جست‌وجوی استاد و پژوهشگر

Tsan Sam Xiaoمشاهده پروفایل

استاد

• Innate Immunity
• Inflammation
• Structural Biology
• +۶ مورد دیگر

Tsan Sam Xiao is a Professor in the Department of Pathology at Case Western Reserve University's School of Medicine. He is also a member of the Developmental Therapeutics Program at the Case Comprehensive Cancer Center, the Center for AIDS Research, and the Cleveland Center for Membrane and Structural Biology. His research focuses on structural and functional studies of gasdermin family proteins, inflammasomes, and inflammatory caspases, with applications in drug development targeting diseases like sepsis, multiple sclerosis, and AIDS. Xiao earned his PhD in Molecular Biophysics from the University of Texas Southwestern Medical Center in 2000, followed by postdoctoral training at Harvard Medical School and NIH before joining Case Western in 2014. Education: Bachelor of Science in Biological Sciences and Technology, Zhejiang University (1992) Master of Science in Developmental Biology, Chinese Academy of Sciences (1995) Doctor of Philosophy in Molecular Biophysics, University of Texas Southwestern Medical Center (2000) Research Interests: Mechanisms of gasdermin-mediated pyroptosis Structural biology of inflammasomes and innate immune receptors Modulation of inflammatory caspases using chemical inhibitors Antiviral immune responses, including SARS-CoV-2 interactions Lab Members: Syrena Bracey (MSTP Student) Brianna Busscher (BSTP Student) Sai Li (Postdoc) Zhonghua Liu (Instructor) Publications: Xiao's work spans structural biology, immunology, and translational medicine. His recent studies highlight the role of gasdermin D in pyroptosis, the development of small-molecule inhibitors, and the structural basis of nucleic acid sensing. These studies contribute to understanding inflammatory disorders and developing targeted therapies.

• Immunometabolism
• Inflammation
• Aging
• +۳ مورد دیگر

Hee-Hoon Kim is a Research Fellow in the Dixit Lab at Yale School of Medicine’s Department of Pathology. His research focuses on immunometabolic pathways, particularly in the context of inflammation and healthy aging. He investigates adipose tissue microenvironment changes during aging using novel models. Kim holds a PhD from KAIST (2022) and a postdoctoral position at KAIST (2023) before joining Yale. His work spans liver disease mechanisms, including alcoholic steatosis, non-alcoholic fatty liver disease (NAFLD), and immunological interactions in fibrosis. Key research areas include glutamate signaling, exosome-mediated therapies, and the role of natural killer and macrophage cells in hepatic pathologies. Recent studies explore NAC and Panax ginseng’s therapeutic potential in NAFLD, as well as IL-11’s role in inflammation and longevity. Kim’s publications emphasize translational approaches, combining molecular biology, systems immunology, and metabolic studies. Notable contributions include identifying GDF-15’s role in Kupffer cell apoptosis and mGluR5’s antifibrotic effects in liver fibrosis. His lab collaborations focus on co-culture systems and exosome-based drug delivery for liver injury mitigation.

Shruti Sharmaمشاهده پروفایل

استادیار

• Immunology
• Innate Immunity
• Nucleic Acid Sensing
• +۵ مورد دیگر

Dr. Shruti Sharma is an Assistant Professor in the Department of Immunology at Tufts University School of Medicine. Her laboratory investigates innate immune responses to nucleic acids, focusing on how these pathways regulate host metabolism, tissue remodeling, fibrosis, and wound healing. Key research examines intracellular DNA sensing mechanisms in immune homeostasis and their implications for inflammatory diseases, autoimmunity, aging, and neurodegeneration. Education: Doctor of Philosophy, University of Maryland, College Park (2008) Master of Science, University of Mumbai (2002) Bachelor of Science, University of Mumbai (2001) Research employs hypothesis-driven and next-generation approaches to map signaling pathways in homeostasis and disease models, aiming to elucidate mechanisms of inflammation resolution across physiological contexts. Awards & Honors: Faculty Awards for Distinguished Mentoring, University of Massachusetts Medical School (2015) Grant Support: NIH: STING-Dependent Pathways in Schistosome Immunopathology (2020-2024) NIH: Nucleic Acid Sensing in Age-Related Inflammation (2019-2023) Arthritis Foundation: STING Pathway in Bone Homeostasis (2017) Teaching activities include courses in Immunology, Cellular Immunology, Inflammation, and Journal Club at both graduate and undergraduate levels.

