جست‌وجوی استاد و پژوهشگر

Chris Youngمشاهده پروفایل

مدرس ارشد

• Skeletal Muscle Pathologies
• Autophagy Mechanisms
• Purinergic Signaling
• +۶ مورد دیگر

Dr Chris Young is a Senior Lecturer in Biomedical Science and Enterprise Lead for the School of Allied Health Sciences at De Montfort University's Faculty of Health and Life Sciences. He also serves as a long-term visiting scientist at the Li Ka Shing Cancer Research UK Research Institute, Addenbrookes, Cambridge, and maintains research collaborations with the University of Portsmouth. Dr Young completed his PhD in Molecular Medicine at the University of Portsmouth (2007-2011), an MSc in Genetic Manipulation and Molecular Cell Biology with Distinction from the University of Sussex (2006-2007), and a BSc in Biochemistry and Organic Chemistry with First Class Honours from The Open University (2003-2006). He also holds a PG-Cert in Learning and Teaching in Higher Education with Distinction (2019) and is a Fellow of the Higher Education Academy. Dr Young's research focuses on skeletal muscle pathologies and in vitro/in vivo modeling of human pathologies, with two main themes: elucidating the role of autophagy in skeletal muscle stem cells, and developing next-generation wound dressings for trauma and disaster medicine. His work on autophagy has therapeutic potential extending to muscle disease, muscle aging, soft tissue injuries, rhabdomyosarcoma, diabetes, and liver disease. His expertise in muscle pathology underpins his co-founded company, Chromar Research & Development Ltd., which customizes IP and technology for human and veterinary markets. Analysis of Dr Young's publication record reveals a strong focus on muscle pathology, particularly Duchenne Muscular Dystrophy, with significant contributions to understanding autophagy mechanisms and purinergic signaling. His recent work has expanded into cancer research, particularly colorectal cancer biomarkers, and medical education innovations, reflecting his diverse research interests and interdisciplinary approach. ICURe Discover, Explore & Exploit awardee for Chromar Research and Development Ltd. (2024-2025) VentureVersity selected case study for success in Enterprise and Innovation (2024) Shortlisted for Academy of Medical Sciences Early Career Award (2023) Blavatnik Award Nominee (2022) Elected Member of the Fisheries Society of the British Isles (2022-present) Member of the Royal Society of Biology (2021-present) Future Research Leader Scholarship (2020) Innovation for International Education Award from Nanolive (2019) Dr Young successfully supervises PhD students including Michal Kozielecki, Kyle Gordon, and Divine Derefaka, and has secured four successive externally funded innovation grants to support Chromar in the last two years. His teaching portfolio includes Chemistry for the Biosciences, Biochemistry and Molecular Cell Biology, Cyto & Histopathology, Clinical Biochemistry, Clinical Genetics, and Cancer Biology, where he serves as Module Lead for Research Projects and as 1st Year Coordinator and Timetabling Coordinator for Biomedical Science. Dr Young maintains an active laboratory focused on skeletal muscle pathologies with two main research themes. He is collaborating with Dr Omar Qutachi to spin out Chromar Research & Development Ltd. with Innovate UK ICURe funding support, demonstrating his commitment to translating research into practical applications for human and veterinary markets.

Holger Bierhoffمشاهده پروفایل

دانشیار

• Epigenetics
• Aging Research
• Non-coding RNA
• +۶ مورد دیگر

Holger Bierhoff serves as an Associate Group Leader at Friedrich Schiller University Jena with an associated position at the Leibniz Institute on Aging (FLI), operating from the Center for Molecular Biomedicine (CMB). His research group maintains a guest status collaboration with FLI while being primarily based at the university. Professor Bierhoff's research focuses on epigenetics of aging, specifically investigating how non-coding RNAs form RNA:DNA triplex structures to regulate chromatin landscape. His lab has developed novel molecular tools to detect and characterize these triplex structures genome-wide, examining how they compete with protein binding or alternative nucleic acid structures at target sites. Current work explores connections between ribosome biogenesis, nucleolar function, and aging processes using human and mouse cell models. His publication record shows consistent high-impact output, with multiple significant papers in 2024 including research on RNA:DNA triplexes as epigenetic communication mechanisms, rRNA synthesis and longevity in C. elegans, and breast cancer mechanisms. His work appears in prestigious journals such as Nature Communications, Cell Reports, and Nucleic Acids Research. Professor Bierhoff leads two major funded projects: AgingComb (funded by European Regional Development Fund) investigating genomic alterations through high-throughput DNA analysis, and 'Nucleolus as a target' (funded by European Social Fund) developing nucleolar changes as biomarkers for healthy aging. Both projects involve interdisciplinary collaborations between university researchers and clinical partners. His lab maintains active supervision of doctoral, master's, and bachelor students, creating a collaborative research environment focused on cutting-edge epigenetic mechanisms in aging. The group is embedded within the Zentrum für Alternsforschung Jena (ZAJ) and the Leibniz Research Alliance Resilient Ageing, providing students with access to advanced facilities and interdisciplinary networks.

