جست‌وجوی استاد و پژوهشگر

Jared E. Toettcherمشاهده پروفایل

دانشیار

• Cell Signaling Pathways
• Optogenetics
• Systems Biology
• +۶ مورد دیگر

Jared E. Toettcher is the Associate Professor of Molecular Biology and Deputy Director of the Omenn-Darling Bioengineering Institute at Princeton University. He holds additional faculty affiliations with the Department of Chemical and Biological Engineering and the Lewis-Sigler Institute for Integrative Genomics. Education: B.S. in Bioengineering, University of California, Berkeley (2004) Ph.D. from Massachusetts Institute of Technology (2009) Research Focus: The Toettcher Lab investigates how cells decode spatial and temporal signaling information to make critical decisions about growth, differentiation, and migration. Their work combines optogenetic tools (Phytochrome B/PIF6 system), high-resolution microscopy, and systems biology to study: Dynamic signal encoding in Ras/Erk pathways Spatiotemporal control of developmental processes Phase separation as a mechanism for cellular memory Cancer-related signaling pathway disruptions Synthetic control of metabolic and developmental systems Key Publication Trends: Recent work focuses on light-regulated systems for controlling signaling pathways (2023-2025), with particular emphasis on interferon receptors, embryonic symmetry breaking, and prime editing techniques. Earlier studies (2013-2018) established foundational optogenetic tools for studying Erk dynamics and metabolic flux control. Scientific Recognition: NSF CAREER Award (2018-2023) NIH New Innovator Award (2016-2021) Cancer Research Institute Fellow (2010-2013) MIT Presidential Fellow (2004) UC Berkeley Regents' Scholar (2000) Laboratory and Collaborations: The Toettcher Lab at Princeton University operates at the intersection of quantitative cell biology and engineering, with active collaborations across bioengineering, genomics, and developmental biology disciplines.

Bryan Phillipsمشاهده پروفایل

استاد

• Cell and Developmental Biology
• Genetics
• Wnt Signaling Pathway
• +۳ مورد دیگر

Bryan Phillips is a Professor in the Department of Biology at the University of Iowa, where he conducts research on cell fate determination and developmental biology using C. elegans as a model organism. His work focuses on understanding how a single undifferentiated oocyte develops into a multicellular organism with numerous, intricately connected cell types through precise molecular mechanisms. Dr. Phillips received his PhD from Texas A&M University. His research primarily investigates the molecular mechanisms of cell-to-cell communication during development, with a particular emphasis on the Wnt signaling pathway and its role in asymmetric cell division where a polarized mother cell generates two daughter cells with different fate determinants. Dr. Phillips' laboratory examines how the Wnt signaling pathway regulates cell fate through β-catenin, with a special focus on SYS-1, a β-catenin homolog in C. elegans that shares structural and functional similarities with vertebrate β-catenin. His research explores how centrosomes, protein degradation mechanisms, and gene duplication events contribute to the regulation of asymmetric cell divisions. The lab's work bridges molecular, cellular, and developmental biology to address fundamental questions about why animal cells differentiate the way they do, with implications for developmental defects and diseases like cancer where Wnt signaling is often misregulated. Analysis of Dr. Phillips' publication record reveals a consistent research trajectory focused on Wnt signaling, β-catenin regulation, and asymmetric cell division across 15 recent publications (2015-2025). His work demonstrates how conserved molecular mechanisms control cell fate determination, with particular attention to the SYS-1 protein and its regulation through centrosomal localization, proteasomal degradation, and transcriptional activation. The research spans multiple levels of investigation from protein structure and evolutionary analysis to developmental processes in a whole organism. Dr. Phillips' laboratory is actively recruiting graduate students through multiple programs including the UI Biology Department, the UI Genetics Program, the UI Molecular and Cellular Biology Program, and the UI Biosciences Program. His research facilities are located in the Biology Building East (BBE) at the University of Iowa, where he maintains both office space (200 BBE) and laboratory facilities with dedicated phone lines for administrative and research communications.