Lan Zhaoمشاهده پروفایل

استادیار

• Osteoarthritis Therapy
• Gene Editing (CRISPR)
• MicroRNA Regulation
• +۴ مورد دیگر

Lan Zhao, PhD, is an Assistant Professor in the Department of Orthopedic Surgery at Rush Medical College, Rush University. Her research focuses on understanding molecular mechanisms underlying joint degeneration and developing innovative therapies for osteoarthritis (OA) using CRISPR gene-editing technologies, microRNA regulation, and stem cell biology. Key areas of investigation include inflammatory pathways, bone remodeling, and the role of epigenetic regulators in joint homeostasis. Education details are not explicitly stated in the provided text, but her extensive publication history indicates advanced training in molecular biology and orthopedic research. Research interests prominently feature osteoarthritis pathogenesis, with emphasis on β-catenin signaling, miRNA networks (miR-204/211), and growth factor interactions. She has pioneered models for studying temporomandibular joint (TMJ) OA and disc degeneration through genetically engineered mouse studies. Her recent work (2020–2024) demonstrates exploration of CRISPR-mediated gene activation/inhibition for therapeutic purposes, investigating how targeting Sox9, RelA, and β-catenin can enhance cell-based therapies. She also examines systemic factors like metformin’s AMPK pathway effects on OA progression. Notable contributions include establishing novel immunocompetent cancer pain models and developing high-throughput viral detection strategies for pandemic response. No scientific awards are listed in the provided data. Her research spans translational medicine, molecular diagnostics (miRNA biomarkers), and cross-disciplinary approaches integrating immunology, genetics, and engineering. Collaborations likely involve orthopedic surgeons, geneticists, and bioengineers given the technical nature of her published work.

Paul Lavenderمشاهده پروفایل

مدرس ارشد

• Epigenetics
• Respiratory Diseases
• Immunology
• +۳ مورد دیگر

Paul Lavender is a Senior Lecturer in Respiratory Epigenetics and School Academic Lead for People & Culture at King's College London's School of Immunology & Microbial Sciences. He holds a PhD from St. Bartholomew's Hospital Medical College, University of London, with postdoctoral training at the Institut Recherches Cliniques de Montreal and the Wellcome/CRC (Gurdon Institute), Cambridge. His research focuses on epigenetic regulation in asthma and immune cell function, particularly glucocorticoid resistance mechanisms. He leads projects on Candida albicans pathogenicity, neonatal T-cell biology, and RNA-binding proteins in leukemia. Collaborations include work with Jon Richardson (FoDOCS) and Deena Gibbons. He is an editorial board member for Journal of Biological Chemistry and Journal of Immunology . Key achievements include multi-omics studies on epigenetic landscapes and machine learning in leukemia. His lab explores asthma epigenetics, T-cell differentiation, and vitamin D signaling in inflammation. Future endeavors include mountain sports and sustainable farming in Ireland.

Kathryn Miller-Jensenمشاهده پروفایل

دانشیار

• Immunology
• Cell Signaling
• Systems Biology
• +۴ مورد دیگر

Kathryn Miller-Jensen is an Associate Professor of Biomedical Engineering at Yale University's School of Engineering & Applied Science. Her research focuses on understanding how intracellular and extracellular signaling networks regulate immune cell functions, particularly in macrophage activation and HIV latency in T cells. She leads the Miller-Jensen Lab, which employs systems immunology approaches combining quantitative experiments with computational models to study cellular heterogeneity and response variability. Education: Ph.D. in Chemical Engineering from MIT (advisor: Doug Lauffenburger), B.E. & B.A. from Dartmouth College. Prior roles include NIH Postdoctoral Fellow at UC Berkeley and Science & Technology Policy Fellow at The National Academies. Research interests include: cellular response diversity in immunity, paracrine signaling in macrophage coordination, HIV reactivation dynamics, and systems-level analysis of tumor microenvironments. Key projects involve NF-κB signaling pathways and engineering tools to dissect immune responses. Selected Awards: NSF CAREER Award (2015), Cellular & Molecular Bioengineering Young Innovator (2014), SEAS Ackerman Teaching Award (2014) Lab activities include developing microfluidic devices for single-cell analysis and co-organizing Systems Immunology conferences. Current initiatives focus on macrophage communication heterogeneity and combinatorial immunotherapies for cancer.

