معرفی
Daniel Gómez Cabello is an Associate Professor in the Cell Biology Department at the University of Seville, Spain, leading the Gene Expression in Eukaryotes research group. His work focuses on DNA repair mechanisms and genome stability with direct implications for cancer therapeutics.
Research centers on double-strand break repair pathway choice, ribosomal DNA stress responses in tumor cells, and microRNA regulation in cellular senescence. Key investigations include:
- Molecular mechanisms of DNA end resection (CtIP, KLF4, PRMT5)
- Nucleolar stress responses under genotoxic conditions
- Therapeutic targeting of repair pathways (RAD52 inhibitors)
- Metabolic pathways in HER2+ breast cancer
Recent publications (2020-2023) demonstrate strong continuity in DNA repair research, with increasing focus on therapeutic applications. The 2020 DNA Repair paper on KLF4 methylation exemplifies mechanistic work directly informing cancer treatment strategies.
Active research funding includes:
- CNS2023-143939: Combination therapy with RAD52/RNAPII inhibitors for cancer radiosensitization
- INVES20017GÓME: Genome integrity in ribosomal DNA under stress
- PRYES235086GOME: Repairosome as radio-biomarker in radioimmunotherapy
The Gene Expression in Eukaryotes group combines molecular biology, genome-wide screening, and cancer cell models to investigate fundamental repair mechanisms with translational applications in oncology.
