Daniel Finley is a Professor of Cell Biology at Harvard Medical School (HMS), leading the Finley Lab focused on the ubiquitin-proteasome pathway and related regulatory mechanisms. He holds academic appointments within the Department of Cell Biology and sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals. His research investigates proteasome function, ubiquitin-like proteins, and proteostasis roles in diseases like Alzheimer’s and ALS. Dr. Finley earned his undergraduate degree in biochemistry from Harvard University and a Ph.D. in molecular biology from MIT. After postdoctoral training at MIT, he joined HMS in 1988. His lab explores topics including erythroid proteome remodeling, mitochondrial dysfunction, and neurodegenerative disease mechanisms. Key research areas include: (1) Ubiquitin-proteasome pathway regulation, (2) Proteasome structure/function, (3) Nonproteolytic roles of ubiquitination, and (4) Pathophysiological roles of proteostasis defects in diseases. His work bridges basic cell biology with translational medicine, particularly in neurodegeneration and anemia. Finley has secured NIH funding for projects like 'Regulation of Proteasome Activity' (R35GM145246) and 'Erythrocyte maturation through global proteome remodeling' (R01HL153970). Collaborations with industry and academic partners extend his impact in drug discovery and proteasome-targeted therapies. His lab’s contributions include defining ubiquitin chain editing mechanisms, identifying USP14’s role in mitophagy, and elucidating proteostasis defects in Alzheimer's models. Research tools developed include advanced cryo-EM analyses of proteasomal structures and functional assays for ubiquitin system enzymes.
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Omer Bayraktarمشاهده پروفایل
پژوهشگر
Omer Bayraktar is a Group Leader at the Wellcome Sanger Institute , leading research in the Cellular Genomics Programme. His work focuses on decoding human brain cellular diversity using spatial transcriptomics , imaging , and functional screening to study neural complexity in health and disease. Bayraktar's educational background includes a PhD from HHMI under Chris Doe, investigating neural diversity development in Drosophila , followed by postdoctoral work at University of California, San Francisco and University of Cambridge as a Life Sciences Research Foundation Fellow. He developed a spatial transcriptomic pipeline during his postdoc to analyze astrocyte heterogeneity in the cerebral cortex. His research explores neural cell type mapping , glial-neuronal interactions , and cellular pathways in neurodevelopmental disorders . Recent publications emphasize 3D tissue mapping , multi-omic integration , and computational tools like Cell2fate and WebAtlas. His work bridges neurogenetics and computational biology to advance understanding of human tissue ecosystems. Bayraktar's lab collaborates with the Human Cell Atlas initiative and develops technologies such as automated histology pipelines and highly-multiplexed smFISH for molecular cell typing. His team also investigates glia-based therapies and astrocyte functional heterogeneity in neurodevelopmental contexts. Key scientific contributions include: Discovering astrocyte layer patterns independent of neuronal laminae Developing cell2location for spatial cell mapping Characterizing Drosophila neural stem cell models with human relevance Notable awards include the Life Sciences Research Foundation Fellowship during his postdoctoral training. His current group includes a PhD student , Senior Data Scientists , and Bioinformaticians .
Daan Christiaens is a tenure track lecturer at KU Leuven's Faculty of Medicine and Faculty of Engineering Sciences. He is affiliated with the Department of Electrical Engineering (ESAT) and Department of Imaging & Pathology, serving as a member of the Medical Imaging Division and the KU Leuven Brain Institute (LBI). His academic responsibilities include membership in the Faculty Councils of Engineering Sciences and Medicine. His research focuses on: Inverse problems in medical imaging reconstruction Neuroimaging techniques for brain analysis Advanced quantitative MRI methodologies Diffusion-weighted imaging for microstructural assessment Dr. Christiaens' recent publications (2023-2025) demonstrate a consistent focus on diffusion MRI innovations, including novel reconstruction algorithms, neonatal brain development mapping, and clinical applications for neurodegenerative disorders. Key technical themes include motion correction, multi-shell modeling, and AI-enhanced image processing, while clinical applications span Alzheimer's disease, cerebral palsy, and autism research. He leads significant research projects including: MRI reconstruction with dynamic field monitoring (2024-2028) Compressed sensing for microstructure imaging (2022-2026) Neonatal diffusion MRI network connectivity analysis (2024-2028) As a core developer of the MRtrix3 software framework for medical image processing, he contributes to essential tools in neuroimaging research.