Jiaqian Wuمشاهده پروفایل

استاد

• Neuroscience
• Genomics
• Stem Cell Biology
• +۵ مورد دیگر

Dr. Jiaqian Wu is a tenured Professor holding the UTHealth Houston Distinguished Professorship in Neurotrauma at McGovern Medical School. She leads a research laboratory in the Vivian L. Smith Department of Neurosurgery and Center for Stem Cell and Regenerative Medicine. Dr. Wu earned her PhD in Molecular and Human Genetics from Baylor College of Medicine and completed postdoctoral training at Yale University and Stanford University. Her research integrates neuroscience, stem cell biology, genomics, and bioinformatics to investigate: Transcriptional mechanisms in neurodegeneration and regeneration Spinal cord injury pathology and recovery pathways Neural stem/progenitor cell differentiation networks Long non-coding RNA functions in CNS development Single-cell genomics of glial heterogeneity Recent publications demonstrate strong focus on glial cell dynamics in spinal cord injury (2023), exosome applications in disease management (2023), and astrocyte functions in neurodegeneration (2021). Her work consistently appears in high-impact journals including Nature Neuroscience, Cell Reports, and PNAS. Scientific Awards: NIH Pathway to Independence (K99/R00) Award NIH Ruth L. Kirschstein National Research Service Award ISSCR Annual Meeting Travel Award Senator Lloyd and B.A. Bentsen Investigator Award Dr. Wu leads an active research group investigating regeneration mechanisms and maintains NIH funding including R01 and R21 grants. Her laboratory ( jiaqianwulab.org ) currently includes postdoctoral fellows, graduate students, and research staff focused on neural transcriptomics and regenerative pathways.

Luca Lambertiniمشاهده پروفایل

پژوهشگر

• Genomic Imprinting
• Epigenetics
• Placental Research
• +۷ مورد دیگر

Dr. Luca Lambertini is a Researcher in the Department of Preventive Medicine at the Icahn School of Medicine at Mount Sinai, where he works in the Environmental Health Lab. His research focuses on identifying and characterizing biomarkers of improper fetal development that lead to chronic and developmental disorders in children. Dr. Lambertini's research spans seven main areas: Genomic Imprinting - studying allele-specific expression in human placenta using allele-specific PCR to measure loss of imprinting Long non-coding RNAs - identifying placental lncRNAs and monitoring their expression in fetal growth Mitochondrial DNA Methylation - deep sequencing placental mtDNA to identify methylation patterns in growth-restricted pregnancies Windows of Susceptibility - investigating how environmental exposures affect epigenetic programming during critical developmental periods PCOS Model - studying epigenetic dysregulation in PCOS pregnancies and child outcomes Mount Sinai Pregnancy Biobank - leading this initiative to collect placental tissue and cord blood for research National Children's Study - participating in this large-scale longitudinal study His recent publications demonstrate interdisciplinary work spanning urology, endocrinology, and regenerative medicine, with a common thread of investigating molecular mechanisms underlying developmental processes and disease pathogenesis. Dr. Lambertini has developed a patent for a new placenta sampling tool and collaborates extensively with clinical researchers across departments. Dr. Lambertini maintains laboratory space in the Atran Berg Laboratory Building on both the 3rd and 5th floors. His work bridges basic science with clinical applications, focusing on how early developmental experiences shape lifelong health trajectories through epigenetic mechanisms.

