جستجوی استاد راهنمای دانشگاهی

Darryl Overby is a Professor of Mechanobiology in the Department of Bioengineering at Imperial College London's Faculty of Engineering. His academic affiliations include the CRUK Convergence Science Centre, Cancer Technology Network, and multiple interdisciplinary networks focused on ocular biomechanics, vascular science, and regenerative medicine. He holds an Orcid identifier (0000-0001-9894-7515) and was previously affiliated with Tulane University and Harvard Medical School. Education: Ph.D. in Mechanical Engineering (2002) from MIT under Prof. Roger Kamm, followed by postdoctoral research at Harvard Medical School under Prof. Donald Ingber. His work focuses on cellular biomechanics, mechanotransduction, and the role of mechanical forces in intraocular pressure regulation and glaucoma pathophysiology. Research interests span mechanobiology of Schlemm’s canal endothelial cells, nitric oxide signaling in ocular tissues, and development of organ-on-chip models for studying aqueous humor outflow dynamics. His lab explores how mechanical signals drive transcellular pore formation and how these mechanisms fail in glaucomatous conditions. Key contributions include consensus guidelines for Brillouin microscopy measurements, ex vivo perfusion studies, and the role of TRPV4 channels in mechanosensing. His work integrates engineering techniques with clinical ophthalmology to advance therapies targeting glaucoma and ocular hypertension. Professional activities include leadership roles in the Ocular Biomechanics Network and Wound Healing and Regeneration Network. His research has led to patents for devices enhancing aqueous humor drainage and RNAi-based therapies.

• Mechanobiology
• Ophthalmology
• Biomedical Engineering
• +۴ مورد دیگر

Professor Maryse Bailly is a Professor of Cell Biology at the UCL Institute of Ophthalmology, University College London, where she has been employed since December 2000, progressing from Lecturer to Reader/Associate Professor and finally to Professor in October 2020. Her research focuses on understanding fibroblast behavior in the context of ocular diseases, scarring, and fibrosis, with particular emphasis on cytoskeletal dynamics and mechanotransduction pathways. Education: Doctor of Philosophy, Universite Claude Bernard (Lyon 1), 1992 Diplome Universitaire de Technologie, Universite Claude Bernard (Lyon 1), 1983 Professor Bailly's research program investigates how fibroblasts sense and respond to mechanical and chemical stimuli in their environment, with applications to multiple ocular pathologies including trachoma, thyroid eye disease, glaucoma scarring, and myopia. Her laboratory has developed innovative in vitro and ex vivo models that allow the study of tissue contraction mechanisms within pseudo-physiological 3D environments, leading to the identification of novel therapeutic targets such as the Rac1 small GTPase and the MRTF/SRF pathway. She has established significant collaborations with clinicians at Moorfields Eye Hospital, particularly with Dr. Annegret Dahlmann-Noor on pediatric eye growth and myopia research. Analysis of Professor Bailly's publication record reveals a consistent focus on fibroblast mechanobiology with increasing emphasis on pediatric ocular development in recent years. Her work bridges fundamental cell biology with translational applications, particularly in understanding the biomechanical properties of fibroblasts in myopia development and post-surgical scarring. The research demonstrates strong interdisciplinary connections between ophthalmology, cell biology, and tissue engineering. Teaching: CELL0016 - Actin cytoskeleton and Intermediate Filaments CELL0017 - Fibrosis and mechanotransduction CELL0009 - Models organisms and techniques MECH0031 MSc Biomaterials & Tissue Engineering - Modeling tissue contraction and fibrosis

