جست‌وجوی استاد و پژوهشگر

Harris H. Wangمشاهده پروفایل

دانشیار

• Systems Biology
• Synthetic Biology
• Genome Engineering
• +۱۷ مورد دیگر

Harris H. Wang is an Associate Professor in the Department of Systems Biology and Department of Pathology and Cell Biology at Columbia University's Vagelos College of Physicians and Surgeons, where he also serves as Interim Chair of Systems Biology. He is affiliated with the Center for Computational Biology and Bioinformatics (C2B2) and the Integrated Program in Cellular, Molecular and Biomedical Studies (CMBS). B.S., Physics and Mathematics, MIT Ph.D., Biophysics, Harvard University Dr. Wang's research lies at the intersection of systems and synthetic biology, focusing on developing foundational technologies for genome engineering, microbiome manipulation, and synthetic genomics. His lab pioneers methods such as MAGE, MAGIC, CAST, and CAMII to enable high-throughput genetic manipulation, in situ microbiome engineering, and AI-driven microbial culturomics. Key research themes include understanding microbial community dynamics, engineering cellular memory systems, designing biocontained genetic circuits, and applying synthetic biology to human health challenges in personalized medicine and infectious disease. His recent publications reveal a strong trend in spatial and functional metagenomics, CRISPR-based microbiome editing, and synthetic biology tools for data storage and genetic stability. The articles span high-impact journals like Nature , Science , and Nature Biotechnology , reflecting his leadership in developing scalable, programmable biological systems. Scientific Awards: NIH Director’s Early Independence Award Forbes 30 Under 30 in Science Sloan Research Fellowship NSF CAREER Award ONR Young Investigator Award Burroughs Wellcome Fund PATH Award Schaefer Scholar Blavatnik National Award Vilcek Prize PECASE Dr. Wang has advised numerous PhD and postdoctoral researchers, many of whom have gone on to independent scientific careers. His lab is supported by major grants from NIH, NSF, DARPA, DOE, and foundations including the Bill & Melinda Gates Foundation and CZ Biohub NY. He is actively involved in educational initiatives, including organizing Columbia’s iGEM team and the Cold Spring Harbor Laboratory Synthetic Biology course. The Wang Lab is based at the Columbia University Irving Medical Center and is part of national consortia such as the Engineering Biology Research Consortium (EBRC) and the Genome Project-Write (GP-Write) initiative. The lab develops and applies cutting-edge technologies in automation, machine learning, and synthetic biology to engineer microbiomes for applications in medicine, global health, and climate change.

Vadim Cherezovمشاهده پروفایل

استاد

• Membrane Protein Structure and Function
• G Protein-Coupled Receptors (GPCRs)
• Lipid-Protein Interactions
• +۳ مورد دیگر

Vadim Cherezov, the Ester Dornsife Chair in Biological Sciences and Professor at the University of Southern California (USC), leads groundbreaking research in membrane protein structure and function. Affiliated with the Bridge Institute, Department of Chemistry, and Michelson Center for Convergent Bioscience, his work focuses on GPCRs, ion channels, and transporters—critical targets for drug discovery. His team leverages advanced techniques like Lipidic Cubic Phase (LCP) and Serial Femtosecond Crystallography (SFX) at XFEL facilities to solve high-resolution structures under physiological conditions. Institutional Affiliations: Bridge Institute, USC Michelson Center, Department of Chemistry, Department of Pharmacology and Pharmaceutical Sciences. Key Collaborations: Katritch Lab, Kuhn Lab, NIH, European XFEL. His research explores the role of lipids in modulating GPCR function, addressing diseases like Alzheimer’s, diabetes, and cancer. By solving the structure of the A 2A adenosine receptor via sulfur SAD phasing at XFEL, Cherezov’s lab demonstrated de novo phasing without heavy atoms. This breakthrough enables structural studies of previously intractable membrane proteins. Scientific Awards & Grants: NIH R01 GM108635, U54 GM094618, U54 GM094599, R01 GM095583 Science Signaling Breakthroughs of the Year (2014) Cherezov mentors a dynamic team, including postdocs (e.g., Dong-Gyun Kim), graduate students (e.g., Behnaz Davoudinasab), and alumni (e.g., Benjamin Stauch at Eli Lilly, Nairie Michaelian at Genentech). His lab’s publications span Nature , Science , and Cell , with recent work on Science Advances (2025) addressing ABEL-FRET for GPCR dynamics.

