جستجوی استاد راهنمای دانشگاهی

Annette Brandt is a researcher affiliated with the Department of Nutritional Sciences within the Faculty of Life Sciences . Her work focuses on metabolic and liver diseases, with a particular emphasis on non-alcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD), and the role of intestinal barrier dysfunction in disease progression. She investigates mechanisms involving microbiota modulation, inflammatory pathways (e.g., TNFα, JNK), and dietary interventions (e.g., choline, beta-glucan, phosphatidylcholine) to mitigate liver damage. Her research also explores the interplay between aging, inflammation ('inflammaging'), and intestinal permeability. Brandt has contributed to over 38 peer-reviewed publications and 47 academic activities, including presentations at conferences. Her studies utilize mouse models to explore therapeutic strategies for liver diseases and metabolic disorders. Key collaborations involve investigating the effects of dietary components (e.g., fructose, soybean oil) and pharmacological agents (e.g., honokiol, 4-methylpyrazole) on liver health. She has also examined the role of toll-like receptors (TLR2/TLR4) in aging-related pathologies and cognitive decline. Her research aligns with UN Sustainable Development Goals related to good health and well-being (SDG 3) and sustainable cities and communities (SDG 11), emphasizing translational approaches to improve public health through dietary and pharmacological interventions.

• Non-Alcoholic Fatty Liver Disease
• Intestinal Mucosal Barrier
• Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
• +۳ مورد دیگر

Joan Steitz is the Sterling Professor of Molecular Biophysics and Biochemistry at Yale University and an Investigator at the Howard Hughes Medical Institute. She holds affiliations with the Yale School of Medicine, the Center for RNA Science and Medicine, and the Yale Cancer Center. Her career includes roles such as Department Chair and leadership in organizations like the American Society for Cell Biology. Education: PhD in Biochemistry from Harvard University (1967); BS from Antioch College (1963). Postdoctoral training at the MRC Laboratory of Molecular Biology, Cambridge. Research focuses on RNA-protein complexes, particularly snRNPs and their roles in RNA processing, viral oncogenesis, and gene expression. Notable discoveries include defining mRNA splicing mechanisms and characterizing noncoding RNAs in herpesviruses. Publications highlight advancements in RNA biology, viral RNA interactions, and stress-induced transcription. Over 300 peer-reviewed articles span molecular biology, virology, and biochemistry. Awards include the Wolf Prize (2021), Lasker Award (2018), and membership in the National Academy of Sciences (1983). Her lab at Yale explores RNA structure-function relationships and viral RNA mechanisms.

• RNA Processing
• Molecular Biophysics
• Biochemistry
• +۳ مورد دیگر

Martin Crespi is a CNRS Researcher at the Institute of Plant Sciences Paris-Saclay (IPS2) since 2018 and has led the "Regulatory RNAs in root plasticity" team since 2003. He served as Director of IPS2 (2015-2024), Director of the Plant Genomics Unit (2014-2015), and held leadership roles at CNRS institutions since 1994. Current Position: Researcher, CNRS, IPS2 Leadership: 14-member team (7 permanent) His research focuses on non-coding RNAs, epigenetics, and root development, exploring how riboregulators interact with splicing/chromatin factors to modulate root adaptability. His work bridges plant molecular biology, symbiosis, and environmental stress responses. Recent publications highlight his contributions to understanding RNA-mediated regulation in Arabidopsis and Medicago truncatula, covering topics like alternative splicing, chromatin looping, and miRNAome plasticity. These studies integrate genomics and molecular biology to decode root-soil interactions. Scientific Awards: Prix Dr. Pedro Berdoy (Argentina), National Society of Experimental Biology Award (Argentina) He has supervised 18 PhD students, 43 postdocs, and 14 Masters while leading 61 projects (including 9 EU grants and 7 Marie Curie grants) and participating in over 30 international scientific committees or review panels.

• RNA binding proteins
• Epigenetics
• Root architecture
• +۵ مورد دیگر

Li Peifeng is a distinguished Professor and Dean at the Institute of Translational Medicine, College of Medicine, Qingdao University, China. He also serves as Director of the Key Laboratory of Nucleic Acid Biology in Cardiovascular Disease (Shandong) and the International Research Centre for Non-coding RNAs and Translational Medicine (Qingdao). His academic career includes roles as Distinguished Professor at the Chinese Academy of Sciences (2006–2013) and a Medical Researcher at the Max-Delbrück-Center for Molecular Medicine in Berlin (1995–2005). Li Peifeng holds an MD and PhD from the Chinese Academy of Medical Science (1990–1993). His research focuses on cardiovascular biology, non-coding RNAs, and molecular mechanisms underlying myocardial infarction, heart failure, and apoptosis. He has led groundbreaking studies on miRNA regulation in cardiac pathologies and oxidative stress responses. Notable awards include the World’s Top 2% Scientists (2020), Highly Cited Chinese Researchers (2020), and multiple national and provincial accolades. He is an editorial board member for journals like Molecular Biotechnology and Circulation Research , and has reviewed grants for institutions including the European Research Council and the American Heart Association. Awards: Taishan Scholar (2018), Leading Innovative Scientist (2018), Tip-top Talent (2017). Leadership Roles: Organized major conferences, including the Annual Conference on Cell Biology (2018) and International Cardiology Conferences (2014–2015). Key Labs: Directs research centers focused on nucleic acid biology and non-coding RNAs in cardiovascular disease.

• Cardiovascular Disease
• Non-coding RNAs
• Molecular Biology
• +۴ مورد دیگر

Joachim Lingner is a Full Professor at the Ecole Polytechnique Fédérale de Lausanne (EPFL) since 2009. He previously held positions as Associate Professor (2005–2008), Senior group leader (2002), and Junior group leader (1997–2001) at EPFL and ISREC, Switzerland. He completed his PhD at the Biozentrum of the University of Basel (1989–1992) and postdoctoral work at HHMI, University of Colorado at Boulder (1993–1997). Research Focus: Telomeres, telomerase, genome stability, DNA repair, oxidative stress, RNA biology, and aging. Key Discoveries: Discovery of the catalytic subunit of telomerase (1993–1997), identification of TERRA (telomeric long noncoding RNA), and mechanisms of telomerase regulation. Technologies Developed: Telomeric chromatin analysis protocols to study telomere protein composition and dynamics. Scientific Awards & Honors: ERC Advanced Investigator Grant (2008) EMBO Member (2005) Friedrich Miescher Prize (2002) START-fellowship (1997) Postdoctoral Fellowship SNF (1995) EMBO Long-Term Postdoctoral Fellowship (1993)

• Telomeres
• Telomerase
• Long noncoding RNA
• +۶ مورد دیگر