جست‌وجوی استاد و پژوهشگر

Mark Warcholمشاهده پروفایل

استاد

• Inner Ear Development
• Hair Cell Regeneration
• Auditory Neuroscience
• +۲ مورد دیگر

Mark Warchol is a Professor in the Department of Otolaryngology-Head and Neck Surgery and the Department of Anatomy & Neurobiology at Washington University School of Medicine, focusing on inner ear development and regeneration mechanisms. Education: BS in Physics, University of Washington, Seattle (1981) PhD in Neurobiology, Northwestern University, Evanston (1989) His research investigates molecular regulation of sensory receptor differentiation, including GATA3 transcription factor roles, PCP/JNK signaling in hair cell orientation, and epigenetic modifications (histone acetylation/DNA methylation) in regeneration. Current projects employ siRNA knockdown, small molecule inhibitors, and chick/mouse models to study ototoxic injury responses and stereocilia regrowth pathways. Analysis of 2010-2014 publications reveals consistent emphasis on hair cell regeneration mechanisms across avian and mammalian models, with key themes including transcriptional networks (PAX/EYA/SIX), epigenetic regulators, and collaborative genomic approaches using microarrays and RNAi screening. Dr. Warchol leads a research laboratory collaborating with Washington University's Department of Genetics on large-scale gene expression studies, utilizing organ cultures, in ovo chick models, and quantitative techniques to map regenerative pathways in sensory epithelia.

• Vestibular System
• Auditory Research
• Sensory Neurobiology
• +۳ مورد دیگر

Associate Professor Rebecca Lim is an academic at the University of Newcastle’s School of Biomedical Sciences and Pharmacy, specializing in Anatomy. She holds an Associate Professorship and serves as a Chief Investigator in vestibular research. Her work focuses on balance mechanisms, auditory systems, and the functional development of vestibular hair cells and neurons. Lim collaborates globally with vestibular experts and is affiliated with HMRI neuroscientists. She supervises multiple PhD students and coordinates the Anatomy course for Biomedical Sciences. Additionally, she is a faculty member of the Australian Course in Advanced Neuroscience (ACAN), training early-career researchers. Education: PhD (Australian National University) Bachelor of Science (Honours) and Bachelor of Science (University of Newcastle) Research Interests: Lim’s research explores sensory neurobiology, particularly the vestibular system’s central and peripheral components. She employs immunofluorescent labeling and microscopy to study neuronal proteins in the inner ear and brain. Her recent work includes NHMRC-funded studies on vestibular hair cell development and the role of central vestibular neurons in postural control. She investigates aging effects on vestibular function and motion sickness susceptibility, leveraging mouse models to dissect synaptic and circuit-level mechanisms. Publications & Grants: Lim has authored over 70 articles, including studies on efferent vestibular system anatomy, neurofilament changes in Parkinson’s disease, and organoid models of reproductive systems. She secured NHMRC grants totaling ~$4.1M for projects like targeting vestibular schwannoma, efferent system therapies for balance disorders, and bioelectronic neural interfaces. Current grants focus on drug delivery systems and precision neuromodulation. Teaching & Outreach: Besides undergraduate anatomy and neuroscience courses, Lim mentors third-year research students and oversees thesis supervision. Her ACAN role emphasizes advanced neuroscience training for early researchers. Labs & Collaborations: Lim’s research integrates with Hunter Medical Research Institute (HMRI) and international teams. She uses cutting-edge techniques like rotary cell culture systems for inner ear organoids and organic semiconductor-based neural interfaces to bridge basic science with clinical applications in balance disorders.

