Deborah Frances Smith is a Professor affiliated with the Centre for Immunology and Infection. She has held former roles including Head Of Department, Biology Pro-Vice-Chancellor for Research, and Special Adviser to the Vice Chancellor in the Vice Chancellor's Office. She is also associated with CNAP (Cancer and Neuroscience Academic Programme) and the Jack Birch Unit. Her research focuses on leishmaniasis, parasite biology, and drug/vaccine development. Key projects include leading the 'C2D2 research 1a & 2b' (2012–2012) to establish sandfly colonies for leishmaniasis studies and co-investigating an integrated crystallization facility (2013–2018). She secured the Wolfson Research merit Award (2009–2010) from the Royal Society. Her work spans academic leadership, collaborative research, and translational medicine targeting neglected tropical diseases.
Dr. Michael Wilczek is Assistant Teaching Professor in Biotechnology/Bioinformatics at Northeastern University's Roux Institute. His research bridges virology, bioinformatics, and educational innovation, with particular focus on JC polyomavirus pathogenesis and graduate education reform. Key research domains include: Molecular mechanisms of viral infections Bioinformatic analysis of host-pathogen interactions Observational health and real-world evidence Evidence-based graduate education His publication record demonstrates: Expertise in JC polyomavirus cellular pathways Innovative applications of machine learning in virology High-throughput drug screening methodologies Health disparities research in aging populations
Masato Kato serves as Professor in the Department of Biochemistry at the University of Texas Southwestern Medical Center since 2020 and concurrently as Team Leader at Japan's National Institutes for Quantum and Radiological Science and Technology. His academic trajectory includes progressive appointments from Assistant Professor (2004-2014) to Associate Professor (2014-2020) at UT Southwestern, with prior postdoctoral training at Harvard Medical School and Nara Institute of Science and Technology. 2020-present: Professor, Department of Biochemistry, UT Southwestern 2020-present: Team Leader, National Institutes for Quantum and Radiological Science and Technology, Japan 2014-2020: Associate Professor, Department of Biochemistry, UT Southwestern 2010-2014: Assistant Professor, Department of Biochemistry and Internal Medicine, UT Southwestern 2004-2010: Assistant Professor, Department of Internal Medicine, UT Southwestern 1999-2004: Postdoctoral Fellow, Ellenberger Lab, Harvard Medical School 1998-1999: Postdoctoral Fellow, Hakoshima Lab, Nara Institute of Science and Technology Dr. Kato's research pioneers the biophysical characterization of protein phase separation, particularly focusing on low-complexity domains (LCDs) in neurodegenerative disease contexts. His work establishes fundamental mechanisms of biomolecular condensate formation, including hydrogel polymerization, liquid-solid transitions, and mutation-induced dysregulation in ALS/FTD. Key contributions demonstrate how C9orf72-encoded poly-dipeptides disrupt nucleocytoplasmic transport and how redox states regulate Ataxin-2 phase behavior, bridging structural biochemistry with pathological mechanisms. Analysis of his 22 publications reveals a cohesive research program centered on LCD-driven phase transitions. The most recent 15 articles (2012-2019) systematically investigate pathological aggregation in neurodegeneration, structural basis of condensate formation, and regulatory mechanisms like phosphorylation and oxidation. This body of work establishes LCDs as central players in both physiological RNA granule assembly and disease-associated solidification, with strong emphasis on C9orf72-related ALS/FTD mechanisms. Dr. Kato maintains active leadership within the McKnight Laboratory at UT Southwestern, where his team employs integrated approaches spanning structural biology, cell biology, and biophysics to dissect phase separation mechanisms. His collaborative network includes prominent neuroscience and biochemistry groups, with co-authorship on key studies in Cell, Science, and PNAS.
