جست‌وجوی استاد و پژوهشگر

Constantinos Savvaمشاهده پروفایل

دانشیار

• Immunometabolism
• Breast Cancer
• Metabolic Reprogramming
• +۳ مورد دیگر

Constantinos Savva is an Associate Professor in Medical Oncology at the University of Southampton , focusing on immunometabolism and metabolic reprogramming in breast cancer. He holds qualifications including an MD from the University of Ioannina, Greece, an MSc in Epidemiology from the London School of Hygiene & Tropical Medicine, and a PGCert in Clinical Bioinformatics from the University of Manchester. NIHR Clinical Lecturer in Medical Oncology (2022–present) CRUK Clinical Research Fellowship (2018) Member of Royal College of Physicians (2015) His research explores how obesity , lifestyle interventions , and metabolic parameters influence tumor microenvironment dynamics in breast cancer, using techniques like targeted transcriptomics and multiplex immunohistochemistry . Recent publications highlight his work on: Crown-like structures (CLS) in HER2+ tumors Metformin's impact on immune cell infiltration Global cancer funding disparities He mentors PhD students like Rachana Yadav and collaborates on projects such as CANDO-4 (sarcopenia and chemotherapy toxicity). Awards include: CRUK Clinical Research Training Fellowship (2018) Cancer Immunology Talent Fund (2021) BRC/NIHR Postdoctoral Bridging Fellowship (2023) Francis Crick Clinical Postdoctoral Fellowship (2023) Constantinos co-leads the Research Skills module for the MSc in Cancer Biology and Immunology and tutors on the Foundation of Medicine course. His work aims to develop novel treatment strategies by integrating lifestyle interventions with immunotherapy.

Shyam Biswalمشاهده پروفایل

استاد

• Environmental Health Sciences
• Molecular Toxicology
• Oxidative Stress
• +۱۲ مورد دیگر

Shyam Biswal, PhD, MPH, is a Professor in the Department of Environmental Health and Engineering at Johns Hopkins University, with joint affiliations in the Bloomberg School of Public Health and the School of Medicine. His research centers on environmental health sciences, particularly the molecular mechanisms linking environmental exposures to chronic diseases. MPH, Johns Hopkins University, 2021 PhD, Indian Institute of Technology, 1996 Dr. Biswal's research interests include environmental health sciences, oxidative stress, air pollution, lung diseases (COPD, asthma, emphysema), cancer, and the KEAP1-NRF2 signaling pathway. His work investigates how cigarette smoke, electronic cigarettes, and particulate matter contribute to inflammation and chronic disease through molecular and genetic mechanisms. His recent publications highlight ongoing research in environmental toxicology and public health, focusing on air pollution effects on respiratory and systemic health, epigenetic changes in lung disease, and immune modulation via redox sensors. The trend in his work shows a strong emphasis on translational research, integrating molecular biology with population health. He has not been mentioned to have received specific scientific awards in the provided text. Dr. Biswal mentors students and collaborates extensively, particularly with researchers in otolaryngology and immunology. He teaches courses such as Molecular Toxicology and Global Sustainability & Health Seminar. His research is supported by ongoing publications and active collaborations, including with the Center for Global Health. He is involved in a research program focusing on environmental health, with active projects on air pollution, electronic cigarettes, and the KEAP1-NRF2 pathway. He collaborates with teams studying COPD, T cell immunology, and environmental carcinogenesis.

