جست‌وجوی استاد و پژوهشگر

Danith Lyمشاهده پروفایل

استاد

• Bioorganic Chemistry
• Chemical Biology
• Gene Regulation
• +۳ مورد دیگر

Danith Ly is a Professor of Chemistry at Carnegie Mellon University and Founding Director of the Institute for Biomolecular Design and Discovery (IBD). She holds a courtesy appointment as Professor in the University of Pittsburgh's Molecular Biophysics and Structural Biology program. Her research focuses on designing molecular tools for gene regulation, cellular delivery, and protein engineering, with applications in cancer therapy, stem cell biology, and genetic disease correction. Ly earned her Ph.D. in Chemistry from the Georgia Institute of Technology (1999), followed by postdoctoral training at UC Berkeley (1999–2000) and The Scripps Research Institute (2000–2001). She has pioneered γ-peptide nucleic acid (γPNA) technology, enabling precise gene editing and diagnostic tools. Her work intersects bioorganic chemistry, molecular self-assembly, and translational medicine. Ly’s research group has developed γPNA-based therapies for β-thalassemia and cancer, leveraging nanoparticle delivery systems. Recent studies highlight in vivo gene editing successes and high-affinity nucleic acid probes for telomere analysis. She co-founded NeuBase Therapeutics (2018), ChiraGen (2017), and PNA Innovations (2009), translating academic discoveries into clinical applications. Awards : Julius Ashkin Teaching Award (2012), Innovative Research Award (2002), National Institute of Aging Emerging Researcher (2000) Leadership Roles : Director of IBD, Principle Investigator at CNAST and MBIC, SPORE Program affiliation Her lab’s innovations span γPNA synthesis, molecular diagnostics, and therapeutic PNA oligomers, with a focus on overcoming genetic disorders and cancer through precision medicine.

Sindhuja Sridharanمشاهده پروفایل

مدرس

• Systems Biochemistry
• Molecular Interaction Networks
• Cellular Metabolism
• +۴ مورد دیگر

Sindhuja Sridharan is a Lecturer (Early Career Researcher) at the Blizard Institute, Queen Mary University of London , affiliated with the Centre for Genomics and Child Health . Her research bridges systems biochemistry, cellular metabolism, and protein condensate biology to unravel mechanisms in brain tumor pathogenesis. She obtained her PhD from the National University of Singapore (NUS) under Prof. Manjunatha Kini, focusing on bioactive peptides for heart failure therapeutics. She later joined the European Molecular Biology Laboratory (EMBL) and GlaxoSmithKline (GSK) to develop proteome-wide technologies for studying protein interactions in cellular contexts. Her research investigates the interplay between metabolic rewiring and protein condensation in brain tumors. She employs quantitative proteomics and systems biology to address how genetic mutations in metabolic enzymes alter cellular processes, how compartment-specific metabolite pools regulate gene expression, and how intercellular metabolic signals reprogram tumor microenvironment dynamics. The 15 most recent publications reflect her expertise in protein condensates , metabolic pathways , and thermal proteome profiling , spanning applications in neurodegenerative diseases (e.g., ALS), viral pathogenesis (e.g., mumps and influenza), and cardiovascular pharmacology (e.g., venom peptides for heart failure). These works highlight her contributions to pharmacological hardening of condensates , redox modulation , and computational methods for ligand-binding analysis . Her work is conducted in collaboration with leading institutions, including the Blizard Institute , EMBL , and GlaxoSmithKline , utilizing advanced technologies such as mass spectrometry , thermal stability profiling , and bioinformatic modeling .

Yamuna Krishnanمشاهده پروفایل

استاد

• Chemical Biology
• Biophysics
• Organic Chemistry
• +۷ مورد دیگر

Yamuna Krishnan is the Louis Block Professor of Chemistry at the University of Chicago, where she leads innovative research at the intersection of chemistry, biology, and nanotechnology. Her work focuses on developing DNA-based nanodevices for quantitative chemical imaging of living systems, with particular emphasis on mapping the chemical composition of cellular organelles. Dr. Krishnan's research interests center on understanding how the lumenal chemical composition of organelles—optimized over evolutionary timescales—impacts organelle function, cell physiology, and ultimately organism behavior. Her lab has pioneered several groundbreaking DNA nanodevices including CalipHluor for calcium measurement in acidic organelles, Clensor for chloride ion measurement, and z-cHOClate for measuring pH and hypochlorous acid levels in phagosomes. Her recent work published in Science Advances (2024) identified the protein responsible for calcium entry into lysosomes, a discovery with significant implications for understanding and potentially treating neurodegenerative disorders like Parkinson's and ALS. The Krishnan lab's publications span diverse areas including organelle-specific ion dynamics, DNA nanotechnology applications, and quantitative chemical imaging methodologies. Major Scientific Awards: Infosys Prize in Physical Sciences (2017) Shanti Swarup Bhatnagar Award, Chemical Sciences (2013) Cell's 40 under 40: next generation of thinkers in biology (2014) Innovator of the Year, Association of Women in Science, Chicago (2016) Scientific Innovations Award from the Brain Research Foundation (2015) Dr. Krishnan mentors a diverse team of graduate students, postdocs, and technicians working across multiple model systems including C. elegans , zebrafish, and mammalian cells. Her lab has received funding from prestigious sources including the National Institutes of Health, Human Frontier Science Program, and Ono Pharma Foundation. The Krishnan Lab is part of the Gordon Center for Integrative Science at the University of Chicago, where they continue to push the boundaries of quantitative chemical imaging in living systems.