• Developmental Biology
• Systems Biology
• Cell Signaling
• +۵ مورد دیگر

Nate Lord, PhD, is an Assistant Professor at the University of Pittsburgh. He holds a PhD in Systems Biology from Harvard University. His research focuses on understanding the robustness of embryonic development, particularly how embryos maintain precise patterning and correct errors despite genetic and environmental challenges. Lord employs optogenetic manipulation, quantitative microscopy, computational modeling, and classical embryology to explore signaling dynamics and cell behavior across scales. His work bridges molecular mechanisms and tissue-level morphogenesis, aiming to uncover principles of developmental reliability. Education: PhD in Systems Biology, Harvard University Research Interests: Lord’s lab investigates how developing systems achieve robustness through multi-scale mechanisms. Key themes include Nodal signaling dynamics, optogenetic control of developmental processes, and stochastic regulation of cell fate decisions. By combining synthetic biology tools with quantitative analysis, his work addresses fundamental questions about error tolerance in embryogenesis, such as how signaling gradients stabilize patterns and how morphogenetic movements are coordinated despite perturbations. Publications: Recent work (2025–2013) highlights Lord’s focus on Nodal signaling pathways, optogenetic regulation of developmental processes, and stochastic mechanisms in microbial systems. His studies on human retinal organoids (e.g., DIO3’s role in photoreceptor development) demonstrate translational potential in modeling human tissue formation. Older studies (e.g., bacterial cell fate switching) reveal foundational insights into stochastic processes in cellular decision-making. Lab & Future Work: Lord’s lab integrates experimental and computational approaches to engineer synthetic systems that mimic developmental reliability. Ongoing projects aim to map feedback mechanisms that stabilize morphogen gradients and to design optogenetic tools for real-time embryonic signaling control.

• Molecular Biology
• Developmental Biology
• Evolutionary Biology
• +۳ مورد دیگر

William Gillis is an Associate Professor in the Department of Biological Sciences at the State University of New York at Old Westbury. His research focuses on molecular and developmental biology, with a strong emphasis on understanding evolutionary processes and gene regulation mechanisms. Key areas of interest include signal transduction pathways (e.g., Wnt, BMP, TGF-β), GATA transcription factors, and systems biology approaches to biological network modeling. His work spans from molecular genetics to evolutionary genomics, often utilizing model organisms like Xenopus and Platynereis dumerilli. Gillis's publications (2003–2016) highlight interdisciplinary research at the intersection of developmental biology and computational methods. Notable topics include the role of Gtpbp2 in Wnt/BMP signaling, evolutionary divergence of GATA factors, and multi-agent systems for simulating biological networks. His contributions bridge experimental and theoretical approaches to unravel complex biological systems. No scientific awards or formal advisees/students are explicitly listed in the provided texts. His professional presence is centered at SUNY Old Westbury, with no indications of part-time roles or former institutional affiliations.

Ariel Paniمشاهده پروفایل

استادیار

• Developmental Biology
• Molecular Biology
• Cell Biology
• +۳ مورد دیگر

Ariel Pani is an Assistant Professor of Biology at the University of Virginia. His research focuses on developmental biology, particularly using the C. elegans model organism to study cell migration, signaling pathways, and organogenesis. He leads the Pani Lab, which explores processes such as FGF-dependent muscle progenitor migration and Wnt signaling dynamics. Education B.A., Cornell University, College Scholar in Organismal Biology (2004) Ph.D., University of Chicago, Evolutionary Biology (2013) Postdoctoral Research, University of North Carolina at Chapel Hill (2013–2019) His research interests include molecular mechanisms of cell behavior, evolutionary developmental processes, and the role of transcription factors in cellular decisions. His lab has developed novel genetic tools for studying Notch and Wnt signaling pathways in vivo. Publications highlight his work on C. elegans organogenesis, microtubule dynamics during meiosis, and the molecular characterization of nervous systems in hemichordates. He collaborates widely, with studies often involving interdisciplinary approaches to developmental biology. The Pani Lab is equipped to investigate cellular processes using advanced microscopy, CRISPR-based genome engineering, and transcriptome analysis. Ongoing projects aim to unravel how physical forces and molecular signals coordinate during development.