Prof. Dr. Markus Meissner is a Professor at the Faculty of Veterinary Medicine, Ludwig Maximilian University of Munich, leading the Chair of Experimental Parasitology. His research focuses on the molecular mechanisms of host cell invasion and modulation by Apicomplexan parasites, particularly Toxoplasma gondii and Plasmodium species. Research Group: Meissner Laboratory Location: Lena-Christ-Str. 48, 82152 Planegg-Martinsried Contact: markus.meissner@lmu.de His work investigates the secretory pathway of parasites, vesicular trafficking systems, and essential genes involved in host cell invasion and intracellular development. Toxoplasma gondii serves as a model organism for studying Apicomplexan biology, including nuclear division and CRMP complex functionality. Recent publications highlight the role of Rab GTPases in protein trafficking, chromatin remodeling in Plasmodium, and actin dynamics in parasite motility. Articles span topics such as egress factors, Golgi pathways, and lineage-specific organelle emergence, reflecting a multidisciplinary approach combining molecular biology, cell biology, and evolutionary analysis. The Meissner Lab includes PhD students (Peipei Qin, Yuan Song, Ella Schadt, Vitoria Catschor dos Santos) and postdocs (Dr. Wei Li, Dr. Miriam Rafajlovic). Research is conducted in Lena-Christ-Str. 48, Planegg-Martinsried, with a focus on experimental systems for studying parasite mechanisms.
Dr. Angelika Rambold is a Group Leader at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany, heading the Laboratory for Metabolic Organelle Networks in Immunology within the Department of Developmental Immunology. Previously affiliated with the University of Münster's Center for Molecular Biology of Inflammation (ZMBE) and Institute of Medical Biochemistry until January 2025, she investigates how intracellular organelle networks regulate immune cell function during inflammation, infection, and metabolic stress. Her research centers on dynamic interactions between mitochondria, lysosomes, lipid droplets, and autophagosomes during cellular adaptation to nutrient deprivation and pathogen challenge. Key interests include organelle communication mechanisms in immune cell activation, metabolic reprogramming in T cells and macrophages, and how defects in organelle networks drive primary immunodeficiencies like Chediak-Higashi syndrome. She employs advanced live-cell microscopy, super-resolution imaging, metabolomics, and single-cell transcriptomics to dissect these processes in primary immune cells and human disease models. Analysis of her publication record reveals consistent focus on mitochondrial dynamics as a central regulator of immune cell metabolism and fate determination. Landmark studies demonstrate TFEB-mediated itaconate synthesis for bacterial control in macrophages and coordinated organelle network responses during starvation, establishing critical links between organelle communication, immunometabolism, and disease pathogenesis across multiple immune cell types. Dr. Rambold serves as a supervisor in the Cells in Motion International Max Planck Research School (CiM-IMPRS) Graduate Programme, mentoring PhD students in interdisciplinary research. Her laboratory maintains active collaboration with the Center for Chronic Immunodeficiency (CCI) at the University of Freiburg to translate basic findings on organelle-mediated immune defects into clinical insights for patient-oriented research.