Choongheon Leeمشاهده پروفایل

استادیار

• Hearing Disorders
• Balance Disorders
• Vestibular Function Assessment
• +۴ مورد دیگر

Choongheon Lee is an Assistant Professor of Research in the Department of Mechanical Engineering at the University of Rochester’s Hajim School of Engineering & Applied Sciences. His research focuses on understanding vestibular and auditory system functions, with particular emphasis on peripheral vestibular function assessment, inner ear drug delivery, and pharmacological interventions for hearing and balance disorders. His work integrates biomechanical, electrophysiological, and pharmacological approaches to study inner ear physiology and develop therapeutic strategies. Education details are not explicitly listed in the provided information, but his current academic role reflects advanced training in biomedical engineering or related fields. Research interests include drug delivery mechanisms in the inner ear, pharmacological modulation of vestibular responses, and the neurobiology of hearing disorders. He employs animal models such as guinea pigs and mice to investigate endolymphatic hydrops, cochlear synapse loss, and the effects of therapeutic agents on sensory pathways. His recent publications explore topics such as cochlear fluid dynamics, the role of KCNQ2/3 ion channels in vestibular function, and the impact of CGRP on sensory hypersensitivity. While no awards are explicitly mentioned, his active research portfolio indicates contributions to understanding balance and hearing mechanisms. Advising and grant details are not provided in the text, though his involvement in collaborative projects and experimental setups suggests potential interdisciplinary collaborations. Lee’s work is closely tied to laboratory research within the Hajim School, focusing on translational studies that bridge basic science and clinical applications in audiology and vestibular medicine.

Carolin Wichmannمشاهده پروفایل

استاد

• Molecular Architecture of Synapses
• Auditory Neuroscience
• Electron Microscopy
• +۴ مورد دیگر

Prof. Carolin Wichmann is a Professor at the University Medical Center Göttingen (UMG), leading the Wichmann group within the Institute for Auditory Neuroscience . Her research focuses on the molecular and structural basis of synapse function, particularly at sensory synapses in the inner ear. Using advanced techniques like electron tomography, high-pressure freezing, and optogenetics, her group investigates how synapse architecture relates to functional properties in hearing mechanisms. Research Interests: Electron microscopy-based 3D structural analysis of synapses Optogenetic stimulation of inner hair cells Role of otoferlin and other synaptic proteins in hearing Calcium channel regulation in auditory synapses Developmental maturation of synaptic structures Funding & Projects: Recipient of REACT-EU/ERDF funding (2022-2023) for acquiring advanced STEM tomography equipment Led the ETomoH&H project studying ultrastructural changes in neurological and cardiological diseases Advising & Team: Current lab members: Julius Bahr, Ruchi Modgekar Prominent former members include Dr. Rituparna Chakrabarti and Dr. Jana Kroll Collaborates with multiple groups (e.g., Cretu, Goßler labs) on auditory neuroscience projects Labs & Facilities: Specializes in ultrastructural imaging with state-of-the-art microscopy Develops SynapseNet deep learning tools for synapse analysis Manages the Otoferlin and CABP2 registries for genetic deafness research

Jan-Philipp Machtensمشاهده پروفایل

استاد

• Neurophysiology
• Ion Channel Biology
• Membrane Proteins
• +۳ مورد دیگر

Prof. Dr. Jan-Philipp Machtens leads the Computational Neurophysiology group at the Institute for Biological Information Processes (IBI-1), Research Center Jülich. His work combines all-atom molecular simulations, machine learning, and experimental techniques to study neuronal signal processing at atomic resolution. Key research areas include ion channel/transporter function, sound amplification in the inner ear, and optogenetic tool development. Research Focus: Structure-dynamics-function relationships of membrane proteins SLC1 glutamate transporters and SLC26A5 (prestin) transport mechanisms Light-gated ion channels for optogenetics Multiscale computational methods for voltage-dependent proteins Techniques: Patch-clamp electrophysiology, time-resolved fluorescence spectroscopy, molecular dynamics simulations, machine learning Labs/Teams: Collaborates with the Calcium Channel Biology group (Prof. Patricia Hidalgo) and the Computational Structure Prediction team Recent work includes groundbreaking studies on outer hair cell electromotility mechanisms (2023), sodium channel stabilization (2023), and glutamate transporter dynamics in neurological disorders (2023). His lab's computational tools like g_elpot (2021) advance biomolecular electrostatic analysis.