• Cell Biology
• Ophthalmology
• Fibrosis
• +۵ مورد دیگر

Dr. Tim Halim is a Sir Henry Dale Fellow and Junior Group Leader at the Cancer Research UK Cambridge Institute (CRUK Cambridge Institute), University of Cambridge. His primary research program focuses on pancreatic cancer, with thoracic cancer as a secondary research focus within the CRUK Cambridge Centre's structured research programs. Dr. Halim's research expertise lies at the intersection of cancer biology and immunology, with particular emphasis on innate lymphoid cells (especially ILC2) and regulatory T cells within the tumor microenvironment. His work investigates how these immune cell populations interact with cancer cells and influence tumor progression, metastasis, and response to therapy. His research has significant implications for developing novel immunotherapeutic approaches for pancreatic and thoracic cancers. His publication record demonstrates a consistent focus on the role of innate lymphoid cells in cancer, with recent work examining IL-33 and ILC2 in pancreatic cancer, cross-talk between ILC2 and regulatory T cells, and the influence of innate lymphoid cells on pancreatic stromal composition. His research employs advanced techniques including in vivo labeling, single-cell analysis, and fate-mapping approaches to understand immune cell behavior in cancer contexts. Dr. Halim has been awarded the prestigious Sir Henry Dale Fellowship, a joint fellowship from the Royal Society and Wellcome Trust that supports early-career researchers of outstanding promise working at the interface of basic and clinical science.

• Cancer Immunology
• Innate Lymphoid Cells
• Regulatory T Cells
• +۵ مورد دیگر

Dame Fiona Powrie is a Professor of Musculoskeletal Sciences at the University of Oxford and Director of the Kennedy Institute of Rheumatology . She leads the Mucosal Immunology Research Group and serves as Director of the Oxford Centre for Microbiome Studies (OCMS) and Cluster Lead in the MRC National Mouse Genetics Network Microbiome Cluster . Roles: Director of Kennedy Institute, Professor, Research Group Leader Relevant Affiliations: Wellcome Trust Governor (2018–present), Deputy Chair (2022), Royal Society Fellow (2011) Research Interests : Fiona specializes in the interplay between the intestinal microbiota and the host immune system, focusing on how dysregulation leads to inflammatory bowel disease (IBD) . Her work has elucidated the role of regulatory T cells in maintaining gut homeostasis and identified the IL-23 pathway as critical in chronic intestinal inflammation. Current efforts aim to translate these findings into clinical therapies for IBD patients. Scientific Awards and Fellowships : Ita Askonas Award (European Federation of Immunological Societies) Louis-Jeantet Prize for Medicine (2012) Honorary Lifetime Membership (British Society of Immunology, 2021) Fellow of the Royal Society (2011), EMBO (2013), Academy of Medical Sciences (2014) International Fellow of the National Academy of Sciences (2020) Advising and Leadership : Fiona leads the Mucosal Immunology group at the Kennedy Institute, mentors researchers, and contributes to national and international scientific governance. She has been instrumental in advancing microbiome and immunology research through leadership roles at the Oxford Centre for Microbiome Studies and the MRC National Mouse Genetics Network . Labs and Teams : Fiona's research group at the Kennedy Institute of Rheumatology investigates mucosal immunity and microbiome interactions, combining experimental and clinical approaches to address inflammatory diseases.

• Mucosal Immunology
• Intestinal Microbiota
• Host-Immune System Interaction
• +۳ مورد دیگر

Professor Sir Peter Barnes is a leading figure in respiratory science at Imperial College London's National Heart and Lung Institute (NHLI) . As Professor of Thoracic Medicine , his work focuses on Asthma, COPD, and cellular senescence in lung disease , with over four decades of contributions to understanding inflammatory pathways and therapeutic innovations. Research Interests Mechanisms of chronic airway inflammation in Asthma and COPD Cellular senescence in lung aging and disease progression MicroRNA transfer via extracellular vesicles in COPD pathogenesis Targeted drug delivery for respiratory conditions Global health implications of lung disease Recent Publications highlight trends in: MicroRNA regulation of senescence and inflammation Extracellular vesicle dynamics in lung disease Biologics and corticosteroid efficacy in respiratory conditions Environmental factors influencing COPD and asthma Scientific Recognition Knighthood (2023) for services to respiratory science Fellow of the Royal Society (FRS) and Academy of Medical Sciences (FMedSci) Collaborative Leadership at NHLI has mentored numerous postdocs and researchers. His work intersects with global initiatives like GOLD (Global Initiative for COPD) , influencing clinical guidelines and public health policy.