Prof. Casper Hoogenraad is a full professor in Molecular Neuroscience at the Department of Cell Biology, Faculty of Science, Utrecht University. His research focuses on understanding how intracellular protein trafficking underlies neuronal development and function, with particular emphasis on the microtubule cytoskeleton, synaptic cargo trafficking, and synaptic plasticity. He leads an active research group within Utrecht University's Cell Biology department and collaborates extensively with other neuroscience research groups. Education: PhD, Erasmus University Rotterdam (1996-2001) Postdoc, Massachusetts Institute of Technology (2002-2005) Hoogenraad's research spans three main themes: cytoskeleton dynamics during neurodevelopment and synaptic plasticity, motor proteins and adaptors as regulators of synaptic transport, and psychiatric and neurologic disease disorders linked to intracellular transport. His work combines genetics, biochemistry, molecular, and cellular biology methods in in vitro (neuron cultures), ex vivo (brain slices), and in vivo (mice) systems, along with advanced microscopy techniques including immunofluorescent confocal microscopy, high-resolution live cell imaging, and photo-activated localization microscopy (PALM). Analysis of Hoogenraad's recent publications reveals a strong focus on microtubule organization, neuronal polarity, and the molecular mechanisms underlying synaptic function and dysfunction. His work frequently explores how disruptions in intracellular transport contribute to neurological disorders including Alzheimer's disease, schizophrenia, and autism spectrum disorders, with particular attention to the relationship between cytoskeletal organization and cargo transport in neuronal compartments. Scientific Awards and Memberships: ZonMW-VIDI (2004) European Young Investigators (EURYI) award (2005) NWO-ALW VICI (2011) ERC Consolidator grants (2013) FENS-Kavli Network of Excellence (2014) European Molecular Biology Organization (EMBO) (2015) Young Academy of Europe (YAE) (2015) IBRO Kemali Prize (2016) Hoogenraad leads a research group studying neuronal development and function, with a particular focus on how intracellular transport mechanisms contribute to both normal brain function and neurological disorders. His laboratory employs a multidisciplinary approach combining molecular, cellular, and systems neuroscience techniques to investigate the molecular basis of neuronal polarity, synaptic plasticity, and the pathogenesis of neurological disorders. He has secured significant research funding through prestigious grants including ERC Consolidator grants. The Hoogenraad lab operates within the Cell Biology department at Utrecht University, collaborating with other research groups focusing on cellular dynamics, biophysics, and neurobiology. The lab utilizes advanced microscopy techniques including immunofluorescent confocal microscopy, high-resolution live cell imaging (spinning disc microscopy and total internal reflection fluorescence microscopy), and quantitative analysis using advanced high-resolution microscopy (photo-activated localization microscopy). Current lab technicians include Phebe Wulf and Bart de Haan.
Dr. Rebecca San Gil is a Lecturer at the School of Medical Sciences , University of Sydney, Australia. She leads the NeuroMolecular Discovery Group within the Neuroscience theme and is a member of the Charles Perkins Centre . Her research focuses on the molecular mechanisms underlying neurodegenerative diseases such as motor neuron disease (MND) and frontotemporal dementia (FTD) , with an emphasis on protein aggregation, stress responses, and therapeutic discovery. PhD, University of Wollongong (2018) Postdoctoral Research, Queensland Brain Institute (2018–2025) Endeavour Research Fellow (University College London) Her research spans molecular biology , neurosciences , and biochemistry , integrating techniques like genome-wide CRISPR screening , multi-omics analysis , and translational research . Key themes include the role of molecular chaperones , heat shock response , and protein folding dynamics in mitigating neurodegeneration. Dr. San Gil’s recent publications (2016–2025) highlight her work on TDP-43 pathology , heat shock proteins , and therapeutic strategies across ALS/FTD models. She has received awards such as the FightMND Early Career Research Fellow and the Sydney Dementia Network Future Research Leader Award (Travel Support Scheme) in 2025. Scientific Awards : FightMND Early Career Research Fellow, Sydney Dementia Network Future Research Leader Award (2025) Dr. San Gil actively mentors researchers like Celine CHYE and collaborates with institutions globally. Her team welcomes new members to explore neurodegenerative disease biology and therapeutic discovery .