Sophie Maiocchiمشاهده پروفایل

پژوهشگر ارشد

• Cardiovascular Disease
• Oxidative Stress
• Nanomedicine
• +۷ مورد دیگر

Sophie Maiocchi is a Research Fellow at the University of North Carolina at Chapel Hill (UNC), affiliated with the Department of Cell Biology and Physiology and the Bahnson research group. Her work focuses on redox biology, nanomedicine, and cardiovascular disease, particularly targeting oxidative stress mechanisms in atherosclerosis and diabetes-related pathologies. Education: Sophie holds an Advanced B.Sc. in Nanotechnology (University of New South Wales, Australia) and a Ph.D. in Pathology (UNSW Sydney, 2016). Her doctoral research under Professors Shane Thomas, Martin Rees, and Jonathan Morris investigated nitroxide-based inhibitors of myeloperoxidase-mediated endothelial dysfunction. Postdoctoral training at the University of Sydney with Prof. Shaun Jackson explored diabetic platelet dysfunction and thrombosis mechanisms. Research Interests: Her current research integrates synthetic chemistry and biomedical engineering to develop nanoparticle-based therapies for targeted antioxidant delivery to atherosclerotic plaques. Key areas include: Redox-based interventions for vascular diseases Myeloperoxidase inhibition strategies Nanoparticle-mediated drug targeting Diabetes-vascular complications interplay Platelet biology and thrombosis Publications: Her work spans 20+ peer-reviewed articles, emphasizing translational approaches like ARAPA nanoparticles (Nrf2-activating systems) and machine learning applications in atherosclerosis analysis. Recent contributions address mitochondrial transplantation therapies and DNase-1-loaded nanoparticles for thrombus resolution. Awards: No specific awards listed, though her research has been recognized through grants and institutional fellowships. Labs/Teams: Active member of the Bahnson cardiovascular research group at UNC, collaborating with interdisciplinary teams in nanomedicine and vascular biology.

Xintong Dongمشاهده پروفایل

استادیار

• Antimicrobial peptide signaling
• Host-microbe interactions
• Neuro-immune crosstalk
• +۴ مورد دیگر

Xintong Dong is an Assistant Professor of Biological Sciences at the University of Texas at Dallas (UT Dallas), affiliated with the School of Natural Sciences and Mathematics. Their research focuses on antimicrobial peptide signaling at host-microbe interfaces, with particular emphasis on neuro-immune interactions in skin diseases like psoriasis and urinary tract infections. Dr. Dong holds a B.S. in Biochemistry from the University of Wisconsin-Madison (2010), a Ph.D. in Biology from Stanford University (2016), and completed postdoctoral training in Neuroscience at Johns Hopkins University (2022). Key research areas include: Antimicrobial peptide signaling in UTIs and skin infections Neuro-immune crosstalk mechanisms driving psoriatic itch Host-microbe interactions in skin microbiota regulation Role of defensins in inflammatory and sensory neuron activation Recent work emphasizes fungal defensins' dual roles in itch/inflammation and the discovery of novel itch-modulating pathways. Publications (2021-2025) highlight breakthroughs in sensory neuron activation, defensin receptor biology, and therapeutic strategies for chronic pruritus. Awards include an NIH R01 grant (2024), National Psoriasis Foundation Discovery Award (2023), and Damon Runyon/HHMI Postdoctoral Fellowship (2017). Their lab investigates translational applications for antimicrobial peptide signaling in clinical settings, with active projects on itch modulation and microbial immune evasion mechanisms.

