جست‌وجوی استاد و پژوهشگر

• Bioinformatics
• Machine Learning
• Deep Learning
• +۵ مورد دیگر

Ole Winther is Professor in High dimensional biological data analysis/Machine learning at the Department of Biology, University of Copenhagen and Professor in Data science and complexity at DTU Compute, Technical University of Denmark. He serves as CRO and co-founder of raffle.ai, CTO and co-founder of FindZebra, Head of ELLIS Unit Copenhagen, and co-PI of the Machine Learning for Life Science Center. His research spans Bioinformatics , Machine Learning , and AI for Science , focusing on applying deep learning to biological sequence analysis, latent variable models, and medical NLP. Winther's work develops predictive and generative models for bioinformatics, with significant contributions to protein localization tools (SignalP, DeepLoc, DeepTMHMM), single-cell genomics, and novel deep learning architectures like variational autoencoders and diffusion models. Analysis of Winther's recent publications (2023-2025) reveals a strong trend toward integrating protein language models with traditional bioinformatics approaches and applying diffusion models to scientific problems. His work bridges theoretical machine learning advancements with practical applications in biology and medicine, particularly in protein sequence analysis, medical search engines, and scientific simulation acceleration. Winther currently supervises a diverse research group including Panagiotis Antoniadis, Rachael M. DeVries, Jun Wang, Beatrix M. G. Nielsen, Felix G. Teufel, Irene R. Rodriguez, Anders Christensen, and Christopher Heje Grønbech. His former students have established successful careers at institutions including Google, Apple, and various startups, with notable alumni like Casper Sønderby (Google Brain) and Søren Sønderby (Apple). He leads significant research initiatives including the ELLIS Unit Copenhagen and the Machine Learning for Life Science Center, while maintaining active industry partnerships through his co-founded companies raffle.ai (enterprise search using NLP) and FindZebra (search engine for rare diseases). His teaching includes Deep Learning courses at both DTU (02456) and University of Copenhagen (NDAK24002U).

Thomas Walzمشاهده پروفایل

استاد

• Membrane Biology
• Structural Biology
• Cryo-electron Microscopy
• +۵ مورد دیگر

Thomas Walz, PhD, is a Professor at The Rockefeller University and Head of the Laboratory of Molecular Electron Microscopy. Previously, he held positions as Assistant, Associate, and Professor at Harvard Medical School (1999–2015) and was an Investigator at the Howard Hughes Medical Institute (2008–2015). He earned his PhD and BS in biophysics from the University of Basel, Switzerland, and completed postdoctoral research at the University of Sheffield. Walz completed his education at the Biozentrum, University of Basel, Switzerland, where he received his Diploma in Biophysics (1992) and PhD in Biophysics (1996). He furthered his training as a postdoctoral researcher at the University of Sheffield (1996–1999). His research focuses on understanding membrane-related processes and the structural biology of membrane proteins in lipid environments. Utilizing cryo-electron microscopy and nanodisc technology, he investigates how lipid bilayers influence membrane protein structure and function. Key areas include mechanosensitive channels, T-cell receptor dynamics, and telomere maintenance mechanisms. Collaborations with the de Lange lab explore the CST-Polα/primase complex's role in telomere regulation. Walz has been recognized with the Genzyme Award for Outstanding Achievement in Biomedical Sciences (2004) and continues to contribute to advancements in structural biology and membrane protein research. While specific student advisees are not listed, Walz actively mentors through his roles in the David Rockefeller Graduate Program and Tri-Institutional programs. His research is supported by grants and institutional funding, though specific grants are not detailed here. He directs the Laboratory of Molecular Electron Microscopy at Rockefeller, a hub for innovative structural biology and membrane protein studies. The lab collaborates widely, integrating cryo-EM with electrophysiology and molecular dynamics simulations.