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

• Biomaterials
• Tissue Engineering
• Regenerative Medicine
• +۱۲ مورد دیگر

Professor Hala Zreiqat AM is a leading biomedical engineer at The University of Sydney , serving as the Director of the ARC Training Centre for Innovative BioEngineering . A Fellow of all major Australian academies (AAS, ATSE, FAHMS, FRSN), she develops 3D printed bioceramics for bone regeneration while championing diversity through initiatives like the IDEAL Society and BIOTech Futures mentorship program. Her work bridges academia, clinical practice, and industry in musculoskeletal research . Research Focus: Her lab creates synthetic bone scaffolds that mimic natural bone architecture, strength, and porosity, enabling non-rejected bone regeneration via patient-matched implants. Key applications include orthopaedic, dental, and maxillofacial repair , with over $18M in competitive funding and multiple patents. Current projects explore AI-driven scaffold performance prediction and anti-senescence strategies for aging-related bone loss. Scientific Trends: Recent publications highlight 3D printed nanovoxelated ceramics , antisenescence biomaterials , and multifunctional theranostic platforms . Her team integrates machine learning for scaffold design, atom probe tomography for interface analysis, and two-photon imaging for cellular monitoring in 3D environments. 2021-2022 Fulbright Senior Scholar 2018 NSW Premier's Woman of the Year 2019 Eureka Prize for Innovative Use of Technology Fellow of Australian Academy of Science (2021) Over $18M in research funding Teaching & Leadership: She designed core courses like Tissue Engineering and Nanomaterials in Medicine , mentoring 158 students in 2020 alone. As Chair of CAAR (2020-2023), she strengthens Australia-Arab collaborations. Her lab trains early-career researchers , with alumni now in academia and industry.

Xiaoyu Caiمشاهده پروفایل

استادیار

• Lung Regeneration
• Inflammation Resolution
• Aging Biology
• +۵ مورد دیگر

Xiaoyu Cai is an Assistant Professor at the Department of Medicine, Loyola University Chicago, specializing in lung regeneration, aging biology, and stem cell plasticity. Her research focuses on the molecular mechanisms governing alveolar type 2 (AT2) stem cell dynamics during aging and chronic lung diseases. Education: Bachelor of Medicine (Peking University, 2012), Master of Science (Peking University, 2015), PhD in Biology of Aging (USC & Buck Institute, 2021) Key Research Areas: Lung regeneration, inflammation resolution, stem cell aging, 3D organoid cultures Methodologies: Single-cell multiome, mouse genetics, multicellular organoid systems Collaborations: Translational partnerships with clinical teams for bench-to-bedside applications Dr. Cai's recent work explores lineage plasticity in aged lung stem cells, ferroptosis suppression via CRISPR screens, and cellular aging atlases across species. She previously held a postdoctoral position at Genentech Inc. and maintains a professional lab website. Contact: xcai2@luc.edu | Office: CTRE 123

Angelika Ramboldمشاهده پروفایل

استادیار

• Immunology
• Cell Biology
• Metabolism
• +۳ مورد دیگر

Dr. Angelika Rambold is a Group Leader at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany, heading the Laboratory for Metabolic Organelle Networks in Immunology within the Department of Developmental Immunology. Previously affiliated with the University of Münster's Center for Molecular Biology of Inflammation (ZMBE) and Institute of Medical Biochemistry until January 2025, she investigates how intracellular organelle networks regulate immune cell function during inflammation, infection, and metabolic stress. Her research centers on dynamic interactions between mitochondria, lysosomes, lipid droplets, and autophagosomes during cellular adaptation to nutrient deprivation and pathogen challenge. Key interests include organelle communication mechanisms in immune cell activation, metabolic reprogramming in T cells and macrophages, and how defects in organelle networks drive primary immunodeficiencies like Chediak-Higashi syndrome. She employs advanced live-cell microscopy, super-resolution imaging, metabolomics, and single-cell transcriptomics to dissect these processes in primary immune cells and human disease models. Analysis of her publication record reveals consistent focus on mitochondrial dynamics as a central regulator of immune cell metabolism and fate determination. Landmark studies demonstrate TFEB-mediated itaconate synthesis for bacterial control in macrophages and coordinated organelle network responses during starvation, establishing critical links between organelle communication, immunometabolism, and disease pathogenesis across multiple immune cell types. Dr. Rambold serves as a supervisor in the Cells in Motion International Max Planck Research School (CiM-IMPRS) Graduate Programme, mentoring PhD students in interdisciplinary research. Her laboratory maintains active collaboration with the Center for Chronic Immunodeficiency (CCI) at the University of Freiburg to translate basic findings on organelle-mediated immune defects into clinical insights for patient-oriented research.