Tatiana Goretskyمشاهده پروفایل

استادیار

• Inflammatory Bowel Disease (IBD)
• Gastrointestinal Physiology
• Epithelial Cell Signaling
• +۷ مورد دیگر

Tatiana Goretsky, PhD, is an Assistant Professor in the Department of Internal Medicine at the University of Kentucky College of Medicine, with a focus on Digestive Health and Nutrition. Her research is centered on the molecular mechanisms underlying inflammatory bowel disease (IBD), epithelial cell signaling, and mucosal repair. Education: Masters in Physiology of Animals and Humans, Lomonosov State University, Moscow, Russia PhD in Biochemistry, Russian Academy of Sciences, Pushchino, Moscow Region, Russia Her research interests span Inflammatory Bowel Disease , β-catenin and NF-kappaB signaling , mitochondrial function in the gut , and epithelial cell apoptosis and regeneration . Her work integrates molecular biology, cell signaling, and translational gastroenterology to understand disease pathogenesis and identify therapeutic targets. Analysis of her recent publications reveals a strong focus on signaling pathways such as PI3K, β-catenin, and TNF in the context of intestinal injury, repair, and cancer. Her studies frequently explore how dysregulation of these pathways contributes to IBD and colitis-associated neoplasia, with emerging work on mitochondrial metabolism and microbiome interactions. Scientific Contributions: Investigated β-catenin cleavage and activation in colitis Elucidated roles of p53 and PHLPP in epithelial apoptosis Demonstrated TNF receptor signaling in mucosal repair Explored mitochondrial function in IBD pathogenesis Examined PI3K signaling in radiation-induced gut injury Dr. Goretsky actively collaborates with Dr. Terrence A. Barrett and other researchers in gastrointestinal pathobiology. While no formal advisees are listed, her publications suggest mentorship roles in collaborative research. She has no publicly listed scientific awards in the provided text. Her lab likely focuses on epithelial signaling mechanisms in digestive diseases, contributing to the broader mission of the Digestive Health and Nutrition division at UK.

• Cartilage Repair
• Stem Cell Biology
• Osteoarthritis
• +۳ مورد دیگر

Anke Roelofs is an Honorary Senior Lecturer affiliated with the School of Medicine, Medical Sciences and Nutrition. Her research focuses on regenerative medicine, stem cell biology, and musculoskeletal disorders, particularly osteoarthritis and cartilage repair. She investigates the molecular mechanisms underlying synovial fibroblast behavior, stem cell therapies, and the role of adipose tissue in joint health. Her work spans preclinical drug evaluations (e.g., Lorecivivint), immunological pathways (e.g., IL-6/PD-L1 interactions), and lipidomic profiling in joint tissues. Roelofs has contributed to understanding BMP signaling's role in osteoarthritis and the therapeutic potential of mesenchymal stromal cells. Her research highlights the interplay between inflammation, cell lineage hierarchies, and tissue regeneration. Recent studies emphasize mechano-activated chondroprogenitors and synovial joint progenitors as targets for regenerative therapies. She employs advanced techniques like single-cell resolution analysis and fluorescent bisphosphonate imaging to study cellular pathways and drug delivery mechanisms in skeletal tissues. Awards and grants are not explicitly mentioned in the provided texts, but her extensive publication record reflects sustained contributions to joint biology and regenerative strategies. Roelofs collaborates on translational research, bridging basic science with clinical applications in musculoskeletal disorders.

Gianrico Farrugiaمشاهده پروفایل

استاد

• Enteric Neurosciences
• Gastrointestinal Motility
• Ion Channel Physiology
• +۵ مورد دیگر

Gianrico Farrugia, M.D., is a Professor of Medicine and Physiology at Mayo Clinic, where he serves as Director of the Enteric Neuroscience Program. He holds the John H. Noseworthy and Jay Alix Distinguished Chair and is a leader in gastrointestinal motility research. His lab focuses on understanding cellular and molecular mechanisms underlying disorders like diabetic gastroparesis, slow transit constipation, and irritable bowel syndrome. Education: Completed medical training at the Royal University of Malta and advanced fellowships in physiology and gastroenterology at Mayo Clinic. Holds academic appointments in both Internal Medicine and Physiology & Biomedical Engineering. Research Interests: His work spans ion channel physiology, interstitial cells of Cajal, and the role of carbon monoxide in gut function. Recent studies include mechanisms of diabetic gastroparesis (linking M2 macrophage dysfunction to interstitial cell loss) and targeted therapies for sodium channel mutations in IBS. Techniques include high-resolution imaging, next-gen sequencing, and cellular models. Grants & Awards: Active NIH grants since 1997; received 2019 NGM Research Mentor Award and multiple academic honors. Leads the Mayo Center for Cell Signaling in Gastroenterology and collaborates with the NIDDK Gastroparesis Clinical Research Consortium. Labs & Teams: Heads the Cellular and Molecular Physiology of Gastrointestinal Disorders Lab, collaborating with the Enteric Neuroscience Program and international motility societies. Trains postdoctoral fellows in translational research.