Sriram Subramaniamمشاهده پروفایل

استاد

• cryo-electron microscopy
• structural biology
• drug-design
• +۴ مورد دیگر

Sriram Subramaniam is a Professor in the Department of Biochemistry and Molecular Biology at the University of British Columbia (UBC) and holds the Gobind Khorana Canada Excellence Research Chair in Precision Cancer Drug Design. His research leverages cryo-electron microscopy (cryo-EM) to advance structural biology and drug design, focusing on protein dynamics and therapeutic target identification. Education: PhD in Physical Chemistry (1987) from Stanford University; MSc in Chemistry (1981) from Indian Institute of Technology, Kanpur. Subramaniam's interdisciplinary work combines cryo-EM with computational tools and molecular biology to study protein structures at atomic resolution. His lab has pioneered cryo-EM applications in precision medicine, including mapping small molecule drugs on patient-specific cancer mutants. Recent publications (2024-2022) highlight his contributions to understanding SARS-CoV-2 immune evasion, structural mechanisms of ATPases, and AI integration in structural biology. His research spans viral entry mechanisms, CRISPR systems, and neurodegenerative disease pathways. Scientific Awards: Gobind Khorana Canada Excellence Research Chair NIH Director’s Award for Scientific Excellence Fellow of the Biophysical Society Breakthrough Prize nomination Based at the Djavad Mowafaghian Center for Brain Health, Subramaniam leads the Program in Cryo-EM Guided Drug Design, contributing to over 177 peer-reviewed publications with a career h-index of 58 and citations exceeding 12,340.

Rainer Haagمشاهده پروفایل

استاد

• Biodegradable Materials
• Sustainable Polymer Chemistry
• Dynamic Hydrogels
• +۷ مورد دیگر

Rainer Haag is a Professor at the Department of Chemistry, Freie Universität Berlin, leading the Haag Group in the Institute of Chemistry and Biochemistry. His research focuses on biodegradable and sustainable materials, dynamic hydrogels, and polymeric nanosystems for biomedical applications. Department of Chemistry, Freie Universität Berlin Member of SFB 1449: Dynamic Hydrogels at Biointerfaces Collaborator in the StemGel startup project Co-founder of CSR|Berlin interdisciplinary research institute Research Interests: Development of stimuli-responsive polymers, multivalent virus inhibitors, and functional biointerfaces. Key projects include: Antiviral coatings using heteromultivalent polymers Thermoresponsive hydrogels for stem cell expansion Graphene derivatives for bacterial capture and disinfection Lignin upcycling for sustainable resin materials Supramolecular nanosystems for drug delivery Publication Trends highlight interdisciplinary work in polymer chemistry, nanotechnology, and biomedical applications. Recent articles focus on: 2D polyglycerols for virus interactions Redox-responsive nanogels Mucus-inspired adhesive hydrogels Tumor-targeting micelles Bacterial disinfection using graphene composites Labs & Collaborations include the Polymeric and Supramolecular Nanosystems subgroup, the Dynamic Hydrogels and Biointerfaces team, and partnerships with MIT in developing bioinspired adhesives. His group contributes to DFG-funded SFB 1449 and CSR|Berlin initiatives.