• Epigenetics
• Chromatin Biology
• Environmental Epigenetics
• +۴ مورد دیگر

Daphne Selvaggia Cabianca is a Group Leader at the Cabianca Lab , affiliated with Helmholtz Munich under the Functional Epigenetics (IFE) group . Her research focuses on understanding how environmental inputs modulate chromatin state, spatial organization, and function using the model organism C. elegans . Research Interests Epigenetic responses to environmental stress Chromatin 3D organization and gene regulation Nutrient and temperature effects on chromatin Stress memory mechanisms Key Techniques CRISPR-Cas9 genetic editing ChIP, DamID, ATACseq RNAseq and organismal stress assays Her work explores the interplay between environmental stimuli and chromatin dynamics across life stages, from development to aging. This research has implications for diseases like obesity, type 2 diabetes, and cancer with strong environmental links. Recent publications highlight her contributions to understanding fasting-induced chromatin reorganization, ferroptosis suppression in neuronal development, and environmental stress memory mechanisms. Collaborative lab members include doctoral researchers and postdocs working on various aspects of chromatin biology and C. elegans genetics. Lab Members Iratxe Estivariz (Postdoc) Fernanda Pabst (Doctoral Researcher) Carole Zaratiegui (Doctoral Researcher) Yuri D'Alessio (Doctoral Researcher) Lorenz Pudelko (Doctoral Researcher)

• Genetics
• Genetically conditioned diseases
• Non-pathogenic mutations
• +۸ مورد دیگر

Hans Rudolf Lytchoff Eiberg is an Associate Professor at the Department of Cellular and Molecular Medicine, University of Copenhagen, specializing in Medical Genetics. With a career spanning over 50 years since 1971, he is renowned for discovering that all blue-eyed humans descend from the same common ancestor. His work primarily focuses on genetic research using the Copenhagen Family Bank containing data from 850 families with at least 4 children. Dr. Eiberg earned his Cand. scient. in Biochemistry from Copenhagen University in Spring 1970, with specialization in Plant Physiology. His professional journey began as an Adjunct at Copenhagen University's Department of Medical Genetics from 1971-1975, progressed to Lecturer and Associate Professor starting in 1975, and evolved into leadership roles as Project Leader of the Family Bank (RC-link) at the Panum Institute since 1980, and Group Leader of the Genome Group/RC-link since 1994. His research interests encompass genetic and molecular mechanisms underlying inherited disorders and normal traits, with particular focus on eye diseases, skin diseases, psychiatric conditions, and common traits like eye and hair color. He has developed extensive laboratory methods for mapping the human genome, including collection of personal data and blood samples, and established techniques for antibody production, genetic polymorphism analysis, and linkage analysis using specialized software. Dr. Eiberg has explored 22 diseases for chromosomal localization of gene defects, successfully localizing more than 10 diseases for the first time in his laboratory. His recent publications reveal a strong focus on genetic mapping of various conditions including ulcerative colitis, psychiatric disorders, nephrotic syndrome, movement disorders, microcephaly, cataracts, and migraine. His work bridges classical genetic techniques with modern genomic approaches, maintaining a consistent emphasis on family-based linkage analysis while incorporating newer technologies like HLA typing and RNA analysis. Among his professional recognitions, Dr. Eiberg received the Silver Medal from Aarhus University in 1972 for his work on band differentiating techniques for human chromosomes. He has served as Vice Chairman of Human Gene Mapping 9 (chromosome 17-19) in Paris 1987 and has been an invited speaker at international conferences in Toronto, Oxford, London, and Verona. Dr. Eiberg has supervised numerous students including Marie-Louise Bisgaard, Ida Berendt, and µslaug Jon sd¢ttir, and has mentored PhD candidates Søren Eckwald and Yang Huan Ming. His laboratory maintains the Copenhagen Family Bank with extensive biological samples including serum, plasma, erythrocytes from all family members, and B-lymphocytes, DNA, mRNA from 300 families, supporting research on psoriasis, asthma, enuresis, migraine, and other conditions. As a member of the Human Genome Organization (HUGO), the Danish Society of Medical Genetics, and the European Society of Human Genetics, Dr. Eiberg has contributed significantly to the field through peer review for journals like Human Genetics, Clinical Genetics, and Genomics, while maintaining an active research program that has produced 190 research outputs to date.