Pearson Millerمشاهده پروفایل

استاد

• Mathematical Biology
• Nonlinear Dynamics
• Biophysics
• +۳ مورد دیگر

Professor Pearson Miller is a faculty member in the Department of Physics at the University of California San Diego (UCSD). He holds a PhD in Physics from MIT (2020) and previously served as a Flatiron Research Fellow at the Center for Computational Biology at the Flatiron Institute (2020–2024). His research focuses on nonlinear dynamics applied to biological systems, including cell polarization, tissue morphogenesis, and pattern formation in developmental biology. Teaching responsibilities include advanced courses on numerical methods. His work bridges physics and biology, with a particular emphasis on mathematical modeling of biological systems. Key research areas include: Cellular mechanics and actomyosin networks Biophysical mechanisms of morphogenesis Evolution of stripe patterns in rodents Topological phenomena in cell membranes His interdisciplinary approach integrates computational modeling with experimental insights to study complex biological processes. While no awards are explicitly listed, his research has been published in top journals across physics and biology. He currently holds no listed lab affiliations or collaborative teams, though his prior fellowship at the Flatiron Institute indicates strong ties to computational biology research networks.

Mark Fleggمشاهده پروفایل

مدرس ارشد

• Mathematical Biology
• Cell Biology
• Stochastic Processes
• +۴ مورد دیگر

Dr. Mark Flegg is a Senior Lecturer in the School of Mathematics at Monash University. He holds a PhD in mathematical modelling of aerosol physics from Queensland University of Technology (2010) and has completed postdoctoral research at the University of Oxford's Oxford Centre for Collaborative Applied Mathematics (OCCAM). His research focuses on applied mathematics in biological systems, including mathematical biology, cell biology, stochastic processes, and biomedical modelling. Education: PhD in Mathematical Modelling (Queensland University of Technology, 2010) Postdoctoral research at OCCAM, University of Oxford Research Interests: Mathematical Biology: Modelling malaria dynamics, wound healing, and developmental processes Stochastic Processes: Particle motion, enzyme kinetics, and reaction-diffusion systems Clinical Applications: Ultrasound in bone modelling and surgical site infection prevention Systems Biology: Signalling pathways (Wnt/β-catenin) and biochemical network analysis Projects & Grants: Controlling cell polarity and asymmetric cell division (ARC, 2016–2018) Stochastic mathematical modelling of the Wnt signalling pathway (ARC, 2014–2017) Lab Affiliation: Monash Academy for Cross and Interdisciplinary Mathematical Applications (MAXIMA), focusing on interdisciplinary research in mathematical sciences.

Danfeng Caiمشاهده پروفایل

استادیار

• Biomolecular Condensates
• Phase Separation
• Transcription Regulation
• +۱۳ مورد دیگر