• Respiratory Science
• Asthma
• COPD
• +۵ مورد دیگر

Julian Knight is a Professor of Genomic Medicine at the University of Oxford, with affiliations including the Centre for Human Genetics , Merton College , and leadership roles in the NIHR Oxford Biomedical Research Centre and Central and South NHS Genomic Medicine Service . His work bridges clinical practice and research, focusing on translational genomics. Principal Investigator Deputy Director, Centre for Human Genetics Honorary Consultant Physician Tutor and Fellow, Merton College Director, Medical Sciences Division Graduate School Genomic Medicine Theme Lead, NIHR Oxford BRC Research interests include mechanisms of dysregulated immune responses in sepsis , autoimmune disease , and infection . Key contributions involve RNA signature stratification for sepsis outcomes and HLA allele associations in COVID-19 immunogenicity. Current work explores genetic/epigenetic modulators of innate immunity and causal relationships in multi-omic datasets. Recent publications highlight diverse applications of his group’s work: from pleural infection endotyping (2025) to TLR7 variants in severe COVID-19 (2024), with methodological advancements in single-cell demultiplexing (2024) and pathway analysis (2025). Keywords span genomic medicine , immunology , and multi-omic integration . Knight’s leadership extends to clinical implementation of genomics, education (DPhil/MSc programs), and public engagement. Collaborations span institutions including Imperial College , Wellcome Sanger Institute , and Queen Mary University of London .

• Genomic Medicine
• Translational Medicine
• Immunogenetics
• +۴ مورد دیگر

Professor Kim Midwood serves as Professor of Matrix Biology and Kennedy Director of Graduate Studies at the University of Oxford's Kennedy Institute of Rheumatology, leading research on extracellular matrix dynamics in inflammatory diseases and cancer. Her academic foundation includes: BSc (Hons) in Biochemistry from the University of Edinburgh (1995) PhD in Pathology from the University of Edinburgh (1999), investigating extracellular matrix changes in arthritis Her research centers on matrix immunology, particularly tenascin-C's role in rheumatoid arthritis, tumor microenvironments, and fibrosis. She examines how tissue-specific matrix composition dictates immune cell behavior through toll-like receptor signaling and chemokine networks, revealing novel therapeutic targets for chronic inflammatory conditions. Publications from 2013-2025 demonstrate evolving focus from arthritis mechanisms to broader applications in cancer immunotherapy and regenerative medicine, consistently highlighting matrix molecules as central regulators of disease progression. Her accolades include: MRC New Investigators Award (2007) Arthritis Research UK Senior Fellowship (2012) She directs the Matrix Immunology research group (established 2004 at Imperial College London, relocated to Oxford in 2011) and founded biotech company Nascient Ltd (2012) to translate matrix-targeting discoveries into clinical therapies.

• Matrix Biology
• Immunology
• Rheumatology
• +۵ مورد دیگر

Simon Arthur is a Professor of Immune Signalling at the University of Dundee, School of Life Sciences, within the Department of Cell Signalling and Immunology. His research focuses on understanding inflammatory processes, particularly the role of innate immune cells in coordinating inflammation and resolving immune responses. He holds a PhD from the University of Oxford (1995) and a BSc from Durham University (1990). Arthur is a Fellow of the Royal Society of Biology (2015) and serves on the editorial board of the Journal of Biological Chemistry . His teaching includes courses on Genetics, Cell Signalling, Immunology, and advanced topics in immunology and cell signalling. He supervises PhD projects on microglial phenotypes in brain ageing and immunomodulatory factors in helminth-host interactions. Arthur leads research projects funded by the Medical Research Council and other agencies, including studies on liver fibrosis, bile acid diarrhoea, and pulmonary fibrosis. Key research themes include cytokine regulation, macrophage function, and the molecular mechanisms underlying chronic inflammation. His work spans from fundamental biology to translational research, aiming to develop therapies for autoimmune and inflammatory diseases. Arthur collaborates internationally and has over 180 publications in high-impact journals.