Prof. Dr. Simon Schäfer leads the Schäfer Lab at the Technische Universität München , focusing on engineering advanced organoid systems to study human brain development, disease modeling, and repair mechanisms. His work bridges stem cell biology, gene editing, and bioengineering to develop personalized therapies for brain disorders. Stem Cell & Organoid Technology Neurodevelopmental Mechanisms Neurodegenerative Disease Models Gene Editing & Neuroimmune Interactions Translational Neuroscience Recent research emphasizes brain organoid development, microglia phenotypes, and neurodevelopmental timing anomalies in autism. His team’s work also explores zika virus interactions with glioblastoma stem cells and neuronal plasticity in psychiatric disorders. Scientific awards and funding include support from the Deutsche Forschungsgemeinschaft (DFG), Brain & Behavior Research Foundation (BBRF), and Munich Cluster for Systems Neurology (SyNergy). Collaborations span institutions like the TUM Center for Organoid Systems. Advises 6 students (2 PhD, 1 MSc, 3 associated) Labs include Schäfer Lab, COS@TranslaTUM Contact: simon.schafer@tum.de
Ian Wilsonمشاهده پروفایل
پژوهشگر
- Medical Genetics
- Nephrology
- Genomics
- +۳ مورد دیگر
Dr. Ian Wilson is a researcher at Newcastle University with a focus on medical genetics, nephrology, and genomic analysis. His work spans genetic determinants of kidney diseases, mitochondrial disorders, and biomarker development. Notable contributions include studies on uromodulin genetics in African populations, copy-number variations in rare diseases, and kidney ciliopathies. He has collaborated extensively on projects involving genome sequencing, mitochondrial replacement therapy, and muscular dystrophy biomarkers. Wilson's research integrates computational tools like machine learning for predictive modeling in urolithiasis and employs advanced imaging techniques for disease progression monitoring. Key areas: Genetic epidemiology, renal genomics, mitochondrial DNA analysis Focus on translational applications: Biomarker development for kidney stones and muscular dystrophies Interdisciplinary collaborations in ophthalmology and orthopedics His publications reflect a commitment to advancing diagnostic accuracy and understanding complex genetic disorders through multi-omics approaches.
- Neuroscience
- Neurology
- Pharmacology
- +۱۲ مورد دیگر
Istvan Mody is a Professor at the University of California, Los Angeles (UCLA) with appointments in the Department of Neurology and Department of Physiology . His research focuses on synaptic signaling in health and disease, including mechanisms of GABAergic transmission, calcium homeostasis, and their roles in neurological disorders such as epilepsy, Alzheimer's disease, Huntington's disease, stress, alcoholism, and postpartum depression. He utilizes advanced techniques like patch-clamp electrophysiology, neuroanatomical and immunohistochemical methods, and molecular biology in animal models and human brain tissue . Research Interests: Dr. Mody investigates the physiology, pharmacology, and pathology of synaptic transmission and extrasynaptic receptor activation , with a particular emphasis on GABA(A) receptors and their subunit-specific modulation. His work explores how disruptions in excitation-inhibition balance contribute to neurological diseases, including mechanisms of tonic inhibition , calcium signaling , and neurosteroid interactions . He also studies the effects of chronic stress and hormonal fluctuations on neural excitability and behavior. Publications Trends: Recent studies highlight his work on gamma oscillations in Alzheimer's models, microglial dynamics , and rehabilitation strategies for stroke. His lab develops optical tools like dqGEVI for neuronal activity monitoring and investigates human brain organoids to model network dysfunction in epilepsy and intellectual disability. Laboratory Location: 635 Charles Young Dr S, Los Angeles, CA 90095, United States.
- Maternal Fetal Medicine
- Ultrasound
- Preeclampsia
- +۳ مورد دیگر
Giuseppe Rizzo is a Full Professor at the Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome. His academic career focuses on Maternal Fetal Medicine, with expertise in ultrasound applications, fetal growth restriction, preeclampsia, and congenital anomalies. Research Interests : Delivery optimization, prematurity prediction, ultrasound diagnostics, and placental anomalies. Recent Publications : Over 15 high-impact studies in 2024-2025 on topics like umbilical cord abnormalities, cerebroplacental ratios, and gestational diabetes complications. Clinical Expertise : Prenatal counseling, Doppler ultrasound, and labor management protocols. Collaborations : Active in multicenter trials across Italy and Europe, with a focus on fetal neurosonology and high-fidelity obstetric simulation.