• Otolaryngology
• Temporal Bone Research
• Otitis Media
• +۳ مورد دیگر

Sebahattin Cureoglu is an Associate Professor at the University of Minnesota Medical School, Department of Otolaryngology. His research focuses on temporal bone pathology, otitis media, and inner ear diseases, contributing to advancements in hearing and balance disorders. Research Interests Temporal Bone Studies Otitis Media Pathogenesis Inner Ear Malformations Host-Pathogen Interactions in Ear Infections Vestibular System Degeneration Research Trends His recent work explores bacterial infections in otitis media, histopathologic damage in meningitis, and vestibular system degeneration using animal models. Publications highlight collaborations with NIH and translational approaches to auditory nerve implants. Projects & Grants NIH NIDCD Resource Center for Human Temporal Bone Research (2022–2027) NIDCD Temporal Bone, Hearing & Balance Pathology Registry (2019–2025) Intracranial Auditory Nerve Implant Development (2018–2025)

• Stem Cell Biology
• Regenerative Medicine
• Inner Ear Hair Cell Research
• +۳ مورد دیگر

Louise Menendez serves as an Assistant Professor of Clinical Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of the University of Southern California. Her research is conducted at the Health Sciences Campus in Los Angeles, California. Dr. Menendez's research focuses on stem cell reprogramming and regenerative approaches for neurological and sensory disorders. Her primary interests include inner ear hair cell regeneration, direct lineage conversion of somatic cells, and modeling neurodegenerative diseases such as ALS and frontotemporal dementia using induced motor neurons. Her work bridges basic stem cell biology with clinical applications, particularly in auditory system regeneration and neurodegenerative disease mechanisms. Analysis of her publication history reveals a strong focus on cellular reprogramming techniques with three significant publications spanning 2018-2025. Her research trajectory shows progression from neurodegenerative disease modeling toward innovative methods for generating specialized cell types like inner ear hair cells. The 2025 bioRxiv preprint demonstrates her current work on scalable, virus-free reprogramming methods, representing an advancement over her earlier 2020 eLife publication on direct lineage conversion. Dr. Menendez collaborates extensively with prominent researchers at USC including Justin Ichida, Radha Kalluri, John Oghalai, Xin Wen, and Berislav Zlokovic. Her conceptual network derived from publications shows strong connections to hair cell biology, cell lineage reprogramming, fibroblast conversion, and neurodegeneration pathways, particularly involving C9ORF72-related ALS/FTD mechanisms.

• Stem Cell Biology
• Retinal Degeneration
• Gene Therapy
• +۶ مورد دیگر

Associate Professor Anai Gonzalez Cordero is a Group Leader at the Children’s Medical Research Institute (CMRI) and Conjoint Senior Lecturer at The University of Sydney. She leads research in stem cell-based therapies for deafness and blindness, focusing on retinal and auditory degenerative diseases. Her work involves developing organoid models to study human development and disease mechanisms. She established the Stem Cell & Organoid Facility at CMRI to support collaborative research. Education: PhD in retinal regeneration (Wellcome Trust Programme, 2013). Research expertise includes stem cell biology, developmental biology, and translational medicine. Research Interests: Stem cell-derived organoids for modeling diseases like Usher syndrome, gene and cell therapies, and mechanisms of sensory cell degeneration. Key projects involve retinal and inner ear organoid differentiation to advance treatments for inherited conditions. Grants & Collaborations: Multiple grants from NHMRC, MRFF, and other bodies for projects on stem cell therapies, retinal degeneration, and gene therapy development. Active collaborations include the Luminesce Alliance and University College London. Students: Advises PhD candidates Jasmeen Issar, Vivienne Kaiser, and William Yates on projects involving retinal diseases and gene therapy. Labs/Teams: Stem Cell Medicine Lab and Stem Cell & Organoid Facility at CMRI, fostering collaborative research in stem cell applications and disease modeling.

• Auditory Neuroscience
• Molecular Biology of Deafness
• Genetics of Hearing Disorders
• +۳ مورد دیگر