• Rheumatology
• Inflammatory Diseases
• Fibroblast Biology
• +۳ مورد دیگر

Christopher Buckley is the Kennedy Professor of Translational Rheumatology and Director of Clinical Research at the Kennedy Institute of Rheumatology, University of Oxford. He holds concurrent roles as Director of NIHR Infrastructure for Birmingham Health Partners. His research focuses on fibroblast biology in rheumatoid arthritis (RA), stromal cell interactions, and translational medicine approaches to stratified therapy. He leads the Arthritis Therapy Acceleration Programme (A-TAP), advancing precision medicine strategies for immune-mediated inflammatory diseases. Educations: BSc Biochemistry, University of Oxford (1985) MBBS Medicine, Royal Free Hospital, London (1990) DPhil in Molecular Medicine (Wellcome Trust Fellowship) under Prof. John Bell (Oxford) Research Interests: Pathogenic fibroblast subpopulations in RA and systemic sclerosis Tissue-resident memory T cells in chronic inflammation Spatial transcriptomics of synovial and tendon tissues Pro-resolving fibroblast networks during inflammation resolution Development of biomarkers for disease flare/remission Awards & Leadership: MRC Senior Clinical Fellowship (2001) Arthritis Research UK Professorship (2002) Director, Birmingham NIHR Clinical Research Facility (2012-2017) Key Projects: Leading A-TAP's stratified pathology approach for drug development Investigating Wnt signaling in stromal inflammation Developing cellular atlases of joints using spatial transcriptomics

Yu Heمشاهده پروفایل

استادیار

• Condensed Matter Physics
• Quantum Materials
• Superconductivity
• +۳ مورد دیگر

Yu He is an Assistant Professor of Applied Physics and Physics at Yale University, affiliated with the Department of Physics. His research focuses on condensed matter physics and experimental techniques such as angle-resolved photoemission spectroscopy (ARPES) and x-ray scattering to study correlated electronic systems and quantum materials. Prior to Yale, he completed a Miller Research Fellowship at UC Berkeley (2019) after earning his Ph.D. in Applied Physics from Stanford University. Key research areas include metal-to-insulator transitions, superconductivity, 2D magnetism, and solid-state quantum simulation. He has contributed to advancements in material characterization techniques, including high-resolution ARPES using tabletop lasers. His work integrates crystal synthesis, electric transport measurements, and surface decoration to explore material properties. Education: B.S. in Physics from University of Science and Technology of China (USTC); M.S. in Electrical Engineering and Ph.D. in Applied Physics from Stanford University. Research Interests: Experimental condensed matter physics, quantum materials, superconductivity, and light-matter interaction studies. His current projects aim to dissect microscopic degrees of freedom (electronic, lattice, spin) in novel materials using cutting-edge spectroscopic methods. The lab employs complementary techniques like electric transport measurements and crystal growth to characterize material properties comprehensively. Awards: Miller Research Fellow, UC Berkeley (2019) Advising & Grants: No student advisees listed. Research supported by Yale University and prior fellowships. Labs & Teams: Leads a research group at Yale focused on experimental condensed matter physics, collaborating on projects involving advanced material characterization and quantum material discovery.