Prof. Ilse Dewachter is the head of the Biomed Neuroscience research group at Hasselt University (UHasselt), specializing in Alzheimer’s therapy and prevention for over 25 years. Her work focuses on multi-targeted therapies targeting tau, inflammation, and ApoE, alongside pioneering research into disease prevention via blood-based biomarkers. Recent studies explore a protective APOE3ch mutation that halted Alzheimer’s progression in a patient, offering hope for new treatments. Research Interests: - Alzheimer’s disease mechanisms (Abeta, tau, inflammation) - Multi-target therapies and biomarker development - Neurodegenerative disease prevention strategies - Genetic mutations impacting disease progression Articles Overview: Her most recent work (2025-2022) addresses neuroinflammation, tau propagation models, and AI-driven neuroimaging. Key themes include APOE genetics, blood-brain barrier dynamics, and exercise impacts on cognition. Funding & Grants: Current projects require significant investment for advanced biomarker equipment and clinical trials. A notable €300,000 grant funded research on brain lipid metabolism’s role in Alzheimer’s. Labs & Teams: Leads the BIOMED Neuroscience group at UHasselt, collaborating internationally on preclinical models and drug development.
Lindsey Kent is a Professor at the University of St Andrews' School of Medicine, where she serves as Deputy Head and Director of Admissions. Her research focuses on the biological foundations of psychiatric disorders, particularly ADHD and developmental language disorders. Education: Medicine (Aberdeen University, 1989), PhD (University of Birmingham, 1998) Academic Appointments: Wellcome Trust Fellow (1999), University Lecturer (University of Cambridge, 2003), Reader (University of St Andrews, 2007) Research Trends: Dr. Kent's work explores psychiatric genetics, neurodevelopmental disorders, and molecular mechanisms through genome-wide association studies, exome sequencing, and genetic epidemiology. Key Collaborations: Psychiatric Genomics Consortium, EAGLE Consortium, 23andMe Technical Focus: ATP2C2 gene variants, TNR gene associations, polygenic risk architectures Awards: Fellow of the Higher Education Academy (2000) Academic Contributions: She has directed two Wellcome Trust-funded projects on ADHD genetics and co-authored over 91 peer-reviewed publications, including significant studies in Nature Communications and Human Molecular Genetics . Her editorial roles include serving on the American Journal of Medical Genetics board (2007–2014).
Manu Sharmaمشاهده پروفایل
دانشیار
Manu Sharma is an Associate Professor of Neuroscience at the Brain and Mind Research Institute , Weill Cornell Medical College (2024–present). His research focuses on the molecular mechanisms underlying neurodegenerative diseases, particularly tauopathies and synucleinopathies (e.g., Alzheimer’s and Parkinson’s diseases), synaptic transmission, and protein aggregation. Education: Ph.D., University of Toronto (2005) B.Sc., University of Toronto (1998) Research Interests: Dr. Sharma investigates how physiological and pathological modifications of tau and α-synuclein proteins contribute to neurodegeneration. His work explores synaptic vesicle dynamics, chaperone-mediated protein stabilization, and the role of lysosomal pathways in disease progression. Grants: He has secured major funding as Principal Investigator and Co-Investigator from the National Institute on Aging and National Institute of Neurological Disorders & Stroke (2024–2029) for studies on tau proteostasis, synucleinopathies, and small molecule inhibitors targeting neurodegenerative pathways. Labs & Teams: Affiliated with the Brain and Mind Research Institute, Dr. Sharma collaborates on multidisciplinary projects involving synaptic biology, protein quality control, and neurodegeneration models.
Kay Jamesمشاهده پروفایل
دانشیار
- Neuroscience
- Education
- Cognitive Science
- +۳ مورد دیگر
Kay James is an Associate Professor of Neuroscience and Education at Teachers College, Columbia University, and serves as Director of the Graduate Program in Neuroscience and Education and the Neurocognition of Language Lab. Their work focuses on neural mechanisms underlying language disorders, second language acquisition, and cognitive processes in schizophrenia. Key affiliations include Biobehavioral Sciences, Neuroscience and Education, Human Development, and Cognitive Science in Education. Research interests emphasize the neural basis of language processing in pathological contexts such as developmental speech disorders and schizophrenia, alongside second language acquisition in adults. Their interdisciplinary approach bridges cognitive neuroscience with clinical and educational interventions. Publications span studies on mismatch negativity in speech disorders, syntactic development in Arabic diglossia, and brain-behavior asymmetry in schizophrenia. Ongoing work explores voice-related cortical potentials and emotional face processing through electrophysiological methods. Labs and teams include the Neurocognition of Language Lab, focusing on language neurobiology and clinical applications. Grants and advising roles are not explicitly detailed in the provided materials.
