Deborah Frances Smith is a Professor affiliated with the Centre for Immunology and Infection. She has held former roles including Head Of Department, Biology Pro-Vice-Chancellor for Research, and Special Adviser to the Vice Chancellor in the Vice Chancellor's Office. She is also associated with CNAP (Cancer and Neuroscience Academic Programme) and the Jack Birch Unit. Her research focuses on leishmaniasis, parasite biology, and drug/vaccine development. Key projects include leading the 'C2D2 research 1a & 2b' (2012–2012) to establish sandfly colonies for leishmaniasis studies and co-investigating an integrated crystallization facility (2013–2018). She secured the Wolfson Research merit Award (2009–2010) from the Royal Society. Her work spans academic leadership, collaborative research, and translational medicine targeting neglected tropical diseases.
James Briscoe is a Senior Group Leader at The Francis Crick Institute in London, where he leads a research group focused on developmental biology and morphogen signaling. He previously held positions at the Medical Research Council's National Institute for Medical Research, which later became part of the Francis Crick Institute. Education: BSc in Microbiology and Virology from the University of Warwick, UK PhD from Imperial Cancer Research Fund/King's College London Postdoctoral training at Columbia University with Thomas Jessell Dr. Briscoe's research focuses on the molecular and cellular mechanisms of graded signaling by morphogens and the role of transcriptional networks in cell fate specification. His laboratory employs a range of experimental and computational techniques using model systems including mouse and chick embryos and embryonic stem cells. His work has significant implications for understanding developmental processes and their relationship to disease. His recent publications demonstrate a continued focus on morphogen gradients, neural tube development, and computational approaches to understanding cell fate decisions. His research increasingly integrates single-cell technologies and computational modeling to unravel the complexities of developmental patterning. Scientific Awards and Honors: EMBO Young Investigator (2001) EMBO Gold Medal (2008) Elected to EMBO (2009) Fellow of the Academy of Medical Sciences (2019) Fellow of the Royal Society (2019) As Editor-in-Chief of the journal Development since 2018, Dr. Briscoe plays a significant role in shaping the field of developmental biology. His leadership extends to mentoring researchers and contributing to scientific policy discussions, as evidenced by his recent publication 'Science under siege: protecting scientific progress in turbulent times.' Dr. Briscoe's laboratory at the Crick Institute is well-equipped with access to advanced facilities including light microscopy, flow cytometry, genomics, and computational resources, enabling a multidisciplinary approach to developmental biology questions.
Colin J Akerman is Professor of Neuroscience and Group Leader in the Department of Pharmacology at the University of Oxford, concurrently serving as Corange Fellow and Medical Tutor at Corpus Christi College. His research investigates fundamental mechanisms of synaptic circuit formation and plasticity, with direct implications for epilepsy, dementia, and schizophrenia through multidisciplinary approaches integrating electrophysiology, optical imaging, and computational modeling. His primary research interests encompass Synaptic Plasticity, Neural Circuit Formation, and Excitatory-Inhibitory Balance, with specific focus on neuronal progenitor influences on connectivity, chloride dynamics in inhibitory transmission, and learning mechanisms in disease contexts. The lab employs custom-built equipment and molecular tools to probe synaptic function across in vivo , in vitro , and in silico platforms, emphasizing how activity-dependent processes shape neural networks during development and disease. Recent publications (2023-2025) reveal strong thematic convergence on intracellular chloride regulation in sleep-wake cycles, cortical circuit assembly from embryonic progenitors, and innovative optical tools for neural monitoring. This work bridges molecular neuroscience with systems-level understanding of synaptic plasticity, particularly regarding ionic mechanisms in epilepsy and sleep homeostasis. No scientific awards or fellowships are explicitly documented in the source materials. Professor Akerman currently mentors four PhD students (Vourvoukelis, Selfe, Wang, Gemayel) and multiple postdoctoral researchers, having previously trained scientists now leading independent groups in Toronto, Edinburgh, Cape Town, Oxford, and London. His research is funded by the European Research Council, Innovative Medicines Initiative, and Wellcome Trust, supporting investigations into synaptic mechanisms underlying neurological disorders. The Akerman Group, established in 2008, operates as an integrative neuroscience hub within Oxford's Pharmacology Department. The 10-member team combines expertise in patch-clamp electrophysiology, optogenetics, multiphoton imaging, and computational modeling, with current projects spanning neuronal progenitor biology, inhibitory synaptic plasticity, and learning rule implementation in neural networks. The lab emphasizes technical innovation, regularly developing custom instrumentation and molecular tools for neural observation and manipulation.