• Cytogenetics
• Translocations and inversions
• Next generation sequencing
• +۷ مورد دیگر

Niels Tommerup is a Professor of Medical Genetics at the Department of Cellular and Molecular Medicine, University of Copenhagen, where he has served since 1996. He previously directed the Wilhelm Johannsen Centre for Functional Genome Research (2001-2013) and was Deputy Head of Department (2007-2019). His research group focuses on mapping balanced chromosomal rearrangements (BCR) to identify disease genes, regulatory domains (Topological Associating Domains), and novel genetic mechanisms, as well as characterizing germline chromothripsis and functional studies of non-coding RNA genes. Tommerup earned his DMSc. in genetics (1994) and medical degree (Cand.med., 1978) from the University of Copenhagen. His early career included positions as a junior doctor, research assistant, and senior doctor at the J.F. Kennedy Institute in Denmark (1978-89), and as a Consultant at the Department of Medical Genetics, Ullevål University Hospital in Oslo, Norway (1989-91). He has held visiting scientist positions at institutions in London, Australia, and Norway. His research spans multiple areas including cytogenetics, translocations and inversions, next generation sequencing, Topological Associating Domains, Long Range Position Effects, 3D-genome organization, and long noncoding RNAs. Tommerup coordinates the International Breakpoint Mapping Consortium (2014-present), involving over 100 diagnostic cytogenetic laboratories from more than 50 countries across six continents. His work has established that direct gene truncation may explain approximately 18% of BCR-associated developmental disorders, and that long-range position effects may be at least as frequent a cause as gene truncation. His recent publications reveal trends in understanding sex differential responses to viral infections (particularly focusing on the X-chromosome), linking anatomical variation to genetic variation, and developing methods for visualization of nuclear genome organization. His work bridges basic genomic research with clinical applications in developmental disorders, intellectual disability, autism, epilepsy, and other conditions. Det Classenske Fideicommis Boglegat (1987) Iris Preuss's Mindelegat (1994) First Harold Klinger Memmorial Award Lecture, Atlanta, USA (2006) Tommerup has supervised 27 PhD students and 10 postdocs. His editorial roles include service on the boards of Briefings in Functional Genomics, Clinical Genetics, Computational and Structural Biotechnology Journal, PeerJ, and Australasian Med J. He has organized numerous academic events including the International Summer School in Functional Genomics and the Wilhelm Johannsen Symposium. His international collaborations include the EU-concerted action Mendelian Cytogenetics Network and the International Breakpoint Mapping Consortium. Tommerup leads the Tommerup Group which coordinates the International Breakpoint Mapping Consortium and collaborates with Michael Talkowski's group at Harvard to accumulate the largest collection of sequence-resolved germline balanced chromosomal rearrangements. His laboratory combines DNA-DNA-interaction (Hi-C) studies with short and long read sequencing to improve the dissection of complex chromosomal rearrangements. The group has initiated systematic X-inactivation studies of sequence-resolved X;autosomal translocations and X-inversions, and conducts research on germline chromothripsis and host genetic factors underlying sex differential responses to viral infections.

• RNA Modifications
• Noncoding RNA Biology
• Cancer Epigenetics
• +۴ مورد دیگر

Sarah Rennie serves as Assistant Professor in the Department of Biology within the Faculty of Science at the University of Copenhagen, specializing in Computational and RNA Biology. Her research focuses on RNA modifications and their implications in cancer biology, particularly gastrointestinal and pancreatic cancers. Her primary research interests span RNA modifications, noncoding RNA biology, cancer epigenetics, and bioinformatics. Current work investigates N6-methyladenosine (m6A) modifications in pancreatic cancer progression, tumor microenvironment adaptations, and computational approaches for RNA analysis. Her lab develops and benchmarks bioinformatic tools for lncRNA research and RNA editing detection, bridging wet-lab experiments with computational modeling. Recent publications demonstrate significant contributions to understanding RNA modification roles in cancer, with 2024-2025 work appearing in high-impact journals including Cancer Science , Cell Reports , and EMBO Journal . Her research shows strong emphasis on translational applications, particularly in developing RNA-based cancer biomarkers and therapeutic targets. Rennie serves as Editor for the journal Non-coding RNA (2023), demonstrating leadership in the field. Her work receives consistent attention across academic platforms with multiple mentions on X (formerly Twitter), Reddit, Bluesky, and Mendeley. Her laboratory operates within the Computational and RNA Biology section at Ole Maaløes Vej 5 in Copenhagen, utilizing both experimental and computational approaches to study RNA modifications in disease contexts. Current projects focus on acid microenvironment adaptations in pancreatic cancer and deep learning applications for RNA modification analysis.