David Briscoeمشاهده پروفایل

استاد

• Transplantation Immunology
• Chronic Allograft Rejection
• Pediatric Transplantation
• +۱۲ مورد دیگر

Dr. David Briscoe is a Professor of Pediatrics at Harvard Medical School and holds the Casey Lee Ball Chair in Transplantation at Boston Children's Hospital. He leads the Briscoe Lab and serves as Director of the Transplant Research Program, focusing on chronic allograft rejection and transplantation immunology. His research bridges basic science and clinical translation to improve long-term outcomes in pediatric organ transplantation. Professor of Pediatrics, Harvard Medical School Casey Lee Ball Chair in Transplantation, Boston Children's Hospital Director, Transplant Research Program Principal Investigator, T32 Training Grant (funded through 2025) Senior Editor, Transplantation Direct Dr. Briscoe earned his medical degree at the Royal College of Surgeons in Ireland and completed residency training in General Medicine and Pediatrics in Dublin, followed by Pediatric Residency at the University of Colorado and a postdoctoral fellowship in Pediatric Nephrology at Boston Children’s Hospital and Harvard Medical School. His research focuses on the intragraft microenvironment, endothelial-immune interactions, T cell regulation, and biomarker development. He investigates how leukocyte-endothelial crosstalk and signaling pathways like mTOR and chemokines influence chronic rejection. His lab applies discoveries to develop novel therapeutics and transformative care initiatives, particularly in pediatric transplantation. The 15 most recent publications (2015–2025) reveal a strong emphasis on immune monitoring using microfluidics, chemokine profiling, endothelial immunomodulation, and mTOR signaling. Key themes include subclinical rejection detection, autophagy in post-transplant cancer, and inflammation resolution mechanisms. His work integrates immunology, vascular biology, and translational engineering to advance personalized care. Among his honors are the Young Investigator Award and Basic Science Investigator Award from the American Society of Transplantation, and election to the American Society of Clinical Investigation. Young Investigator Award, American Society of Transplantation Basic Science Investigator Award, American Society of Transplantation Elected Member, American Society of Clinical Investigation Dr. Briscoe has been Principal Investigator of an NIH T32 training grant since 2008, mentoring postdoctoral fellows and supporting physician-scientist training. He has also held multiple NIH R01 grants supporting discovery-based research. He serves on NIH study sections and editorial boards, advocating for translational research and education in transplantation science. He leads the Briscoe Lab, which investigates the molecular basis of chronic rejection, and directs the Transplant Research Program at Boston Children’s Hospital. The program fosters innovation through interdisciplinary research on alloimmune responses, novel signaling pathways, and clinical translation to improve pediatric transplant outcomes.

• Cystic Fibrosis
• Primary Ciliary Dyskinesia
• Rhinology
• +۵ مورد دیگر

Virginie Escabasse is a Professor in the Department of ENT at the University of Paris Est Créteil, France. She is actively engaged in research and clinical work focusing on cystic fibrosis, primary ciliary dyskinesia, and rhinology in both children and adults. Her research interests lie at the intersection of otolaryngology and respiratory medicine, particularly in mucociliary disorders. She investigates the pathophysiology of ciliary dysfunction, inflammatory responses in nasal epithelia, and potential therapeutic agents such as specialized pro-resolving mediators. Her work bridges molecular mechanisms with clinical outcomes. The trends in her recent publications highlight a strong focus on cystic fibrosis and primary ciliary dyskinesia, particularly in sinonasal manifestations and ciliary dynamics. She integrates molecular biology with clinical studies, including prognostic assessments in viral infections like COVID-19. She has collaborated with numerous researchers across pneumology and ENT departments, though no formal awards are mentioned in the provided text. Virginie Escabasse contributes to multidisciplinary patient care through reference centers for rare respiratory diseases. Her work is supported by collaborative networks across France, particularly in the management of chronic rhinosinusitis and genetic respiratory conditions.