Professor Trevor Lithgow is a Research Professor in Microbiology at Monash University, affiliated with the Monash Biomedicine Discovery Institute. He holds a PhD from La Trobe University (1992) and has held fellowships including the ARC Federation Fellowship (2008) and ARC Laureate Fellowship (2014). His research focuses on bacterial cell biology, antimicrobial resistance (AMR), and phage therapies, leveraging nanoscale imaging techniques like cryo-EM and super-resolution microscopy. He leads the Monash Centre to Impact AMR, an interdisciplinary initiative addressing global AMR challenges through collaborations across engineering, social sciences, and clinical medicine. Key achievements include the HFSP Tenth Anniversary Award (1999), Lemberg Medal (2020), and Royal Society of Victoria Medal (2017). His work on bacterial outer membrane assembly, phage-bacteria interactions, and structural analysis of the mitochondrial TOM complex has advanced understanding of pathogen resilience and novel antimicrobial strategies. Current projects include developing phage therapies and cross-sectoral AMR surveillance frameworks. Education: PhD in Biochemistry (La Trobe University, 1992) Research Interests: Bacterial cell surface visualization, nanoscale imaging, phage biology, AMR mechanisms Leadership: Director of Monash Centre to Impact AMR since 2020 Awards: 10+ national/international honors, including ARC Fellowships Publications span over 250 articles on bacterial membrane biology, AMR dynamics, and phage applications, with recent focus on polymyxin dependence in Acinetobacter and phage-driven resistance resensitization.
Prof Jean Van Den Elsen is a Professor of Biochemistry at the University of Bath , affiliated with the Department of Life Sciences and several research centers including the Centre for Sustainable Chemical Technologies (CSCT) , Centre for Therapeutic Innovation , and Milner Centre for Evolution . They are actively accepting doctoral students and leading multidisciplinary projects at the intersection of structural biology and immunology. Education: Not explicitly mentioned Appointments: University of Bath (current), with collaborations across Chemistry, Biology & Biochemistry departments Research Focus: The laboratory investigates protein structural biology in two major areas: Complement System Interactions: Studying how pathogenic microbes like Staphylococcus aureus evade host immunity through complement system manipulation , with structural analysis of proteins such as C3d and C5 complexes. This work directly informs vaccine design and autoimmune disease treatment . Glycation Mechanisms: Developing diagnostic tools for detecting non-enzymatic sugar modifications linked to diabetes , Alzheimer's , and aging, with commercial partnerships like Abcam . Article Trends: Recent publications demonstrate: Structural analysis of complement evasion proteins (2022-2025) Engineering knob domains as miniature antibodies (2023) Evolutionary studies on cooperative behavior (2021-2025) Advancements in peptide synthesis platforms (2022-2023) Applications of AI protein folding (2020) Scientific Contributions: ORCID: 0000-0002-0367-1956 BBSRC Funding recipient (2023) 100+ citations across 76 research outputs Student Mentorship: Directly supervising 4 current PhD students and 1 postdoc, with a track record of mentoring 11 previous students including Daphne Jackson Fellows and MSCA researchers. Collaborations: Maintains active partnerships with Dr. Tony James (Chemistry), Dr. Rob Williams (Biochemistry), and industry partners UCB Celltech and Porton Biopharma Ltd. Their work contributes to UN Sustainable Development Goals 3 (Good Health), 12 (Responsible Consumption), and 13 (Climate Action).
Maria Fällman is a Professor at the Department of Molecular Biology at Umeå University, where she also serves as Deputy Head of Department. She is affiliated with Molecular Infection Medicine Sweden (MIMS), a leading research center for molecular infection medicine in Sweden. Dr. Fällman's research focuses on understanding the molecular mechanisms behind bacterial adaptation to different environments, with particular emphasis on Yersinia pseudotuberculosis and Salmonella enterica Typhimurium. Her group investigates gene regulation critical for establishing and maintaining infections, bacterial stress responses, and the molecular mechanisms of the Type Three Secretion System (T3SS). The lab has developed advanced methods for RNA extraction from complex tissue samples and performs in vivo gene expression analyses. Her publication record shows consistent contributions to understanding bacterial pathogenesis, with recent articles in high-impact journals including Nature Communications, Science, and PLOS Pathogens. Her work spans from fundamental molecular mechanisms of bacterial virulence to computational approaches for analyzing pathogen stress responses. A significant contribution is the PATHOgenex database (http://www.pathogenex.org), containing gene expression data of over 30 human pathogens exposed to different stress conditions. Dr. Fällman leads the Maria Fällman Lab, which has made important discoveries including the finding that sub-lethal doses of Yersinia result in persistent infection in mice with reprogramming of bacterial gene expression. Current projects focus on stress response modeling and deciphering heterogeneous populations of infecting bacteria using single-cell RNA-seq.