Danfeng Cai, PhD, is an Assistant Professor in the Department of Biochemistry and Molecular Biology at the Johns Hopkins Bloomberg School of Public Health and the School of Medicine. Her research focuses on biomolecular condensates and their roles in transcription regulation and cancer. The Cai Lab employs advanced imaging, genomics, and proteomics to investigate phase separation in cellular processes, particularly in renal cell carcinoma and YAP/TEAD-driven transcription. PhD, Johns Hopkins University, 2014 BS, Peking University, 2009 The Cai Lab investigates how liquid-like condensates regulate transcription and chromatin organization in normal and cancer cells. Key research areas include the formation and function of YAP/TEAD transcription hubs and the role of membrane-less organelles in papillary renal-cell carcinoma (PRCC). Using super-resolution microscopy, single-particle tracking, and optogenetics, the lab explores how phase separation influences gene expression and cellular homeostasis. The lab's recent publications highlight a strong focus on phase separation, transcriptional reprogramming, and cancer progression. Articles span topics such as TFE3 fusion oncoprotein condensates, ADP-ribosylation in p62 bodies, and chemoproteomic probes, reflecting interdisciplinary research at the intersection of cell biology, cancer, and proteomics. Scientific Awards: Kavli Fellow, National Academy of Sciences Leading Edge Fellow, Leading Edge Symposium The Lorraine Flaherty Award, International Mammalian Genome Society Forbeck Scholar Award, William Forbeck Research Foundation Fellows Award for Research Excellence, National Institute of Health Damon Runyon-Dale F. Frey Award for Breakthrough Scientists, Finalist Bae Gyo Jung Award, Johns Hopkins University Danfeng Cai has secured significant research funding, including an R35 MIRA grant from the National Institute of General Medical Sciences (NIH), funding from the Department of Defense’s Kidney Cancer Research Program, and institutional support from Johns Hopkins Bloomberg School of Public Health. She actively mentors trainees in cutting-edge microscopy and proteomics techniques. The Cai Lab is interdisciplinary, fostering collaborations with physician scientists, engineers, and mathematicians. The Cai Lab is based in the Department of Biochemistry and Molecular Biology at Johns Hopkins Bloomberg School of Public Health. The lab is actively recruiting and emphasizes curiosity-driven research using advanced imaging and proteomics tools to study biomolecular condensates. The team collaborates widely across Johns Hopkins and internationally.

• Mathematical Modeling
• Microfluidics
• Gene Regulatory Networks
• +۷ مورد دیگر

Claudiu Vasile Giuraniuc is a Lecturer in the School of Natural and Computing Sciences at the University of Aberdeen, where he has been actively contributing since 2010. His interdisciplinary research bridges physics, biology, and computational modeling, with a strong emphasis on microfluidics, gene regulatory networks, and medical image analysis. BSc in Physics, “Al.I. Cuza” University, Iasi, Romania MSc in Physics, Lille 1 University, France PhD in Physics, Katholieke Universiteit Leuven, Belgium (2006) His research focuses on mathematical modeling of biological systems , particularly in developmental biology and microbial pathogenesis. He applies microfluidics and lab-on-a-chip technologies to study cellular behavior under dynamic conditions, including chemical gradients and electrical stimulation. His work in gene regulatory networks and Wnt signaling has provided insights into embryogenesis and tissue development. Additionally, he contributes to orthopedic research through statistical shape modeling of the hip joint and its relation to osteoarthritis. The 15 most recent publications reflect a strong trend toward interdisciplinary systems biology , combining experimental microfluidics with computational modeling. Key themes include cell signaling dynamics , developmental morphogenesis , genetic regulation of bone shape , and synthetic biology applications . The work spans from fundamental physics-based models to translational biomedical research. Scientific contributions are recognized through publications in high-impact journals such as eLife , mBio , and Journal of Bone and Mineral Research . Notable collaborations include work with researchers in immunology, orthopedics, and synthetic biology. As a Principal Investigator, he has led projects such as Microfluidic tools for personalized medicine (NHS Endowment grant) and industry partnerships with ibidi® . He has also served as Co-Investigator on grants related to nanoparticle-embedded membranes and nerve-muscle co-cultures. He mentors research through collaborative projects, though no formal students are listed. His lab integrates microfluidic culture systems , mathematical modeling , and image analysis pipelines to study complex biological phenomena across scales.