• Immunology
• Cell Signalling
• Inflammation Biology
• +۳ مورد دیگر

Professor Daniel Davis MBE FMedSci is the Head of the Department of Life Sciences and Professor of Immunology at Imperial College London. He holds affiliations with the Institute of Chemical Biology, the CDT in Chemical Biology: Innovation in Life Sciences (as a supervisor), and research groups in Immunology and Molecular Mechanisms of Disease. His academic journey includes a doctorate in Physics from Harvard University and prior roles as Director of Research at the Manchester Collaborative Centre for Inflammation Research (University of Manchester). His research focuses on nanoscale biology of immune cell interactions, employing advanced microscopy techniques to study immune synapse formation, cytotoxicity mechanisms, and immunological regulation. Notable contributions include elucidating how immune cells use adhesion, signaling, and structural reorganization to target pathogens and cancer cells. Professor Davis has authored four popular science books, including Self Defence: A Myth-Busting Guide to Immune Health (2025), The Beautiful Cure (2018), and The Compatibility Gene (2014), which bridge public understanding of immunology and biology. His work has been recognized with prestigious awards such as the Royal Society Science Book Prize and the Prose Award. His articles span topics like NK cell heterogeneity, gene therapy for neurological disorders, and super-resolution microscopy applications. Grants and collaborations include work on AAV-based gene therapies and immunomodulatory drug development. Davis actively engages in public science communication through festivals, media outlets (e.g., BBC, Guardian), and international speaking engagements. His research labs at Imperial College focus on interdisciplinary approaches, combining biophysics, genetics, and clinical applications to advance immunology and translational medicine.

• Immunology
• Biochemistry and Cell Biology
• Clinical Sciences
• +۳ مورد دیگر

Dr Michael Boemo is an Assistant Professor at the University of Cambridge, holding dual appointments in the Department of Pathology and Department of Genetics. He leads research at the intersection of computational biology, DNA replication, and cancer genomics, developing machine learning tools to analyze replication stress and genomic instability. Academic Background: BA in Mathematics (Rutgers University), PhD in Physics (University of Oxford) Research Focus: Genomic instability in cancer, DNA replication/repair defects, computational modeling using machine learning and high-performance simulations Teaching: Lectures in Natural Sciences Tripos (mathematical biology, genetics, systems biology), module organizer for cancer biology and biological modeling His research group leverages nanopore sequencing and AI to map replication fork dynamics, revealing how stalled forks generate mutations in cancer cells and pathogens. Recent work examines extrachromosomal DNA replication vulnerabilities and transcription-replication conflicts. Dr Boemo collaborates across computational biology and cancer research domains, with publications spanning journals like Nature Methods, Cell, and PLoS Computational Biology. His lab develops tools such as DNAscent for replication fork analysis and explores therapeutic targeting of replication stress.

• Genomic Instability
• DNA Replication and Repair
• Computational Biology
• +۵ مورد دیگر

