Dr. Fadi Gabriel Akar is a Professor of Medicine (Cardiovascular Medicine) and Biomedical Engineering at Yale University School of Medicine. He holds affiliations with the Cardiovascular Medicine Department, the Yale Cardiovascular Research Center, and the Molecular Medicine Program. His primary appointment is as a Professor in the Department of Medicine, specializing in cardiovascular research and translational medicine. Dr. Akar’s research focuses on unraveling mechanisms promoting arrhythmias in structural heart diseases and developing gene-based therapies to prevent malignant arrhythmias. His lab investigates mitochondrial dysfunction, metabolic signaling, and mechano-electrical feedback in arrhythmogenesis, with a translational pipeline from target identification to pre-clinical testing in large animal models. Key areas include arrhythmias in heart failure, myocardial infarction, obesity, diabetes, atrial fibrillation, and pulmonary hypertension. Notable achievements include his role as Chairman of the AHA Cardiac Electrophysiology Fellowships Committee (2022). His work bridges basic science and clinical applications, emphasizing mechanism-based therapies over traditional antiarrhythmic approaches. Collaborations include studies on AMPK deletion models, mitochondrial network remodeling, and resolvin D1’s role in post-MI atrial remodeling. Publications highlight contributions to understanding arrhythmia mechanisms in metabolic diseases, mitochondrial dysfunction, and translational therapies. His research is supported by NIH grants and industry partnerships, focusing on advancing diagnostics and treatments for electrical cardiac disorders.