• cellular metabolism
• biochemistry
• genetics
• +۳ مورد دیگر

Hongying (Hoy) Shen is an Assistant Professor in Cellular & Molecular Physiology at Yale School of Medicine and Systems Biology Institute at Yale West Campus since January 2020. Her research focuses on cellular metabolism, using interdisciplinary approaches including biochemistry, genetics, and metabolomics to study enzymes and transporters critical to human health and disease. She is particularly known for her work on 'deorphanizing' uncharacterized proteins in the human genome, especially those involved in mitochondrial function and metabolism. Dr. Shen received her B.S. in Chemistry from Nanjing University (2006) and her Ph.D. in Molecular Biophysics and Biochemistry from Yale University (2013). Her postdoctoral training at Massachusetts General Hospital/Harvard Medical School with Dr. Vamsi Mootha established her expertise in CRISPR screens and metabolomics. She has been recognized with prestigious awards including the Rita Allen Foundation Scholar (2023) and the Klingenstein-Simons Fellowship (2021). Her lab investigates mitochondrial transporters, metabolic pathways, and their roles in diseases like cancer and cystic disorders. Recent work includes identifying NAT10 as a master regulator of brain metastasis and elucidating the role of SLC25A39 in mitochondrial glutathione transport. Collaborations span Yale’s Diabetes Research Center, Interdepartmental Neuroscience Program, and the Wu Tsai Institute. Notable achievements include over 30 peer-reviewed publications, including high-impact articles in Cell , Nature Communications , and Molecular Cell . Her research bridges basic science and translational medicine, aiming to uncover new diagnostic and therapeutic targets.

Benjamin G. Neelمشاهده پروفایل

استاد

• Cell Signaling
• Protein-Tyrosine Phosphatases
• Cancer Biology
• +۱۲ مورد دیگر

Benjamin G. Neel, MD, PhD, is a Professor in the Department of Medicine at NYU Grossman School of Medicine. His research is centered on cell signaling pathways, particularly those involving protein-tyrosine phosphatases such as SHP2, and their implications in cancer and genetic disorders like RASopathies. He leads an active research laboratory that integrates molecular biology, genomics, and translational models to uncover mechanisms of oncogenesis and therapy resistance. MD from Cornell University PhD from Rockefeller University Dr. Neel’s research focuses on the role of tyrosine phosphatases in signal transduction, especially the RAS-ERK pathway, and how dysregulation contributes to diseases including breast and ovarian cancers, lung cancer, and developmental syndromes. His lab employs advanced techniques such as CRISPR/Cas9 screens, proteomics, organoids, and genetically engineered mouse models (GEMMs) to dissect signaling networks and identify therapeutic vulnerabilities. His recent publications highlight key advances in understanding resistance to SHP2 inhibitors, hypoxia-induced cell death, neoantigen creation via covalent drugs, and tumor microenvironment remodeling. These works span high-impact journals like Nature , PNAS , and Cancer Cell , reflecting a strong trend toward integrating targeted therapy with immunomodulation and systems biology. Dr. Neel has mentored several successful scientists, including Dr. Wei Wei and Dr. Shengqing Gu, who have gone on to leadership roles in academia and cancer research. His lab fosters collaboration, notably with the Koide Lab, to develop novel immunotherapies. His scientific contributions have not been explicitly tied to named awards in the provided text, but his publication record and leadership position indicate national recognition. Through the Neel Lab, he continues to explore fundamental mechanisms in cancer signaling, with implications for drug development and precision oncology.

Brian Turnerمشاهده پروفایل

دانشیار

• Roman History
• Military History
• Ancient Mediterranean History
• +۳ مورد دیگر