Jonny Kohl is a Group Leader at the Francis Crick Institute , where he established the State-dependent Neural Processing Laboratory in 2019. His work bridges neural circuits and internal physiological states (e.g., hunger, pregnancy) to decode instinctive behaviors like parenting and aggression in mice. PhD: MRC Laboratory of Molecular Biology, Cambridge (2013) Postdoc: Harvard University (2014–2019) with support from EMBO, HFSP, and Wellcome Trust fellowships Research Interests : Kohl investigates how hormonal and metabolic states dynamically rewire neural circuits to drive adaptive behaviors. His lab combines circuit neuroscience , molecular biology , and behavioral profiling to study: State-dependent neural processing in parental behavior Chemosensory dominance hierarchies in mice Plasticity mechanisms in aggression circuits Development of ultrafast tissue labeling and cryoanesthesia tools Scientific Trends : His recent publications highlight hormone-mediated synaptic remodeling (2023), cost-effective lab tools (2023), and brain-wide activity mapping (2016). Collaborative work spans computational biology , metabolism , and imaging disciplines. Honors: NARSAD Young Investigator Award (2019), ERC Starting Grant (2019), Wellcome Trust Discovery Award (2025) Grants: BBSRC Research Grant (2025), BBSRC Pioneer Grant (2023) His lab mentors PhD and MSc students and has developed open-source neuroscience tools (e.g., cryoanesthesia device, 2023). Kohl's research has been featured in Nature , Science , and Cell .
Dr. Gabriele Schweikert is a Senior Lecturer and Principal Investigator with a joint appointment between the Division of Computational Biology in the School of Life Sciences at University of Dundee and Cyber Valley in Tuebingen. Her research focuses on applying machine learning techniques to understand epigenetic mechanisms and molecular processes in living cells. Dr. Schweikert completed her PhD at the Max Planck Institute Tuebingen working with Schoelkopf, Weigel, and Raetsch labs on machine learning for computational gene finding. She subsequently joined Adrian Bird's lab at the Wellcome Trust Center for Cell Biology in Edinburgh, a pioneer in epigenomic research. Prior to her current position, she held prestigious Marie Curie and EMBO Fellowships at the School of Informatics, University of Edinburgh. Her research interests center on using machine learning to decode epigenetic mechanisms that determine cellular identity and function. She investigates how cells with identical DNA can differentiate into specialized cell types through epigenetic regulation, with particular focus on applications in understanding tumorigenesis where epigenetic machinery malfunctions. Her work combines high-throughput epigenomic data with advanced computational approaches to address complex biological questions. Analysis of her recent publications reveals a strong focus on epigenomic data analysis, machine learning applications in biology, and computational approaches to understanding gene regulation. Her work spans from fundamental epigenetic mechanisms to practical applications in disease research, with growing emphasis on individual-specific epigenomic analysis and explainable AI in biomedical contexts. UKRI Future Leaders Fellowship (2020, £1.6 million) Marie Curie Fellowship EMBO Fellowship Dr. Schweikert actively supervises PhD students and has received significant research funding for projects including 'Machine Learning Methods to Re-Annotate Histone Modifications,' 'Unlocking The Alternative Splicing Code,' and 'GPU-Based Machine Learning System For Fundamental Biological Research.' She is involved in multiple interdisciplinary collaborations and frequently presents her work at major conferences including ELLIS Health program retreat, Epigenetics Meetings, and RECOMB workshops. She maintains active research laboratories in both Dundee and Tuebingen, fostering international collaboration between computational biologists, machine learning experts, and experimental biologists to advance our understanding of epigenetic regulation in health and disease.