Manuel Etzkornمشاهده پروفایل

پژوهشگر

• Structural Biology
• Biophysics
• NMR Spectroscopy
• +۳ مورد دیگر

Dr. Manuel Etzkorn leads the Heisenberg Research Group at the Institute of Physical Biology, Heinrich Heine University Düsseldorf. His work bridges structural biology, biophysics, and biocatalysis, with a focus on membrane proteins and DNAzymes in native environments. The team develops advanced NMR methodologies and nanodisc systems to study molecular dynamics. Faculty of Mathematics and Natural Sciences Institute of Physical Biology Research emphasizes overcoming structural biology limitations through tailored methods. Key areas include membrane protein stabilization (e.g., aescin-lipid nanoparticles), DNAzyme structural analysis (8-17 and 10-23 DNAzymes), and NMR spectroscopy innovations (local deuteration, solid-state NMR). Recent publications (2022-2025) reveal trends in RUNX1-ETO inhibition , electroneutral nanodiscs , and DNA catalyst therapeutic applications . Notable scientific recognitions include Inside cover article (2016) PNAS highlight commentary (2014) "Article of the month" award (2008) The group actively mentors PhD students (Justin Boecker, Ci Chu, Lora Denson, Christopher Ruth, Jessica Schmuck) and collaborates on projects involving ubiquitin dynamics , α-synuclein aggregation , and PAS domain signal transduction .

Olivier Lichtargeمشاهده پروفایل

استاد

• Computational Biology
• Structural Biology
• Clinical Genomics
• +۸ مورد دیگر

Olivier Lichtarge, M.D., Ph.D. is the Cullen Chair and Professor at Baylor College of Medicine , with appointments in Molecular and Human Genetics, Biochemistry & Molecular Biology, and Pharmacology. He directs the Computational and Integrative Biomedical Research Center and co-directs the Structural & Computational Biology program. Education: BS (McGill), PhD & MD (Stanford), Residency & Fellowships (UCSF) Research: Integrates evolutionary principles with machine learning for multi-scale data analysis in Protein functional site prediction Mutation impact quantification Network diffusion for disease mechanism discovery Cognitive computing applications Key Contributions: Developed Evolutionary Trace and Action Equation methods, network compression schemes for cross-species analysis, and text-mining approaches for automated hypothesis generation. His work spans Alzheimer's disease , autism , cancer , and malaria research. Scientific Recognition: Fellow, AAAS (2019) Michael E. DeBakey Excellence in Research Award (2015) Raymond & Beverley Sackler Fellowship (2005) Basil O’Connor Award (2001) Multiple AHA Fellowships & Awards

• RNA Biochemistry
• Protein Synthesis
• Translation Mechanisms
• +۵ مورد دیگر

Jinfan Wang is an Assistant Professor and UT Southwestern Endowed Scholar in the Department of Biochemistry at University of Texas Southwestern Medical Center (UTSW). He obtained his B.S. in Biotechnology from the University of Science and Technology Beijing (2010) and a Ph.D. in Biochemistry from Uppsala University (2016), where he studied prokaryotic translation under Dr. Anthony Forster. Supported by the Knut and Alice Wallenberg Foundation, he conducted postdoctoral research at Stanford University (2016–2023) with Dr. Jody Puglisi, developing single-molecule methods to study eukaryotic translation. His lab at UTSW combines quantitative biochemistry, structural biology, and genetics to investigate cytosolic and mitochondrial translation mechanisms. Education B.S., Biotechnology – University of Science and Technology Beijing (2010) Ph.D., Biochemistry – Uppsala University (2016) His research focuses on the dynamic interplay between mRNA structure, ribosome function, and translation regulation in eukaryotes. Using single-molecule fluorescence microscopy, his team established frameworks for understanding start codon recognition, elongation fidelity, and drug-induced translation arrest. Recent work explores mitochondrial translation and its dysregulation in human diseases. Key publications reveal insights into: Eukaryotic translation initiation (Cell 2022, Nature 2019) Ribosome interactions with modified mRNA (Nat Struct Mol Biol 2018) Engineering of translation systems (Nucleic Acids Res 2017) Kinetic bottlenecks in unnatural amino acid incorporation (ACS Chem Biol 2015) Scientific Awards Knut and Alice Wallenberg Foundation Postdoctoral Fellowship UT Southwestern Endowed Scholar Dr. Wang’s lab seeks to bridge fundamental translation mechanisms with therapeutic applications, particularly in diseases linked to mitochondrial dysfunction. They actively recruit graduate students, technicians, and postdocs for interdisciplinary research.