Dr. Andrew Bassett serves as Head of the Cellular and Gene Editing Research group at the Wellcome Sanger Institute, where he develops cutting-edge genome engineering techniques using human pluripotent stem cells to investigate neurodegenerative diseases including Alzheimer's and Parkinson's. His work focuses on scaling genetic screening approaches and improving CRISPR specificity for modeling complex disease mechanisms. His academic training includes: PhD at the MRC Laboratory of Molecular Biology (MRC-LMB) with Andrew Travers on chromatin remodelling in heterochromatin formation Postdoctoral research with David Baulcombe at the University of Cambridge studying small RNA roles in chromatin modification Additional postdoctoral work with Chris Ponting at the MRC Functional Genomics Unit (MRC-FGU) in Oxford, where he pioneered CRISPR applications in Drosophila Bassett's research program centers on developing advanced genome engineering methodologies for precise modulation of gene expression networks during development and neurodegeneration. His group specializes in creating complex editing events (SNPs, paired knockouts, enhancer perturbations) within iPSC-derived models, with particular emphasis on epigenetic regulation and transcriptional control. Current projects integrate single-cell 'omics and phenotypic assays to decode genetic causes of neurodegenerative disorders through the OpenTargets consortium. Analysis of his 15 most recent publications reveals dominant trends in CRISPR technology development (35%), neurodegenerative disease modeling (30%), and single-cell functional genomics (25%). His work consistently bridges methodological innovation with disease mechanism studies, increasingly incorporating multi-omics approaches and expanding into cancer immunology and infectious disease applications since 2022. As group leader, Bassett mentors postdoctoral researchers and PhD students while securing major funding for genome engineering initiatives. His team operates within the Sanger Institute's Cellular Operations division and maintains critical partnerships with the OpenTargets consortium for therapeutic target validation. The laboratory specializes in high-throughput screening platforms using iPSC-derived neural and microglial models, with recent methodological advances including scSNV-seq and ONE-STEP tagging systems that significantly enhance precision genome editing capabilities.
Dr. Richard Y. Zhao is a tenured Professor in the Department of Pathology and Microbiology-Immunology at the University of Maryland School of Medicine. His research combines molecular biology, fission yeast genetics, mammalian biology, and virology to study virus-host interactions, particularly for HIV and Zika virus. He previously held academic positions at Northwestern University and Columbia University and has contributed to over 120 peer-reviewed articles. B.S., China Oceanography University (1981) M.S., Oregon State University (1995) Ph.D., Oregon State University (1991) Postdoctoral Training, Columbia University (1991-1992) Dr. Zhao's research focuses on: Virus-host interactions and pathogenicity High-throughput drug screening for antivirals Role of viral proteins in neuroinflammation and cancer Translational genomics in precision medicine His recent publications highlight SARS-CoV-2 ORF3a, Zika envelope proteins, and HIV protease inhibitors, emphasizing host-pathogen mechanisms across species. He has served on NIH panels and editorial boards for journals like Cell Research and Retrovirology . Scientific awards include: Fellow, American Academy of Microbiology (2019) Bernard L Mirkin Endowed Chair (2001-2004) Honorary Director, Shandong Gallo Institute (2009) Distinguished Service from SCBA (2015) Outstanding Service from CBA-USA (2016) Dr. Zhao also contributes to clinical diagnostics and personalized medicine through molecular testing and pharmacogenetics programs.