Brian Turner serves as an Associate Professor in the Department of History at Portland State University's College of Liberal Arts and Sciences, with his office located in CH 441U. His contact information includes phone (503) 725-3992 and email brian.turner@pdx.edu. He specializes in the Ancient Mediterranean world, particularly Roman history, military history, and historical geography, teaching courses such as HST 309U (Roman Republic), HST 310U (Roman Empire), HST 390U (Global History of Warfare), and HST 416 (Geography and Worldview in the Ancient Mediterranean). His educational background features a PhD from the University of North Carolina at Chapel Hill, an MA from Queen's University, Canada, and a BA (Honours) from Queen's University, Canada. This foundation underpins his scholarly contributions to ancient historical studies. Turner's research explores Roman military psychology, worldview construction through mapping, and commemoration of victories/defeats. His 2022 monograph Pliny the Elder's World (Cambridge) examines geographical knowledge in antiquity, while his 2018 edited volume Brill's Companion to Military Defeat pioneered analysis of Roman loss narratives. His work bridges historical methodology with sociological and geographical frameworks. Analysis of his 15 most recent publications reveals a core focus on Roman history (e.g., military cohesion, Batavian Revolt) but unexpectedly spans public health (SARS-CoV-2 pediatric studies), surgery (robotic cholecystectomy), political science (Paraguay's democracy), environmental science (invasive predators), and AI (image generation). This diversity suggests interdisciplinary collaborations despite his history department affiliation, particularly in medical/public health fields where multiple 2021-2023 papers share co-authors. Scientific Awards: No scientific awards were listed in the provided text. Turner advises potential Master of Arts students in Roman history at Portland State University, inviting them to review expanded field descriptions. While no specific grant funding is mentioned, his international cohort study (2023) indicates cross-institutional partnerships. His editorial work on Brill's Companion highlights leadership in academic collaborations. No dedicated laboratories or research teams were referenced. However, his involvement in international surgical studies, editorial projects, and Paraguay-focused political analysis implies participation in multi-institutional networks. His Google Scholar profile suggests active engagement in both primary historical research and applied interdisciplinary projects.

• Cellular Reprogramming
• Transdifferentiation
• Liver Development
• +۷ مورد دیگر

Zoe Burke is a faculty member and Director of Teaching in the Department of Life Sciences at the University of Bath. Her research focuses on cellular reprogramming, transdifferentiation, liver development, and pancreatic biology, with a strong emphasis on the Wnt signaling pathway and its role in organogenesis and disease. She has published extensively on topics including hepatocyte generation, metaplasia, and stem cell biology. Her research interests span Cellular Reprogramming , Transdifferentiation , Liver and Pancreatic Development , Wnt/β-catenin signaling , and metaplastic transitions in disease . Her work bridges developmental biology and regenerative medicine, aiming to understand how cell identity can be manipulated for therapeutic applications. Analysis of her recent publications shows a consistent focus on molecular mechanisms governing cell fate transitions, particularly in liver and pancreas. Her studies integrate in vitro and in vivo models to dissect signaling pathways such as Wnt and the role of transcription factors like Hnf4α. The work has implications for regenerative therapies, cancer development (especially Barrett’s esophagus), and drug toxicity screening using hepatocyte models. Scientific Contributions: Key role in elucidating Wnt/β-catenin in liver zonation and development Pioneering studies on transdifferentiation of pancreatic to hepatic cells Identification of Hnf4α as a driver of metaplasia Development of in vitro models for drug toxicity using miR-122 Dr. Burke has collaborated extensively with Prof. David Tosh and others on understanding cellular plasticity. While no formal advising list is available, her editorial and collaborative roles suggest active mentorship. Her work has been cited in patents and Wikipedia, indicating broad scientific impact. She is involved in academic leadership as Director of Teaching, contributing to curriculum development in life sciences.

Zev Gartnerمشاهده پروفایل

استاد

• Tissue Engineering
• Regenerative Medicine
• Cancer Biology
• +۳ مورد دیگر

Zev Gartner is a Professor at the University of California San Francisco, leading a multidisciplinary research lab focused on cellular self-organization in tissue development and cancer progression. His work integrates chemistry, biology, and engineering to uncover how tissue structure regulates information flow between cells, with applications in regenerative medicine and cancer therapy. Education: University of California, Berkeley (B.S. in Chemistry, 1994-1999) Harvard University (M.S. and Ph.D. in Chemical Biology, 1999-2004) University of California, Berkeley (Postdoctoral in Chemical Biology, 2005-2008) His research spans tissue engineering, single-cell analysis, and mechanobiology, with particular emphasis on intestinal morphogenesis and breast cancer mechanics. Recent work includes 4D bioprinting technologies and computational modeling of gene regulatory networks. Scientific Awards: National Science Foundation Graduate Research Fellowship (2000) Bristol-Myers Squibb Fellowship (2003) NIH New Innovator Award (2017) Chan Zuckerberg Biohub Investigator (2020)