Weiping Tangمشاهده پروفایل

استاد

• Targeted Protein Degradation
• PROTACs
• Medicinal Chemistry
• +۵ مورد دیگر

Weiping Tang is a Professor of Pharmaceutical Sciences and Chemistry at the University of Wisconsin-Madison, holding the Janis Apinis Professorship in the School of Pharmacy and the Vilas Distinguished Achievement Professorship. He also serves as Director of the Medicinal Chemistry Center at the School of Pharmacy and maintains a faculty appointment with the Department of Chemistry in the College of Letters and Science. Janis Apinis Professor of Pharmaceutical Sciences Vilas Distinguished Achievement Professor Director of Medicinal Chemistry Center Faculty Appointment with Department of Chemistry Dr. Tang received his B.S. in Chemistry from Peking University in 1997, M.S. in Chemistry from New York University in 1999, Ph.D. in Organic Chemistry from Stanford University in 2005, and completed a postdoctoral fellowship in Medicinal Chemistry, Chemical Biology and Drug Discovery at Harvard University in 2007. Dr. Tang's research program focuses on drug discovery for cancer, infectious diseases, and neurodegenerative disorders through three interconnected areas: Organic Synthesis (advancing glycoscience through novel carbohydrate synthesis technologies), Medicinal Chemistry (developing small molecules that selectively remove disease-associated proteins), and Chemical Biology (dissecting biological pathways using novel small molecule probes). His group operates as an interdisciplinary team where chemists and biologists collaborate closely on drug discovery projects, with particular emphasis on developing novel degraders for disease-causing proteins. Analysis of Dr. Tang's publication record reveals a significant shift toward targeted protein degradation technologies, particularly PROTACs and molecular glues, while maintaining strong foundations in carbohydrate chemistry. His most impactful recent work includes developing degraders for extracellular and membrane proteins (previously considered 'undruggable'), creating rapid synthesis platforms like Rapid-TAC and Rapid-Glue, and advancing understanding of ternary complex formation for novel PROTAC design. His research spans both chemical methodology development and therapeutic applications across multiple disease areas. Vilas Distinguished Achievement Professorship Janis Apinis Professorship Numerous high-impact publications in leading chemistry and pharmacology journals Editor's pick and hot paper designations for significant contributions Dr. Tang mentors a diverse team of graduate students, postdoctoral fellows, and staff scientists with expertise spanning synthetic chemistry, medicinal chemistry, carbohydrate chemistry, computational chemistry, biochemistry, and cell biology. His group has developed innovative platforms for the rapid synthesis of protein degraders and has made significant contributions to understanding the mechanisms of action for these novel therapeutics. Current research includes developing selective degraders for cancer targets like RIPK1, BRD4, and CARM1, as well as advancing delivery systems for clinical translation. The Tang Research Group maintains state-of-the-art facilities within the School of Pharmacy at UW-Madison, equipped for comprehensive chemical synthesis, compound characterization, and biological evaluation. The group actively collaborates with researchers across campus and with industry partners to advance discoveries toward clinical applications, with particular focus on cancer therapeutics and protein degradation technologies.

Vadim Cherezovمشاهده پروفایل

استاد

• Membrane Protein Structure and Function
• G Protein-Coupled Receptors (GPCRs)
• Lipid-Protein Interactions
• +۳ مورد دیگر

Vadim Cherezov, the Ester Dornsife Chair in Biological Sciences and Professor at the University of Southern California (USC), leads groundbreaking research in membrane protein structure and function. Affiliated with the Bridge Institute, Department of Chemistry, and Michelson Center for Convergent Bioscience, his work focuses on GPCRs, ion channels, and transporters—critical targets for drug discovery. His team leverages advanced techniques like Lipidic Cubic Phase (LCP) and Serial Femtosecond Crystallography (SFX) at XFEL facilities to solve high-resolution structures under physiological conditions. Institutional Affiliations: Bridge Institute, USC Michelson Center, Department of Chemistry, Department of Pharmacology and Pharmaceutical Sciences. Key Collaborations: Katritch Lab, Kuhn Lab, NIH, European XFEL. His research explores the role of lipids in modulating GPCR function, addressing diseases like Alzheimer’s, diabetes, and cancer. By solving the structure of the A 2A adenosine receptor via sulfur SAD phasing at XFEL, Cherezov’s lab demonstrated de novo phasing without heavy atoms. This breakthrough enables structural studies of previously intractable membrane proteins. Scientific Awards & Grants: NIH R01 GM108635, U54 GM094618, U54 GM094599, R01 GM095583 Science Signaling Breakthroughs of the Year (2014) Cherezov mentors a dynamic team, including postdocs (e.g., Dong-Gyun Kim), graduate students (e.g., Behnaz Davoudinasab), and alumni (e.g., Benjamin Stauch at Eli Lilly, Nairie Michaelian at Genentech). His lab’s publications span Nature , Science , and Cell , with recent work on Science Advances (2025) addressing ABEL-FRET for GPCR dynamics.

Steven G. Clarkeمشاهده پروفایل

استاد

• Biochemistry
• Systems Biology
• Biological Regulation
• +۸ مورد دیگر

Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.