• Epigenetics
• Chromatin Structure
• Histone Modifications
• +۴ مورد دیگر

Prof. Asifa Akhtar is Scientific Member and Director at the Max Planck Institute for Immunobiology and Epigenetics (Freiburg) and Vice President of the Biological-Medical Section at the Max Planck Society. Her academic journey includes: PhD from Imperial Cancer Research Fund, London (1997) Postdoctoral research at EMBL Heidelberg and Adolf Butenandt Institute Group Leader at EMBL Heidelberg (2001–2009) Her laboratory investigates epigenetic regulation through: Chromatin dynamics and histone modification mechanisms Functional roles of long non-coding RNAs Cross-species gene regulation in flies, mice, and humans Integration of biochemical, genetic, and bioinformatic methodologies Major scientific recognitions include: Gottfried Wilhelm Leibniz Prize (2021) FEBS|EMBO Women in Science Award (2025) Election to EMBO (2013) and Leopoldina (2019) Ellis Island Medal of Honor (2023)

Antonio Giraldezمشاهده پروفایل

استاد

• Developmental Biology
• Gene Expression Regulation
• Genomics
• +۹ مورد دیگر

Antonio Giraldez is the Fergus F. Wallace Professor of Genetics at Yale School of Medicine, where he has led his research laboratory since 2007. He served as Director of Graduate Studies (2012-2016) and Chair of the Genetics Department (2017-2023). His academic appointments span multiple departments and centers including Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS), the Center for RNA Science and Medicine, Yale Cancer Center, Yale Center for Genomic Health, Yale Combined Program in the Biological and Biomedical Sciences (BBS), and the Yale Stem Cell Center. Professor Giraldez's research focuses on understanding the regulatory code that governs gene expression during vertebrate development after fertilization. His lab investigates four interconnected areas: genome activation during the maternal-to-zygotic transition, post-transcriptional regulation of gene expression, modeling of therapeutic mRNA design, and modeling of gene regulatory networks. Using zebrafish as a primary model organism combined with advanced genomic, computational, and imaging approaches, his lab has made significant contributions to understanding how transcription factors activate the embryonic genome and how RNA regulatory elements control mRNA stability and translation. Analysis of Professor Giraldez's recent publications reveals a strong focus on the molecular mechanisms of embryonic development, particularly the maternal-to-zygotic transition where control of development passes from maternal to embryonic factors. His work increasingly integrates high-throughput genomic approaches with computational modeling to decode regulatory elements in RNA that determine stability, translation efficiency, and tissue-specific expression - knowledge directly applicable to therapeutic mRNA design for gene therapy and vaccines. Scientific Awards and Honors: HHMI Faculty Scholar (2016) Blavatnik Award for Young Scientists National Finalist (2016) Vilcek Prize for Creative Promise in Biomedical Science (2014) Pew Scholar in Biomedical Sciences (2008) NYAS Blavatnik Young Investigator Award Finalist (2007) Professor Giraldez has established a productive research program with consistent funding and publication in top-tier journals. His lab maintains active collaborations with researchers across Yale and beyond, as evidenced by his frequent co-authorship with scientists from multiple departments. He has trained numerous students and postdocs who have gone on to independent research careers. The Giraldez Lab maintains a diverse team of researchers working at the intersection of developmental biology and genomics. The lab provides extensive resources including published datasets, computational tools like CRISPRscan, and detailed genomic annotations available through their data repository. Professor Giraldez's research program continues to advance our understanding of fundamental gene regulatory mechanisms with implications for both basic science and therapeutic applications.