Avlant Nilssonمشاهده پروفایل

استادیار

• Bioinformatics
• Computational Biology
• Cell and Molecular Biology
• +۷ مورد دیگر

Avlant Nilsson is an Assistant Professor at the Department of Cell and Molecular Biology, Karolinska Institutet. His research focuses on applying interactome-based deep learning to unravel cancer mechanisms, particularly in pancreatic cancer stroma interactions and drug target discovery. Education: PhD in Biology and Biological Engineering (Chalmers, 2019), M.S. Engineering Physics (Chalmers, 2014), B.S. Biological Engineering (Chalmers, 2012) The group develops constrained deep learning models aligned with physical biomolecular interactions, integrating transcriptomics, metabolomics, and proteomics data to study metabolism, signal transduction, and gene regulation networks in cancer. Key research themes include: Precision cancer medicine Drug resistance mechanisms Tumor microenvironment modeling Computer-aided drug design Metabolic network simulations Scientific awards include: DDLS Fellow (Knut and Alice Wallenberg Foundation, 2024-2029) Junior Investigator Award (Swedish Cancer Society, 2024-2026) Deep learning grants from Swedish Cancer Society and Vetenskapsrådet Current lab members: Avlant Nilsson (Group Leader) Olof Nordenstorm (PhD Student) Xinhe Xing (PhD Student) Xuechun Xu (Postdoctoral Researcher)

Joerg Huelskenمشاهده پروفایل

دانشیار

• Cancer Biology
• Tumor Heterogeneity
• Cancer Stem Cells
• +۱۱ مورد دیگر

Joerg Huelsken is an Associate Professor at the School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), where he leads the Huelsken Lab at the Institut de Recherche en Ingénierie Moléculaire et en Imagerie Cellulaire (ISREC). He holds multiple teaching appointments within EPFL’s graduate programs, including roles in the Doctoral Program in Molecular and Cellular Life Sciences (EDMS) and the School of Life Sciences (SSV). His research is centered on cancer biology, particularly tumor heterogeneity, cancer stem cells, metastasis, and the role of the microenvironment and signaling pathways such as Wnt and integrin in disease progression. His research interests span cancer stem cells , metastatic niches , organoid models , Wnt/β-catenin signaling , integrin-mediated adhesion , and hematopoietic stem cell regulation . His lab employs cutting-edge approaches including patient-derived organoids, single-cell transcriptomics, and in vivo mouse models to dissect the molecular mechanisms underlying tumor initiation, progression, and therapy resistance. A major focus is understanding how cancer cells adopt stem-like states in response to therapy, particularly immunotherapy, and how the niche supports metastatic colonization. The trends in his recent publications reflect a strong integration of basic molecular mechanisms with translational applications . His work bridges developmental biology, stem cell regulation, and oncology, with recurring themes of signaling crosstalk, cellular plasticity, and microenvironmental control. He has developed platforms for personalized cancer treatment using organoids and statistical modeling, and his team investigates metabolic dependencies in metastasis-initiating cells. His research has been published in high-impact journals such as Nature , Cell Stem Cell , Nature Communications , and Cancer Cell . Metabolic dependencies of metastasis-initiating cells in female breast cancer (Nature Communications, 2023) IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy (Cell Stem Cell, 2023) Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma (Journal of Experimental & Clinical Cancer Research, 2023) Prof. Huelsken has supervised numerous PhD students at EPFL, including Maxim Norkin, Candice Young, Angela Madurga Alonso, Mathieu Girardin, and Zuzana Tatárová. His lab is actively involved in teaching, offering courses such as Cancer Biology II and practical lab modules. He also contributes to institutional education through roles in the EDMS and SSV-ENS programs. The Huelsken Lab operates at EPFL’s SV campus, focusing on interdisciplinary research that combines molecular oncology, stem cell biology, and systems approaches to understand and target the root causes of cancer progression and therapy resistance.

