- Neuroscience
- Neurology
- Autism Research
- +۳ مورد دیگر
Carlos Portera-Cailliau is a Professor at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) , with joint appointments in the Departments of Neurology and Neurobiology . He co-directs the UCLA-Caltech Medical Scientist Training Program and is affiliated with UCLA’s Brain Research Institute , Integrated Center for Learning & Memory , and Neuroscience Theme . Dr. Portera-Cailliau earned a B.A. in Biochemistry & Cell Biology from UC San Diego (1990), followed by an MD-PhD from Johns Hopkins School of Medicine (1997). After neurology residency at Massachusetts General Hospital and Brigham & Women’s Hospital (2001), he conducted postdoctoral research at Columbia University and Cold Spring Harbor Laboratory. The Portera-Cailliau laboratory employs a symptom-to-circuit approach to study neurodevelopmental disorders like autism and Fragile X syndrome. Key research areas include sensory hypersensitivity , neuronal connectivity , and synaptic plasticity , using in vivo two-photon calcium imaging , patch-clamp electrophysiology , and head-fixed behavioral assays . Recent work explores GABAA receptor roles in cortical development and EPAC2 as a therapeutic target in Fragile X mice. Publications highlight neurodevelopmental circuit defects , excitation-inhibition imbalance , and interventions to restore plasticity in autism and Fragile X models. His lab also develops open-source tools like EZcalcium for calcium imaging analysis. Dr. Portera-Cailliau’s affiliations include UCLA’s Brain Research Institute , Integrated Center for Learning & Memory , and Neuroscience Theme . His research integrates behavioral assays , optogenetics , and chemogenetics to identify therapies for neuropsychiatric conditions.