• Mathematical Biology
• Developmental Biology
• Systems Biology
• +۳ مورد دیگر

Professor Nick Monk is a faculty member at the School of Mathematical and Physical Sciences, University of Sheffield. His research spans mathematical biology, developmental biology, and systems biology, with a focus on modeling regulatory processes in biological systems. Monk's work explores dynamical systems theory, including pattern formation, gene regulatory networks, and cellular signaling. His publications analyze phenomena such as Turing reaction-diffusion models, Notch signaling robustness, and plant developmental processes. Recent research trends include applications of mathematical modeling to developmental gene networks, computational ecology, and industrial biotechnology. His teaching activities cover advanced calculus, linear algebra, and mathematical biology. Current grants include the EPSRC Maths DTP 2020 and EPSRC Research Associateship, alongside past funding for biofuel production via microbubble technology. Monk's research group specializes in mathematical biology, and his full contact details are available via the University of Sheffield's website.

Linda Barlowمشاهده پروفایل

استاد

• Developmental Biology
• Sensory Neuroscience
• Regenerative Medicine
• +۳ مورد دیگر

Linda Barlow, Ph.D. is a Professor at the University of Colorado Anschutz Medical Campus , affiliated with the Department of Cell and Developmental Biology and the Rocky Mountain Taste and Smell Center . Her work bridges developmental biology and sensory neuroscience. Graduate program affiliations: Biomedical Sciences, Cell Biology, Neuroscience, and Medical Scientist Training Program (MSTP) Dr. Barlow investigates three core questions: How taste buds form during embryogenesis, how their cells renew lifelong, and why cancer therapies disrupt taste function. Her lab employs drug-inducible mouse models , confocal microscopy , and RNAseq on FACS-purified cells. Key research themes include: Taste Bud Development: Role of Wnt/β-catenin and FGF signaling Regeneration Dynamics: SHH pathways and injury models for cancer therapy effects Translational Impact: Bridging mouse genetics to human taste dysfunction Her recent publications focus on ectodermal-endodermal taste bud interactions , Sox2+ progenitor identification , and COVID-19 implications for chemical senses. Work is supported by NIH grants .

Samantha Joanna Butlerمشاهده پروفایل

استاد

• Developmental Neurobiology
• Axon Guidance
• Spinal Cord Patterning
• +۶ مورد دیگر

Samantha Joanna Butler, Ph.D. , is Professor and Director of the Department of Neurobiology at the David Geffen School of Medicine, University of California, Los Angeles . She previously held the prestigious Eleanor Leslie Chair in Pioneering Brain Research (2018–2023). Education & Training Ph.D. (field not specified in text) Research Focus Dr. Butler’s laboratory investigates the molecular cues that pattern the embryonic spinal cord, with emphasis on axon guidance , progenitor specification , and cell fate decisions . Central molecules include Netrin-1 , Bone Morphogenetic Proteins (BMPs) , and Wnt signals . Using mouse genetics, human pluripotent stem-cell models, and advanced imaging, her team has elucidated how these cues create the dorsal–ventral architecture of the spinal cord and specify sensory interneuron subtypes. Grant Portfolio NIH R01 NS107509 (PI): “Assessing the contact-mediated role of netrin1 in axon guidance” (2019–2024) NIH R01 NS085097 (PI): “Diverse roles of the Bone Morphogenetic Proteins in the developing spinal cord” (2014–2020) NIH R01 NS063999 (PI): “Regulation of axonal outgrowth in the developing spinal cord” (2008–2014) Selected Honors Eleanor Leslie Chair in Pioneering Brain Research (2018–2023) Laboratory & Team Dr. Butler leads an active research group within the UCLA Neurobiology Department. While specific trainees are not listed in the provided text, her extensive publication record with multiple co-first authors indicates a vibrant training environment for graduate students and postdoctoral fellows.