• Cardiovascular Science
• Pulmonary Hypertension
• Extracellular Vesicles
• +۵ مورد دیگر

Fernando De La Cuesta is a Marie Curie Research Fellow at the Centre for Cardiovascular Science, University of Edinburgh, specializing in molecular mechanisms of pulmonary hypertension. His research centers on extracellular vesicle (EV) mediated communication between vascular cells, with emphasis on long non-coding RNA roles in pulmonary arterial hypertension pathogenesis. He developed a novel Cre-loxP recombination imaging technique that visually tracks EV transfer through fluorescent color switching in recipient cells, coupled with RNA-Seq analysis of EV cargo. Collaborative projects extend to proteomics of gene therapy vectors and Single-Cell RNA-Seq applications. Scientific recognition includes: Marie Skłodowska-Curie Actions Individual Fellowship 2016 (EV-LNC project) His supervision includes completed PhD training for Ilaria Passalacqua, with current research sustained through EU Commission grant funding. Methodological innovations in EV imaging and RNA analysis form the core technical infrastructure for ongoing vascular biology investigations.

Mamta Chawla Sarkarمشاهده پروفایل

استاد

• Virology
• Molecular Epidemiology
• Host-Pathogen Interactions
• +۵ مورد دیگر

Dr. Mamta Chawla Sarkar serves as Scientist G at the National Institute of Cholera and Enteric Diseases (NICED), Kolkata, leading virology research under the Indian Council of Medical Research. Her work bridges fundamental molecular studies and public health implementation through NICED's WHO Collaborating Centre designation and national surveillance networks for rotavirus and influenza. Her research expertise spans: Molecular epidemiology of enteric/respiratory viruses Host-pathogen interactomics using proteomics and RNA-seq Development of low-cost diagnostic assays Host-targeted antiviral therapeutics Recent publications reveal a strategic pivot toward lncRNA-mediated mechanisms in viral pathogenesis, with 8 of 15 recent papers exploring non-coding RNA roles in rotavirus and SARS-CoV-2 infection. The work demonstrates sophisticated integration of clinical samples from NICED's hospital collaborations with advanced OMICS platforms to identify druggable host pathways. Her scientific recognition includes: Fellowship of Indian National Science Academy (2020) DBT National Women Bioscientist Award (2013) ICMR Kanishka Oration Award (2017) Fellowships from NASI and West Bengal Academy of Science Mentorship and funding reflect sustained excellence: 21 PhD students trained (15 awarded), continuous project funding since 2006 including ICMR's Centre for Product Development (2019-2024) and DST-SERB grants. During pandemics, her lab provided critical diagnostic support while advancing mechanistic studies - exemplifying translational research impact. The laboratory operates within NICED's BSL-3 facility as part of the Virology Division, coordinating eastern India's viral disease surveillance through 12+ network laboratories. Current work focuses on lncRNA-mediated ferroptosis in rotavirus infection and HDAC6 modulation in SARS-CoV-2 replication.

Barbara Bakerمشاهده پروفایل

استاد

• Plant Pathology
• Plant-Microbe Interactions
• Plant Immunity
• +۵ مورد دیگر

Dr. Barbara Baker is a Professor in the Department of Plant and Microbial Biology at the University of California, Berkeley, with a joint appointment at the Plant Gene Expression Center. Her research focuses on plant immunity mechanisms against viral pathogens, particularly through NLR receptor-mediated immunity and RNA silencing pathways. Dr. Baker's research interests span Plant Pathology , Plant-Microbe Interactions , and Molecular Plant Immunity . Her laboratory investigates how plants recognize viral pathogens and activate defense responses, with particular emphasis on NLR immune receptors and the role of non-coding RNAs in immune regulation. Current work explores transcriptional regulation of immune responses and biotechnological applications for developing viral resistance in crop plants. Analysis of Dr. Baker's recent publications reveals a consistent focus on viral resistance mechanisms in plants, with increasing emphasis on molecular regulation of immune responses. Her work bridges fundamental plant immunology with practical applications for crop protection, particularly against economically significant viruses like tomato brown rugose fruit virus and cucumber green mottle mosaic virus. The research demonstrates strong integration of genetic, molecular, and biotechnological approaches. Dr. Baker actively collaborates with researchers across institutions including the United States Department of Agriculture and Shaanxi Academy of Forestry. Her laboratory employs advanced molecular techniques to develop artificial microRNA systems for viral resistance, representing innovative approaches to plant disease management. Current research directions include understanding transcriptional networks regulating plant immunity and developing multiplex resistance strategies for crop protection. The Plant Immunity and Pathogen Resistance Laboratory provides training in molecular plant pathology, genetic engineering, and plant-virus interactions. Students and researchers in the lab gain expertise in cutting-edge techniques for studying plant immune responses and developing biotechnological solutions for agricultural challenges.