Ralph H. Colbyمشاهده پروفایل

استاد

• Polymer Physics
• Rheology
• Ionomers
• +۵ مورد دیگر

Ralph H. Colby serves as Professor of Materials Science and Engineering and Chemical Engineering at Pennsylvania State University's College of Earth and Mineral Sciences, holding the Corning Faculty Fellowship. His research focuses on molecular-level dynamics in complex fluids, particularly polymers, ionomers, and liquid crystalline systems. With over 130 publications and authorship of the textbook Polymer Physics (2003), he directs an active research program examining structure-property relationships in soft matter. B.S. in Materials Science and Engineering, Cornell University (1979) M.S. in Chemical Engineering, Northwestern University (1983) Ph.D. in Chemical Engineering, Northwestern University (1985) Professor Colby's research spans polymer physics, rheology, and materials for energy applications. His group employs mechanical rheology, dielectric spectroscopy, and scattering techniques to investigate ion transport in single-ion conductors for batteries, dynamics of glass-forming liquids, and self-assembly in polyelectrolyte systems. Current work emphasizes structure-property relationships in ionomers, liquid crystalline polymers, and branched architectures. Analysis of recent publications reveals consistent focus on ionomer membranes for energy applications, processing-structure relationships in advanced polymers, and fundamental dynamics of complex fluids. Key trends include increasing integration of computational modeling with experimental characterization, expansion into sustainable materials processing, and growing emphasis on applications in battery technology and biomedical materials. Penn State Faculty Scholar Medal for Outstanding Achievement (2022) Bingham Medal, Society of Rheology (2012) American Chemical Society Fellowship Corning Faculty Fellowship in Materials Science and Engineering Professor Colby leads multiple federally funded projects including NSF's 'Fundamental Studies of Flow-Induced Polymer Crystallization' and DOE's 'Conduction mechanisms and structure of ionomeric single-ion conductors'. His group maintains strong industry partnerships with Corning Incorporated and participates in interdisciplinary initiatives like the Penn State Intercollege Graduate Degree Program in Materials Science and Engineering. Current research includes collaborations on breast cancer adherence interventions in Rwanda and conjugated polymer development for flexible electronics. The Colby Research Group operates specialized facilities for rheological characterization, dielectric spectroscopy, and X-ray scattering at Penn State's Materials Research Institute. The team maintains active collaborations with national laboratories and international research groups, focusing on translating fundamental polymer physics discoveries into practical applications for energy storage and advanced manufacturing.

• Virology
• Molecular Biology
• Genomics
• +۶ مورد دیگر

James Van Etten is the William Allington Distinguished Professor of Plant Pathology at the University of Nebraska-Lincoln, affiliated with the School of Biological Sciences and Nebraska Center for Virology. His research focuses on chloroviruses—large dsDNA viruses infecting Chlorella-like algae—with emphasis on DNA replication, restriction systems, and membrane transport proteins. Key research themes include: Viral DNA modification systems Host-virus interactions Structural virology Evolution of organellar genomes Recent work analyzed: SMRT sequencing of viral methylation patterns Chlorovirus cryopreservation methods Potassium channel biophysics Host chemical signaling mechanisms Lab webpage: vanettenlab.unl.edu