Professor Ziad Mallat is a distinguished Professor of Cardiovascular Medicine at the University of Cambridge, where he serves as the BHF Professor of Cardiovascular Medicine since 2010. He is affiliated with the Victor Phillip Dahdaleh Heart & Lung Research Institute and is a Principal Investigator in the Cardiovascular and Respiratory Medicine section of the Department of Medicine. Elected as a Fellow of the Academy of Medical Sciences (FMedSci) in 2020, Professor Mallat has established himself as a leading figure in cardiovascular immunology research. Professor Mallat received his MD and degree in Cardiovascular Disease from University of Paris VI, and his PhD from University of Paris VII. He was appointed Director of Research at Inserm, France, in 2007. His academic journey has positioned him at the forefront of cardiovascular research, with particular expertise in immune mechanisms of cardiovascular disease. Professor Mallat's research focuses on the immune mechanisms leading to cardiovascular inflammation in atherosclerosis, post-ischaemic injury (such as myocardial infarction), and aortic aneurysm and dissection. His laboratory develops novel immuno-modulatory and vaccination-based strategies to promote protective immune responses, aiming to radically change the management and treatment of these common and serious cardiovascular diseases. His approach combines basic science research, pre-clinical experimentation in animals, and translation clinical investigation in patients. Analysis of Professor Mallat's recent publications reveals a strong focus on the intersection of immunology and cardiovascular disease, particularly investigating regulatory T cells, B cell responses in atherosclerosis, and immune-modulatory therapies. His work spans from fundamental mechanisms to clinical translation, with several studies examining therapeutic approaches like low-dose interleukin-2 for cardiovascular inflammation. Fellow of the Academy of Medical Sciences (FMedSci) Co-Editor of Atherosclerosis journal Editorial Board member of Circulation Research and JCI Insight Professor Mallat has published over 250 papers in peer-reviewed journals, with landmark contributions including identifying prominent roles for specific pathogenic and regulatory immune pathways in atherosclerosis and post-ischaemic remodeling. His basic research activities are complemented by proof-of-concept clinical trials using immune-modulatory therapies in patients with coronary artery disease. He maintains active collaborations with the British Heart Foundation and is involved in the Cambridge BHF Centre of Research Excellence.

• Cardiovascular biology
• immune mechanisms of cardiovascular disease
• atherosclerosis
• +۳ مورد دیگر

Helen Byrne is a Professor of Applied Mathematics at the University of Oxford and a Tutorial Fellow at Keble College. Her academic roles include former Examiner for Final Honour School Mathematics, Associate Head of Department for Planning and Equality and Diversity, and Director of Equality and Diversity in the university’s MPLS Division. DPhil MSc BA/MA Her research focuses on developing mathematical and computational models to study biomedical systems, particularly solid tumours, wound healing, and tissue engineering. She aims to uncover mechanisms behind biological phenomena and derive novel mathematical insights from these models. Recent publications highlight her work in tumor-immune interactions, atherosclerosis, antibody dynamics, and radiation therapy, employing techniques like spatial modeling, agent-based simulations, and multiscale approaches. Her research bridges theoretical mathematics and practical biomedical challenges. 2019: Leah Edelstein-Keshet Prize (Senior Award), Society for Mathematical Biology 2020: Fellow of the Society for Mathematical Biology Helen Byrne has supervised numerous students and researchers, contributing to mathematical biology and biomedical modeling. Her teaching includes courses on multivariable calculus, applied partial differential equations, and advanced mathematical biology.

• Mathematical Biology
• Computational Biology
• Tumour Modeling
• +۵ مورد دیگر

Aparna Ratheesh serves as an Associate Professor at the Centre for Mechanochemical Cell Biology at the University of Warwick, where she leads research in the Wellcome-Warwick Quantitative Biomedicine Programme. Her work bridges cell biology, developmental biology, and biophysics, focusing on the mechanical and biochemical interactions that govern cell migration in living organisms. Dr. Ratheesh's research centers on cell migration through complex tissue barriers, a process essential for embryonic development, immune homeostasis, and pathological conditions like cancer metastasis. Her lab utilizes Drosophila melanogaster macrophages during embryonic development as a model system, leveraging the genetic tractability of fruit flies combined with quantitative live imaging, biophysical tools, and mathematical modeling. Current research focuses on how macrophages sense tissue stiffness and alter their force-generating machinery for migration, and how macrophage-generated forces affect surrounding tissue mechanics, cell fate, and positioning. Analysis of her publication record reveals a consistent focus on cellular mechanobiology, with particular emphasis on cell migration, tissue mechanics, and immune cell behavior. Her work spans both fundamental cell biological mechanisms and their implications for understanding disease processes, particularly in inflammation and cancer. The publications demonstrate a progression from basic molecular mechanisms of cell adhesion to more complex tissue-level mechanical interactions. Dr. Ratheesh maintains an active research program investigating the mechanical dialogue between migrating cells and their environment. Her work combines advanced imaging techniques with genetic manipulation in the Drosophila model system to address fundamental questions about how cells navigate through complex tissues during development and disease processes.