Caetano Reis e Sousa is a Professor of Immunology at Imperial College London and Senior Group Leader/Assistant Research Director at the Francis Crick Institute. He leads the Immunobiology Laboratory, focusing on dendritic cell biology, immune responses to pathogens, and cancer immunotherapy. His research explores how dendritic cells detect pathogens and dying cells, triggering adaptive immunity. Key roles include investigating cross-presentation mechanisms, C-type lectin receptors (e.g., DNGR-1), and vaccine development strategies. Education: BSc (Hons) Biology from Imperial College London (1989), DPhil in Immunology from University of Oxford (1992). Postdoctoral training at NIH under Ron Germain. Career milestones include founding the Immunobiology Lab at CRUK London Research Institute (1998–2015) before joining the Crick. Awards & Recognition: Highly Cited Researcher (Thomson Reuters), BD Biosciences Prize (2002), Liliane Bettencourt Award (2008), Louis-Jeantet Prize (2017), Fellowships at Royal Society (2019), Academy of Medical Sciences (2006), and EMBO (2006). Named Officer of the Order of Sant'Iago da Espada (Portugal, 2009). Research Themes: Dendritic cell activation pathways, cross-presentation of tumor antigens, microbiome-cancer immunity links, and immune evasion mechanisms. Collaborations involve institutions like UCL, King's College London, and global health networks. Labs/Teams: Head of Immunobiology Lab at Crick, with expertise in immunology, cell biology, and virology. Facilities include Flow Cytometry, Genomics, and Light Microscopy cores. Active in pandemic response (e.g., SARS-CoV-2 testing initiatives).
Dr. Thomas A. Hughes is an Associate Professor of Cancer Biology at the University of Leeds and Professor of Biosciences at York St John University. As a Group Leader at the Leeds Institute of Medical Research, he focuses on gene regulation, tumour microenvironment, and nanomedicine approaches to improve cancer outcomes. Specializes in breast cancer, colorectal cancer, and rare diseases Develops therapeutic strategies using microRNAs and biomarkers Collaborates with clinicians, engineers, and chemists for translational research His research integrates molecular pathology with clinical data through partnerships with Leeds NHS Trusts, aiming to identify novel biomarkers and targets for therapy. Recent work emphasizes cholesterol metabolism, oxysterol signaling, and nanomedicine-based drug delivery systems. Key contributions include: Over 80 peer-reviewed publications in cancer biology and molecular therapeutics Leadership in MSc programs in Molecular Medicine and Cancer Biology and Therapy Extensive experience in grant review, editorial work, and doctoral supervision Scientific awards include Fellowship of the Higher Education Academy. His lab has mentored 26 doctoral students and numerous alumni in academia, clinical practice, and industry.
Philip Burnet is a Professor of Neuroscience at the University of Oxford, affiliated with the Department of Psychiatry . He serves as the Director of Graduate Studies for Psychiatry , teaches on the MSc Neuroscience and MRCPsych courses, and sits on the editorial board of Nutrition and Aging . His research bridges neuroscience and psychiatry, focusing on neurotransmitter modulation and brain health. Research interests: Burnet investigates the regulation of serotonin and glutamic acid systems in aging and psychiatric disorders. Key projects include exploring D-amino acid oxidase (DAO) inhibition to restore cognition in schizophrenia, analyzing the microbiome-gut-brain axis , and testing dietary interventions like probiotics and ketogenic diets for mental health applications. His work combines molecular techniques with behavioral studies in preclinical and clinical contexts. Article trends reveal a focus on neurotransmitter dynamics , microbiome-brain interactions , and metabolic interventions . Notable methods include RNA interference , animal models , and clinical trial protocols . Professional activities: Collaborates across Oxford and with industry partners, contributes to academic editing, and engages in graduate education leadership.