Michael G. Kharasمشاهده پروفایل

استاد

• Hematopoietic Stem Cell Biology
• Leukemia Pathogenesis
• RNA Regulation
• +۵ مورد دیگر

Michael G. Kharas is a Professor at Weill Cornell Medicine's Pharmacology Graduate Program and an Investigator at Memorial Sloan-Kettering Cancer Center's Molecular Pharmacology Program. His research focuses on RNA regulators in hematopoietic stem cells and leukemia pathogenesis, particularly Musashi-2 and m6A methylation mechanisms. Dr. Kharas investigates how post-transcriptional RNA regulation affects symmetric/asymmetric cell division balance in HSCs and leukemic stem cells. His lab develops small molecules targeting RNA-binding proteins and studies metabolic adaptations in leukemia, including fructose utilization and serine synthesis pathways. Current projects explore RNA methylation, chromatin regulation, and screening approaches for self-renewal modulation. His publications reveal trends in RNA biology, epigenetics, and leukemic stem cell targeting. Key subfields include m6A-dependent differentiation control, Musashi-2 networks, metabolic dependencies, chromatin maintenance, and therapeutic strategies against RNA regulators. Leukemia and Lymphoma Society Career Development Award Alex Lemonade Stand Foundation ‘A’ Award American Society of Hematology Junior Faculty Scholar Award Kimmel and V-Scholar Awards Louis V. Gerstner Young Investigator Award As lab head, he mentors researchers and collaborates across institutions. His work spans basic HSC biology, translational leukemia models, and drug discovery platforms targeting RNA-protein interactions.

• Retinoid Signaling
• Stem Cell Biology
• Cancer Biology
• +۷ مورد دیگر

Lorraine Gudas is a distinguished Professor and Chair of the Department of Pharmacology and Toxicology at Weill Cornell Medical College , Cornell University. Her research focuses on the roles of retinoids (vitamin A derivatives) in stem cell signaling , cancer pathogenesis (head and neck, kidney, and liver), and metabolic diseases . She leads a lab that utilizes mouse models and cell culture systems to develop novel therapies.

• Biochemistry
• Cell and Molecular Biology
• Genetics
• +۷ مورد دیگر

Pekka Katajisto is a Professor at the University of Helsinki's Faculty of Biological and Environmental Sciences, affiliated with the Molecular and Integrative Biosciences Research Programme. His research focuses on stem cell metabolism, aging, and tissue regeneration. Active projects include investigating mitochondrial inheritance in stem cells and its role in aging Developing 3D scaffolds for tissue engineering (2025) Exploring metabolic regulation in intestinal regeneration and cancer Recent publications highlight mitochondrial dynamics in stem cell fate determination and metabolic reprogramming in age-related diseases. He supervises doctoral students in biomedicine and integrative life sciences, with funding from Business Finland and private foundations. Media coverage includes discoveries on cancer cells exploiting aging pathways (2021).