• Protein structure-function relationships
• Physical biochemistry
• Gene regulation and transcription factor biology
• +۵ مورد دیگر

Professor Joel Mackay is a physical biochemist at the University of Sydney, where he holds the Chair of the Biochemistry, Molecular and Cell Biology cluster in the School of Life and Environmental Sciences and serves as President of the Australian Society for Biochemistry and Molecular Biology. Since arriving in 1995 he has built an internationally recognised laboratory focused on protein structure–function, gene regulation and designer peptide engineering, supported by ~$30 M of competitive funding. Education: PhD — University of Cambridge, UK (1994) Research interests: The Mackay group deciphers how proteins work at the molecular level, concentrating on two synergistic themes: Molecular mechanisms that govern eukaryotic gene expression, with emphasis on transcription factors, chromatin remodelers (CHD4/NuRD), epigenetic modifications and zinc-finger domains. Exploitation of cutting-edge library-display technologies to create bespoke peptides and mini-proteins that modulate challenging therapeutic targets such as BET bromodomains. Methodologically the lab integrates molecular biology, cell biology, biophysics and structural techniques (NMR, X-ray crystallography, SPR, AUC, MST, XL-MS) and has access to 600 & 800 MHz NMR, crystallisation, fermentation and proteomics facilities. Major discoveries: First demonstration that zinc-finger domains can act as protein–protein interaction modules, overturning the dogma that they bind only nucleic acids. Elucidation of how acetylation of the transcription factor GATA1 recruits the epigenetic reader BRD3, providing early mechanistic insight into post-translational control of transcription factors. Structural and functional characterisation of AHSP, the long-sought chaperone for α-globin, illuminating molecular bases of β-thalassemia and sickle-cell disease. Scientific honours: Biophysics Young Investigator Award 1997 Roche Molecular Biochemicals Medal 2001 Science Minister’s Prize for Life Sciences (under 35) 2002 ANZMAG Young Investigator Medal 2002 Gottschalk Medal (AAS) 2006 Labgear Discovery Science Award 2016 ARC & NHMRC Research Fellowships (1995-2019) Leadership & grants: Prof. Mackay has secured continuous national (ARC DP, Linkage, ITTC; NHMRC Project & Program) and international (NIH R01) funding totalling ~$30 M. He currently leads a 40-member academic cluster and mentors five doctoral researchers working on epigenetic inheritance, hemoglobinopathies, pollinator protection and chromatin dynamics. Collaborations & infrastructure: Active partnerships with groups in Germany, New Zealand, the USA and the UK leverage the University of Sydney’s flagship institutes—Sydney Institute of Agriculture, Centre for Drug Discovery Innovation and Sydney Nano—to translate fundamental protein discoveries into agricultural, medical and biotechnological applications.

• Pharmaceutical Sciences
• Pharmacology
• Toxicology
• +۵ مورد دیگر

Björn Kull serves as Head of Department for Joint Operational Support within the Department for Research Support and External Relations at Karolinska Institutet, one of Europe's foremost medical universities. He earned his Doctoral Degree of Medicine from Karolinska Institutet's Department of Physiology and Pharmacology in 2000, establishing a strong foundation for his career in academic research and administration. Professor Kull's research expertise spans pharmaceutical sciences, pharmacology, toxicology, and neurosciences, with a particular focus on adenosine receptor pharmacology and its interactions with dopamine signaling pathways. His work has significantly contributed to understanding receptor signaling mechanisms in the central nervous system. Analysis of his publication record from 1996-2012 reveals a consistent focus on adenosine receptors, particularly the A2A subtype, and their interactions with dopamine receptors. His research trajectory shows progression from basic receptor characterization to more complex studies of receptor interactions and signaling pathways, demonstrating increasing sophistication in experimental approaches over time. While no specific scientific awards are mentioned in the available information, Professor Kull's publication record in high-impact journals such as Nature Biotechnology, Molecular Pharmacology, and Neuroscience indicates recognition within his field. His transition from active research to research administration reflects a career evolution common among senior academics who apply their scientific expertise to institutional leadership. In his current administrative role, Professor Kull oversees research support operations at Karolinska Institutet, leveraging his deep understanding of the research process to facilitate scientific discovery across the institution. His leadership contributes to maintaining Karolinska Institutet's position at the forefront of medical research.