Ilse Dewachter

Prof. Ilse Dewachter is the head of the Biomed Neuroscience research group at Hasselt University (UHasselt), specializing in Alzheimer’s therapy and prevention for over 25 years. Her work focuses on multi-targeted therapies targeting tau, inflammation, and ApoE, alongside pioneering research into disease prevention via blood-based biomarkers. Recent studies explore a protective APOE3ch mutation that halted Alzheimer’s progression in a patient, offering hope for new treatments.

Research Interests:
- Alzheimer’s disease mechanisms (Abeta, tau, inflammation)
- Multi-target therapies and biomarker development
- Neurodegenerative disease prevention strategies
- Genetic mutations impacting disease progression

Articles Overview:
Her most recent work (2025-2022) addresses neuroinflammation, tau propagation models, and AI-driven neuroimaging. Key themes include APOE genetics, blood-brain barrier dynamics, and exercise impacts on cognition.

Funding & Grants:
Current projects require significant investment for advanced biomarker equipment and clinical trials. A notable €300,000 grant funded research on brain lipid metabolism’s role in Alzheimer’s.

Labs & Teams:
Leads the BIOMED Neuroscience group at UHasselt, collaborating internationally on preclinical models and drug development.