• Cancer Immunology
• Innate Lymphoid Cells
• Regulatory T Cells
• +۵ مورد دیگر

Dr. Tim Halim is a Sir Henry Dale Fellow and Junior Group Leader at the Cancer Research UK Cambridge Institute (CRUK Cambridge Institute), University of Cambridge. His primary research program focuses on pancreatic cancer, with thoracic cancer as a secondary research focus within the CRUK Cambridge Centre's structured research programs. Dr. Halim's research expertise lies at the intersection of cancer biology and immunology, with particular emphasis on innate lymphoid cells (especially ILC2) and regulatory T cells within the tumor microenvironment. His work investigates how these immune cell populations interact with cancer cells and influence tumor progression, metastasis, and response to therapy. His research has significant implications for developing novel immunotherapeutic approaches for pancreatic and thoracic cancers. His publication record demonstrates a consistent focus on the role of innate lymphoid cells in cancer, with recent work examining IL-33 and ILC2 in pancreatic cancer, cross-talk between ILC2 and regulatory T cells, and the influence of innate lymphoid cells on pancreatic stromal composition. His research employs advanced techniques including in vivo labeling, single-cell analysis, and fate-mapping approaches to understand immune cell behavior in cancer contexts. Dr. Halim has been awarded the prestigious Sir Henry Dale Fellowship, a joint fellowship from the Royal Society and Wellcome Trust that supports early-career researchers of outstanding promise working at the interface of basic and clinical science.

David Junckerمشاهده پروفایل

استاد

• Microfluidics
• Nanotechnology
• Lab-on-a-Chip
• +۶ مورد دیگر

David Juncker is a Professor and Department Chair of the Department of Biomedical Engineering at McGill University. He serves as a Principal Investigator at the McGill University & Genome Quebec Innovation Centre and holds associate memberships in the Department of Neurology and Neurosurgery, Department of Electrical and Computer Engineering, Division of Experimental Medicine, Department of Surgery, and Goodman Cancer Research Centre. His research focuses on micro- and nano-bioengineering technologies for bioanalysis, precision medicine, and organs-on-chips. Key areas include microfluidics, lab-on-a-chip devices, biomedical sensors, medical diagnostics, biomaterials, tissue engineering, and cancer biomarker discovery. His lab develops scalable antibody microarrays, self-powered diagnostic platforms, microfluidic probes for brain tissue perfusion, and nanogradients for neuronal navigation, with applications in cancer diagnostics, global health, and neuroscience. Recent publications (2023-2025) reveal strong emphasis on extracellular vesicle analysis, single-cell proteomics, 3D-printed microfluidic/organ-on-a-chip systems, and capillary-driven circuits. Key trends include low-cost point-of-care diagnostics, advanced circulating tumor cell isolation methods, and biomimetic synthetic vesicles for drug delivery, demonstrating translational potential in early disease detection. Dr. Juncker leads a highly interdisciplinary team comprising undergraduate and graduate students, post-doctoral fellows, and staff from diverse scientific, engineering, and cultural backgrounds. His lab actively recruits Canadian/permanent resident graduate students for projects on single extracellular vesicle and protein detection in cancer and infectious diseases, leveraging microfluidics and wearables for biomarker discovery. The Juncker Lab operates from the McGill University & Genome Quebec Innovation Centre (740 Dr. Penfield Avenue, Room 6206). It maintains a collaborative, multicultural environment focused on developing transformative micro- and nano-bioengineering technologies with significant potential impact on human health diagnostics and treatment.

• Molecular Imaging
• Biomedical Imaging
• Optical Coherence Tomography
• +۳ مورد دیگر

Adam de la Zerda is an Associate Professor at Stanford University's Department of Structural Biology (School of Medicine) and Electrical Engineering (by courtesy). He develops advanced optical molecular imaging technologies combining nanoparticle contrast agents and adaptive OCT systems for cancer and ophthalmic disease research. Technion-Israel Institute of Technology (BSc, 2005) Stanford University (PhD, 2011) UC Berkeley (Postdoctoral Fellowship) Research Themes : Virtual biopsy using machine learning-enhanced OCT Gold nanorod-based molecular contrast agents Speckle noise reduction for cellular resolution Needle beam optical coherence tomography angiography His 15 most recent publications demonstrate technical innovations in: Metasurface optics for extended depth-of-field Spectral deconvolution of multiple contrast agents Speckle modulation for improved diagnostic clarity Noninvasive lymphatic system mapping Scientific Honors : Pew-Stewart Scholar for Cancer Research AFOSR Young Investigator NIH Early Independence Award Forbes 30 Under 30 (x2) Chan Zuckerberg BioHub Investigator His lab team has developed clinical prototypes including OcuBell Inc. 's ophthalmic imaging systems and Visby Medical 's diagnostic platforms. Current research spans from in vivo glycoprotein imaging to de novo biosensor development for real-time disease monitoring in awake animal models.