• Cell Migration
• Developmental Biology
• Mechanobiology
• +۴ مورد دیگر

Filipa Simões is a Group Leader and British Heart Foundation Intermediate Basic Science Research Fellow at the Institute of Developmental and Regenerative Medicine (IDRM), University of Oxford. She holds a Hugh Price Fellowship in Regenerative Medicine at Jesus College, Oxford. Her work focuses on immune cell programming in cardiac repair, leveraging genomics, spatial omics, and in vivo/in vitro models to dissect macrophage roles in heart regeneration. She completed her PhD at the University of Coimbra (Portugal) and postdoctoral research at Oxford, identifying epicardial subpopulations and macrophage contributions to cardiac scarring. Education: BSc Microbiology and Genetics, Faculty of Sciences, University of Lisbon PhD Biochemistry, University of Coimbra (research at Oxford’s Weatherall Institute) Postdoctoral Training: Department of Physiology, Anatomy, and Genetics, University of Oxford Research Interests: Filipa’s lab explores how macrophages are programmed by neighboring cells to repair heart attack damage. Key themes include immune-cell-cardiac crosstalk, fibrosis pathways, and regenerative signaling. Techniques employed span spatial genomics, functional assays, and zebrafish models to map cellular microenvironments. Awards: British Heart Foundation Intermediate Basic Science Research Fellowship British Heart Foundation Centre of Research Excellence Transition Fellowship Teaching: Leads undergraduate courses in Cardiovascular Development, Genomics, and Developmental Biology. Oversees postgraduate modules on cardio-immuno genomics and cardiac regeneration. Labs/Teams: Heads a multidisciplinary team at IDRM, integrating developmental biology, immunology, and regenerative medicine approaches to advance cardiac repair strategies.

• Regenerative Medicine
• Cardiovascular Biology
• Immunology
• +۳ مورد دیگر

Matthew Ronshaugen is a Senior Lecturer in the Division of Developmental Biology & Medicine (L5) at the Faculty of Life Sciences, University of Manchester. He has held academic positions since 2007 as a Manchester Fellow, followed by Lecturer (2012-2017), and Senior Lecturer since 2017. 1991-1995: Bachelor of Arts in Philosophy and Linguistics, University of Nevada, Las Vegas 1995-1997: Master of Science in Systematics, University of Nevada, Las Vegas 1997-2002: Doctor of Philosophy in Cell and Molecular Biology, University of California, San Diego 2003-2007: Ruth L. Kirschstein NIH Postdoctoral Fellow at University of California, Berkeley His research focuses on non-coding RNAs (ncRNAs), particularly their roles in gene expression and developmental differentiation. His lab investigates how ncRNA evolution contributes to metazoan body plan diversification, centering on the Hox complex—a conserved genomic region rich in ncRNAs. He uses tiling microarrays and fluorescent in situ hybridization to analyze ncRNA dynamics in Drosophila, Tribolium, and Parhyale. Recent publications highlight his work on miRNA functions in embryonic development, aging-related changes in myeloid cells, and comparative transcriptomics across arthropods. His team employs genetics tools to dissect ncRNA roles in transcriptional regulation, epigenetic control, and silencing mechanisms. Scientific Awards: Ruth L. Kirschstein NIH Postdoctoral Fellow Manchester Fellow He supervises research on developmental transcriptomes and contributes to datasets on piRNA expression and Hox complex analysis. Collaborations span immunology, genomics, and evolutionary development, with outputs cited in fields like RNA interference, transgenics, and wound healing.

• Non-coding RNA
• Gene Expression
• Developmental Biology
• +۶ مورد دیگر