Giel van Dooren is an Associate Professor at the Research School of Biology , Australian National University. His research focuses on the cell biology and metabolism of apicomplexan parasites , particularly Toxoplasma gondii and Plasmodium falciparum , aiming to develop novel therapeutic strategies against these pathogens. Education: Bachelor of Arts/Bachelor of Science (University of Melbourne, 2000), PhD (University of Melbourne, 2005) His work explores three core areas: Nutrient acquisition (plasma membrane transporters), Mitochondrial biology (electron transport chain inhibitors, apicoplast-mitochondrion metabolic integration), and Toxoplasma life cycle (felid host genetics). Collaborations include Kiaran Kirk , Adele Lehane , Alex Maier , and Kevin Saliba . Recent publications highlight advancements in understanding mitochondrial transporter functions , divergent respiratory complexes , and nutrient pathway drug targets . His lab actively seeks innovative tools for combating parasitic diseases through molecular physiology and metabolomics. Scientific Awards: College of Science Dean’s Commendation for Excellence in Education - Teaching Excellence (2024) College of Science Dean’s Commendation for Excellence in Education - Outstanding Contribution to Student Learning (2023) Bancroft-Mackerras Medal of the Australian Society for Parasitology (2021) College of Science Dean’s Commendation for Excellence in Education (2020, 2020) Grants & Projects: Na+-dysregulating antimalarials: PfATP4 physiology (2024-2027) Metal transporters in Toxoplasma gondii (2023-2026) Amino acid acquisition in Apicomplexans (2023-2025) Targeting mitochondrial ETC in parasites (2020-2023) Regulating nutrient uptake in intracellular parasites (2020-2022)
Dijin Xu is an Associate Research Scientist in the Department of Microbial Pathogenesis at Yale School of Medicine, Yale University. His research focuses on lipid metabolism, immunology, and molecular mechanisms underlying metabolic disorders and host-pathogen interactions. He holds a PhD from Tsinghua University (2016). Education: PhD in Microbiology, Tsinghua University, 2016 Research Interests: Dr. Xu’s work spans immunology (e.g., B cell biology and somatic hypermutation), lipid metabolism (lipid droplet dynamics and adipose tissue homeostasis), and virology (antiviral defense mechanisms against SARS-CoV-2). His studies integrate cellular biology, molecular genetics, and biochemical approaches to understand disease processes. Publications Overview: His recent work explores mechanisms of lipid droplet regulation, metabolic disorder prevention, and immune system function. Notable contributions include studies on Rab GTPases in lipid storage and ELOF1’s role in antibody diversification. Labs & Affiliations: He is affiliated with the West Campus Integrative Science & Technology Center at Yale University, focusing on interdisciplinary research in cellular and molecular biology.
Anna Seekatz is an Assistant Professor in the Department of Biological Sciences at Clemson University, affiliated with the College of Science. Her research focuses on the gut microbiome, particularly its role in health and disease, with emphasis on Clostridioides difficile infection (CDI) and fecal microbiota transplantation (FMT). She received her PhD from the University of Maryland School of Medicine and completed postdoctoral training at the University of Michigan. Education : PhD, Molecular Microbiology and Immunology, University of Maryland School of Medicine, 2013 BS, Cellular and Molecular Biology, Western Washington University, 2006 Research Interests : Dr. Seekatz studies microbial interactions within the gut microbiota, including CDI pathogenesis and FMT mechanisms. Her lab investigates how microbial communities contribute to disease resistance and recovery, with a focus on identifying key species and metabolites involved in CDI clearance. Current projects include characterizing commensal Clostridia and their functional dependencies in the gut environment. Techniques employed include bioinformatics, animal models, and traditional microbiology. Lab & Advising : Her research group includes PhD students Sophie Millard, Clara Flores, Christine Woelfel-Monsivais, and postdoctoral fellow Disha Bhattacharjee. She teaches Pathogenic Bacteriology and a creative inquiry course on commensal Clostridia characterization. Lab Locations : Life Sciences Building 157A (Office), 160F and 172 (Labs).
