معرفی
Professor Ziad Mallat is a distinguished Professor of Cardiovascular Medicine at the University of Cambridge, where he serves as the BHF Professor of Cardiovascular Medicine since 2010. He is affiliated with the Victor Phillip Dahdaleh Heart & Lung Research Institute and is a Principal Investigator in the Cardiovascular and Respiratory Medicine section of the Department of Medicine. Elected as a Fellow of the Academy of Medical Sciences (FMedSci) in 2020, Professor Mallat has established himself as a leading figure in cardiovascular immunology research.
Professor Mallat received his MD and degree in Cardiovascular Disease from University of Paris VI, and his PhD from University of Paris VII. He was appointed Director of Research at Inserm, France, in 2007. His academic journey has positioned him at the forefront of cardiovascular research, with particular expertise in immune mechanisms of cardiovascular disease.
Professor Mallat's research focuses on the immune mechanisms leading to cardiovascular inflammation in atherosclerosis, post-ischaemic injury (such as myocardial infarction), and aortic aneurysm and dissection. His laboratory develops novel immuno-modulatory and vaccination-based strategies to promote protective immune responses, aiming to radically change the management and treatment of these common and serious cardiovascular diseases. His approach combines basic science research, pre-clinical experimentation in animals, and translation clinical investigation in patients.
Analysis of Professor Mallat's recent publications reveals a strong focus on the intersection of immunology and cardiovascular disease, particularly investigating regulatory T cells, B cell responses in atherosclerosis, and immune-modulatory therapies. His work spans from fundamental mechanisms to clinical translation, with several studies examining therapeutic approaches like low-dose interleukin-2 for cardiovascular inflammation.
- Fellow of the Academy of Medical Sciences (FMedSci)
- Co-Editor of Atherosclerosis journal
- Editorial Board member of Circulation Research and JCI Insight
Professor Mallat has published over 250 papers in peer-reviewed journals, with landmark contributions including identifying prominent roles for specific pathogenic and regulatory immune pathways in atherosclerosis and post-ischaemic remodeling. His basic research activities are complemented by proof-of-concept clinical trials using immune-modulatory therapies in patients with coronary artery disease. He maintains active collaborations with the British Heart Foundation and is involved in the Cambridge BHF Centre of Research Excellence.