Zachary Schaferمشاهده پروفایل

دانشیار

• Cancer Biology
• Cancer Metabolism
• Metastasis
• +۱۰ مورد دیگر

Zachary Schafer is the Coleman Foundation Associate Professor of Cancer Biology in the Department of Biological Sciences at the University of Notre Dame. His research centers on understanding how cancer cells survive during metastasis, particularly under stress conditions such as loss of attachment to the extracellular matrix (ECM). He leads an active research laboratory focused on cancer metabolism, cell death pathways, and tumor progression. Research Interests: Cancer Metabolism and Metabolic Reprogramming Metastasis and Anoikis Resistance Cell Death Mechanisms (Ferroptosis, Apoptosis, Pyroptosis) Mitophagy and Mitochondrial Biology Iron Metabolism in Detached Cancer Cells Signal Transduction in Tumor Microenvironment The most recent publications reflect a consistent and deep focus on metabolic vulnerabilities in detached cancer cells, especially in the context of ferroptosis, mitophagy, and immune evasion. His work bridges molecular oncology, cell biology, and metabolism, aiming to uncover therapeutic targets in metastatic cancer. Scientific Awards and Recognition: No specific awards listed in the provided text. Advising and Grants: Dr. Schafer leads an active research group and mentors students and postdoctoral researchers, as evidenced by his extensive publication record with multiple trainees as co-authors. His lab is supported by competitive research funding, likely from NIH or similar agencies, though specific grants are not listed. His long-standing research program since 2009 indicates sustained funding and academic leadership. Labs and Teams: The Schafer Laboratory, located in the Galvin Life Science Center at Notre Dame, employs cell-based models to study metabolic and survival mechanisms in cancer cells. The team collaborates widely, as seen in multi-institutional publications, and maintains a strong focus on translational relevance in cancer biology.

Marc Thierمشاهده پروفایل

پژوهشگر

• Stem Cell Research
• Neural Reprogramming
• Clinical Translation
• +۳ مورد دیگر

Dr. Marc Thier is a Researcher at the German Cancer Research Center (DKFZ) and Heidelberg University, leading the Neural Reprogramming and Clinical Translation group. His work bridges stem cell biology, direct cellular reprogramming, and clinical applications in cancer and endocrinology. Key Research Themes: Stem Cell Engineering Neural Reprogramming Cancer Metastasis Mechanisms Hyperparathyroidism Surgery Outcomes Notable Collaborations: Prof. Frank Edenhofer, Prof. Andreas Trumpp, Dr. Michael Milsom Dr. Thier's recent publications focus on glioblastoma neuron-tumor interactions (2025), miRNA-driven reprogramming (2012), and stem cell dormancy models (2016). He has contributed to over 15 peer-reviewed studies since 2009. His laboratory develops protocols for converting somatic cells into expandable neural progenitors and investigates cancer stem cell dynamics. Current projects include retrograde tracing in glioblastomas and longitudinal metabolic studies in post-surgical endocrinology.

• Immunology
• Regulatory T cells
• Autoimmune diseases
• +۱۱ مورد دیگر

Ye Zheng is a Professor at the Salk Institute for Biological Studies, where he holds the Becky and Ralph S. O'Connor Chair and leads research at the NOMIS Center for Immunobiology and Microbial Pathogenesis. His work focuses on regulatory T cells and immune regulation, with implications for autoimmune diseases and cancer. BS in Biochemistry and Molecular Biology, Peking University PhD, Columbia University Postdoctoral Fellow, University of Washington Memorial Sloan-Kettering Cancer Center Research Scholar Cancer Research Institute Postdoctoral Fellowship Dr. Zheng's research centers on the molecular and genetic regulation of regulatory T (Treg) cells, particularly the role of the Foxp3 protein in immune homeostasis. His lab investigates how Treg cells maintain their identity and function, and how nuclear hormone receptors modulate T cell differentiation. This work has major implications for treating autoimmune diseases such as type 1 diabetes and multiple sclerosis, as well as for improving cancer immunotherapy and organ transplantation outcomes. His recent publications span immunology, epigenetics, and metabolism, revealing how chromatin architecture, metabolites like succinate and bile acids, and nuclear receptors such as PPARδ and FXR control immune cell function. His research integrates molecular, genomic, and pharmacological approaches to uncover novel therapeutic targets. Rita Allen Foundation Scholar Award (2010–2015) Dr. Zheng has mentored numerous graduate students, postdoctoral fellows, and research staff, many of whom have gone on to academic and industry positions. He has collaborated on major grants, including a $1.5 million award from the Sol Goldman Charitable Trust for multiple sclerosis research. His lab continues to explore the intersection of metabolism and immunity, with a focus on translating findings into clinical applications. He leads the Zheng Lab, which is actively recruiting new members to advance research in immunobiology.