Scott L. Diamondمشاهده پروفایل

استاد

• Mechanobiology
• Thrombolysis
• Coagulation
• +۱۰ مورد دیگر

Scott L. Diamond is the Arthur E. Humphrey Professor of Chemical and Biomolecular Engineering and Bioengineering at the University of Pennsylvania's School of Engineering and Applied Sciences. He serves as Director of the Penn Center for Molecular Discovery, Director of the Penn Biotechnology Masters Program (one of the largest in the country with over 130 students), and Associate Director of the Institute for Medicine and Engineering (IME). His laboratory is located in the Roy and Diana Vagelos Laboratories at 3340 Smith Walk, 1020 Vagelos Research Laboratories, Philadelphia, PA. Diamond's research spans multiple interconnected fields in blood biology and biotechnology. His work focuses on mechanobiology, thrombolysis, coagulation, bioadhesion, gene therapy, drug/device development, proteomics, drug discovery, systems biology, and microfluidics. His laboratory has developed numerous specialized microfluidic devices for studying blood clotting under various flow conditions, including 8-channel devices for high-throughput clotting assays, side-view devices for clot structure analysis, stenosis devices for high shear clotting assays, and impingement-post devices for studying von Willebrand factor fibers. Diamond's research group has pioneered approaches to model and predict blood function using systems biology principles. His team has developed computational models that integrate reaction-transport phenomena with platelet signaling networks to predict thrombus formation under flow. These models have enabled the development of 'virtual blood' computer simulations that can predict the effectiveness of anticoagulation drugs for individual patients, contributing significantly to personalized medicine approaches in hemostasis and thrombosis. His extensive publication record demonstrates a consistent focus on understanding the fundamental mechanisms of blood clot formation and dissolution. Recent work has emphasized microfluidic approaches for point-of-care diagnostics, patient-specific modeling of platelet function, and the development of novel therapeutic strategies for thrombotic disorders. His research bridges engineering principles with clinical hematology to address significant challenges in cardiovascular medicine. NSF National Young Investigator Award NIH FIRST Award American Heart Association Established Investigator Award AIChE Allan P. Colburn Award George Heilmeier Excellence in Research Award Elected Fellow of the Biomedical Engineering Society (BMES) Diamond has secured significant research funding, including a $2.8 million NIH grant for 'Blood Systems Biology' and a $9.5 million NIH grant for the Penn Center for Molecular Discovery. His laboratory has developed numerous microfluidic devices for blood analysis and has collaborated extensively with clinicians and industry partners. Diamond has served on advisory committees for NSF, NIH, AHA, and NASA, and has consulted extensively for industry and government. With over 180 publications and patents, his work has significantly advanced the understanding of blood clotting mechanisms and the development of diagnostic and therapeutic approaches for thrombotic disorders.

Trond Vidar Hansenمشاهده پروفایل

استاد

• Organic Chemistry
• Biochemistry
• Pharmacology
• +۳ مورد دیگر

Trond Vidar Hansen is a Professor at the Department of Pharmacy, University of Oslo , and leads the LIPCHEM research group . He collaborates with institutions including the University of Bergen and Vestlandets Innovasjonsselskap through the VITADEL project, which recently received NOK 5,000,000 in verification support from the Research Council of Norway. His research focuses on the synthesis and biological evaluation of specialized pro-resolving lipid mediators derived from omega-3 fatty acids, with applications in inflammation resolution, neuroinflammation, and drug development. University : University of Oslo Department : Department of Pharmacy Research Group : LIPCHEM Collaborations : University of Bergen, Vestlandets Innovasjonsselskap Research Interests : H Hansen's work centers on the organic synthesis of bioactive lipid derivatives, particularly pro-resolving mediators from omega-3 polyunsaturated fatty acids. His team investigates their roles in inflammatory disease models , neuroinflammation , and PPAR receptor activation , aiming to develop therapeutic agents for conditions like chronic pain, diabetes, and neurodegenerative disorders. The research integrates stereoselective chemistry , biochemical profiling , and pharmacological evaluation to validate these mediators' clinical potential. Recent Awards : 2025: NOK 2,000,000 verification support from Research Council of Norway 2025: Co-leader of NOK 5,000,000 VITADEL project Publications : His articles (2015–2024) reveal a focus on stereoselective synthesis of resolvins, protectins, and maresins, with applications in anti-inflammatory and neuroprotective therapies . Key subfields include omega-3 metabolite profiling , PPAR agonist design , and biosynthetic pathway elucidation , often utilizing human cell models and mouse disease models . Collaborative projects emphasize commercialization of academic research and translational medicine .