• Immunology
• Virology
• Molecular Biology
• +۷ مورد دیگر

Thomas Balligand is a researcher at the Namur Research Institute for Life Sciences, with significant contributions in immunology, virology, and nanobody engineering. His work spans both basic and translational research, focusing on novel therapeutic strategies against influenza viruses and cancer. He has strong collaborative ties with institutions such as Boston Children's Hospital and Harvard Medical School. Research Interests: Dr. Balligand's research is centered on the development of nanobody-based therapeutics. He investigates how engineered nanobodies—often derived from alpacas—can neutralize influenza viruses by targeting conserved regions like the hemagglutinin stem or immunoglobulin light chains. His work also extends to cancer immunotherapy, where he explores CAR NK cells armed with nanobodies targeting MICA+ tumors. Additionally, he contributes to structural studies of receptor mutants involved in oncogenesis, such as the thrombopoietin receptor. Publication Trends: Over the past decade, his research output has increasingly focused on engineered biologics for disease intervention. The most recent publications (2023–2025) highlight dual-function therapeutics, in vivo imaging tools, and structural insights into receptor activation. These works appear in high-impact journals such as Science Immunology , PNAS , and eLife , indicating strong scientific recognition. Scientific Awards: No specific awards are listed in the provided text. Advising and Grants: While no formal students are listed, his involvement in a doctoral thesis suggests mentorship activity. His research is likely supported by grants related to virology, immunology, and translational medicine, given the nature of his projects and institutional affiliations. Labs and Teams: Dr. Balligand is part of a collaborative network involving the Ploegh lab (known for nanobody and immune engineering) and works with teams specializing in molecular imaging, cancer immunotherapy, and structural biology. His use of congenic mouse models and PET imaging indicates access to advanced preclinical research infrastructure.

• Neuroblastoma
• Medulloblastoma
• Childhood Cancer
• +۵ مورد دیگر

Marie Arsenian Henriksson is a Professor and Academic Vice President at Karolinska Institutet, leading the "Neural differentiation as a strategy for neuroblastoma treatment" research group within the Department of Microbiology, Tumor and Cell Biology. Her work focuses on neuroblastoma, the most common extra-cranial solid tumor in children that causes the highest number of cancer-related deaths in infants, as well as medulloblastoma tumors. Her research primarily investigates the role of the MYCN oncogene, which is amplified in high-risk neuroblastoma patients and strongly associated with poor survival and an undifferentiated tumor phenotype. A key discovery from her group demonstrated that the MYCN-regulated miR-17~92 cluster targets multiple nuclear hormone receptors, with the glucocorticoid receptor (GR) emerging as particularly significant. They found that GR is a direct target of this miRNA cluster, is the most significantly downregulated nuclear hormone receptor in MYCN-amplified neuroblastoma, and shows high prognostic value for patient outcomes. Her research has revealed that low GR expression correlates with an undifferentiated phenotype and decreased patient survival. Importantly, her team showed that MYCN inhibition and subsequent reactivation of GR signaling promotes neural differentiation and reduces tumor burden. This work provides a potential differentiation-based therapeutic approach for treating neuroblastoma patients. Her research group has received substantial funding from numerous sources including the Swedish Research Council, Swedish Cancer Society, Swedish Childhood Cancer Foundation, Knut and Alice Wallenberg Foundation, and other major Swedish research organizations. Knut and Alice Wallenberg Grant for over 30M SEK (2016) Featured researcher of the month at The Swedish Childhood Cancer Foundation (2015) Professor Henriksson supervises multiple PhD students and maintains collaborations with both national and international research groups. Her work aims to translate basic molecular discoveries into novel therapeutic strategies for childhood cancers, with potential applications extending to other MYC-driven cancers.