Sylvia Richardson is an MRC Investigator at the MRC Biostatistics Unit and holds a Research Professorship at the University of Cambridge, where she served as Director of the Biostatistics Unit from 2012 to 2021. She is affiliated with the Cambridge Mathematics of Information in Healthcare Hub (CMIH) at the Centre for Mathematical Sciences. Her work bridges advanced statistical methodology with critical healthcare applications, particularly in the analysis of complex biomedical data. Richardson's research spans multiple domains of biostatistics with a strong emphasis on Bayesian approaches. Her work has significantly advanced spatial modeling and disease mapping techniques, developed sophisticated methods for handling measurement error in epidemiological studies, and pioneered mixture and clustering models for integrative analysis of heterogeneous data sources. Her research addresses fundamental challenges in analyzing longitudinal health data, multimorbidity patterns, and complex disease trajectories. Her publication record demonstrates consistent methodological innovation applied to pressing healthcare challenges. Recent work focuses on traumatic brain injury outcomes, multimorbidity progression, genomic analysis, and statistical approaches to pandemic data. The articles reveal a strong pattern of methodological development driven by real-world healthcare challenges, with particular attention to longitudinal analysis, Bayesian computation, and integrative modeling approaches that can handle diverse and complex data structures. While specific awards are not detailed in the available information, Richardson's leadership as Director of the MRC Biostatistics Unit for nearly a decade and her continued Research Professorship reflect significant recognition of her contributions to the field. Her work with major international consortia like CENTER-TBI demonstrates her role in large-scale collaborative research efforts addressing critical health challenges. Richardson's research has substantial implications for healthcare policy and practice, particularly in understanding disease progression, developing predictive models for patient outcomes, and creating methodological frameworks that can integrate diverse data sources to generate meaningful clinical insights. Her work continues to influence both statistical methodology and healthcare applications through ongoing research and leadership in the field.
Professor Richard Wade-Martins is a leading academic in University of Oxford 's Department of Physiology, Anatomy and Genetics . He directs the Molecular Neurodegeneration Research Laboratory and the Oxford Parkinson’s Disease Centre (OPDC). With degrees from Cambridge (MA) and Oxford (DPhil), he has held prestigious fellowships including Wellcome Trust Research Career Development Fellowship and NIH reviewer roles. His research targets molecular mechanisms in Parkinson’s and Alzheimer’s diseases through iPSC models , transgenic mice , and lysosomal function studies . He pioneered work on SNCA , MAPT , and LRRK2 gene pathways. Current projects focus on gene therapy and mitochondrial dysfunction in neurodegeneration. Key publications (2019–2025) reveal trends in single-cell transcriptomics , calcium channel inhibition , and TFEB/TFE3 lysosome modulation . His awards include Wellcome Trust Fellowships and advisory roles for Parkinson's UK , Alzheimer's Research UK , and EU consortia like StemBANCC and EFACTS . He leads the UK Dementia Platform iPSC Initiative and serves on international boards in Luxembourg and Canada.
Lindsey Kent is a Professor at the University of St Andrews' School of Medicine, where she serves as Deputy Head and Director of Admissions. Her research focuses on the biological foundations of psychiatric disorders, particularly ADHD and developmental language disorders. Education: Medicine (Aberdeen University, 1989), PhD (University of Birmingham, 1998) Academic Appointments: Wellcome Trust Fellow (1999), University Lecturer (University of Cambridge, 2003), Reader (University of St Andrews, 2007) Research Trends: Dr. Kent's work explores psychiatric genetics, neurodevelopmental disorders, and molecular mechanisms through genome-wide association studies, exome sequencing, and genetic epidemiology. Key Collaborations: Psychiatric Genomics Consortium, EAGLE Consortium, 23andMe Technical Focus: ATP2C2 gene variants, TNR gene associations, polygenic risk architectures Awards: Fellow of the Higher Education Academy (2000) Academic Contributions: She has directed two Wellcome Trust-funded projects on ADHD genetics and co-authored over 91 peer-reviewed publications, including significant studies in Nature Communications and Human Molecular Genetics . Her editorial roles include serving on the American Journal of Medical Genetics board (2007–2014).