Benjamin Machtaمشاهده پروفایل

استادیار

• Biophysics
• Condensed Matter Physics
• Statistical Physics
• +۳ مورد دیگر

Benjamin Machta is an Assistant Professor of Physics at Yale University, affiliated with the Department of Physics and the QBio Institute. He holds a BS from Brown University and a PhD from Cornell University, followed by a postdoctoral fellowship at Princeton University. His research focuses on applying theoretical physics to understand biological systems, particularly leveraging statistical physics and information theory to study biological membranes near critical points and the energetic constraints of biological signaling. Education: BS in Physics (Brown University), PhD in Physics (Cornell University), Postdoc at Princeton University (Lewis-Sigler Theory Fellow). Research Interests include: membrane criticality, phase transitions in biological systems, information-theoretic limits in organism function, and energy dissipation in biological processes. His work often bridges theoretical models with experimental data, such as collaborations with Sarah Veatch’s lab on membrane phase behavior. Publications highlight themes like membrane criticality, protein phase separation, and energy constraints in signaling. His group’s current projects explore cochlear mechanics, thermodynamic control in biological systems, and the role of criticality in sensory systems. Awards: 2019 Simons Investigator Award. Lab Affiliations: QBio Institute and Department of Physics at Yale, located in YSB-C164. Group members include postdocs Isabella Graf and Michael Abbott, and graduate students Asheesh Momi, Mason Rouches, and others.

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

Martin Burkeمشاهده پروفایل

استاد

• Organic Chemistry
• Small-Molecule Synthesis
• Molecular Prosthetics
• +۷ مورد دیگر

Martin Burke is the May and Ving Lee Professor for Chemical Innovation and Professor of Chemistry at the University of Illinois Urbana-Champaign , with additional appointments in Biochemistry, Biomedical & Translational Sciences, and multiple campus institutes including the Beckman Institute and the Carl R. Woese Institute for Genomic Biology. Education B.S. Johns Hopkins University , 1998 Ph.D. Harvard University , 2003 M.D. Harvard Medical School , 2003 Research Interests Burke’s program centers on molecular prosthetics : the design, synthesis and application of small molecules that replicate or replace missing or dysfunctional proteins. His group pioneered iterative cross-coupling (ICC) using MIDA-protected haloboronic acids to automate the construction of complex natural products and function-oriented small molecules. Current projects target ion-channel replacement in cystic fibrosis, iron-transport restoration in anemia, and non-toxic antifungals that overcome drug resistance. Scientific Awards & Honors National Academy of Medicine (2021) AAAS Fellow (2021) ASCI Member (2021) iCON Award (2019) Mukaiyama Award, Japan (2019) ACS Nobel Laureate Award for Graduate Education (2017) Thieme-IUPAC Prize in Synthetic Organic Chemistry (2014) Elias J. Corey Award (2013) Arthur C. Cope Scholar Award (2011) Research Output & Impact Burke has authored >120 peer-reviewed articles, >30 patents, and his work has been cited >20,000 times. High-impact publications in Nature , Science , and Angewandte Chemie have advanced automated synthesis, molecular prosthetics, and cystic fibrosis therapeutics. Laboratory & Training The Burke Laboratories house a multidisciplinary team of graduate students, post-doctoral researchers, and physician-scientists developing next-generation molecular prosthetics. The group is supported by NIH, NSF, private foundations, and industry partnerships aimed at democratizing molecular innovation.

Christoph Schmidtمشاهده پروفایل

استاد

• Biophysics
• Cell Mechanics
• Microrheology
• +۵ مورد دیگر

Christoph F. Schmidt is the Hertha Sponer Distinguished Professor of Physics at Duke University with cross-appointments in the Thomas Lord Department of Mechanical Engineering and Materials Science, Biology, and Biomedical Engineering. He serves as Co-Director of the Duke Materials Initiative and leads an active research program at the intersection of physics and biology. His educational background includes a D.R. from the Technical University of Munich (Germany) in 1988. Schmidt has established himself as a leading researcher in biophysics through decades of innovative work. Professor Schmidt's research spans multiple scales of biological organization, from single molecules to whole organisms. His lab investigates cellular mechanics using advanced techniques including optical trapping, atomic force microscopy, and microrheology. A significant innovation from his group involves single-walled carbon nanotubes for high-bandwidth intracellular tracking. Current research focuses on cardiomyocyte mechanics, Drosophila tissue dynamics, and computational analysis of complex biological systems. His work on motor proteins like Eg5 and ncd has provided fundamental insights into cellular division mechanics. His recent publications (2021-2025) demonstrate increasing integration of computational approaches with experimental biophysics, particularly in analyzing cardiac tissue mechanics and Drosophila sensory systems. The work shows progression from fundamental biophysical measurements toward applications in understanding disease mechanisms and biological function. Professor Schmidt teaches several courses including PHYSICS 995 (Graduate Training Internship), PHYSICS 493 (Research Independent Study), PHYSICS 415 (Biophysics II), PHYSICS 174 (Introduction to Frontiers of Biophysics), and BIOLOGY 425 (Biophysics II). He has successfully mentored numerous graduate students to completion, including recent PhD graduates Dr. Mingru Li and Dr. Xiaoxuan Jian. The Schmidt Lab, part of Duke's Physics Department and the Duke Soft Matter Center, maintains state-of-the-art equipment for optical trapping, atomic force microscopy, and advanced light microscopy. The lab participates in the Triangle Soft Matter Workshop, fostering collaborations with researchers from Duke, UNC Chapel Hill, and NC State University. Current research directions include mechanical responses of suspended cells, tracking non-equilibrium cellular fluctuations, nuclear mechanics, and bacterial membrane mechanics under turgor pressure.

