جست‌وجوی استاد و پژوهشگر

Carrie Wieseمشاهده پروفایل

استادیار

• Cardiometabolic physiology
• Sex differences in disease
• Genetic sex impact on physiology
• +۴ مورد دیگر

Dr. Carrie Wiese is an Assistant Professor in the Department of Pharmacology at the LSU Health Sciences Center School of Medicine in New Orleans, Louisiana. Her research focuses on the impact of sex components—gonads and sex chromosomes—on cardiometabolic physiology, with particular emphasis on how genetic sex influences disease mechanisms. Education: Postdoctoral Fellowship in Human Genetics, University of California, Los Angeles (2024) Ph.D. in Molecular Physiology & Biophysics, Vanderbilt University (2019) B.S. in Molecular Biology, University of Tennessee, Chattanooga (2008) Dr. Wiese's research investigates how the sex chromosome complement (XX and XY) causes unequal gene dosage through two mechanisms: 1) the presence and absence of Y chromosome genes and 2) a subset of X chromosome genes escaping X chromosome inactivation, leading to higher expression in XX cells than XY cells. These mechanisms modulate cellular function and impact whole-body physiology. Her current research projects include utilizing multi-omics approaches to assess the impact of gonadal and genetic sex on hepatic function during fatty liver disease, evaluating the impact of sex on epigenetic regulation in atherosclerosis, and determining the role of X chromosome gene Kdm6a in brown adipose energy metabolism. Dr. Wiese has published extensively on sex differences in cardiometabolic disease, with recent publications focusing on X chromosome dosage effects, sex differences in lipid metabolism, and the role of specific genes in sex-biased disease phenotypes. Her work bridges basic genetic mechanisms with clinical implications for understanding sex differences in disease susceptibility and treatment response. Scientific Awards: No specific awards mentioned in the provided text Dr. Wiese is actively mentoring graduate students and post-doctoral fellows in her laboratory. Her research has significant implications for understanding sex differences in disease mechanisms and developing more personalized approaches to treating cardiometabolic disorders. She is currently accepting new graduate students and post-doctoral fellows to join her research team. Dr. Wiese's laboratory is part of the Cardiovascular Center at LSU Health Sciences Center, where she collaborates with other researchers investigating cardiovascular disease mechanisms and potential therapeutic approaches.

Barabino Silviaمشاهده پروفایل

دانشیار

• RNA Biology
• Neurodegeneration
• Gene Expression
• +۳ مورد دیگر

Barabino Silvia is an Associate Professor of Molecular Biology at the University of Milan-Bicocca's Department of Biotechnology and Biosciences. She leads the Barabino Lab (#BarabinoLab_BtBS), specializing in RNA biology and neurodegeneration research. Her work investigates RNA-binding proteins in transcription/RNA processing and their links to human diseases. Current projects focus on: miRNA dysregulation in amyotrophic lateral sclerosis (ALS) pathogenesis FET protein functions in DNA damage response and genome stability Molecular mechanisms connecting RNA metabolism to neurodegeneration Experimental approaches include biochemical assays, advanced microscopy, and transgenic mouse models. Recent publications demonstrate broad impact across molecular neuroscience and RNA biology, including therapeutic target identification for ALS (2020), leukemia proliferation mechanisms (2019), and oxidative stress regulation of RNA processing (2017). She maintains active collaborations with European institutions including King's College London and Stockholm University.

• DNA Repair
• Genome Stability
• Cancer Biology
• +۲ مورد دیگر

Daniel Gómez Cabello is an Associate Professor in the Cell Biology Department at the University of Seville, Spain, leading the Gene Expression in Eukaryotes research group. His work focuses on DNA repair mechanisms and genome stability with direct implications for cancer therapeutics. Research centers on double-strand break repair pathway choice , ribosomal DNA stress responses in tumor cells, and microRNA regulation in cellular senescence. Key investigations include: Molecular mechanisms of DNA end resection (CtIP, KLF4, PRMT5) Nucleolar stress responses under genotoxic conditions Therapeutic targeting of repair pathways (RAD52 inhibitors) Metabolic pathways in HER2+ breast cancer Recent publications (2020-2023) demonstrate strong continuity in DNA repair research, with increasing focus on therapeutic applications. The 2020 DNA Repair paper on KLF4 methylation exemplifies mechanistic work directly informing cancer treatment strategies. Active research funding includes: CNS2023-143939: Combination therapy with RAD52/RNAPII inhibitors for cancer radiosensitization INVES20017GÓME: Genome integrity in ribosomal DNA under stress PRYES235086GOME: Repairosome as radio-biomarker in radioimmunotherapy The lab maintains international collaborations through EU FP7 projects and global conference participation. The Gene Expression in Eukaryotes group combines molecular biology, genome-wide screening, and cancer cell models to investigate fundamental repair mechanisms with translational applications in oncology.

Lars Maegdefesselمشاهده پروفایل

استاد

• vascular disease
• atherosclerosis
• aortic aneurysm
• +۴ مورد دیگر

Lars Maegdefessel is a Professor of Molecular Vascular Medicine at the Technical University Munich (TUM), School of Medicine and Health. He leads the Experimental Vascular Medicine unit at Klinikum rechts der Isar and serves as a DZHK Junior Group Leader. His research focuses on the therapeutic and biomarker potential of non-coding RNAs in vascular diseases including atherosclerosis, aortic aneurysm, and related vascular pathologies. Dr. Maegdefessel's research interests center on the role of non-coding RNAs in vascular diseases, with particular focus on the vulnerability of atherosclerotic vascular lesions and the progression and rupture of abdominal aortic aneurysms. His laboratory utilizes unique human biobank materials and various pre-clinical experimental models to investigate novel molecular approaches for combating cardiovascular diseases. His work spans from basic research on microRNAs, long non-coding RNAs, and circular RNAs to translational applications in vascular medicine. Analysis of Dr. Maegdefessel's publication record reveals a strong focus on non-coding RNA mechanisms in vascular pathology, with particular emphasis on atherosclerosis stabilization, aneurysm development, and vascular inflammation. His research has evolved from basic miRNA characterization to sophisticated therapeutic applications including targeted delivery systems and novel biomarker discovery. The publications demonstrate a consistent trajectory toward clinical translation of RNA-based vascular therapeutics. ERC Consolidator Grant (2023) Russel Ross Award from American Heart Association (2023) Heisenberg Professorship of German Research Foundation (2016) Werner Risau Award of American Heart Association (2016) ERC Starting Grant (2015) Prince Daniel Research Award of Swedish Heart and Lung Foundation (2014) Ragnar Söderberg Fellowship in Medicine (2014) Dr. Maegdefessel's research program includes extensive collaboration with international teams and utilizes advanced methodologies including RNA sequencing, microarrays, proteomics, and epigenomic analyses. His laboratory investigates ncRNA function in human vascular tissues and pre-clinical models, with recent work focusing on artery-on-a-chip technology and novel therapeutic delivery systems for vascular applications.