms of cell death , with particular expertise in innate immune cells (especially macrophages) and retinal pigment epithelial cells . She employs advanced techniques including in vitro cell culture , protein biochemistry , patch clamp electrophysiology , and fluorescent microscopy . Her group has developed innovative tools such as fluorescent peroxynitrite probes in collaboration with Prof. Tony James and is pioneering retina-on-a-chip technology with Dr. Paul De Bank to study age-related macular degeneration (AMD) and scleroderma-related pulmonary hypertension. The most recent articles highlight a strong trend in biomedical diagnostics , inflammatory biomarkers , and translational research . Key themes include the development of fluorescent probes for theranostics , organ-on-a-chip models for retinal disease, and molecular mechanisms of cell death in inflammatory and degenerative conditions. These works reflect a multidisciplinary approach combining chemical biology , immunology , and tissue engineering . She contributes significantly to academic education, convening modules such as Receptors to Genes , Pharmacology Placement Landmark Dissertations , and Pharmacology Communication Skills . She previously served as the Bath lead for the GW4 BioMed MRC Doctoral Training Programme and as the Bath Pharmacology Industrial Placement Tutor . Her educational research explores the use of Peerwise for peer learning and formative feedback, enhancing student engagement through digital tools. Dr. Mackenzie leads multiple funded research projects from organizations including the BBSRC , Dunhill Medical Trust , MRC , and Bath Institute for Rheumatic Diseases . These projects focus on hypoxic imaging , retinal dysfunction , angiogenesis in arthritis , and inflammatory signalling . She collaborates widely with researchers in Pharmacy & Pharmacology (Bath), Royal United Hospital , and international partners. Her lab fosters a collaborative environment for PhD students and postdoctoral researchers, welcoming self-funded candidates and those applying for fellowships.

• Immunology
• Cardiovascular Aging
• Metabolic Dysfunction
• +۳ مورد دیگر

Dr. Daniel Wayne Trott is an Associate Professor in the Department of Kinesiology at the University of Texas at Arlington. He specializes in immunology and aging, focusing on how the immune system interacts with cardiovascular and metabolic systems. His research explores age-related pathologies like hypertension and diabetes, emphasizing lifestyle interventions like exercise to mitigate these conditions. Education : - PhD in Kinesiology, Texas A&M University (2010) - B.S. in Exercise Science, University of New Mexico (2004) Research Interests : Dr. Trott's lab investigates the role of T-cells in arterial aging, metabolic dysfunction, and the effects of exercise. Key topics include: - Immune-mediated vascular dysfunction - CD8+ T-cell contributions to hypertension - Senolytic drug impacts on aging tissues Awards & Honors : - Kinesiology Faculty Teaching Award (2023) - NIH Early Career Reviewer (2020) - Bulter-Williams Scholar (2018) Grants & Funding : - NIH grants totaling over $1M for T-cell studies in aging - Collaborative projects with institutions like Vanderbilt University and University of Utah - Pilot grants exploring gut virome interventions for arterial aging Labs & Teams : Director of the Integrative Immunology Laboratory at UTA, focusing on translational approaches from cell culture to human studies.

• Ion Channel Biophysics
• Cellular Signaling
• Cancer Biology
• +۱ مورد دیگر

Dr. Damien Samways is Associate Professor of Biology at Clarkson University's Lewis School of Health & Life Sciences. His laboratory investigates cellular signaling mechanisms through membrane receptors and ion channels, with applications in cancer research and drug delivery. Research focuses on: Functional characterization of ATP-gated P2X receptors and TRPV channels Calcium signaling dynamics in cellular responses Receptor-targeted drug delivery strategies for cancer Development of polymeric drug carriers for chemotherapeutic agents His publications demonstrate innovative approaches to modulating cellular uptake of therapeutic agents, with recent work on selective permeabilization of cancer cells and novel polymer-based delivery systems. The research spans molecular biophysics, pharmacology, and materials science. He teaches neurobiology, comparative physiology, and pharmacology courses at undergraduate and graduate levels.

Darek Goreckiمشاهده پروفایل

استاد

• Molecular Medicine
• Muscular Dystrophy
• Purinergic Receptors
• +۴ مورد دیگر

Professor Darek Gorecki is a Professor of Molecular Medicine at the University of Portsmouth, affiliated with the Faculty of Science & Health and the School of Medicine, Pharmacy and Biomedical Sciences. His research focuses on muscular dystrophies, purinergic signaling pathways, and neurodegenerative diseases, with particular emphasis on the role of P2X7 purinoceptors and dystrophin-related proteins in disease mechanisms and therapy. He leads studies into gene therapy, drug delivery systems (including nanoparticle-based approaches for brain delivery), and the molecular basis of Duchenne muscular dystrophy and related conditions. His work spans translational research, including investigations into ectopic calcification, inflammation, and cellular repair mechanisms. He collaborates internationally on projects addressing the pathogenesis of muscular dystrophies and developing therapeutic strategies. Professor Gorecki supervises PhD students and is part of the Institute of Life Sciences and Healthcare at the University of Portsmouth. Key research themes include: (1) Role of purinergic receptors in muscle and neuronal pathologies, (2) Dystrophin variants in cancer and muscle diseases, (3) Nanomedicine for targeted drug delivery, and (4) Mechanisms of immunogenicity in gene therapies. His publications highlight advancements in understanding dystrophic brain abnormalities, P2X7-mediated mitochondrial exchange, and biomaterial engineering.