• Developmental Biology
• Wnt Signaling
• Bone Morphogenetic Proteins
• +۶ مورد دیگر

Edward M. De Robertis is a Distinguished Professor of Biological Chemistry at the University of California Los Angeles (UCLA) School of Medicine, holding the Norman Sprague Chair in Molecular Oncology since 1985. A member of the National Academy of Sciences and the Pontifical Academy of Sciences, his research focuses on morphogen gradient formation in early development and cancer, particularly the Chordin/BMP/Tolloid pathway and Wnt signaling mechanisms. MD from Universidad de la Republica, Uruguay (1971) PhD in Chemistry from Instituto Leloir, Buenos Aires (1974) Postdoctoral training in Embryology at MRC Laboratory of Molecular Biology, Cambridge (1980) under John Gurdon His work has defined the molecular basis of the Spemann organizer, morphogen gradients, and endolysosomal regulation in development. He discovered key mechanisms in Wnt signaling translocation and macropinocytosis, with recent studies linking developmental pathways to human cancers like colorectal tumors. His laboratory uses Xenopus embryos as a primary model system. Scientific contributions include 15 major publications since 2022 on topics ranging from Xenopus axial patterning to cancer metabolism. His research team has developed innovative protocols for analyzing lysosomal activity and ectodermal cell dynamics. Current funding includes NIH R01 grants and the Norman Sprague Endowment. 2024 LASDB Prize (Latin American Society of Developmental Biology) 2023 Honorary Member, Society of Developmental Biology Academy 2021 Lifetime Achievement Award, Society of Developmental Biology 2020 Kowalevsky Medal in Evo-Devo De Robertis has trained numerous researchers through his UCLA laboratory and HHMI Investigator role (1995-2019). His work bridges evolutionary and developmental biology, with applications in oncology and regenerative medicine.

• Biophysics
• Immunology
• Statistical Mechanics
• +۴ مورد دیگر

Aleksandra Walczak is a Researcher (CNRS Directrice de Recherche) at the Laboratoire de Physique de l’ENS (LPENS) at École Normale Supérieure in Paris, France. She leads the Statistical Biophysics group, focusing on theoretical and computational approaches to biological systems. Her work bridges physics and biology, addressing challenges in cellular processes, immune systems, and evolutionary dynamics. Research Interests: Walczak’s research explores the interplay between biological function and physical principles. Key areas include gene regulatory networks, collective behavior in biological systems (e.g., immune responses), and population genetics. She develops models to understand how interactions between molecular components influence phenotypes and how immune systems encode complex functions using probabilistic frameworks. Recent projects include studying antigenic escape in viral populations and applying machine learning to immune repertoire analysis. Affiliations & Collaborations: She co-leads the GDRI network on Evolution, Regulation, and Signaling, fostering international collaboration. Her work is supported by the Fondation Bettencourt Schueller and involves interdisciplinary initiatives like the Paris Biological Physics Community Day. Education & Career: Walczak earned her PhD in Physics from UC San Diego (2007) and an HDR (Habilitation) from ENS Paris (2012). She held postdoctoral positions at Princeton University and the Kavli Institute for Theoretical Physics. As a CNRS researcher since 2010, she has contributed to over 100 publications, advancing our understanding of biological systems through physics-based models.

Paola Bovolentaمشاهده پروفایل

استاد پژوهشی

• Developmental Neurobiology
• Neuroinflammation
• Neurodegeneration
• +۶ مورد دیگر

Paola Bovolenta is a Research Professor at the Spanish National Research Council (CSIC) - Universidad Autónoma de Madrid (UAM), with international recognition in Developmental Neurobiology. She has held leadership roles including Chair of the Tissue and Organ Homeostasis Program (2019–present) and former Chair of the Development and Differentiation Department (2012–2019). Her research spans: Mechanisms of visual axon sorting at the chiasm Morphogen signaling in eye development Neuroinflammation in Alzheimer's disease ADAM10-SFRP1 interactions in neurodegeneration Interdisciplinary approaches to life sciences Recent publications highlight her work on zebrafish models for optic cup morphogenesis, neuroinflammatory crosstalk in Alzheimer's, and synthetic biology applications. Awards include EMBO membership (2012), two Fundaluce Awards (2009, 2012), and ERC Scientific Council membership (2017). She has mentored 21 PhD students (4 ongoing) and 20 postdocs, with active involvement in European research policy through the ERC Open Science Working Group and UE Core Group on Reform of Research Assessment.