Moira Whyteمشاهده پروفایل

استاد

• Respiratory medicine
• Inflammation
• Neutrophil biology
• +۵ مورد دیگر

Moira Whyte serves as Sir John Crofton Professor of Respiratory Medicine and Head of Edinburgh Medical School at the University of Edinburgh, while directing the MRC University of Edinburgh Centre for Inflammation Research. Her leadership spans clinical academia and major research initiatives focused on respiratory pathophysiology. Her educational background includes a 1st Class B.Sc. (1981), M.B., B.S. (1984), and Ph.D. (1993) from the University of London, complemented by professional qualifications: M.R.C.P. (1987), F.R.C.P. (1998), and F.Med.Sci. (2005) from the Academy of Medical Sciences. Whyte's research centers on neutrophil biology, macrophage function, and hypoxia signaling pathways in respiratory diseases. Her work explores how oxygen-sensing mechanisms like HIF pathways regulate immune cell function in COPD, pulmonary fibrosis, and bacterial infections, with particular focus on cellular metabolism and inflammation resolution. Analysis of her 15 most recent publications reveals consistent focus on neutrophil and macrophage biology within respiratory diseases, with growing emphasis on metabolic regulation of immune responses. Her work bridges basic science (using zebrafish models) with clinical applications, particularly in COPD and pulmonary fibrosis. Her scientific recognition includes: 2014 OBE for Services to Respiratory Medicine 2014 Foundation Fellow of the European Respiratory Society 2005 Fellow, Academy of Medical Sciences 2002 Tudor Edwards Lecturer of the Royal College of Physicians 1994 Wellcome Trust Advanced Fellowship 1989 MRC Clinical Training Fellowship Whyte directs substantial research funding, including a £6.4M Wellcome Trust Clinical PhD Programme (ECAT-Plus) and multiple grants investigating macrophage function in COPD, hypoxia pathways in pulmonary fibrosis, and neutrophilic inflammation regulation. Her collaborative approach is evident in multi-institutional projects like the EME-TIPAC study on pulmonary fibrosis. As Director of the MRC Centre for Inflammation Research, she leads a multidisciplinary team investigating fundamental mechanisms of inflammation across multiple disease contexts, with particular strength in respiratory immunology and translational applications.

James C. Geeمشاهده پروفایل

استاد

• Biomedical Image Analysis
• Medical Imaging Computing
• Image Segmentation
• +۵ مورد دیگر

James C. Gee is a Professor of Radiologic Science in Radiology at the University of Pennsylvania's Perelman School of Medicine. He serves as Director of the Penn Image Computing and Science Laboratory and Co-Director of the Translational Biomedical Imaging Center , with affiliations in Bioengineering and Applied Mathematics graduate groups. His research focuses on biomedical image analysis, specialization in segmentation, registration, and morphometry applied to neurodegenerative diseases and multi-organ systems. Education : B.S. in Computer Science/Electrical Engineering (University of Washington, 1987), Ph.D. in Computer and Information Science (University of Pennsylvania, 1996) Research : Quantitative medical imaging methods, brain connectomics, neurodegeneration mapping, and translational imaging technologies Publications : 15+ recent works on AI-driven image analysis for Alzheimer's disease, cardiac amyloidosis, and radiomics applications Leadership : Directs MSE-DS Online Degree Program, co-chairs Radiology DCOAP Committee, and founded RISE (Radiology Initiative to Support Inclusive Excellence) His laboratory develops advanced computational tools like ITK-SNAP for biomedical imaging, with applications in both in vivo clinical imaging and ex vivo histology . The work spans cross-disciplinary collaborations in computer science, neuroscience, and clinical medicine.