• Pharmacology
• Cellular Signal Transduction
• Inflammation
• +۳ مورد دیگر

Prof. Dr. Günther Weindl is a Professor at the Pharmaceutical Institute, University of Bonn. His research focuses on experimental pharmacology and cellular signal transduction, particularly understanding molecular mechanisms of drugs involved in inflammatory and immunological processes. Current investigations examine immunomodulatory drug characterization, Toll-like receptor modulators, synthetic peptides, autophagy regulation, and lysosomotropic drug mechanisms. Research interests span pharmacology, inflammation biology, and cellular signaling pathways, with emphasis on developing therapeutic strategies for inflammatory diseases. Work integrates immunopharmacology concepts with molecular characterization of drug-receptor interactions. Publications demonstrate consistent focus on inflammatory pathways and immunomodulation, with recent work exploring oxidative stress responses, TLR signaling inhibition, peptide-mediated wound healing, and glucocorticoid interactions.

• Haematology
• Genetics
• Haematological malignancy
• +۳ مورد دیگر

Professor Stephen Fuller is a Professor of Medicine and Head of Nepean Clinical School at the University of Sydney. He holds affiliations with the Brain and Mind Centre and Charles Perkins Centre. His research focuses on haematology, genetics of blood disorders, and purinergic receptor biology (P2X7/P2Y receptors). Key interests include chronic lymphocytic leukemia (CLL), sepsis pathogenesis, and inflammatory mechanisms. Education: MBBS, PhD, FRACP (Fellow of the Royal Australasian College of Physicians), FRCPA (Fellow of the Royal College of Pathologists of Australasia). Research highlights include genetic studies of CLL susceptibility, P2X7 receptor polymorphisms in sepsis outcomes, and cytokine signaling in immunological diseases. Recent work explores P2X7 receptor structure using AlphaFold2 and deep learning. Grants include Ion Channel Drug Discovery Consortium (2017), P2X7 Cancer Research (2016), and projects investigating familial haematological malignancies. Advises current PhD students researching B-cell receptor interactions, bariatric surgery pathways, and P2X7R in sepsis pathogenesis. Labs/teams: Leads research groups in Nepean Clinical School focusing on haematological malignancies and purinergic signaling. Collaborates with interdisciplinary teams in immunology, oncology, and structural biology.

James Barrettمشاهده پروفایل

استاد مدعو

• Pharmacology
• Behavioral Pharmacology
• Neuropsychopharmacology
• +۷ مورد دیگر

James Barrett, PhD, is an Adjunct Professor in the Department of Neural Sciences at the Lewis Katz School of Medicine, Temple University, and is affiliated with the Center for Substance Abuse Research. He has a distinguished career in pharmacology, behavioral neuroscience, and translational research, with extensive leadership experience in academia and the pharmaceutical industry, including roles as Chair of Pharmacology and Physiology and Founding Director of key research and educational programs at Drexel University. Education and Training: Postdoctoral Fellowship, Neuropsychopharmacology and Behavioral Pharmacology, Worcester Foundation for Experimental Biology, Shrewsbury, MA PhD, Biopsychology/Neurobiology, Pennsylvania State University, State College, PA Research Interests: Dr. Barrett's research spans the pharmacology of pain and substance abuse disorders, with a focus on drug discovery and development. His work integrates behavioral models with molecular and translational approaches to understand CNS disorders. His expertise includes behavioral pharmacology, ion channel modulation, neuroinflammation, and epigenetic regulation of pain and psychiatric conditions. Publication Trends: His recent publications emphasize the role of ion channels (e.g., Orai1, P2X7), microRNA signatures, and epigenetic mechanisms in pain and neurobehavioral disorders. There is a strong translational focus, with studies bridging preclinical models and clinical applications in pain, addiction, and mental health. Scientific Awards and Honors: Solvay-Duphar Award for Preclinical Research on Affective Disorders (1991) George B. Kolle Award (2010) P.B. Dews Lifetime Achievement Award (2012) Torald Sollmann Award (2015) Distinguished Lecturer, University of Texas Medical Branch (2015) Leadership and Mentorship: Dr. Barrett has held major leadership roles in academic pharmacology, including Past President of the Behavioral Pharmacology Society, ASPET, and the Association of Medical School Pharmacology Chairs. He has contributed significantly to graduate education and curriculum development in pharmacology, aiming to prepare students for careers in biotechnology and pharmaceutical industries. While specific students are not listed, his extensive collaborative work suggests a strong advisory and mentorship role. Laboratories and Research Teams: His research has been conducted in collaboration with multidisciplinary teams, particularly through the Center for Substance Abuse Research. His work often involves partnerships across institutions, focusing on CNS drug development and behavioral assessment models.

• Pharmacology
• Inflammation
• Immunopharmacology
• +۳ مورد دیگر

Victor Collado Diaz is a researcher at the Universitat de València, affiliated with the Faculty of Medicine and Odontology and the Department of Pharmacology. He is associated with the UFDI (Digestive and Inflammatory Diseases Research Unit) and GINFAR (Pharmacology of Inflammation) research groups, focusing on inflammatory disease mechanisms and pharmacological responses. His research interests center on pharmacology, particularly the role of the P2X7 receptor in drug-induced inflammation. His work lies at the intersection of molecular pharmacology and immunology, with a focus on understanding proinflammatory drug effects such as those caused by abacavir. The Ramón y Cajal Fellowship highlights his recognition as a competitive postdoctoral researcher in Spain, supporting his independent research trajectory in pharmacological sciences. He completed his doctoral training under the supervision of Dr. Ángeles Álvarez and Dr. Juan V. Esplugues Mota, contributing to the mechanistic understanding of purinergic signaling in inflammation. No formal advisees are listed, and there is no mention of external grants beyond his fellowship. He is actively involved in research teams focused on digestive and inflammatory diseases.