Dr Prathamesh Thangaraj Nadar Ponniah is a Research Fellow at the MDNL group within the School of Medical Sciences , University of Sydney , affiliated with the Kolling Institute . His work focuses on the molecular mechanisms underlying auditory disorders with translational applications. Research Focus: Pathophysiology of Meniere's disease, genetics of hearing loss, and molecular biology of inner ear development Key Approaches: Mouse models, cellular/molecular studies, and single-cell analysis Recent publications highlight his expertise in RNA-binding proteins, cochlear regeneration, and noise-induced hearing loss vulnerability. His research has attracted multiple competitive travel awards and research grants. Scientific Honors 2024 Research Support Grant (Royal North Shore Hospital) 2018 MBHD Travel Award (Göttingen, Germany) 2017 Constantiner Travel Scholarship (Tel Aviv, Israel) 2015 Aegean Conference Travel Award (Crete, Greece) 2015 Third Prize at Technion's Inter-Lab Competition 2014 Best Proposal at Technion's Inter-Lab Competition Dr Nadar Ponniah supervises students including Pablo Cruz-Granados, with a focus on single-cell multiome analysis of immune responses in Meniere's disease patients. His work contributes to the Neurosciences and Mental Health theme at his institution.

• Auditory Physiology
• Biophysics
• Neuroscience
• +۷ مورد دیگر

Dr. Joseph Santos-Sacchi is a Professor in the Departments of Surgery (Otolaryngology), Cellular and Molecular Physiology, and Neuroscience at Yale School of Medicine. His research focuses on understanding the biophysical mechanisms of hearing, particularly the role of outer hair cells (OHCs) and the motor protein prestin in cochlear amplification. He is affiliated with the Yale Ear Lab and has collaborations with researchers like Lei Song and Dhasakumar Navaratnam. Education: MPhil and PhD in Audiology from Columbia University (1978), BA in Psychology from Columbia College (1973). He holds an honorary Master of Arts from Yale University (1995). Research Interests: Electrophysiology of OHCs, molecular mechanisms of hearing, cochlear amplification, genetic models of hearing loss, and evolutionary adaptations in auditory systems. His work integrates biophysical techniques with molecular biology to study auditory transduction. Publications Highlight Trends: Recent work emphasizes prestin’s structural and functional dynamics, naked mole-rat hearing adaptations, and mitochondrial mechanisms in hearing loss. Articles span biophysics, genetics, and evolutionary biology, often linking molecular details to system-level auditory function. Awards: Awarded the Honoris Cuasa Master of Arts by Yale University in 1995 for contributions to auditory research. Grants & Advising: His research is supported by grants focusing on cochlear mechanics and deafness mechanisms. No formal student advisees are listed, though collaborations involve postdoctoral researchers. News coverage highlights his exploration of links between hearing loss and neurodegenerative diseases like Alzheimer’s. Labs & Teams: Lead researcher at the Yale Ear Lab, part of the Yale Center for Cellular and Molecular Imaging (CCMI), and collaborates with interdisciplinary teams in neuroscience and physiology.

Amy Kiernanمشاهده پروفایل

دانشیار

• Sensory Organ Development
• Genetics
• Molecular Biology
• +۳ مورد دیگر

Amy Kiernan, Ph.D., is an Associate Professor in the Department of Ophthalmology at the University of Rochester School of Medicine and Dentistry (SMD). Her research focuses on understanding molecular pathways in sensory organ development using mouse genetics. Key projects include studying Notch signaling and SOX2 in inner ear and eye development, with applications to therapies for deafness, vision loss, and vestibular dysfunction. She leads the Kiernan Lab, which employs advanced genetic tools like conditional gene targeting to investigate sensory organ formation and disease. Education: PhD in Biology from Boston College (1997), BA in Biology from College of the Holy Cross (1992). Research Interests: Sensory organ development, Notch signaling pathways, SOX2 transcription factor roles, mouse genetic models of glaucoma and deafness. Current projects address anterior segment dysgenesis (ASD), JAGGED1’s role in inner ear precursor cells, and SOX2’s role in prosensory lineage development. Recent Work Trends: Recent articles emphasize Notch pathway regulation in supporting cells and vestibular function (2025), Notch1’s role in cochlear maturation (2022), and SOX2’s impact on inner ear neurogenesis (2017). Studies often integrate mouse models to explore translational therapies for sensory organ diseases. Labs/Teams: Kiernan Lab at URMC, collaborating with experts in otology, ophthalmology, and developmental biology. The lab’s work bridges basic science and clinical applications, particularly in understanding congenital defects and age-related sensory decline.