Mark Wallaceمشاهده پروفایل

استاد

• Membrane Biology
• Biophysics
• Optical Microscopy
• +۳ مورد دیگر

Mark Wallace is a Professor of Chemistry at King's College London, affiliated with the Department of Chemistry and the Faculty of Natural, Mathematical & Engineering Sciences. He holds a Royal Society University Research Fellowship (2005–2016) and has been a lecturer at Oxford University before joining King's in 2016. His research focuses on membrane protein function and artificial membrane mimics, combining optical microscopy and nanotechnology. He earned a PhD from the University of Cambridge (2002) and postdoctoral training at Stanford University and the National Institute for Medical Research. Key research interests include membrane protein dynamics, lipid bilayer engineering, and single-molecule imaging. He has pioneered techniques like droplet interface bilayers and interferometric scattering microscopy. His work has led to patents and applications in molecular sensing and medical research. Awards include the 2002 Gregorio Weber Prize and the 2015 RSC Norman Heatley Award. He is actively involved in public outreach, including video podcasts and educational competitions. Recent publications emphasize artificial ion channels, nanoparticle formation monitoring, and mitochondrial protein dynamics. His lab collaborates with institutions like the London Centre for Nanotechnology and the Rosalind Franklin Institute. Over 30 students and researchers have been mentored, with active grants from EPSRC, Wellcome Trust, and BBSRC.

Sebastian Schuckمشاهده پروفایل

استاد

• Cell Biology
• Molecular Biology
• Membrane Biology
• +۴ مورد دیگر

Overview Sebastian Schuck is a Professor of Biochemistry and Molecular Cell Biology at Heidelberg University's Biochemistry Center (BZH). His research focuses on organelle homeostasis, particularly the endoplasmic reticulum (ER), with emphasis on ER membrane biogenesis, ER-phagy, and SHRED pathways. He leads an international team investigating how cells adapt ER structure and function under stress or disease conditions. Education & Career Since 2021: Professor at Heidelberg University BZH 2013–2021: Independent Group Leader at Heidelberg University's Center for Molecular Biology 2006–2013: Postdoc with Peter Walter at UCSF 2001–2006: PhD and Postdoc with Kai Simons at Dresden's Max Planck Institute 1995–2000: Biochemistry studies at Universities of Hannover and Tübingen Research Interests Dr. Schuck's lab explores molecular mechanisms underlying ER homeostasis, including: 1. ER expansion during stress via lipid synthesis 2. Microautophagy-mediated ER degradation via ESCRT machinery 3. SHRED pathway regulation of proteasomal degradation of misfolded proteins 4. Links between ER stress and neurodegenerative diseases/cancer Awards & Honors No specific awards listed, but recognized for pioneering contributions to understanding microautophagy and ER quality control mechanisms. Advising & Collaborations Advised over 20 PhD/Master's students and postdocs Collaborations with Carlos Bas-Orth (MPI Biochemistry), Liam Holt (NY), and others Labs & Teams Current lab includes 10+ members focusing on: - Human ER morphogenesis - Microautophagy dynamics - SHRED pathway mechanisms