Lars Maegdefesselمشاهده پروفایل

استاد

• vascular disease
• atherosclerosis
• aortic aneurysm
• +۴ مورد دیگر

Lars Maegdefessel is a Professor of Molecular Vascular Medicine at the Technical University Munich (TUM), School of Medicine and Health. He leads the Experimental Vascular Medicine unit at Klinikum rechts der Isar and serves as a DZHK Junior Group Leader. His research focuses on the therapeutic and biomarker potential of non-coding RNAs in vascular diseases including atherosclerosis, aortic aneurysm, and related vascular pathologies. Dr. Maegdefessel's research interests center on the role of non-coding RNAs in vascular diseases, with particular focus on the vulnerability of atherosclerotic vascular lesions and the progression and rupture of abdominal aortic aneurysms. His laboratory utilizes unique human biobank materials and various pre-clinical experimental models to investigate novel molecular approaches for combating cardiovascular diseases. His work spans from basic research on microRNAs, long non-coding RNAs, and circular RNAs to translational applications in vascular medicine. Analysis of Dr. Maegdefessel's publication record reveals a strong focus on non-coding RNA mechanisms in vascular pathology, with particular emphasis on atherosclerosis stabilization, aneurysm development, and vascular inflammation. His research has evolved from basic miRNA characterization to sophisticated therapeutic applications including targeted delivery systems and novel biomarker discovery. The publications demonstrate a consistent trajectory toward clinical translation of RNA-based vascular therapeutics. ERC Consolidator Grant (2023) Russel Ross Award from American Heart Association (2023) Heisenberg Professorship of German Research Foundation (2016) Werner Risau Award of American Heart Association (2016) ERC Starting Grant (2015) Prince Daniel Research Award of Swedish Heart and Lung Foundation (2014) Ragnar Söderberg Fellowship in Medicine (2014) Dr. Maegdefessel's research program includes extensive collaboration with international teams and utilizes advanced methodologies including RNA sequencing, microarrays, proteomics, and epigenomic analyses. His laboratory investigates ncRNA function in human vascular tissues and pre-clinical models, with recent work focusing on artery-on-a-chip technology and novel therapeutic delivery systems for vascular applications.

Yuyang Tangمشاهده پروفایل

استادیار

• HIV research
• Neurovirology
• HIV-associated neurocognitive disorders
• +۴ مورد دیگر

Yuyang Tang, PhD serves as an Assistant Professor of Medicine in the Division of Infectious Diseases at the University of North Carolina at Chapel Hill School of Medicine. Their research program focuses on understanding the molecular mechanisms of HIV persistent infection in the central nervous system and identifying risk factors contributing to HIV-associated neurocognitive disorders (HAND). Dr. Tang received their PhD from Peking Union Medical College and completed postdoctoral training at both the University of North Carolina at Chapel Hill and Emory University. This strong foundation in virology and infectious disease research has positioned them to investigate novel strategies targeting HIV reservoirs in the CNS. Dr. Tang's research interests span multiple critical areas of HIV pathogenesis, with particular emphasis on developing approaches to screen compound libraries for ligands that specifically recognize latently infected immune cells. Their work bridges molecular virology with clinical applications aimed at eradicating persistent HIV reservoirs. The research program employs advanced molecular techniques to identify signaling pathways that contribute to HAND pathogenesis and reservoir establishment in the CNS. Analysis of Dr. Tang's recent publications reveals a diverse yet focused research trajectory, with significant contributions to HIV neurovirology alongside collaborative work in stroke treatment, cancer therapeutics, depression subtyping, and aging research. This interdisciplinary approach demonstrates their ability to apply virological expertise to broader medical challenges while maintaining their core HIV research focus. Dr. Tang maintains an active research laboratory investigating HIV persistence mechanisms, with potential implications for therapeutic interventions targeting viral reservoirs. Their work represents a critical component of the broader HIV cure research initiative at UNC Chapel Hill, contributing to the institution's strong reputation in infectious disease research.