Aziz El Amraouiمشاهده پروفایل

پژوهشگر

• Sensory Neuroscience
• Hearing Disorders
• Vision Impairment
• +۱۲ مورد دیگر

Aziz El Amraoui is a leading researcher and Head of the Progressive Sensory Disorders (PSD) research unit at the Institut de l’Audition, part of the Institut Pasteur in Paris, France. His work focuses on understanding and treating progressive sensory impairments, particularly those affecting hearing, balance, and vision, with a special emphasis on Usher syndrome. His research spans molecular genetics, advanced imaging, electrophysiology, and gene therapy. He investigates disease mechanisms, environmental modulators (e.g., aging, noise), and develops innovative treatments using AAV vectors, mini-genes, and CRISPR-based technologies. His team utilizes murine and porcine models to study disease progression and therapeutic efficacy across species. Recent key discoveries include identifying CLRN2 as a novel deafness gene (DFNB117), developing effective gene therapy for progressive hearing loss with a narrow therapeutic window, and resolving the Usher vision loss paradox by identifying the role of calyceal processes in human photoreceptors—structures absent in mice. His publication record shows consistent output in high-impact journals such as Molecular Therapy, EMBO Molecular Medicine, and PNAS, with work spanning genetics, neurobiology, and translational medicine. His research has direct implications for early diagnosis, personalized treatment, and the development of scalable gene therapies for sensory disorders. Progressive Hearing Loss and CLRN2 gene therapy Usher Syndrome pathogenesis and treatment Evolution of sensory systems (e.g., spectrin βV) Noise- and age-induced hearing loss Vestibular deficits in deafness Gene editing and delivery systems He leads multiple funded projects including FFB USH1B, UsherModels, HearInNoise, and TherapUsher, and actively mentors PhD and Master’s students. His collaborative network includes institutions in the UK, Germany, and beyond. Aziz El Amraoui’s work is central to advancing precision medicine for sensory disorders, bridging fundamental science with therapeutic innovation to improve the lives of millions affected by hearing and vision loss.

Jennie Cederholmمشاهده پروفایل

دانشیار

• auditory neuroscience
• electrophysiology
• sensory neuroscience
• +۶ مورد دیگر

Jennie Cederholm is an Associate Professor and Head of Physiology at the University of New South Wales (UNSW), Faculty of Medicine & Health, School of Biomedical Sciences. She maintains her research laboratory at the Translational Neuroscience Facility, Level 3SW, Wallace Wurth, UNSW. Dr. Cederholm earned her MSc in Medical Biology from Linköping University in Sweden and completed her PhD in Biomedical Sciences from the University of South Australia, Adelaide. She further enhanced her educational credentials with a Graduate Certificate in University Learning and Teaching from UNSW Sydney. Her research program focuses on auditory neuroscience, with particular expertise in integrated cellular and systems electrophysiology. Dr. Cederholm has developed significant expertise in biophysical analysis of recombinant protein expression in neurons, evoked potential electrophysiology analysis of sensory circuits, and transcriptomic analysis of gene regulation in response to physiological stimuli. Her groundbreaking work on purinergic hearing adaptation led to a patent filing that enables prediction of vulnerability to noise-induced hearing loss, with support from both industry partners and NHMRC Ideas grants. Her research demonstrates a clear trajectory from fundamental neuroscience discoveries to clinical applications , particularly in developing diagnostic tools and therapeutic approaches for hearing disorders. Dr. Cederholm has received numerous accolades including the Mark A. Smith prize (2010), Advanced Higher Education Fellowship (2021), School of Biomedical Sciences Teacher of the Year (2022), and multiple Faculty of Medicine & Health awards in 2023. She serves as the NSW Coordinator of the Australian Brain Bee Challenge since 2017 and co-leads the Faculty of Medicine & Health Gender Equity group. As an education-focused academic, she teaches extensively across UNSW Medicine and Science programs in Physiology and Neuroscience. Dr. Cederholm has supervised 3 ILP students and 7 Honours students, and currently supervises a PhD student in auditory neuroscience. She has secured significant funding as a Chief Investigator on multiple category I grants including NHMRC and Australia's Economic Accelerator Seed grant for projects utilizing Bionic-array Directed Gene Electrotransfer (BaDGE®) technology for treating brain disorders and macular degeneration. Dr. Cederholm is actively engaged in translational research through her role as co-inventor on a patent related to hearing diagnostics and through her leadership in the Australian and New Zealand Purine Club, which she helped establish as a forum for researchers studying purinergic signaling.