Sven Bölte is a Professor at Karolinska Institutet where he leads the research group focused on Autism, ADHD and other developmental neurological conditions as part of the Center for Neurodevelopmental Disorders (KIND). His work bridges clinical research, education, and practical implementation of evidence-based approaches for neurodevelopmental conditions. Professor Bölte's research spans multiple domains within neurodevelopmental disorders, with particular emphasis on implementing the International Classification of Functioning, Disability and Health (ICF) Core Sets for autism and ADHD using digital solutions. His group has developed and evaluated social skills training programs (KONTAKT, SKOLKONTAKT, iKONTAKT) for autistic children and adolescents, conducted twin research through the Roots of Autism and ADHD Twin Study in Sweden (RATSS), and advanced diagnostic instruments for autism, ADHD, social cognition, and adaptive behavior. His recent publications reveal a strong focus on translating research into practice, with significant work on strengths-based approaches, social inclusion, neurodiversity-affirmative assessment, and the development of practical tools for clinicians and educators. The research demonstrates increasing attention to adult experiences of autism, cross-cultural validation of interventions, and the integration of digital technology in assessment and intervention. Bölte's group also delivers extensive educational components for professionals through KI-Utbildning (Assignment Education), making it one of the largest providers of training on diagnosis and support for individuals with developmental neurological conditions within Karolinska Institutet. His work frequently addresses policy implications, as evidenced by participation in Swedish parliamentary discussions about autism and ADHD.
Dr. Brent Fogel is a Professor in the Departments of Neurology and Human Genetics at the David Geffen School of Medicine, UCLA. He directs the Neurogenetics Clinic and the UCLA Clinical Neurogenomics Research Center , focusing on diagnosing and managing genetic neurological disorders such as cerebellar ataxia , ataxia with oculomotor apraxia , spastic paraplegia , and leukodystrophies . His research integrates genomics , bioinformatics , and neuroimaging to improve precision medicine in prenatal counseling and rare disease diagnosis. Education: MD, PhD from Medical College of Wisconsin (2003) PhD in Genetics (2001) Internship in Internal Medicine (Northwestern University, 2004) Residency in Neurology (UCLA, 2007) Fellowship in Neurogenetics (UCLA, 2009) Board Certified in Neurology (2009) Research Focus: Dr. Fogel’s work spans neurogenetics , spinocerebellar ataxia , leukodystrophy , and genomic technologies . He has pioneered gene discovery in hereditary ataxias, developed transcriptional biomarkers , and contributed to diagnostic guidelines for rare disorders. His studies on lysosomal genes in Parkinson’s disease and exome sequencing disparities address critical gaps in neurogenetic research. Key Collaborations: He leads multicenter studies with the Ataxia Global Initiative , Undiagnosed Diseases Network , and Genomics England Research Consortium . His lab ( FogelLab ) develops tools like multiWGCNA for gene network analysis.
Professor Richard Wade-Martins is a leading academic in University of Oxford 's Department of Physiology, Anatomy and Genetics . He directs the Molecular Neurodegeneration Research Laboratory and the Oxford Parkinson’s Disease Centre (OPDC). With degrees from Cambridge (MA) and Oxford (DPhil), he has held prestigious fellowships including Wellcome Trust Research Career Development Fellowship and NIH reviewer roles. His research targets molecular mechanisms in Parkinson’s and Alzheimer’s diseases through iPSC models , transgenic mice , and lysosomal function studies . He pioneered work on SNCA , MAPT , and LRRK2 gene pathways. Current projects focus on gene therapy and mitochondrial dysfunction in neurodegeneration. Key publications (2019–2025) reveal trends in single-cell transcriptomics , calcium channel inhibition , and TFEB/TFE3 lysosome modulation . His awards include Wellcome Trust Fellowships and advisory roles for Parkinson's UK , Alzheimer's Research UK , and EU consortia like StemBANCC and EFACTS . He leads the UK Dementia Platform iPSC Initiative and serves on international boards in Luxembourg and Canada.
Catherine Mooney is a Professor in the School of Computer Science at University College Dublin (UCD), leading the Life Science Data Analytics Group (LiSDA). Her research focuses on applying machine learning to healthcare challenges, including biomarker development, clinical decision support systems, and addressing ethical and technical barriers in healthcare AI. Education: BSc in [field unspecified] from Trinity College Dublin PhD in Computer Science from UCD Prof Dip University Teaching & Learning from UCD Research Interests: Machine Learning applications in healthcare Biomarker discovery for neurological and metabolic conditions Explainable AI for clinical decision support Promoting diversity and inclusion in STEM education Her work bridges computational methods with medical challenges, emphasizing ethical AI and translational research. Notable Awards: Best Paper Award in Applied Biosciences (2023) UCD Long-Service Award (2022) Best Poster Award at ITiCSE ’20 (2020) Her research has led to impactful tools like LiSDA’s clinical decision support systems for epilepsy and pregnancy care. She also advocates for gender diversity in computing, serving in leadership roles like Vice Principal for EDI in UCD’s College of Science (2022–2024).
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