Professor Paul C. Bressloff holds the Chair in Applied Mathematics and Stochastic Processes at Imperial College London's Department of Mathematics within the Faculty of Natural Sciences. His research focuses on stochastic and non-equilibrium processes, particularly in molecular and cell biology, utilizing tools from probability theory, statistical physics, and dynamical systems. He authored a seminal textbook Stochastic Processes in Cell Biology (Springer), with a 2nd edition published in 2022. Previously, he led the graduate program in mathematical biology at the University of Utah from 2001 to 2023. Research interests include stochastic multi-particle systems, active particles, phase separation, and diffusion across semi-permeable interfaces. His work spans applications in neural field theory, cytoneme-mediated morphogenesis, and protein trafficking. He is affiliated with the Biomathematics Group and Mathematical Physics Group at Imperial. Recent articles explore stochastic resetting in search processes, narrow-capture problems, and hybrid models of switching diffusions. His advising includes over 20 graduate students, many now faculty in mathematical biology. His contributions bridge applied mathematics and biological systems, emphasizing interdisciplinary approaches to complex stochastic phenomena.
Sarah Lummis is a Professor in the Department of Biochemistry at the University of Cambridge. Her research focuses on understanding the structure-function relationships of Cys-loop ligand-gated ion channels (pLGICs), which are critical for neurotransmission and targets for pharmaceuticals. Her work addresses how structural features of these receptors influence their function and drug interactions. Research interests include ion channel biology, molecular pharmacology, and structural biology. Key publications investigate residues affecting receptor activity in 5-HT3 receptors, glycine receptors, and the prokaryotic channel ELIC. Her studies contribute to drug development for neurological disorders like epilepsy and Alzheimer's disease. Contact: sl120sec@bioc.cam.ac.uk | Group accepts interns, students, and researchers. Located at the Hopkins Building, Downing Site, Cambridge.
Professor Gabriele Kaminski Schierle is affiliated with the Department of Chemical Engineering and Biotechnology at the University of Cambridge. She is a Senior Fellow of the Higher Education Academy and collaborates with other researchers, including Professor Clemens Kaminski, Professor J. Axel Zeitler, and Professor Sabine Bahn. Her research focuses on neurodegenerative diseases and advanced imaging technologies. Her work spans Alzheimer's, Parkinson's, and Huntington's diseases , utilizing brain organoids, fluorescence lifetime imaging, and machine learning . She leads the Molecular Neuroscience Group and contributes to the EPSRC Centre for Doctoral Training in Sensor Technologies and Applications. Email: gsk20@cam.ac.uk Contact: +44 (0)1233 766549
Andrew Sutherland is Professor of Organic Chemistry at the University of Glasgow , School of Chemistry. His research integrates synthetic organic chemistry with molecular imaging, focusing on PET/SPECT tracer development, fluorescent amino acid probes, and transition-metal catalysis for rapid scaffold assembly. Education: Not explicitly listed in the provided text. Research Interests: Molecular imaging of neurological diseases and cancer using PET/SPECT tracers Development of fluorescent amino acid probes for cell imaging Transition-metal-catalyzed transformations (Fe, Cu, Pd, Ni) One-pot multi-reaction processes for drug-like scaffolds and natural products Publication Trends: His 2024–2025 work emphasizes fluorogenic amino acids, radiohalogenation for PET imaging, and iron/copper-catalyzed C–H functionalization. Earlier work includes natural product synthesis and mechanistic studies on halodeboronation. Scientific Awards: None listed in the provided text. Grants & Collaborations: Extensive collaborations with imaging scientists (e.g., Sally Pimlott, Adriana Tavares) and synthetic chemists, evidenced by multi-author papers and joint PET ligand development. Research Group: Leads the Sutherland group , housed in the Joseph Black Building (C5-06), with active projects in chemical biology and organic synthesis.