• Hearing and Balance Disorders
• Neurobiology
• Neurology
• +۶ مورد دیگر

Dhasakumar Navaratnam, MD, PhD, is a Professor of Neurology at Yale School of Medicine, with clinical and research expertise in hearing and balance disorders, stroke, and auditory neuroscience. He directs Yale's clinical neuroscience module for medical students and leads the Navaratnam Lab, focusing on molecular mechanisms of auditory/vestibular physiology and regeneration. His affiliations include Yale Medicine, Stroke Center, Hearing & Balance Program, and Interdepartmental Neuroscience Program. MD: University of Colombo (1986) PhD: Oxford University (1991) Residency/Postdoc: University of Pennsylvania (2001/1997) Research interests span auditory neuroscience, stroke pathology, and regenerative medicine. Key themes include electrical resonance in hair cells via ion channel interactions, Prestin's role in cochlear amplification, Id2-mediated regeneration in auditory epithelium, and cholinergic synaptic function. His lab explores molecular scaffolding proteins and cyclic AMP pathways in cellular regeneration. Recent publications cover high-frequency prestin dynamics, clot composition in stroke etiology, single-cell transcriptomics for inner ear regeneration, and clinical imaging strategies for dizziness. Articles integrate biophysical, molecular, and clinical approaches across neuroscience and neurology disciplines. Dr. Navaratnam contributes to Yale's Stroke Center clinical trials using single-cell RNA sequencing and serves as course director for neuroscience education. His clinical practice at Yale New Haven Hospital includes Hearing & Balance Center and 24/7 stroke service.

• Vestibular System
• Inner Ear Physiology
• Hair Cell Biology
• +۵ مورد دیگر

Ruth Anne Eatock is a Professor in the Department of Neurobiology at the University of Chicago, where she leads research on mechanosensory signaling in the inner ear. Her laboratory focuses on the mouse utricle to study fundamental neurobiological questions including mechanotransduction, sensory mapping, synaptic transmission across calyceal synapses, and neural encoding of sensory information in primary afferent neurons. PhD in Biology from Caltech, Pasadena B.Sc. Honours in Neurobiology from McGill University, Montreal M.Sc. in Biology from McGill University, Montreal Auditory Physiology training at MIT & Harvard, Cambridge/Boston Dr. Eatock's research centers on vestibular physiology with specific expertise in hair cell biology, ion channel function, and neural coding in the inner ear. Her work investigates how mechanosensitive receptor cells and primary afferent neurons process information about head movements and position. She has made significant contributions to understanding voltage-gated potassium, sodium, and calcium channels in vestibular hair cells, and how these channels shape neural signaling in the vestibular system. Her research program integrates electrophysiological, molecular, and behavioral approaches to understand sensory processing in the vestibular system. Analysis of her recent publications reveals a strong focus on potassium channel subunits (particularly KV1.8/Kcna10) and their role in vestibular hair cell function, sodium channel diversity in vestibular ganglion neurons, and the structural organization of vestibular hair cells including mirror-image orientation and membrane contact sites. Her work demonstrates how specific ion channel properties enable precise neural coding of vestibular stimuli, with implications for understanding balance disorders and developing potential therapeutic approaches. Dr. Eatock served as Principal Investigator on NIH grant R01DC012347 (Synaptic Processing in the Vestibular System) from February 2012 to February 2023. Her laboratory has trained numerous students and postdoctoral fellows who have gone on to successful careers in neuroscience and related fields. She has made significant methodological contributions to the field, particularly in techniques for recording from hair cells and vestibular afferents. The Eatock Lab at the University of Chicago comprises a team of researchers investigating signaling mechanisms in the inner ear. The lab maintains strong collaborations with other laboratories studying sensory systems, both within the University of Chicago and at other institutions. Current research focuses on understanding how specific ion channel properties enable precise neural coding of vestibular stimuli, with implications for understanding balance disorders and developing potential therapeutic approaches.